chlorogenic-acid has been researched along with Hepatitis-C* in 1 studies
1 other study(ies) available for chlorogenic-acid and Hepatitis-C
| Article | Year |
|---|---|
Synthesis, Anti-HCV, Antioxidant and Reduction of Intracellular Reactive Oxygen Species Generation of a Chlorogenic Acid Analogue with an Amide Bond Replacing the Ester Bond.
Chlorogenic acid is a well known natural product with important bioactivities. It contains an ester bond formed between the COOH of caffeic acid and the 3-OH of quinic acid. We synthesized a chlorogenic acid analogue, 3α-caffeoylquinic acid amide, using caffeic and quinic acids as starting materials. The caffeoylquinc acid amide was found to be much more stable than chlorogenic acid and showed anti-Hepatitis C virus (anti-HCV) activity with a potency similar to chlorogenic acid. The caffeoylquinc acid amide potently protected HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide. Topics: Amides; Antioxidants; Caffeic Acids; Chlorogenic Acid; Esters; Hepatitis C; Humans; Oxidative Stress; Quinic Acid; Reactive Oxygen Species; tert-Butylhydroperoxide | 2016 |