chlorocresol has been researched along with Anesthesia Related Hyperthermia in 34 studies
chlorocresol: injections for relief of intractable pain; RN given refers to parent cpd
4-chloro-m-cresol : A hydroxytoluene that is 3-methylphenol which is substituted by a chlorine at position 4. A ryanodine receptor agonist.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adenosine accumulation was markedly increased in malignant hyperthermia-susceptible lymphocytes compared with controls reflecting higher than normal adenosine 5'-triphosphate degradation in the malignant hyperthermia-susceptible cells." | 1.42 | Is lymphocyte adenosine a diagnostic marker of clinical malignant hyperthermia? A pilot study. ( Bina, S; Bünger, R; Capacchione, J; Muldoon, S; Munkhuu, B, 2015) |
| "Identifying patients predisposed to malignant hyperthermia is done through the Ca-induced Ca release test in Japan." | 1.37 | Analysis of human cultured myotubes responses mediated by ryanodine receptor 1. ( Hamada, H; Kawamoto, M; Kobayashi, M; Migita, T; Mukaida, K; Yuge, O, 2011) |
| "Mutations in the RYR1 gene are linked to malignant hyperthermia (MH), central core disease and multi-minicore disease." | 1.35 | Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes. ( Carsana, A; De Sarno, C; Di Noto, R; Ferrara, M; Fortunato, G; Gravino, E; Klingler, W; Lehmann-Horn, F; Melzer, W; Perrotta, G; Salvatore, F; Zullo, A, 2009) |
| "Malignant hyperthermia is an uncommon complication encountered during the treatment of patients with diabetic ketoacidosis." | 1.34 | Malignant hyperthermia associated with diabetic hyperosmolar hyperglycemic nonketotic state in a young man. ( Baluch, AR; Oommen, SP, 2007) |
| " Reproducible shifts in the dose-response of skeletal muscle to caffeine and halothane are the basis of the current in vitro diagnostic caffeine-halothane contracture test." | 1.33 | Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis. ( Bina, S; Bünger, R; Cowan, G; Karaian, J; Mongan, P; Muldoon, S, 2006) |
| "This disease is associated with malignant hyperthermia susceptibility and has been linked to the gene of skeletal muscle ryanodine receptor RYR1." | 1.32 | The Ile2453Thr mutation in the ryanodine receptor gene 1 is associated with facilitated calcium release from sarcoplasmic reticulum by 4-chloro-m-cresol in human myotubes. ( Koenig, F; Meinecke, CD; Olthoff, D; Rueffert, H; Wehner, M, 2003) |
| " MHEh muscles revealed a dose-response curve similar to that found in MHN specimens." | 1.30 | Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol. ( Bittner, RE; Fricker, R; Gilly, H; Kress, HG; Musat, I; Steinbereithner, K, 1997) |
| "Chlorocresol was demonstrated to be a potent activator of Ca++ release from skeletal muscle sarcoplasmic reticulum." | 1.30 | [Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients]. ( Adnet, PJ; Ben-Abraham, R; Haudcoeur, G; Krivosic-Horber, RM; Perel, A, 1997) |
| " The aims of this study were to (1) examine the in vivo effects of 4-chloro-m-cresol on swine susceptible to malignant hyperthermia and (2) contrast in vivo versus in vitro dose-response curves." | 1.30 | 4-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations. ( Gallagher, WJ; Iaizzo, PA; Johnson, BA; Nagao, K, 1999) |
