chlorophyll-a has been researched along with Poisoning* in 3 studies
1 trial(s) available for chlorophyll-a and Poisoning
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Promotive excretion of causative agents of Yusho by one year intake of FBRA in Japanese people.
Thirty-six years have passed since the outbreak of Kanemi rice oil poisoning, namely, Yusho in the western Japan. However, even now the patients with Yusho have been still suffering from several objective and subjective symptoms. In order to improve or, if possible, to cure the such symptoms, the most important therapeutic treatment is considered to actively excrete the causative agents, that is, polychlorinated dibenzofurans (PCDFs) and polychlorinated dibenzo-p-dioxins (PCDDs) from the bodies of the patients and to reduce their body burdens. In rats, dietary fiber and chlorophyll have been shown to promote the fecal excretion of dioxins and to reduce their levels in rat liver. In this study, we examined whether such kinds of effect were also observed by FBRA, which was the health food and relatively rich with dietary fiber and chlorophyll, in nine married Japanese couples. As a result, concentrations of PCDFs and PCDDs on the lipid weight basis in the blood of the FBRA-intake group in which they took 7.0 to 10.5g of FBRA after each meal and three times a day for one year were more lowered than those in the blood of the non-intake group; Blood levels of PCDFs and PCDDs in the FBRA-intake group were decreased by 41.0 and 37.2%, respectively, and those decreases were 33.7 and 29.4% in the non-intake group. Their total body burdens just before and one year after the study were calculated on the assumptions that the body fat was also contaminated with these dioxins at their blood levels on the lipid weight basis and the content of body fat was 20% of the body weight. Then, we computed the average amounts in excretion of PCDFs and PCDDs from the body in both the FBRA-intake and non-intake groups. Consequently, the amounts of excretion of PCDFs and PCDDs in the FBRA-intake group were 1.81 and 1.74 times, respectively, greater than those in the non-intake group. Therefore, FBRA seemed to promote the fecal excretion of causative agents of Yusho, from the human body. We also expect FBRA to reduce their body burdens of patients with Yusho and to improve some objective and subjective symptoms of Yusho patients. Topics: Adult; Animals; Benzofurans; Body Burden; Chlorophyll; Dibenzofurans, Polychlorinated; Dietary Fiber; Feces; Female; Food Contamination; Food, Organic; Humans; Japan; Male; Middle Aged; Oryza; Plant Oils; Poisoning; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Rats; Time Factors | 2005 |
2 other study(ies) available for chlorophyll-a and Poisoning
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Physiological characterization of Chlamydomonas reinhardtii acclimated to chronic stress induced by Ag, Cd, Cr, Cu and Hg ions.
Acclimation to heavy metal-induced stress is a complex phenomenon. Among the mechanisms of heavy metal toxicity, an important one is the ability to induce oxidative stress, so that the antioxidant response is crucial for providing tolerance to heavy metal ions. The effect of chronic stress induced by ions of five heavy metals, Ag, Cu, Cr (redox-active metals) Cd, Hg (nonredox-active metals) on the green microalga Chlamydomonas reinhardtii was examined at two levels - the biochemical (content of photosynthetic pigments and prenyllipid antioxidants, lipid peroxidation) and the physiological (growth rate, photosynthesis and respiration rates, induction of nonphotochemical quenching of chlorophyll fluorescence). The expression of the genes which encode the enzymes participating in the detoxification of reactive oxygen species (APX1, CAT1, FSD1, MSD1) was measured. The other gene measured was one required for plastoquinone and α-tocopherol biosynthesis (VTE3). The application of heavy metal ions partly inhibited growth and biosynthesis of chlorophyll. The growth inhibition was accompanied by enhanced lipid peroxidation. An increase in the content of prenyllipid antioxidants was observed in cultures exposed to Cr2O7(2-), Cd(2+) (α- and γ-tocopherol and plastoquinone) and Cu(2+) (only tocopherols). The induction of nonphotochemical quenching was enhanced in cultures exposed to Cu(2+), Cr2O7(2-) and Cd(2+), as compared to the control. Chronic heavy metal-induced stress led to changes in gene expression dependent on the type and concentration of heavy metal ions. The up-regulation of antioxidant enzymes was usually accompanied by the up-regulation of the VTE3 gene. Topics: Adaptation, Physiological; Antioxidants; Chlamydomonas reinhardtii; Chlorophyll; Environmental Pollutants; Gene Expression Regulation; Heavy Metal Poisoning; Ions; Lipid Peroxidation; Lipid Peroxides; Metals, Heavy; Oxidative Stress; Photosynthesis; Poisoning; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Respiration; Up-Regulation | 2016 |
Excess copper induced proteomic changes in the marine brown algae Sargassum fusiforme.
Copper (Cu) is an essential micronutrient for algal growth and development; however, it is also generally considered to be one of the most toxic metals when present at higher levels. Seaweeds are often exposed to low concentrations of metals, including Cu, for long time periods. In cases of ocean outfall, they may even be abruptly exposed to high levels of metals. The physiological processes that are active under Cu stress are largely unknown. In this study, the brown macroalga Sargassum fusiforme was cultured in fresh seawater at final Cu concentrations of 0, 4, 8, 24 and 47 μM. The Cu(2+) concentration and chlorophyll autofluorescence were measured to establish the toxic effects of Cu on this economically important seaweed. The accumulation of Cu by S. fusiforme was also dependent upon the external Cu concentration. Algal growth displayed a general decline with increasing media Cu concentrations, indicating that S. fusiforme was able to tolerate Cu stress at low concentrations, while it was negatively impacted at high concentrations. The term "acute stress" was employed to indicate exposure to high Cu concentrations for 1 day in this study. On the other hand, "chronic stress" was defined as exposure to lower sub-lethal Cu concentrations for 7 days. Proteins were extracted from control and Cu-treated S. fusiforme samples and separated by two-dimensional gel electrophoresis. Distinct patterns of protein expression in the acute and chronic stress conditions were observed. Proteins related to energy metabolism and photosynthesis were reduced significantly, whereas those related to carbohydrate metabolism, protein destination, RNA degradation and signaling regulation were induced in S. fusiforme in response to acute copper stress. Energy metabolism-related proteins were significantly induced by chronic Cu stress. Proteins from other functional groups, such as those related to membranes and transport, were present in minor quantities. These results suggest that S. fusiforme is sensitive to excess Cu, regardless of the presence of acute or chronic stress. We discuss the possible function of these identified proteins, taking into consideration the information available from other plant models. Topics: Chlorophyll; Copper; Electrophoresis, Gel, Two-Dimensional; Energy Metabolism; Environmental Monitoring; Heavy Metal Poisoning; Metals, Heavy; Photosynthesis; Poisoning; Proteome; Proteomics; Sargassum; Seawater; Seaweed; Water Pollutants, Chemical | 2015 |