Compounds > chlorocresol
Page last updated: 2024-10-21

chlorocresol and Muscle Contraction

chlorocresol has been researched along with Muscle Contraction in 34 studies

chlorocresol: injections for relief of intractable pain; RN given refers to parent cpd
4-chloro-m-cresol : A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

ExcerptRelevanceReference
" Furthermore, an increase in cytosolic Ca(2+) activity induced a more marked shift of dose-response curves toward lower concentrations for 4-CmC than caffeine."1.31Differential effects of 4-chloro-m-cresol and caffeine on skinned fibers from rat fast and slow skeletal muscles. ( Choisy, S; Huchet-Cadiou, C; Léoty, C, 2000)
" MHEh muscles revealed a dose-response curve similar to that found in MHN specimens."1.30Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol. ( Bittner, RE; Fricker, R; Gilly, H; Kress, HG; Musat, I; Steinbereithner, K, 1997)
"Chlorocresol was demonstrated to be a potent activator of Ca++ release from skeletal muscle sarcoplasmic reticulum."1.30[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients]. ( Adnet, PJ; Ben-Abraham, R; Haudcoeur, G; Krivosic-Horber, RM; Perel, A, 1997)
" The aims of this study were to (1) examine the in vivo effects of 4-chloro-m-cresol on swine susceptible to malignant hyperthermia and (2) contrast in vivo versus in vitro dose-response curves."1.304-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations. ( Gallagher, WJ; Iaizzo, PA; Johnson, BA; Nagao, K, 1999)
"If an unequivocal episode of malignant hyperthermia occurred, as indicated by venous carbon dioxide concentration > or = 70 mmHg, pH < or = 7."1.304-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine. ( Fiege, M; Kolodzie, K; Kudlik, C; Scholz, J; Schulte am Esch, J; Wappler, F; Weisshorn, R, 1999)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19902 (5.88)18.7374
1990's11 (32.35)18.2507
2000's17 (50.00)29.6817
2010's3 (8.82)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Skaliczki, M1
Lukács, B1
Magyar, ZÉ1
Kovács, T1
Bárdi, M1
Novák, S1
Diszházi, G1
Sárközi, S2
Márton, I1
Péli-Szabó, J1
Jóna, I1
Nánási, P1
Almássy, J1
Johannsen, S1
Treves, S3
Müller, CR1
Mögele, S1
Schneiderbanger, D1
Roewer, N2
Schuster, F1
Kaufmann, A1
Kraft, B1
Michalek-Sauberer, A1
Weigl, LG2
Prosser, BL1
Hernández-Ochoa, EO1
Lovering, RM1
Andronache, Z1
Zimmer, DB1
Melzer, W2
Schneider, MF1
Ullrich, ND1
Fischer, D1
Kornblum, C1
Walter, MC1
Niggli, E1
Zorzato, F2
Oba, T1
Kurono, C1
Nakajima, R1
Takaishi, T1
Ishida, K1
Fuller, GA1
Klomkleaw, W1
Yamaguchi, M1
Allen, PD3
López, JR1
Sei, Y1
Brandom, BW1
Bina, S1
Hosoi, E1
Gallagher, KL1
Wyre, HW1
Pudimat, PA1
Holman, SJ1
Venzon, DJ1
Daly, JW1
Muldoon, S1
Klingler, W3
Baur, C1
Georgieff, M2
Lehmann-Horn, F4
Yang, T1
Ta, TA1
Pessah, IN2
Wappler, F4
Anetseder, M2
Baur, CP2
Censier, K1
Doetsch, S1
Felleiter, P2
Fiege, M4
Fricker, R3
Halsall, PJ1
Hartung, E2
Heffron, JJ2
Heytens, L1
Hopkins, PM1
Nivoche, Y1
Tegazzin, V3
Tzanova, I1
Urwyler, A1
Weisshorn, R2
Schulte am Esch, J3
BIGGS, DF1
Wehner, M2
Rueffert, H2
Koenig, F2
Olthoff, D2
Ludwig-Papst, C1
Kress, HG2
Yamada, T1
Mishima, T1
Sakamoto, M1
Sugiyama, M1
Matsunaga, S1
Wada, M1
González Narváez, AA1
Castillo, A1
Herrmann-Frank, A2
Richter, M1
Mohr, U1
Scutari, E1
Gilly, H1
Musat, I1
Bittner, RE1
Steinbereithner, K1
Ben-Abraham, R1
Krivosic-Horber, RM1
Haudcoeur, G1
Perel, A1
Adnet, PJ1
Gronert, GA1
Ording, H2
Glahn, K2
Gardi, T1
Fagerlund, T1
Bendixen, D1
Scholz, J2
von Richthofen, V1
Steinfath, M1
Westerblad, H1
Andrade, FH1
Islam, MS1
Iaizzo, PA1
Johnson, BA1
Nagao, K1
Gallagher, WJ1
Kolodzie, K1
Kudlik, C1
Ingalls, CP1
Warren, GL1
Armstrong, RB1
Bellon, L1
Jurkat-Rott, K1
Lehane, M1
Ritter, L1
Horbaschek, H1
Choisy, S2
Huchet-Cadiou, C2
Léoty, C2
Fessenden, JD1
Wang, Y1
Moore, RA1
Chen, SR1
Divet, A1
Galloway, GJ1
Denborough, MA1