| "If an unequivocal episode of malignant hyperthermia occurred, as indicated by venous carbon dioxide concentration > or = 70 mmHg, pH < or = 7." | 1.30 | 4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine. ( Fiege, M; Kolodzie, K; Kudlik, C; Scholz, J; Schulte am Esch, J; Wappler, F; Weisshorn, R, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 9 (26.47) | 18.2507 |
| 2000's | 19 (55.88) | 29.6817 |
| 2010's | 5 (14.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kondo, T | 1 |
| Yasuda, T | 1 |
| Mukaida, K | 2 |
| Otsuki, S | 1 |
| Kanzaki, R | 1 |
| Miyoshi, H | 1 |
| Hamada, H | 2 |
| Nishino, I | 1 |
| Kawamoto, M | 2 |
| Schiemann, AH | 1 |
| Paul, N | 1 |
| Parker, R | 1 |
| Pollock, N | 1 |
| Bulger, TF | 1 |
| Stowell, KM | 1 |
| Bina, S | 3 |
| Capacchione, J | 1 |
| Munkhuu, B | 1 |
| Muldoon, S | 3 |
| Bünger, R | 2 |
| Johannsen, S | 1 |
| Treves, S | 3 |
| Müller, CR | 1 |
| Mögele, S | 1 |
| Schneiderbanger, D | 1 |
| Roewer, N | 2 |
| Schuster, F | 1 |
| Kaufmann, A | 1 |
| Kraft, B | 1 |
| Michalek-Sauberer, A | 1 |
| Weigl, LG | 2 |
| Levano, S | 1 |
| Vukcevic, M | 1 |
| Singer, M | 1 |
| Matter, A | 1 |
| Urwyler, A | 2 |
| Girard, T | 1 |
| Zullo, A | 1 |
| Klingler, W | 4 |
| De Sarno, C | 1 |
| Ferrara, M | 1 |
| Fortunato, G | 1 |
| Perrotta, G | 1 |
| Gravino, E | 1 |
| Di Noto, R | 1 |
| Lehmann-Horn, F | 5 |
| Melzer, W | 2 |
| Salvatore, F | 1 |
| Carsana, A | 1 |
| Kobayashi, M | 1 |
| Migita, T | 1 |
| Yuge, O | 1 |
| Wehner, M | 4 |
| Rueffert, H | 4 |
| Koenig, F | 4 |
| Neuhaus, J | 1 |
| Olthoff, D | 4 |
| Allen, PD | 3 |
| López, JR | 2 |
| Sei, Y | 1 |
| Brandom, BW | 1 |
| Hosoi, E | 1 |
| Gallagher, KL | 1 |
| Wyre, HW | 1 |
| Pudimat, PA | 1 |
| Holman, SJ | 1 |
| Venzon, DJ | 1 |
| Daly, JW | 1 |
| Baur, C | 1 |
| Georgieff, M | 2 |
| Yang, T | 1 |
| Ta, TA | 1 |
| Pessah, IN | 2 |
| Meinecke, CD | 1 |
| Wappler, F | 4 |
| Anetseder, M | 2 |
| Baur, CP | 2 |
| Censier, K | 1 |
| Doetsch, S | 1 |
| Felleiter, P | 2 |
| Fiege, M | 4 |
| Fricker, R | 3 |
| Halsall, PJ | 1 |
| Hartung, E | 2 |
| Heffron, JJ | 2 |
| Heytens, L | 1 |
| Hopkins, PM | 1 |
| Nivoche, Y | 1 |
| Tegazzin, V | 3 |
| Tzanova, I | 1 |
| Weisshorn, R | 2 |
| Schulte am Esch, J | 3 |
| Ludwig-Papst, C | 1 |
| Kress, HG | 2 |
| Linares, N | 1 |
| Cowan, G | 1 |
| Karaian, J | 1 |
| Mongan, P | 1 |
| McKinney, LC | 1 |
| Butler, T | 1 |
| Mullen, SP | 1 |
| Klein, MG | 1 |
| Baluch, AR | 1 |
| Oommen, SP | 1 |
| Scutari, E | 1 |
| Zorzato, F | 1 |
| Herrmann-Frank, A | 2 |
| Richter, M | 1 |
| Gilly, H | 1 |
| Musat, I | 1 |
| Bittner, RE | 1 |
| Steinbereithner, K | 1 |
| Ben-Abraham, R | 1 |
| Krivosic-Horber, RM | 1 |
| Haudcoeur, G | 1 |
| Perel, A | 1 |
| Adnet, PJ | 1 |
| Gronert, GA | 1 |
| Ording, H | 2 |
| Glahn, K | 2 |
| Gardi, T | 1 |
| Fagerlund, T | 1 |
| Bendixen, D | 1 |
| Scholz, J | 2 |
| von Richthofen, V | 1 |
| Steinfath, M | 1 |
| Iaizzo, PA | 1 |
| Johnson, BA | 1 |
| Nagao, K | 1 |
| Gallagher, WJ | 1 |
| Kolodzie, K | 1 |
| Kudlik, C | 1 |
| Bellon, L | 1 |
| Jurkat-Rott, K | 1 |
| Lehane, M | 1 |
| Ritter, L | 1 |
| Horbaschek, H | 1 |
| Galloway, GJ | 1 |
| Denborough, MA | 1 |
2 trials available for chlorocresol and Anesthesia Related Hyperthermia
| Article | Year |
|---|---|
Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant | 2003 |
A multicenter study of 4-chloro-m-cresol for diagnosing malignant hyperthermia susceptibility.
