chlorophyll-a and Glioblastoma

chlorophyll-a has been researched along with Glioblastoma* in 1 studies

Other Studies

1 other study(ies) available for chlorophyll-a and Glioblastoma

Article	Year
Squalene-PEG: Pyropheophorbide-a nanoconstructs for tumor theranostics. Nanomedicine : nanotechnology, biology, and medicine, 2019, Volume: 15, Issue:1 Novel nanoscale drug delivery biomaterials are of great importance for the diagnosis and treatment of different cancers. We have developed a new pegylated squalene (SQ-PEG) derivative with self-assembly properties. Supramolecular assembly with a lipophilic photosensitizer pyropheophorbide-a (Ppa) by nanoprecipitation gave nanoconstructs SQ-PEG:Ppa with an average size of 200 nm in diameter and a drug loading of 18% (w/w). The composite material demonstrates nanoscale optical properties by tight packing of Ppa within Sq-PEG:Ppa resulting in 99.99% fluorescence self-quenching. The biocompatibility of the nanomaterial and cell phototoxicity under light irradiation were investigated on PC3 prostate tumor cells in vitro. SQ-PEG:Ppa showed excellent phototoxic effect at low light dose of 5.0 J/cm Topics: Animals; Apoptosis; Cell Proliferation; Chick Embryo; Chlorophyll; Chorioallantoic Membrane; Drug Delivery Systems; Female; Glioblastoma; Humans; Light; Male; Mice; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Prostatic Neoplasms; Squalene; Theranostic Nanomedicine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019

Article

Year

Squalene-PEG: Pyropheophorbide-a nanoconstructs for tumor theranostics.

Nanomedicine : nanotechnology, biology, and medicine, 2019, Volume: 15, Issue:1

Novel nanoscale drug delivery biomaterials are of great importance for the diagnosis and treatment of different cancers. We have developed a new pegylated squalene (SQ-PEG) derivative with self-assembly properties. Supramolecular assembly with a lipophilic photosensitizer pyropheophorbide-a (Ppa) by nanoprecipitation gave nanoconstructs SQ-PEG:Ppa with an average size of 200 nm in diameter and a drug loading of 18% (w/w). The composite material demonstrates nanoscale optical properties by tight packing of Ppa within Sq-PEG:Ppa resulting in 99.99% fluorescence self-quenching. The biocompatibility of the nanomaterial and cell phototoxicity under light irradiation were investigated on PC3 prostate tumor cells in vitro. SQ-PEG:Ppa showed excellent phototoxic effect at low light dose of 5.0 J/cm

Topics: Animals; Apoptosis; Cell Proliferation; Chick Embryo; Chlorophyll; Chorioallantoic Membrane; Drug Delivery Systems; Female; Glioblastoma; Humans; Light; Male; Mice; Nanoparticles; Photochemotherapy; Photosensitizing Agents; Polyethylene Glycols; Prostatic Neoplasms; Squalene; Theranostic Nanomedicine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2019