chlorine has been researched along with Seizures in 158 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest." | 7.78 | Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. ( Akerman, CJ; Ilie, A; Raimondo, JV, 2012) |
| "To study the effects of low-frequency cortical electrical stimulation (CES) on seizures and behaviour in a rat model of epilepsy induced by ferric chloride (FeCl3)." | 7.78 | Alleviation of ferric chloride-induced seizures and retarded behaviour in epileptic rats by cortical electrical stimulation treatment. ( Gao, G; He, F; Heng, G; Jing, X; Liang, Q; Wang, C; Wang, L; Wu, H; Zhang, H, 2012) |
| "The present study was carried out to investigate the effect of trans-resveratrol, a potent antioxidant, against FeCl3-induced posttraumatic seizures." | 7.71 | Protective effect of resveratrol against intracortical FeCl3-induced model of posttraumatic seizures in rats. ( Chaudhary, G; Gupta, YK; Sinha, K; Srivastava, AK, 2001) |
| "Mental status changes and metabolic acidosis may occur with topiramate therapy." | 7.70 | Acute mental status changes and hyperchloremic metabolic acidosis with long-term topiramate therapy. ( Bollinger, T; Farrar, HC; Griebel, ML; Haley, TM; James, LP; Stowe, CD, 2000) |
| "The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine." | 7.68 | [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. ( Coyle, JT; Saltarelli, MD; Yamada, K, 1991) |
| " Therefore, the concentrations of three second messengers, inositol 1,4,5 trisphosphate (Ins 1,4,5P3), cyclic adenosine monophosphate (AMP), and cyclic guanosine monophosphate (GMP), were measured in rat cerebral cortex and hippocampus after acute or chronic lithium administration, as well as after treatment with the cholinergic agonist pilocarpine alone or in combination with lithium at a dose that induces seizures only in lithium pretreated rats." | 7.68 | Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures. ( Jope, RS; Kolasa, K; Song, L, 1992) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 7.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| "Injection of ferric chloride (FC) into the left amygdala of rats produced limbic seizures that lasted at least 3 weeks." | 7.67 | Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures. ( Bonnet, KA; Csernansky, CA; Csernansky, JG; Hollister, LE, 1985) |
| "The characteristics and consequences of limbic seizures evoked by single peripheral injections of lithium (3 mEq/kg) and pilocarpine (30 mg/kg) were investigated over a three-year period." | 7.67 | Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. ( Bradley, JC; Makarec, K; Persinger, MA, 1988) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 7.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "The risk of seizures increases to the extent that the injury is associated with sub-arachnoid hemorrhage and hematoma." | 5.32 | Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. ( Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL, 2004) |
| "Cesium chloride is an unregulated agent that has been reported to have antineoplastic properties." | 5.32 | Acquired long QT syndrome and monomorphic ventricular tachycardia after alternative treatment with cesium chloride for brain cancer. ( Dalal, AK; Harding, JD; Verdino, RJ, 2004) |
| "When lithium serum levels were within the (human) therapeutic range, young and old adult male and female rats (housed singly or in groups) all displayed faster limbic seizure onset times in response to a muscarinic cholinergic agonist (pilocarpine 20 mg/kg) if a single systemic dosage of chlorpromazine was injected 24 hours previously." | 5.28 | Cholinergic rebound after chlorpromazine exacerbates lithium muscarinic-induced limbic seizures in rats: implications for psychiatric treatment. ( Bureau, YR; Persinger, MA, 1991) |
| "Tacrine and LiCl were ineffective when given individually." | 5.28 | Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester. ( Bagetta, G; Iannone, M; Nisticò, G; Scorsa, AM, 1992) |
| " Using the kainic acid model of status epilepticus, we have studied the effects of repetitive neonatal episodes of status epilepticus on the expression of cation chloride cotransporter KCC2 in the neonatal hippocampus." | 4.84 | Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures. ( Galanopoulou, AS, 2007) |
| " The aim of this study was evaluating as well as comparing the effects of rubidium chloride (RbCl) and lithium chloride (LiCl) on different seizures paradigms in mice and determining the involvement of NMDA receptors and nitrergic pathway." | 3.91 | Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium. ( Bahramnejad, E; Dehpour, AR; Faghir-Ghanesefat, H; Hassanipour, M; Pourshadi, N; Rahimi, N; Yarmohammadi, F, 2019) |
| "Dehydroepiandrosterone (DHEA), a neuroactive androgen steroid, has antiepileptic action in iron-induced experimental epilepsy (which models post-traumatic clinical epilepsy)." | 3.79 | Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters. ( Mishra, M; Mukherjee, S; Sharma, D; Singh, R, 2013) |