Topics: Caffeine; Central Nervous System Stimulants; Cresols; Europe; Humans; In Vitro Techniques; Malignant | 2000 |
32 other studies available for chlorocresol and Anesthesia Related Hyperthermia
| Article | Year |
|---|---|
Genetic and functional analysis of the RYR1 mutation p.Thr84Met revealed a susceptibility to malignant hyperthermia.
Topics: Animals; Caffeine; Calcium; Child; Cresols; Genetic Predisposition to Disease; HEK293 Cells; Humans; | 2018 |
Functional characterization of 2 known ryanodine receptor mutations causing malignant hyperthermia.
Topics: Adolescent; Adult; Anesthesia; B-Lymphocytes; Calcium; Child; Computational Biology; Cresols; DNA Mu | 2014 |
Is lymphocyte adenosine a diagnostic marker of clinical malignant hyperthermia? A pilot study.
Topics: Adenosine; Anesthetics, Inhalation; Biomarkers; Calcium; Cresols; Female; Halothane; Humans; Lymphoc | 2015 |
Functional characterization of the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia.
Topics: Anesthetics; Arginine; B-Lymphocytes; Caffeine; Cell Line, Transformed; Cresols; Family Health; Fema | 2016 |
Novel ryanodine receptor mutation that may cause malignant hyperthermia.
Topics: Amino Acid Substitution; Anesthetics, Inhalation; Austria; Caffeine; Calcium; Cells, Cultured; Centr | 2008 |
Increasing the number of diagnostic mutations in malignant hyperthermia.
Topics: Caffeine; Calcium; Cell Line, Transformed; Cresols; DNA Mutational Analysis; Dose-Response Relations | 2009 |
Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes.
Topics: B-Lymphocytes; Cell Line, Transformed; Chromatography, High Pressure Liquid; Cresols; DNA Mutational | 2009 |
Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.
Topics: Adolescent; Adult; Aged; Caffeine; Calcium; Cells, Cultured; Child; Child, Preschool; Cresols; Dose- | 2011 |
Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation.
Topics: Amino Acid Substitution; Caffeine; Calcium; Cresols; Female; Humans; Male; Malignant Hyperthermia; M | 2002 |
"Noninvasive" testing for malignant hyperthermia susceptibility.
Topics: Caffeine; Calcium; Cresols; Disease Susceptibility; Halothane; Humans; Malignant Hyperthermia; Muscl | 2002 |
Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.
Topics: Adolescent; Adult; B-Lymphocytes; Caffeine; Calcium; Child; Cresols; Disease Susceptibility; Halotha | 2002 |
Detection of proton release from cultured human myotubes to identify malignant hyperthermia susceptibility.
Topics: Calcium; Cells, Cultured; Cresols; Disease Susceptibility; Dose-Response Relationship, Drug; Humans; | 2002 |
Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling.
