chloroquine has been researched along with Abnormalities, Multiple in 3 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroquine treatment and other manipulations that produce chromatin defects in the absence of detectable double strand breaks also trigger ATM phosphorylation and the phosphorylation of p53 in primary human fibroblasts, while other downstream substrates of ATM that are involved in the repair of DNA double strand breaks remain unphosphorylated." | 1.33 | Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity. ( Gamo, K; Gartler, SM; Gatti, RA; Goldstine, JV; Hansen, RS; Marahrens, Y; Nahas, S; Roelfsema, JH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldstine, JV | 1 |
| Nahas, S | 1 |
| Gamo, K | 1 |
| Gartler, SM | 1 |
| Hansen, RS | 1 |
| Roelfsema, JH | 1 |
| Gatti, RA | 1 |
| Marahrens, Y | 1 |
| Ambroso, JL | 1 |
| Harris, C | 1 |
| Landauer, W | 1 |
3 other studies available for chloroquine and Abnormalities, Multiple
| Article | Year |
|---|---|
Constitutive phosphorylation of ATM in lymphoblastoid cell lines from patients with ICF syndrome without downstream kinase activity.
Topics: Abnormalities, Multiple; Androstadienes; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cy | 2006 |
Chloroquine embryotoxicity in the postimplantation rat conceptus in vitro.
Topics: Abnormalities, Multiple; Animals; Chloroquine; DNA; Embryo, Mammalian; Embryonic and Fetal Developme | 1993 |
Cholinomimetic teratogens. VI. The interaction of cholinomimetic teratogens with the antimalarial drugs chloroquine and chlorguanide.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Chick Embryo; Chloroquine; Drug Inter | 1978 |