| "To study the effects of low-frequency cortical electrical stimulation (CES) on seizures and behaviour in a rat model of epilepsy induced by ferric chloride (FeCl3)." | 3.78 | Alleviation of ferric chloride-induced seizures and retarded behaviour in epileptic rats by cortical electrical stimulation treatment. ( Gao, G; He, F; Heng, G; Jing, X; Liang, Q; Wang, C; Wang, L; Wu, H; Zhang, H, 2012) |
| "Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest." | 3.78 | Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. ( Akerman, CJ; Ilie, A; Raimondo, JV, 2012) |
| " Consistent with these observations, acetoacetate reduced quantal size at hippocampal synapses and suppresses glutamate release and seizures evoked with 4-aminopyridine in the brain." | 3.76 | Metabolic control of vesicular glutamate transport and release. ( Edwards, RH; Gray, JA; Hara, C; Inoue, T; Juge, N; Miyaji, T; Moriyama, Y; Nicoll, RA; Omote, H; Uneyama, H, 2010) |
| "Phenobarbital failed to abolish or depress recurrent seizures in 70% of hippocampi." | 3.74 | Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. ( Brumback, AC; Dzhala, VI; Staley, KJ, 2008) |
| "5 hours later by administration of saline vehicle or a regimen of bicuculline (1 mg/kg, sc), a GABA(A) receptor antagonist, which does not produce any intrinsic effects on seizures." | 3.73 | Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins. ( Frye, CA; Rhodes, ME, 2005) |
| " Housing conditions did not alter the anticonvulsant activity of diazepam or ethanol, although the anticonvulsant effect of ethanol was significantly greater against PTZ-induced seizures." | 3.72 | Sex differences in effects of mild chronic stress on seizure risk and GABAA receptors in rats. ( Chadda, R; Devaud, LL, 2004) |
| "The present study was carried out to investigate the effect of trans-resveratrol, a potent antioxidant, against FeCl3-induced posttraumatic seizures." | 3.71 | Protective effect of resveratrol against intracortical FeCl3-induced model of posttraumatic seizures in rats. ( Chaudhary, G; Gupta, YK; Sinha, K; Srivastava, AK, 2001) |
| "Mental status changes and metabolic acidosis may occur with topiramate therapy." | 3.70 | Acute mental status changes and hyperchloremic metabolic acidosis with long-term topiramate therapy. ( Bollinger, T; Farrar, HC; Griebel, ML; Haley, TM; James, LP; Stowe, CD, 2000) |
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| " after they had been assigned to one of 8 groups in a 3-way analysis of variance design that involved (1) induction of limbic seizures by a systemic injection of lithium/pilocarpine, (2) physical restraint, and (3) administration of acepromazine." | 3.68 | Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury. ( Bureau, YR; Persinger, MA, 1993) |
| "The specific binding of [3H]hemicholinium-3 ([3H]HCh-3) and high-affinity [3H]choline uptake were measured in rats with status epilepticus induced by lithium and pilocarpine." | 3.68 | [3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine. ( Coyle, JT; Saltarelli, MD; Yamada, K, 1991) |
| " Therefore, the concentrations of three second messengers, inositol 1,4,5 trisphosphate (Ins 1,4,5P3), cyclic adenosine monophosphate (AMP), and cyclic guanosine monophosphate (GMP), were measured in rat cerebral cortex and hippocampus after acute or chronic lithium administration, as well as after treatment with the cholinergic agonist pilocarpine alone or in combination with lithium at a dose that induces seizures only in lithium pretreated rats." | 3.68 | Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures. ( Jope, RS; Kolasa, K; Song, L, 1992) |
| " Of amino-gamma-carbolines, Trp-P-1 antagonized the suppressive effect of diazepam on the pentylenetetrazol-induced convulsions and death, whereas Trp-P-2 by itself precipitated seizures and death in male mice." | 3.67 | Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens. ( Kato, R; Muraki, T; Yamazoe, Y, 1984) |
| "The characteristics and consequences of limbic seizures evoked by single peripheral injections of lithium (3 mEq/kg) and pilocarpine (30 mg/kg) were investigated over a three-year period." | 3.67 | Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine. ( Bradley, JC; Makarec, K; Persinger, MA, 1988) |
| "Injection of ferric chloride (FC) into the left amygdala of rats produced limbic seizures that lasted at least 3 weeks." | 3.67 | Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures. ( Bonnet, KA; Csernansky, CA; Csernansky, JG; Hollister, LE, 1985) |
| "Two strains of mice were shown to possess a differential sensitivity to picrotoxinin-induced convulsions; picrotoxinin elicited both tonic and clonic seizures at lower doses in the DBA/2J (DBA) strain compared to the BALB/c ByJ (BALB) strain." | 3.67 | Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. ( Paul, SM; Schwartz, RD; Seale, TW; Skolnick, P, 1989) |
