Robotic surgery (Auckland), 2017, Volume: 4Current practice in neurosurgical needle insertion is limited by the straight trajectories inherent with rigid probes. One technique allowing curvilinear trajectories involves flexible bevel-tipped needles, which bend during insertion due to their asymmetry. In the brain, safety will require avoidance of the sharp tips often used in laboratory studies, in favor of a more rounded profile. Steering performance, on the other hand, requires maximal asymmetry. Design of safe bevel-tipped brain needles thus involves management of this tradeoff by adjusting needle gauge, bevel angle, and fillet (or tip) radius to arrive at a design that is suitably asymmetrical while producing strain, strain rate, and stress below the levels that would damage brain tissue.. The prototype needle selected was 1.66 mm in diameter, with bevel angle of 10° and fillet radius of 0.25 mm. Upon examination of postoperative CT and histological images, no differences in tissue trauma or hemorrhage were noted between the prototype needle and the Sedan needle.. The study indicates a general design technique for safe bevel-tipped brain needles based on comparison with relevant damage thresholds for strain, strain rate, and stress. The full potential of the technique awaits the determination of more exact safety thresholds.. Immunological responses after stings varied in bee and vespid venom-allergic patients. In patients under VIT, sIgE and sIgG Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alkaline Phosphatase; Allergens; Animals; Antibody Specificity; Arthropod Venoms; Asymptomatic Diseases; Biological Variation, Population; Blood Cells; Catalysis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Count; Chlorophyll; Chlorophyll A; Chlorophyta; Cross-Sectional Studies; Crystallography, X-Ray; Dehydration; Dietary Supplements; Electromagnetic Fields; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Exercise; Exercise Therapy; Female; Goats; Hand Strength; Hemoglobins; Humans; Hypersensitivity; Immunoassay; Immunoglobulin E; Immunoglobulin G; Insect Bites and Stings; Lab-On-A-Chip Devices; Lichens; Light; Long-Term Care; Male; Mice; Microfluidic Analytical Techniques; Middle Aged; Muscle, Skeletal; Mutation; Osmotic Pressure; Paper; Peroxidases; Phenotype; Photosynthetic Reaction Center Complex Proteins; Polychaeta; Powders; Rabbits; Radio Frequency Identification Device; Rats; Rats, Sprague-Dawley; Sarcopenia; Seasons; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Streptavidin; Substrate Specificity; Textiles; Water; Whole-Body Irradiation; Young Adult | 2017 |