chloroacetic acid has been researched along with Body Weight in 5 studies
chloroacetic acid: urinary metabolite of vinyl chloride; RN given refers to parent cpd; structure
chloroacetic acid : A chlorocarboxylic acid that is acetic acid carrying a 2-chloro substituent.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chloroacetic acid solutions were prepared at concentrations which provided an approximate intake of 1/4 the LD50 dose per day: MCA, 1." | 1.28 | Ninety day toxicity study of chloroacetic acids in rats. ( Ansari, GA; Bhat, HK; Campbell, GA; Kanz, MF, 1991) |
| " Based on the observation of toxicity at all treatment levels in males, a lowest observed adverse effect level (LOAEL) of 15 mg/kg per day is proposed for a 90-day exposure to SMCA by oral gavage to the Sprague--Dawley rat." | 1.28 | Ninety-day toxicity study of sodium monochloroacetate in Sprague-Dawley rats. ( Daniel, FB; Olson, GR; Page, NP; Robinson, M; Stober, JA, 1991) |
| " Dosing F344 rats with 200 mg/kg TCA in water or corn oil for 10 days increased peroxisome proliferation 179 and 278%, respectively, above the vehicle controls." | 1.28 | Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids. ( Daniel, FB; DeAngelo, AB; McMillan, L; Savage, RE; Wernsing, P, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DeAngelo, AB | 2 |
| Daniel, FB | 3 |
| Most, BM | 1 |
| Olson, GR | 2 |
| Bryant, BJ | 1 |
| Jokinen, MP | 1 |
| Eustis, SL | 1 |
| Thompson, MB | 1 |
| Abdo, KM | 1 |
| Bhat, HK | 1 |
| Kanz, MF | 1 |
| Campbell, GA | 1 |
| Ansari, GA | 1 |
| Robinson, M | 1 |
| Stober, JA | 1 |
| Page, NP | 1 |
| McMillan, L | 1 |
| Wernsing, P | 1 |
| Savage, RE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for chloroacetic acid and Body Weight
| Article | Year |
|---|---|
Failure of monochloroacetic acid and trichloroacetic acid administered in the drinking water to produce liver cancer in male F344/N rats.
Topics: Acetates; Administration, Oral; Animals; Body Weight; Liver Neoplasms, Experimental; Male; No-Observ | 1997 |
Toxicity of monochloroacetic acid administered by gavage to F344 rats and B6C3F1 mice for up to 13 weeks.
Topics: Acetates; Aconitate Hydratase; Animals; Body Weight; Carcinogens; Cardiomyopathies; Female; Kidney; | 1992 |
Ninety day toxicity study of chloroacetic acids in rats.
Topics: Acetates; Animals; Body Weight; Brain; Dichloroacetic Acid; Lethal Dose 50; Liver; Lung; Male; Rats; | 1991 |
Ninety-day toxicity study of sodium monochloroacetate in Sprague-Dawley rats.
Topics: Acetates; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Body Weig | 1991 |
Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids.
Topics: Acetates; Animals; Body Weight; Carcinogens; Carnitine O-Acetyltransferase; Corn Oil; Dichloroacetic | 1989 |