| "Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain." | 3.66 | Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. ( Honchar, MP; Olney, JW; Sherman, WR, 1983) |
| "Aluminum chloride injected into the brains of developing rabbits produced profound neurofibrillary changes to neurons of spinal cord and cerebrum similar to those produced in adult rabbits, along with a variety of clinical symptoms with the exception of seizures." | 3.66 | Aluminum chloride induced neurofibrillary changes in the developing rabbit a chronic animal model. ( Shek, JW; Sturman, JA; Wisniewski, HM, 1980) |
| "Currently, the treatment for epilepsy includes the administration of drugs or surgery, but about 30% of the patients treated with antiepileptic drugs develop time-dependent pharmacoresistence." | 2.82 | Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2. ( Belperio, G; Corso, C; Duarte, CB; Mele, M, 2022) |
| "The antiseizure properties of benzodiazepines are mediated by γ-aminobutyric acid type A (GABA(A) ) receptors." | 2.48 | Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures. ( Deeb, TZ; Maguire, J; Moss, SJ, 2012) |
| "In animal experiments, seizures were found to increase NKCC1 expression, lower the KCC2 expression and accelerate neuronal differentiation." | 2.47 | Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia. ( Kalkman, HO, 2011) |
| "The causes of epilepsies and epileptic seizures are multifactorial." | 2.46 | Mutations affecting GABAergic signaling in seizures and epilepsy. ( Galanopoulou, AS, 2010) |
| "Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates." | 1.51 | Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels. ( Bai, Y; Chen, G; Dong, F; Feng, M; Huo, Q; Li, ST; Long, C; Lüscher, B; Ren, L; Wang, GL; Wang, Y; Wu, G; Wu, Z, 2019) |
| "In most witnessed cases of SUDEP generalized seizures and respiratory failure preceded death, and pre-mortem neuroimaging studies in SUDEP patients observed changes in specific subcortical structures." | 1.46 | Specific subcortical structures are activated during seizure-induced death in a model of sudden unexpected death in epilepsy (SUDEP): A manganese-enhanced magnetic resonance imaging study. ( Brozoski, TJ; Faingold, CL; Kommajosyula, SP; Odintsov, BM; Randall, ME, 2017) |
| "Epilepsy of infancy with migrating focal seizures (EIMFS) is one of the early-onset epileptic syndromes characterized by migrating polymorphous focal seizures." | 1.43 | Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay. ( Akita, T; Beng, KT; Fukuda, A; Kato, M; Matsumoto, H; Matsumoto, N; Miyake, N; Miyatake, S; Nakashima, M; Ohba, C; Ong, WP; Saitoh, S; Saitsu, H; Shiraishi, H; Sugai, K; Watanabe, M; Yuasa, S, 2016) |
| " Long-term use of OTC medicines containing bromvalerylurea may result in the development of bromoderma." | 1.43 | Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives. ( Kanno, K; Murakami, A; Oda, F; Sayama, K; Sonobe, N; Tohyama, M, 2016) |
| "These characteristics may suggest that seizure susceptibility was increased in the postintroduction group." | 1.42 | Impact of rotavirus vaccine introduction on rotavirus-associated seizures and a related possible mechanism. ( Kim, RB; Kim, YS; Lim, JY; Park, CH; Park, E; Park, JS; Seo, JH; Woo, HO; Yeom, JS; Youn, HS, 2015) |
| "After neocortical seizure was induced by ferric chloride injection into the left sensorimotor cortex, SNr was stimulated ipsilaterally, contralaterally, or bilaterally at frequencies of 130 or 20 Hz in rats." | 1.40 | Electrical stimulation of the substantia nigra pars reticulata (SNr) suppresses chemically induced neocortical seizures in rats. ( Gao, G; Gu, J; Guo, H; Jing, X; Kuang, Y; Wang, C; Zhang, H, 2014) |
| "Evans blue was used as BBB tracer." | 1.39 | The effects of zinc treatment on the blood-brain barrier permeability and brain element levels during convulsions. ( Demir, G; Oztaş, B; Seker, FB; Yalçın, IE; Yorulmaz, H, 2013) |
| "At the partial seizure stage, upregulation of phospholipase A2 (PLA2) and lipid metabolism were observed, which have been reported to be caused by brain injury and seizures in previous studies." | 1.37 | Hippocampal gene network analysis in an experimental model of posttraumatic epilepsy. ( Kitamoto, A; Kojima, T; Ueda, Y; Willmore, LJ, 2011) |
| "One patient presented with a seizure induced by hyponatremia." | 1.36 | Hypochloremia and hyponatremia as the initial presentation of cystic fibrosis in three adults. ( Augusto, JF; Bonneau, D; Malinge, MC; Priou-Guesdon, M; Rodien, P; Rohmer, V; Subra, JF, 2010) |
| "Occurrence of spontaneous epileptic seizures was analyzed at 2 months post-SE using continuous video-EEG monitoring." | 1.35 | Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus. ( Einula, C; Gröhn, OH; Immonen, RJ; Kharatishvili, I; Pitkänen, A; Sierra, A, 2008) |
