chlormethiazole has been researched along with Brain Ischemia in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (55.00) | 18.2507 |
| 2000's | 9 (45.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaulk, D; Corbett, D; Evans, S; Jackson, D; Wells, J | 1 |
| Grocott, HP | 1 |
| Bredberg, U; Cross, AJ; Green, AR; Jones, JA; Jostell, KG; Snares, M | 1 |
| Cross, AJ; Green, AR | 1 |
| Baldwin, HA; Cross, AJ; Ferreira, T; Green, AR; Snares, M; Williams, JL | 1 |
| Baldwin, HA; Cross, AJ; Green, AR; Snape, MF | 1 |
| Cross, AJ; Green, AR; Sydserff, SG | 2 |
| Baldwin, HA; Cross, AJ; Ingelman-Sundberg, M; Tindberg, N | 1 |
| Kanthan, R; Liang, SP; Shuaib, A; Wishart, T | 1 |
| Allain, H; Bentué-Ferrer, D; Heresbach, N; Lechat, P; Reymann, JM; Thaminy, S | 1 |
| Green, AR | 1 |
| Ashwood, T; Claesson, L; Franke, CL; Ranasinha, KW; Rosolacci, T; van Erven, PM; Wahlgren, NG | 1 |
| Cross, AJ; Green, AR; Jones, JA; Misra, A; Murray, TK; Snape, MF | 1 |
| Green, AR; Hainsworth, AH; Jackson, DM | 1 |
| Green, AR; Hainsworth, AH; Lambert, DG; Nelson, RM | 1 |
| Cross, AJ; Gabrielsson, J; Green, AR; Hainsworth, AH; Jones, JA; Lambert, DG; Murray, TK; Nelson, RM; Richards, DA | 1 |
| Albers, G; Ashwood, T; Jacoby, M; Lyden, P; Mazzeo, P; Nordlund, A; Odergren, T; Schim, J | 1 |
| Ashwood, T; Atkinson, RP; Claesson, L; Levin, K; Lyden, P; Ng, K; Odergren, T; Rajput, A; Salazar-Grueso, E; Shuaib, A; Wechsler, L | 1 |
| Hankey, GJ | 1 |
4 review(s) available for chlormethiazole and Brain Ischemia
| Article | Year |
|---|---|
Pharmacologic neuroprotection: the search continues.
Topics: Aprotinin; Brain Ischemia; Cardiopulmonary Bypass; Chlormethiazole; Humans; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Thoracic Surgery | 2007 |
The neuroprotective actions of chlormethiazole.
Topics: Animals; Brain Edema; Brain Ischemia; Chlormethiazole; Mice; Neurotoxins; Rats; Receptors, GABA | 1994 |
Clomethiazole (Zendra) in acute ischemic stroke: basic pharmacology and biochemistry and clinical efficacy.
Topics: Animals; Brain Ischemia; Chlormethiazole; Disease Models, Animal; Humans; Models, Chemical; Neuroprotective Agents; Neurotoxins | 1998 |
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Chlormethiazole; GABA Agonists; gamma-Aminobutyric Acid; Humans; Muscimol; Neuroprotective Agents; Receptors, GABA-A | 2000 |
3 trial(s) available for chlormethiazole and Brain Ischemia
| Article | Year |
|---|---|
Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Cerebrovascular Disorders; Chlormethiazole; Female; Humans; Incidence; Male; Middle Aged; Neuroprotective Agents; Placebos; Survival Analysis | 1999 |
The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results.
Topics: Acute Disease; Aged; Brain Ischemia; Chlormethiazole; Double-Blind Method; Drug Therapy, Combination; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Plasminogen Activator; Treatment Outcome | 2001 |
Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results.
