chloroquine has been researched along with Abnormalities, Drug-Induced in 26 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone-proguanil (AP) is not recommended because of insufficient safety evidence." | 7.88 | A survey on outcomes of accidental atovaquone-proguanil exposure in pregnancy. ( Fairley, JK; Gutman, JR; Tan, KR; Wang, M, 2018) |
| "Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy." | 7.70 | Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998) |
| "Although the use of chloroquine (C) and hydroxychloroquine (HC) in the treatment of malaria prophylaxis during pregnancy is probably safe, the use of much higher doses for treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis during pregnancy has been controversial." | 7.68 | Pregnancy outcome following first trimester exposure to chloroquine. ( Buskila, D; Gladman, DD; Koren, G; Levy, M; Urowitz, MB, 1991) |
| "A cohort of 169 births to women who were exposed throughout pregnancy to chloroquine 300 mg base once a week for chemosuppression of malaria was studied." | 7.67 | Safety of chloroquine in chemosuppression of malaria during pregnancy. ( Cordero, JF; Wolfe, MS, 1985) |
| " D-Penicillamine may be teratogenic thus it should not be commenced during pregnancy and if a patient becomes pregnant whilst receiving the drug, it should be slowly withdrawn or the dosage reduced." | 4.77 | Antirheumatic medication in pregnancy. ( Brooks, PM; Needs, CJ, 1985) |
| "Malaria chemoprophylaxis options in pregnancy are limited, and atovaquone-proguanil (AP) is not recommended because of insufficient safety evidence." | 3.88 | A survey on outcomes of accidental atovaquone-proguanil exposure in pregnancy. ( Fairley, JK; Gutman, JR; Tan, KR; Wang, M, 2018) |
| "Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy." | 3.70 | Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998) |
| "Although the use of chloroquine (C) and hydroxychloroquine (HC) in the treatment of malaria prophylaxis during pregnancy is probably safe, the use of much higher doses for treatment of systemic lupus erythematosus (SLE) and rheumatoid arthritis during pregnancy has been controversial." | 3.68 | Pregnancy outcome following first trimester exposure to chloroquine. ( Buskila, D; Gladman, DD; Koren, G; Levy, M; Urowitz, MB, 1991) |
| "A cohort of 169 births to women who were exposed throughout pregnancy to chloroquine 300 mg base once a week for chemosuppression of malaria was studied." | 3.67 | Safety of chloroquine in chemosuppression of malaria during pregnancy. ( Cordero, JF; Wolfe, MS, 1985) |
| " It also appears that although the individual enantiomers show minimal embryotoxicity at the dosage used, they potentiate each other's effects in the racemic mixture." | 1.29 | Effects of chloroquine and its enantiomers on the development of rat embryos in vitro. ( Ofori-Adjei, D; Tagoe, CN, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (73.08) | 18.7374 |
| 1990's | 5 (19.23) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tan, KR | 1 |
| Fairley, JK | 1 |
| Wang, M | 1 |
| Gutman, JR | 1 |
| SPILLANE, JD | 1 |
| HART, CW | 1 |
| NAUNTON, RF | 2 |
| Wiltz, SA | 1 |
| Crawford, P | 1 |
| Nichols, W | 1 |
| Hayes, M | 1 |
| D'Arcy, PF | 1 |
| Howard, EM | 1 |
| Shao, BR | 1 |
| Zhan, CQ | 1 |
| Ha, SH | 1 |
| Ni, YC | 1 |
| Tanenbaum, L | 1 |
| Tuffanelli, DL | 1 |
| Feberwee, JD | 1 |
| Karol, MD | 1 |
| Conner, CS | 1 |
| Watanabe, AS | 1 |
| Murphrey, KJ | 1 |
| Brain, SD | 1 |
| de Silva, HA | 1 |
| Walker, B | 2 |
| Tagoe, CN | 1 |
| Ofori-Adjei, D | 1 |
| Phillips-Howard, PA | 1 |
| Steffen, R | 1 |
| Kerr, L | 1 |
| Vanhauwere, B | 1 |
| Schildknecht, J | 1 |
| Fuchs, E | 1 |
| Edwards, R | 1 |
| Landauer, W | 1 |
| Yielding, LW | 1 |
| Riley, TL | 1 |
| Yielding, KL | 1 |
| Cook, GC | 1 |
| Levy, M | 1 |
| Buskila, D | 1 |
| Gladman, DD | 1 |
| Urowitz, MB | 1 |
| Koren, G | 1 |
| Sharma, A | 1 |
| Rawat, AK | 1 |
| Burkhard, W | 1 |
| Fritz-Niggli, H | 1 |
| Harrison, HC | 1 |
| Needs, CJ | 1 |
| Brooks, PM | 1 |
| Wolfe, MS | 1 |
| Cordero, JF | 1 |
| Trnavský, K | 1 |
| Trnavská, Z | 1 |
| Warner, C | 1 |
| Lewis, R | 1 |
| Lauersen, NH | 1 |
| Birnbaum, S | 1 |
| Copeman, PW | 1 |
| Matz, GJ | 1 |
5 reviews available for chloroquine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Clinical inquiries. What is the most effective and safe malaria prophylaxis during pregnancy?