| "There were 23 patients with convulsions, including 13 with benign convulsions, 9 with febrile seizures, and 1 with epilepsy." | 1.35 | Clinical characteristics of benign convulsions with rotavirus gastroenteritis. ( Furukawa, S; Ichiyama, T; Kajimoto, M; Matsushige, T; Motoyama, M; Shiraishi, M, 2009) |
| "Sanjoinine A also significantly blocked seizure-form electroencephalogram alterations induced by KA." | 1.35 | Sanjoinine A isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions. ( Hong, JT; Jo, YJ; Kim, HC; Kim, YB; Nam, SY; Oh, KW; Yang, S; Yoon, SR, 2009) |
| "Electroclinical uncoupling of neonatal seizures refers to electrographic seizure activity that is not clinically manifest." | 1.35 | Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. ( Augustine, G; Bacskai, BJ; Dzhala, VI; Feng, G; Glykys, J; Kuchibhotla, KV; Kuner, T; Staley, KJ, 2009) |
| "The development of behavioral Racine seizure stages was delayed only in rats infused with 1,000 microM ZnCl(2) (p < 0." | 1.35 | Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. ( Elsas, SM; Gregory, WL; Hazany, S; Mody, I, 2009) |
| "The risk of seizures increases to the extent that the injury is associated with sub-arachnoid hemorrhage and hematoma." | 1.32 | Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat. ( Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL, 2004) |
| "Although no spontaneous seizures were observed, Kcc3(-/-) mice displayed reduced seizure threshold and spike-wave complexes on electrocorticograms." | 1.32 | Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold. ( Boettger, T; Ehmke, H; Faulhaber, J; Horst, J; Hübner, CA; Jentsch, TJ; Keating, DJ; Lemcke, B; Leuwer, R; Maier, H; Pape, HC; Pfeffer, C; Rust, MB; Scheel, O; Schweizer, M; Seidenbecher, T; Völkl, H, 2003) |
| "Cesium chloride is an unregulated agent that has been reported to have antineoplastic properties." | 1.32 | Acquired long QT syndrome and monomorphic ventricular tachycardia after alternative treatment with cesium chloride for brain cancer. ( Dalal, AK; Harding, JD; Verdino, RJ, 2004) |
| "No sensitization to audiogenic seizure was found but the lesion induced an increase of open arm exploration in the elevated plus maze, suggesting an anxiolytic effect." | 1.31 | Behavioral effects of intra-nigral microinjections of manganese chloride: interaction with nitric oxide. ( Del Bel, EA; Garcia-Cairasco, N; Guimarães, FS; Ponzoni, S, 2000) |
| "With acute seizures, at +5 days after the injection, levels of GluR1, NMDAR1, and NMDAR2 were markedly increased in both hippocampi, with quantities at least 2-4 times baseline." | 1.31 | Sequential changes in AMPA and NMDA protein levels during Fe(3+)-induced epileptogenesis. ( Doi, T; Mitsuyama, Y; Tokumaru, J; Ueda, Y; Willmore, LJ, 2001) |
| "In the presence of diazepam to prevent seizures, co-injection of TPEN and kainate into the hippocampus also failed to prevent the direct cytotoxicity of kainate." | 1.30 | Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid. ( Cuajungco, MP; Lees, GJ; Leong, W, 1998) |
| "These spontaneous seizures occurred in a pattern associated with stage 4 kindling, with rearing and bilateral forelimb clonus." | 1.30 | Amygdalar injection of FeCl3 causes spontaneous recurrent seizures. ( Triggs, WJ; Ueda, Y; Willmore, LJ, 1998) |
| "Kainic acid evokes behavioral convulsions and causes lesions in hippocampal pyramidal cell layers in rats." | 1.29 | Influence of ZnCl2 pretreatment on behavioral and histological responses to kainic acid in rats. ( Connor, JD; Nave, JM, 1993) |
| "Experiments examining seizure sensitivity were conducted on adult male offspring exposed to diazepam at 1." | 1.28 | Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex. ( Bitran, D; Kellogg, CK; Primus, RJ, 1991) |
| "Tacrine and LiCl were ineffective when given individually." | 1.28 | Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester. ( Bagetta, G; Iannone, M; Nisticò, G; Scorsa, AM, 1992) |
| " Chronic administration of lorazepam reduces the coupling between the benzodiazepine agonist site and the chloride channel and concomitantly increases coupling between the channel and the inverse agonist site, while withdrawal resets the receptor coupling back to control response levels." | 1.28 | Effects of lorazepam tolerance and withdrawal on GABAA receptor operated chloride channels in mice selected for differences in ethanol withdrawal severity. ( Allan, AM; Baier, LD; Zhang, X, 1992) |
| "When lithium serum levels were within the (human) therapeutic range, young and old adult male and female rats (housed singly or in groups) all displayed faster limbic seizure onset times in response to a muscarinic cholinergic agonist (pilocarpine 20 mg/kg) if a single systemic dosage of chlorpromazine was injected 24 hours previously." | 1.28 | Cholinergic rebound after chlorpromazine exacerbates lithium muscarinic-induced limbic seizures in rats: implications for psychiatric treatment. ( Bureau, YR; Persinger, MA, 1991) |