Topics: Acute Disease; Adult; Aged; Brain Ischemia; Chlormethiazole; Double-Blind Method; Female; GABA Modulators; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Time Factors | 2002 |
13 other study(ies) available for chlormethiazole and Brain Ischemia
| Article | Year |
|---|---|
Long-term effects of clomethiazole in a model of global ischemia.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Brain Ischemia; Cell Count; Chlormethiazole; Disease Models, Animal; Disease Progression; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Gerbillinae; Hippocampus; In Vitro Techniques; Neurons; Neuroprotective Agents; Spatial Behavior; Time | 2003 |
The protective action of chlormethiazole against ischaemia-induced neurodegeneration in gerbils when infused at doses having little sedative or anticonvulsant activity.
Topics: Animals; Brain; Brain Ischemia; Cell Death; Chlormethiazole; Dose-Response Relationship, Drug; Gerbillinae; Hippocampus; Injections, Intraperitoneal; Injections, Intravenous; Male; Neurons; Temperature; Time Factors | 1995 |
Attenuation by chlormethiazole administration of the rise in extracellular amino acids following focal ischaemia in the cerebral cortex of the rat.
Topics: Amino Acids; Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Chlormethiazole; Extracellular Space; Hypoxia, Brain; Male; Microdialysis; Rats | 1994 |
The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischaemia in the rat.
Topics: Animals; Body Temperature; Brain Ischemia; Cerebral Infarction; Chlormethiazole; Evans Blue; Male; Nimodipine; Photochemistry; Rats; Tetrazolium Salts | 1993 |
The neuroprotective effect of chlormethiazole on ischaemic neuronal damage following permanent middle cerebral artery ischaemia in the rat.
Topics: Analysis of Variance; Animals; Brain Ischemia; Cerebral Arterial Diseases; Chlormethiazole; Chronic Disease; Male; Neurons; Neuroprotective Agents; Rats; Rats, Inbred Strains | 1995 |
The effect of oedema and tissue swelling on the measurement of neuroprotection; a study using chlormethiazole and permanent middle cerebral artery occlusion in rats.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Ischemia; Cerebral Arteries; Chlormethiazole; Male; Nerve Degeneration; Neuroprotective Agents; Rats; Rats, Inbred Strains; Regression Analysis | 1996 |
Induction of cytochrome P450 2E1 expression in rat and gerbil astrocytes by inflammatory factors and ischemic injury.
Topics: Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Chlormethiazole; Chlorzoxazone; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Induction; Enzyme Inhibitors; Gerbillinae; Hydroxylation; Inflammation; Interleukin-1; Kinetics; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Effects of clomethiazole on radial-arm maze performance following global forebrain ischemia in gerbils.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Chlormethiazole; Gerbillinae; Male; Maze Learning; Memory; Motor Activity; Neuroprotective Agents; Prosencephalon | 1997 |
Is chlormethiazole neuroprotective in experimental global cerebral ischemia? A microdialysis and behavioral study.
Topics: Animals; Brain Ischemia; Chlormethiazole; Corpus Striatum; Dopamine; Extracellular Space; Hippocampus; Male; Maze Learning; Microdialysis; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Serotonin | 1997 |
The metabolism of clomethiazole in gerbils and the neuroprotective and sedative activity of the metabolites.
Topics: Animals; Brain; Brain Ischemia; Chlormethiazole; Gerbillinae; Hypnotics and Sedatives; Male; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Thiazoles | 2000 |
On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and pentobarbitone.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Chlormethiazole; Female; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Pentobarbital; Rats; Rats, Wistar; Receptors, GABA-A | 2000 |
Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.
Topics: Animals; Brain Ischemia; Chlormethiazole; Female; gamma-Aminobutyric Acid; Gerbillinae; Glutamic Acid; Hippocampus; Male; Methylamines; Neuroprotective Agents; Rats; Rats, Wistar; Stroke; Thiazoles | 2001 |
Clomethiazole: an unsuccessful bachelor, but perhaps a prosperous married man?
Topics: Acute Disease; Animals; Brain Ischemia; Chlormethiazole; Clinical Trials as Topic; Drug Therapy, Combination; Fibrinolytic Agents; Humans; Neuroprotective Agents; Stroke; Tissue Plasminogen Activator | 2002 |