Topics: Abnormalities, Drug-Induced; Antimalarials; Chemoprevention; Chloroquine; Doxycycline; Female; Human | 2008 |
Antimalarial agents. Chloroquine, hydroxychloroquine, and quinacrine.
Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents; Chloroquine; DNA; Eye Diseases; Female; Hemat | 1980 |
The use of chloroquine during pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Chloroquine; Female; Humans; Malaria; Pregnancy; Pregnancy Com | 1994 |
Antirheumatic medication in pregnancy.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Antineoplas | 1985 |
Chloroquine.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Child; Chloroquine; Enzymes; Eye Diseases; Fema | 1967 |
21 other studies available for chloroquine and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
A survey on outcomes of accidental atovaquone-proguanil exposure in pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antimalarials; Atovaquone; Chemopreventio | 2018 |
IATROGENIC NEUROLOGICAL DISEASES. DRUG-INDUCED NEUROLOGICAL DISORDERS.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Anti-Bacterial Agents; Antihypertensive Agents | 1964 |
THE OTOTOXICITY OF CHLOROQUINE PHOSPHATE.
Topics: Abnormalities, Drug-Induced; Abortion, Induced; Ataxia; Cerebellar Diseases; Child; Chloroquine; Coc | 1964 |
A new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Animals; Anti-Inflammatory Agents; Betamethaso | 1967 |
[Embryotoxicity of chloroquine and pyrimethamine in rats].
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Chloroquine; Embryo, Mammalian; F | 1983 |
A pyrimethamine-chloroquine combination for malaria prophylaxis during pregnancy.
Topics: Abnormalities, Drug-Induced; Chloroquine; Drug Combinations; Female; Fetus; Humans; Malaria; Pregnan | 1982 |
Podophyllum: suspected teratogenicity from topical application.
Topics: Abnormalities, Drug-Induced; Administration, Topical; Adult; Chloroquine; Condylomata Acuminata; Fem | 1980 |
Effects of chloroquine and its enantiomers on the development of rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Anthropometry; Antimalarials; Chloroquine; Embryo, Mammalian; | 1995 |
Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Adverse Drug Reaction Reporting Systems; | 1998 |
Cholinomimetic teratogens. VI. The interaction of cholinomimetic teratogens with the antimalarial drugs chloroquine and chlorguanide.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Chick Embryo; Chloroquine; Drug Inter | 1978 |
Preliminary study of caffeine and chloroquine enhancement of x-ray induced birth defects.
Topics: Abnormalities, Drug-Induced; Animals; Caffeine; Chloroquine; Drug Synergism; Female; Male; Mice; Mic | 1976 |
Use of antiprotozoan and anthelmintic drugs during pregnancy: side-effects and contra-indications.
Topics: Abnormalities, Drug-Induced; Anthelmintics; Antimalarials; Antiprotozoal Agents; Chloroquine; Contra | 1992 |
Pregnancy outcome following first trimester exposure to chloroquine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adolescent; Adult; Arthritis, Rheumatoid; Chloro | 1991 |
Toxicological consequences of chloroquine and ethanol on the developing fetus.
Topics: Abnormalities, Drug-Induced; Animals; Chloroquine; Embryonic and Fetal Development; Ethanol; Rats; R | 1989 |
Antiteratogenic and anticarcinogenic effects of X-rays in urethane-treated NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Ascorbic Acid; Chloroquine; Female; Lung Neoplasms; Male; Mice | 1987 |
Chemoprophylaxis of malaria.
Topics: Abnormalities, Drug-Induced; Chloroquine; Deafness; Female; Humans; Infant, Newborn; Lupus Erythemat | 1986 |
Safety of chloroquine in chemosuppression of malaria during pregnancy.
Topics: Abnormalities, Drug-Induced; Chloroquine; Female; Humans; Infant, Newborn; Malaria; Male; Pregnancy; | 1985 |
The effect of antirheumatic drugs on the extractable collagen in lathyric chick embryos.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Animals; Chick Embryo; Chloroquine; Collagen; Hydro | 1968 |
Proceedings: A preliminary investigation of the teratogenic action of chloroquine in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Chloroquine; Female; Pregnancy; Rats; Teratogens | 1974 |
Malaria associated with pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Chloroquine; Female; Humans; Malaria; Plasmodium falciparum; Pre | 1973 |
Ototoxicity of chloroquine.
Topics: Abnormalities, Drug-Induced; Child; Chloroquine; Cochlea; Deafness; Female; Humans; Infant, Newborn; | 1968 |