| "Patients with Bartter syndrome were often born after pregnancies complicated by polyhydramnios (8/18) or premature delivery (7/18) and had short stature (11/18) or polyuria, polydipsia, and a tendency to dehydration (16/18) during infancy (12/18) or before school age (18/18)." | 1.28 | Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromes. ( Appiani, AC; Bettinelli, A; Bianchetti, MG; Caringella, A; Cecconi, M; Gastaldi, R; Girardin, E; Isimbaldi, C; Lama, G; Pavanello, L, 1992) |
| "Rats were observed for seizure activity for 2 h, survivors were killed 24 h later and edema was measured in samples from parietal and piriform cortices, dorsal thalmus, and hippocampus." | 1.28 | Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats. ( Nelson, SR; Padzernik, TL; Terry, JB, 1990) |
| "These findings indicate that seizure activity causes structural brain changes at anatomical sites distant from the hippocampal seizure focus." | 1.28 | Structural changes in astrocytes induced by seizures in a mode of temporal lobe epilepsy. ( Castiglioni, AJ; Peterson, SL; Sanabria, EL; Tiffany-Castiglioni, E, 1990) |
| "gamma-HCH was a potent seizure-inducing agent in mice while the alpha or the delta isomer significantly decreased mouse motor activity." | 1.27 | CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse. ( Fishman, BE; Gianutsos, G, 1988) |
| "Convulsive seizures are a potential side effect of antidepressant drug treatment and can be produced by all classes of antidepressants." | 1.27 | Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex. ( Ikeda, M; Knapp, RJ; Malatynska, E; Yamamura, HI, 1988) |
| "The overall incidence of seizures due primarily to derangements in serum chemistry was 2." | 1.27 | Serum chemistry abnormalities in adult patients with seizures. ( Powers, RD, 1985) |
| "In audiogenic seizure mice, glial CA activity is increased and glial anion transport is reduced." | 1.27 | Ionic and acid-base regulation of neurons and glia during seizures. ( Chen, CF; Chow, SY; Engstrom, FL; Kemp, JW; White, HS; Woodbury, DM, 1984) |
| "In behavioral studies, ethanol prevents convulsions induced by bicuculline, picrotoxin and maximal electroshock seizures." | 1.27 | Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol. ( Ticku, MK, 1987) |
| "In the seizure group a slightly but significantly lower magnesium, potassium and calcium in CSF and a significant decrease of potassium and calcium in serum were revealed." | 1.26 | Electrolyte changes and acid base balance after alcohol withdrawal, with special reference to rum fits and magnesium depletion. ( Meyer, JG; Urban, K, 1977) |
| "Grand mal seizures were observed in unanesthetized animals (+/-SD) 133+/-37 min after administration of insulin, at a time when brain glucose was normal, but brain tissue content of Na(+), K(+), osmoles, and water was significantly greater than normal." | 1.25 | Mechanisms of seizures and coma in hypoglycemia. Evidence for a direct effect of insulin on electrolyte transport in brain. ( Arieff, AI; Doerner, T; Massry, SG; Zelig, H, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 74 (46.84) | 18.7374 |
| 1990's | 25 (15.82) | 18.2507 |
| 2000's | 27 (17.09) | 29.6817 |
| 2010's | 24 (15.19) | 24.3611 |
| 2020's | 8 (5.06) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, KN | 1 |
| Guan, QW | 1 |
| Yin, XX | 1 |
| Wang, ZJ | 1 |
| Zhou, HH | 1 |
| Mao, XY | 1 |
| Casas-Alba, D | 1 |
| Oliva, C | 1 |
| Salgado, MDC | 1 |
| Codina, A | 1 |
| Agut, T | 1 |
| García-Alix, A | 1 |
| Garcia-Puig, M | 1 |
| García-Cazorla, À | 1 |
| Taglialatela, M | 1 |
| Jou, C | 1 |
| Artuch, R | 1 |
| Fons, C | 1 |
| Belperio, G | 1 |
| Corso, C | 1 |
| Duarte, CB | 1 |
| Mele, M | 1 |
| Aussel, A | 1 |
| Ranta, R | 1 |
| Aron, O | 1 |
| Colnat-Coulbois, S | 1 |
| Maillard, L | 1 |
| Buhry, L | 1 |
| Lopez-Sola, E | 1 |
| Sanchez-Todo, R | 1 |
| Lleal, È | 1 |
| Köksal-Ersöz, E | 1 |
| Yochum, M | 1 |
| Makhalova, J | 1 |
| Mercadal, B | 1 |
| Guasch-Morgades, M | 1 |
| Salvador, R | 1 |
| Lozano-Soldevilla, D | 1 |
| Modolo, J | 1 |
| Bartolomei, F | 1 |
| Wendling, F | 1 |
| Benquet, P | 1 |
| Ruffini, G | 1 |
| Kapur, J | 1 |
| Long, L | 1 |
| Dixon-Salazar, T | 1 |
| Weiss, SA | 1 |
| Perucca, E | 1 |
| Bialer, M | 1 |
| White, HS | 3 |
| Kommajosyula, SP | 1 |
| Randall, ME | 1 |
| Brozoski, TJ | 1 |
| Odintsov, BM | 1 |
| Faingold, CL | 1 |
| Wang, Y | 4 |
| Chen, Z | 1 |
| Magloire, V | 1 |
| Cornford, J | 1 |
| Lieb, A | 1 |
| Kullmann, DM | 1 |
| Pavlov, I | 1 |
| Wu, Z | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Bumetanide for Newborn Seizures: A Phase I Study of Pharmacokinetics and Safety of Bumetanide for Neonatal Seizures[NCT00830531] | Phase 1 | 43 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for chlorine and Seizures
| Article | Year |
|---|---|
Molecular Mechanisms of Epilepsy: The Role of the Chloride Transporter KCC2.