Trials

2 trials available for chlorocresol and Muscle Contraction

ArticleYear
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
    European journal of anaesthesiology, 2003, Volume: 20, Issue:7

    Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant

2003
A multicenter study of 4-chloro-m-cresol for diagnosing malignant hyperthermia susceptibility.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:1

    Topics: Caffeine; Central Nervous System Stimulants; Cresols; Europe; Humans; In Vitro Techniques; Malignant

2000

Other Studies

32 other studies available for chlorocresol and Muscle Contraction

ArticleYear
4-chloro-orto-cresol activates ryanodine receptor more selectively and potently than 4-chloro-meta-cresol.
    Cell calcium, 2020, Volume: 88

    Topics: Adenosine Triphosphatases; Animals; Caffeine; Calcium; Cresols; Hydrolysis; Ion Channel Gating; Ions

2020
Functional characterization of the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia.
    Neuromuscular disorders : NMD, 2016, Volume: 26, Issue:1

    Topics: Anesthetics; Arginine; B-Lymphocytes; Caffeine; Cell Line, Transformed; Cresols; Family Health; Fema

2016
Novel ryanodine receptor mutation that may cause malignant hyperthermia.
    Anesthesiology, 2008, Volume: 109, Issue:3

    Topics: Amino Acid Substitution; Anesthetics, Inhalation; Austria; Caffeine; Calcium; Cells, Cultured; Centr

2008
S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle.
    American journal of physiology. Cell physiology, 2010, Volume: 299, Issue:5

    Topics: Action Potentials; Aniline Compounds; Animals; Biomarkers; Calcium; Chelating Agents; Cresols; Egtaz

2010
Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle.
    Human mutation, 2011, Volume: 32, Issue:3

    Topics: Calcium; Calcium Channels; Calcium Channels, L-Type; Caveolin 3; Cells, Cultured; Cresols; Excitatio

2011
H2O2 activates ryanodine receptor but has little effect on recovery of releasable Ca2+ content after fatigue.
    Journal of applied physiology (Bethesda, Md. : 1985), 2002, Volume: 93, Issue:6

    Topics: Animals; Caffeine; Calcium; Catalase; Cresols; Homeostasis; Hydrogen Peroxide; Membrane Potentials;

2002
"Noninvasive" testing for malignant hyperthermia susceptibility.
    Anesthesiology, 2002, Volume: 97, Issue:5

    Topics: Caffeine; Calcium; Cresols; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscl

2002
Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.
    Anesthesiology, 2002, Volume: 97, Issue:5

    Topics: Adolescent; Adult; B-Lymphocytes; Caffeine; Calcium; Child; Cresols; Disease Susceptibility; Halotha

2002
Detection of proton release from cultured human myotubes to identify malignant hyperthermia susceptibility.
    Anesthesiology, 2002, Volume: 97, Issue:5

    Topics: Calcium; Cells, Cultured; Cresols; Disease Susceptibility; Dose-Response Relationship, Drug; Humans;

2002
Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling.
    The Journal of biological chemistry, 2003, Jul-11, Volume: 278, Issue:28

    Topics: Animals; Caffeine; Calcium; Cell Membrane; Central Nervous System Stimulants; Collagen; Cresols; DNA

2003
EXPERIMENTS ON THE MECHANISM OF ACTION OF CHLOROCRESOL AND CAFFEINE.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Acetylcholine; Animals; Anura; Caffeine; Calcium; Cholinesterase Inhibitors; Cresols; Cyanides; Edet

1965
Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.
    Genetic testing, 2003,Fall, Volume: 7, Issue:3

    Topics: Adult; Aged; Caffeine; Calcium; Child; Child, Preschool; Cresols; Female; Genetic Predisposition to

