chloroacetaldehyde has been researched along with Leukemia in 1 studies
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alkylation of DNA by acrolein and/or chloroacetaldehyde may result in the mutations that lead to the therapy-induced leukemia associated with cyclophosphamide (and ifosfamide) treatment." | 3.71 | Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies. ( Balu, N; Colvin, ME; Colvin, OM; Dolan, ME; Gamcsik, MP; Ludeman, SM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Balu, N | 1 |
| Gamcsik, MP | 1 |
| Colvin, ME | 1 |
| Colvin, OM | 1 |
| Dolan, ME | 1 |
| Ludeman, SM | 1 |
1 other study available for chloroacetaldehyde and Leukemia
| Article | Year |
|---|---|
Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
Topics: Acetaldehyde; Acrolein; Alkylation; Antineoplastic Agents, Alkylating; Cyclophosphamide; DNA Damage; | 2002 |