Topics: Chlorides; Epilepsy; Female; Humans; Male; Quality of Life; Receptors, GABA-A; Seizures; Symporters | 2022 |
Chloride ion dysregulation in epileptogenic neuronal networks.
Topics: Chlorides; gamma-Aminobutyric Acid; Humans; Neurons; Receptors, GABA-A; Seizures; Synaptic Transmiss | 2023 |
New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System.
Topics: Animals; Anticonvulsants; Brain; Chlorides; Epilepsy; Humans; Mammals; Seizures | 2023 |
Double-edged GABAergic synaptic transmission in seizures: The importance of chloride plasticity.
Topics: Animals; Chlorides; Epilepsy; GABA Agents; GABAergic Neurons; gamma-Aminobutyric Acid; Humans; K Cl- | 2018 |
Mutations affecting GABAergic signaling in seizures and epilepsy.
Topics: Angelman Syndrome; Animals; Channelopathies; Chloride Channels; Chlorides; CLC-2 Chloride Channels; | 2010 |
Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia.
Topics: Age Factors; Animals; Chlorides; Epilepsy; gamma-Aminobutyric Acid; Humans; Mice; Neural Stem Cells; | 2011 |
Possible alterations in GABAA receptor signaling that underlie benzodiazepine-resistant seizures.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chlorides; Drug Resistance; Epilepsy; GABA Modulators; Ho | 2012 |
Developmental patterns in the regulation of chloride homeostasis and GABA(A) receptor signaling by seizures.
Topics: Animals; Animals, Newborn; Brain; Chlorides; Disease Models, Animal; Fluoresceins; Hippocampus; Home | 2007 |
The GABA postsynaptic membrane receptor-ionophore complex. Site of action of convulsant and anticonvulsant drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Bicuculline; Brain; Chlorides; Convulsants; Diazepam | 1981 |
Benzodiazepine receptor ligands with positive and negative efficacy.
Topics: Acoustic Stimulation; Animals; Carbolines; Chlorides; gamma-Aminobutyric Acid; Humans; Ligands; Rece | 1983 |
Benzodiazepine/barbiturate/GABA receptor-chloride ionophore complex in a genetic model for generalized epilepsy.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Binding Sites; Chlorides; Disease Models, A | 1986 |
Ionic changes and alterations in the size of the extracellular space during epileptic activity.
Topics: Action Potentials; Aluminum Oxide; Animals; Chlorides; Epilepsy; Extracellular Space; Forecasting; H | 1986 |
146 other studies available for chlorine and Seizures
| Article | Year |
|---|---|
Ferrostatin-1 obviates seizures and associated cognitive deficits in ferric chloride-induced posttraumatic epilepsy via suppressing ferroptosis.
Topics: Animals; Chlorides; Cognition; Cognitive Dysfunction; Cyclohexylamines; Ferric Compounds; Ferroptosi | 2022 |
Cerebrospinal Fluid Ion Analysis in Neonatal Seizures.
Topics: Age Factors; Calcium; Chlorides; Female; Humans; Infant, Newborn; Ions; Male; Potassium; Retrospecti | 2022 |
Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations.
Topics: Chlorides; Electroencephalography; Epilepsy; Hippocampus; Humans; Models, Neurological; Potassium; S | 2022 |
A personalizable autonomous neural mass model of epileptic seizures.
Topics: Chlorides; Electroencephalography; Epilepsy; Humans; Pyramidal Cells; Seizures | 2022 |
Consequences: Bench to home.
Topics: Chlorides; Epilepsy, Generalized; gamma-Aminobutyric Acid; Humans; Quality of Life; Receptors, GABA- | 2022 |
Specific subcortical structures are activated during seizure-induced death in a model of sudden unexpected death in epilepsy (SUDEP): A manganese-enhanced magnetic resonance imaging study.
Topics: Acoustic Stimulation; Animals; Brain; Chlorides; Contrast Media; Death, Sudden; Disease Models, Anim | 2017 |
KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition.
Topics: Animals; Chlorides; Disease Models, Animal; Electrocorticography; Electrodes; Female; Genetic Vector | 2019 |
Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels.
Topics: Animals; Animals, Newborn; Brain; Cells, Cultured; Chloride Channels; Chlorides; Down-Regulation; ga | 2019 |
Nitric oxide and glutamate are contributors of anti-seizure activity of rubidium chloride: A comparison with lithium.