2003
Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.
    Neuromuscular disorders : NMD, 2004, Volume: 14, Issue:7

    Topics: Adolescent; Adult; Aged; Anesthetics; Biopsy; Caffeine; Calcium; Cells, Cultured; Central Nervous Sy

2004
4-chloro-m-cresol cannot detect malignant hyperthermia equivocal cells in an alternative minimally invasive diagnostic test of malignant hyperthermia susceptibility.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:1

    Topics: Caffeine; Calcium; Calibration; Cells, Cultured; Central Nervous System Stimulants; Cresols; DNA Mut

2004
Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 100, Issue:5

    Topics: Animals; Body Weight; Cresols; Glutathione; Hyperthyroidism; Immunoblotting; Male; Muscle Contractio

2006
Ca2+ store determines gating of store operated calcium entry in mammalian skeletal muscle.
    Journal of muscle research and cell motility, 2007, Volume: 28, Issue:2-3

    Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cells, Cultured; Cr

2007
4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor.
    Biochimica et biophysica acta, 1996, Feb-09, Volume: 1289, Issue:1

    Topics: Animals; Calcium; Calcium Channels; Cresols; Muscle Contraction; Muscle Proteins; Muscle, Skeletal;

1996
Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel.
    Anesthesiology, 1996, Volume: 84, Issue:6

    Topics: Animals; Caffeine; Calcium; Calcium Channels; Cresols; Dose-Response Relationship, Drug; Humans; In

1996
Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:1

    Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Cresols; Disease Susceptibility; Dose-Re

1997
[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients].
    Harefuah, 1997, Jun-15, Volume: 132, Issue:12

    Topics: Adolescent; Adult; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques

1997
Testing for MH susceptibility.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:8

    Topics: Cresols; Disease Susceptibility; Genetic Markers; Humans; Malignant Hyperthermia; Muscle Contraction

1997
4-Chloro-m-cresol test--a possible supplementary test for diagnosis of malignant hyperthermia susceptibility.
    Acta anaesthesiologica Scandinavica, 1997, Volume: 41, Issue:8

    Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Dose-Response Relationship, Drug; Halothane; Huma

1997
[4-chloro-m-cresol-induced contractures of skeletal muscle specimen from patients at risk for malignant hyperthermia].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1997, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Calcium; Child; Child, Preschool; Cresols; Culture Techniques; Dose-Response Rela

1997
Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle.
    Cell calcium, 1998, Volume: 24, Issue:2

    Topics: Animals; Caffeine; Calcium; Chlorophenols; Cresols; Dantrolene; Electric Stimulation; Male; Membrane

1998
4-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations.
    Anesthesiology, 1999, Volume: 90, Issue:6

    Topics: Animals; Cresols; Hemolysis; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Preser

1999
4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine.
    Anesthesiology, 1999, Volume: 90, Issue:6

    Topics: Animals; Calcium; Cresols; Heart Rate; In Vitro Techniques; Malignant Hyperthermia; Muscle Contracti

1999
Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 87, Issue:1

    Topics: Animals; Calcium; Cresols; Female; Hindlimb; Intracellular Fluid; Mice; Mice, Inbred ICR; Muscle Con

1999
The impact of 4-chloro-m-cresol in heparin formulas on malignant hyperthermia: in vitro and in vivo.
    Acta anaesthesiologica Scandinavica, 2000, Volume: 44, Issue:3

    Topics: Adult; Cresols; Dose-Response Relationship, Drug; Female; Heparin; Humans; In Vitro Techniques; Male

2000
Differential effects of 4-chloro-m-cresol and caffeine on skinned fibers from rat fast and slow skeletal muscles.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Animals; Caffeine; Calcium; Contractile Proteins; Cresols; In Vitro Techniques; Male; Muscle Contrac

2000
Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line.
    Biophysical journal, 2000, Volume: 79, Issue:5

    Topics: Animals; Biophysical Phenomena; Biophysics; Caffeine; Calcium Signaling; Cell Line; Cresols; Electro

2000
Sarcoplasmic reticulum Ca(2+) content affects 4-CmC and caffeine contractures of rat skinned skeletal muscle fibers.
    The Japanese journal of physiology, 2001, Volume: 51, Issue:6

    Topics: Animals; Caffeine; Calcium; Cresols; Dose-Response Relationship, Drug; Fungicides, Industrial; Male;

2001
Suxamethonium chloride and malignant hyperpyrexia.
    British journal of anaesthesia, 1986, Volume: 58, Issue:4

    Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Cresols; In Vitro Techniques; Malignant Hyperthermia; Musc

1986