Topics: Animals; Caffeine; Calcium; Cell Membrane; Central Nervous System Stimulants; Collagen; Cresols; DNA | 2003 |
The Ile2453Thr mutation in the ryanodine receptor gene 1 is associated with facilitated calcium release from sarcoplasmic reticulum by 4-chloro-m-cresol in human myotubes.
Topics: Adolescent; Adult; Aged; Calcium; Child; Cresols; Female; Genetic Predisposition to Disease; Humans; | 2003 |
Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.
Topics: Adult; Aged; Caffeine; Calcium; Child; Child, Preschool; Cresols; Female; Genetic Predisposition to | 2003 |
Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.
Topics: Adolescent; Adult; Aged; Anesthetics; Biopsy; Caffeine; Calcium; Cells, Cultured; Central Nervous Sy | 2004 |
4-chloro-m-cresol cannot detect malignant hyperthermia equivocal cells in an alternative minimally invasive diagnostic test of malignant hyperthermia susceptibility.
Topics: Caffeine; Calcium; Calibration; Cells, Cultured; Central Nervous System Stimulants; Cresols; DNA Mut | 2004 |
Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.
Topics: Animals; Animals, Newborn; Caffeine; Calcium; Central Nervous System Stimulants; Chelating Agents; C | 2005 |
Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.
Topics: Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; A | 2006 |
Characterization of ryanodine receptor-mediated calcium release in human B cells: relevance to diagnostic testing for malignant hyperthermia.
Topics: Animals; B-Lymphocytes; Caffeine; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells | 2006 |
Malignant hyperthermia associated with diabetic hyperosmolar hyperglycemic nonketotic state in a young man.
Topics: Adult; Cresols; Humans; Hyperglycemic Hyperosmolar Nonketotic Coma; Male; Malignant Hyperthermia | 2007 |
Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel.
Topics: Animals; Caffeine; Calcium; Calcium Channels; Cresols; Dose-Response Relationship, Drug; Humans; In | 1996 |
4-Chloro-m-cresol: a specific tool to distinguish between malignant hyperthermia-susceptible and normal muscle.
Topics: Animals; Caffeine; Calcium; Cresols; Malignant Hyperthermia; Muscle, Skeletal; Protein Binding; Ryan | 1996 |
Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Caffeine; Cresols; Disease Susceptibility; Dose-Re | 1997 |
[Effect of chlorocresol vs caffeine on muscle contracture in malignant hyperthermia susceptible patients].
Topics: Adolescent; Adult; Caffeine; Cresols; Disease Susceptibility; Halothane; Humans; In Vitro Techniques | 1997 |
Testing for MH susceptibility.
Topics: Cresols; Disease Susceptibility; Genetic Markers; Humans; Malignant Hyperthermia; Muscle Contraction | 1997 |
4-Chloro-m-cresol test--a possible supplementary test for diagnosis of malignant hyperthermia susceptibility.
Topics: Biopsy; Caffeine; Cresols; Disease Susceptibility; Dose-Response Relationship, Drug; Halothane; Huma | 1997 |
[4-chloro-m-cresol-induced contractures of skeletal muscle specimen from patients at risk for malignant hyperthermia].
Topics: Adolescent; Adult; Calcium; Child; Child, Preschool; Cresols; Culture Techniques; Dose-Response Rela | 1997 |
4-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations.
Topics: Animals; Cresols; Hemolysis; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Preser | 1999 |
4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine.
Topics: Animals; Calcium; Cresols; Heart Rate; In Vitro Techniques; Malignant Hyperthermia; Muscle Contracti | 1999 |
The impact of 4-chloro-m-cresol in heparin formulas on malignant hyperthermia: in vitro and in vivo.
Topics: Adult; Cresols; Dose-Response Relationship, Drug; Female; Heparin; Humans; In Vitro Techniques; Male | 2000 |
Suxamethonium chloride and malignant hyperpyrexia.
Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Cresols; In Vitro Techniques; Malignant Hyperthermia; Musc | 1986 |