Topics: Animals; Anticonvulsants; Chlorides; Glutamic Acid; Lithium Chloride; Male; Mice; Neuroprotective Ag | 2019 |
Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters.
Topics: Amino Acid Transport System X-AG; Animals; Anticonvulsants; Chlorides; Dehydroepiandrosterone; Elect | 2013 |
Electrical stimulation of the substantia nigra pars reticulata (SNr) suppresses chemically induced neocortical seizures in rats.
Topics: Animals; Chlorides; Deep Brain Stimulation; Ferric Compounds; Male; Neocortex; Pars Reticulata; Rats | 2014 |
EFFECT OF CARBON DIOXIDE EXPOSURE ON ELECTROLYTE DISTRIBUTION AND ITS RELATIONSHIP TO CONVULSIVE ACTIVITY IN RATS. CONTRACTS NONR(04) AND 4343(00). TECHN REP NO. 64-2.
Topics: Anions; Brain Chemistry; Carbon Dioxide; Chlorides; Electrolytes; Ions; Potassium; Rats; Research; S | 1965 |
Impact of rotavirus vaccine introduction on rotavirus-associated seizures and a related possible mechanism.
Topics: Calcium; Child, Preschool; Chlorides; Female; Fever; Gastroenteritis; Humans; Incidence; Infant; Mal | 2015 |
BDNF is required for seizure-induced but not developmental up-regulation of KCC2 in the neonatal hippocampus.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain-Derived Neurotrophic Factor; Calpain; Chlorides; | 2015 |
Bromoderma mimicking pyoderma gangrenosum caused by commercial sedatives.
Topics: Acid-Base Equilibrium; Adult; Anorexia Nervosa; Biopsy; Bromides; Bromisovalum; Chlorides; Cyclospor | 2016 |
Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay.
Topics: Adult; Biological Transport; Child, Preschool; Chlorides; Female; Humans; Infant; Male; Mutation; Po | 2016 |
Hyponatraemia in Paediatric Bronchiolitis - a Harmful Complication not to be Ignored.
Topics: Brain Diseases; Bronchiolitis; Chlorides; Diseases in Twins; Female; Humans; Hyponatremia; Infant; I | 2016 |
Calcium sensitive non-selective cation current promotes seizure-like discharges and spreading depression in a model neuron.
Topics: Calcium; Calcium Channels; Chlorides; Computer Simulation; Cortical Spreading Depression; Membrane P | 2009 |
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Clinical characteristics of benign convulsions with rotavirus gastroenteritis.
Topics: Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Chlorides; Creatinine; Female; | 2009 |
Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy.
Topics: Analysis of Variance; Animals; Chelating Agents; Chlorides; Disease Models, Animal; Drug Delivery Sy | 2009 |
Synchronization of GABAergic inputs to CA3 pyramidal cells precedes seizure-like event onset in juvenile rat hippocampal slices.
Topics: Aging; Animals; CA3 Region, Hippocampal; Chlorides; GABA Antagonists; gamma-Aminobutyric Acid; Gluta | 2009 |
Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures.
Topics: Amygdala; Animals; Animals, Newborn; Anticonvulsants; Bumetanide; Chlorides; Female; gamma-Aminobuty | 2009 |
Hypochloremia and hyponatremia as the initial presentation of cystic fibrosis in three adults.
Topics: Adult; Asthenia; Body Mass Index; Chlorides; Cystic Fibrosis; Dehydration; Female; Hemodynamics; Hum | 2010 |
Sanjoinine A isolated from Semen Zizyphi Spinosi protects against kainic acid-induced convulsions.
Topics: Administration, Oral; Alkaloids; Animals; Anticonvulsants; Apoptosis; Calcium; Cells, Cultured; Chlo | 2009 |
Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures.
Topics: Animals; Animals, Newborn; Chlorides; Disease Progression; Female; Hippocampus; Intracellular Fluid; | 2010 |
Metabolic control of vesicular glutamate transport and release.
Topics: 4-Aminopyridine; Acetoacetates; Animals; Astrocytes; Behavior, Animal; Cells, Cultured; Chlorides; C | 2010 |
Hippocampal gene network analysis in an experimental model of posttraumatic epilepsy.
Topics: Animals; Chlorides; Epilepsy, Post-Traumatic; Ferric Compounds; Gene Expression Profiling; Gene Regu | 2011 |
Convulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structures.
Topics: Animals; Anticonvulsants; Chlorides; Drug Evaluation, Preclinical; Electroshock; Flavones; Hydroxide | 2011 |
[Analysis of the blood and serum biochemistry findings in patients demonstrating convulsion with mild gastroenteritis].
