chlormezanone has been researched along with Stevens-Johnson Syndrome in 6 studies
Chlormezanone: A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm.
chlormezanone : A 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 16 days previously she had started to take chlormezanone (Muskel Trancopal) and some other medications for pain in the shoulder and neck." | 3.70 | [Undesired drug effects after taking chlormezanone (Muscle Trancopal) with lethal results]. ( Breidenbach, K; Höhler, H; Köbberling, J; von Boxberg, C, 1998) |
| "The use of antibacterial sulfonamides, anticonvulsant agents, oxicam NSAIDs, allopurinol, chlormezanone, and corticosteroids is associated with large increases in the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis." | 3.69 | Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. ( Anderson, T; Auquier, A; Bastuji-Garin, S; Correia, O; Kelly, JP; Locati, F; Naldi, L; Roujeau, JC; Rzany, B; Stern, RS, 1995) |
| "Toxic epidermal necrolysis with epidermal shedding over almost the entire body occurred in a patient with classical rheumatoid arthritis treated with sulindac, penicillamine and a combination analgesic containing paracetamol and chlormezanone." | 3.67 | Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts. ( Ahlmén, M; Fagerberg, B; Roupe, G; Suurküla, M, 1986) |
| "Patients with the acquired immunodeficiency syndrome (AIDS) exhibit a dramatically increased risk of TEN." | 1.28 | Drug-induced toxic epidermal necrolysis (Lyell syndrome) in patients infected with the human immunodeficiency virus. ( Caumes, E; Chosidow, O; Revuz, J; Roujeau, JC; Saiag, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roujeau, JC | 2 |
| Kelly, JP | 1 |
| Naldi, L | 1 |
| Rzany, B | 1 |
| Stern, RS | 1 |
| Anderson, T | 1 |
| Auquier, A | 1 |
| Bastuji-Garin, S | 1 |
| Correia, O | 1 |
| Locati, F | 1 |
| von Boxberg, C | 1 |
| Breidenbach, K | 1 |
| Höhler, H | 1 |
| Köbberling, J | 1 |
| Saiag, P | 1 |
| Caumes, E | 1 |
| Chosidow, O | 1 |
| Revuz, J | 1 |
| Rosenthal, E | 1 |
| Bodokh, I | 1 |
| Chichmanian, RM | 1 |
| Pesce, A | 1 |
| Vinti, H | 1 |
| Reboulot, B | 1 |
| Cassuto, JP | 1 |
| Roupe, G | 1 |
| Ahlmén, M | 1 |
| Fagerberg, B | 1 |
| Suurküla, M | 1 |
6 other studies available for chlormezanone and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.
Topics: Adrenal Cortex Hormones; Allopurinol; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal | 1995 |
[Undesired drug effects after taking chlormezanone (Muscle Trancopal) with lethal results].
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Chlormezanone; Colon; Fatal Outcome; F | 1998 |
Drug-induced toxic epidermal necrolysis (Lyell syndrome) in patients infected with the human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Chlormezanone; Clindamycin; Female; Humans; Male; Middle | 1992 |
[Lyell's syndrome in 2 HIV infected patients. Sulfamides are not the only culprits].
Topics: Acquired Immunodeficiency Syndrome; Adult; Chlormezanone; Fluoxetine; HIV Infections; Humans; Male; | 1991 |
[The Lobac overview: little risk of adverse effects. Effects on skin and liver are the most common and the most severe].
Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlormezanone; Drug Combinations; Humans; Ris | 1991 |
Toxic epidermal necrolysis with extensive mucosal erosions of the gastrointestinal and respiratory tracts.
Topics: Acetaminophen; Arthritis, Rheumatoid; Biopsy; Chlormezanone; Drug Combinations; Female; Humans; Inte | 1986 |