chlorogenic-acid has been researched along with Seizures* in 1 studies
1 other study(ies) available for chlorogenic-acid and Seizures
| Article | Year |
|---|---|
Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity.
On high performance liquid chromatography, the caffeoylquinic acid (CQ) occupying the highest proportion of the water-ethanol (7:3) extract of Aster glehni (Compositae) leaves was 3-Op-coumaroylquinic acid (46.10 ± 4.22 mg/g of dried weight) among CQs tested. The IC₅₀ of the water-ethanol (7:3) extract was 4.23 ± 0.24 μg/mL in the peroxynitrite (ONOO(-))-scavenging assay. Phytochemical isolation from A. glehni extract yielded three kaempferol glycosides. The water-ethanol (7:3) extract and both p-coumaric acid and caffeic acid, phenylpropanoid moieties of CQs, had sedative effects in pentobarbital-induced sleeping time in mice and anticonvulsant effects in pentylenetetrazole-induced mice. Furthermore, the phenolic substance-rich W-E (7:3) extract of A. glehni could be used to treat anxiety or convulsion partly due to its peroxynitrite-scavenging mechanism. Topics: Animals; Anticonvulsants; Aster Plant; Chromatography, High Pressure Liquid; Disease Models, Animal; Ethanol; Free Radical Scavengers; Hypnotics and Sedatives; Kaempferols; Male; Mice; Mice, Inbred ICR; Pentobarbital; Pentylenetetrazole; Peroxynitrous Acid; Phenols; Plant Extracts; Plant Leaves; Quinic Acid; Seizures; Sleep; Solvents; Time Factors; Water | 2012 |