Topics: Acidosis; Blood Cell Count; Chlorides; Female; Gastroenteritis; Humans; Infant; Male; Seizures; Uric | 2011 |
Alleviation of ferric chloride-induced seizures and retarded behaviour in epileptic rats by cortical electrical stimulation treatment.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Ch | 2012 |
Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; CA3 Region, Hippocampal; Chlorides; Epilepsy, Te | 2012 |
The effects of zinc treatment on the blood-brain barrier permeability and brain element levels during convulsions.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain Stem; Cerebellum; Chlorides; Convulsants; Copper | 2013 |
Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.
Topics: Animals; Autoradiography; Bicuculline; Blotting, Western; Cerebral Cortex; Chlorides; Convulsants; F | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepa | 2002 |
Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetazolamide; Animals; Animals, Newborn; Anti-Ulcer Agents; A | 2003 |
[The effect of DCA compound E testosterone, progesterone and ACTH in modifying agene-induced convulsions in dogs].
Topics: Adrenocorticotropic Hormone; Androgens; Animals; Chlorides; Cortisone; Dogs; Nitrogen Compounds; Pro | 1952 |
The effect of agene-induced convulsions on adrenal steroid excretion in normal and castrate dogs.
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Animals; Chlorides; Dogs; Nitrogen Compounds; Seizures; Ste | 1953 |
ELECTROSHOCK SEIZURES AND BRAIN CHEMISTRY AFTER ACUTE EXPOSURE TO MODERATE COLD.
Topics: Adrenal Glands; Blood; Blood Chemical Analysis; Body Weight; Brain; Brain Chemistry; Carbohydrate Me | 1963 |
CHANGES IN ELECTRIC BRAIN ACTIVITY AFTER LOCAL KCI APPLICATION ON EPILEPTOGENIC FOCUS IN CATS.
Topics: Brain; Cats; Chlorides; Electroencephalography; Nervous System Physiological Phenomena; Pharmacology | 1964 |
CNS DISORDER DURING MECHANICAL VENTILATION IN CHRONIC PULMONARY DISEASE.
Topics: Adrenal Cortex Hormones; Alkalosis; Bicarbonates; Blood; Carbon Dioxide; Central Nervous System Dise | 1964 |
EFFECTS OF CHEMICAL INJECTION INTO THE RETICULAR FORMATION OF RATS.
Topics: Chlorides; Citrates; Coma; Fear; Injections; Nikethamide; Pentobarbital; Potassium; Procaine; Rats; | 1964 |
CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS.
Topics: Aminobutyrates; Bemegride; Benzene; Calcium; Central Nervous System Stimulants; Chlorides; Coronary | 1964 |
CHLORURETIC, NATRIURETIC, AND DEPRESSOR ACTIVITIES OF SOME SUBSTITUTED SYDNONES.
Topics: Antihypertensive Agents; Blood; Chlorides; Cholesterol; Dogs; Growth; Natriuresis; Oxadiazoles; Pota | 1964 |
THE EFFECT OF HYPERTONIC UREA SOLUTION ON ELECTROSHOCK SEIZURE THRESHOLD AND ELECTROLYTE DISTRIBUTION IN RATS.
Topics: Blood; Brain Chemistry; Chlorides; Electricity; Electrolytes; Electroshock; Hypertonic Solutions; Io | 1964 |
CONTROL OF ACIDOSIS IN HYPERBARIC OXYGENATION.
Topics: Acidosis; Blood Chemical Analysis; Carbon Dioxide; Chlorides; Dogs; Humans; Hyperbaric Oxygenation; | 1965 |
EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS.
Topics: Aluminum; Animals; Brain; Brain Chemistry; Brain Stem; Cerebellum; Chlorides; Cytoplasm; Neurofibril | 1965 |
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold.
Topics: Animals; Cell Size; Cerebellum; Chlorides; Deafness; Embryonic and Fetal Development; Gene Deletion; | 2003 |
Some biochemical changes observed during agene-induced convulsions.
Topics: Chlorides; Humans; Nitrogen Compounds; Seizures | 1950 |
Elimination of zinc-65 from the brain under kainate-induced seizures.
Topics: Animals; Brain; Chlorides; Excitatory Amino Acid Agonists; Kainic Acid; Male; Metalloproteins; Mice; | 2004 |
Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat.
Topics: Animals; Antioxidants; Chlorides; Disease Models, Animal; Electroencephalography; Ferric Compounds; | 2004 |
Sex differences in effects of mild chronic stress on seizure risk and GABAA receptors in rats.
Topics: Animals; Chlorides; Chronic Disease; Corticosterone; Diazepam; Ethanol; Female; Male; Rats; Rats, Sp | 2004 |
Acquired long QT syndrome and monomorphic ventricular tachycardia after alternative treatment with cesium chloride for brain cancer.
Topics: Adult; Brain Neoplasms; Cesium; Chlorides; Complementary Therapies; Electric Countershock; Electroca | 2004 |
Studies on nitrogen trichloride-treated prolamines; suppression of the development of convulsions with methionine.
Topics: Chlorides; Humans; Methionine; Nitrogen Compounds; Phenylpropanolamine; Seizures | 1950 |
The effect of some anticonvulsant agents upon agene-induced convulsions in dogs.
Topics: Animals; Anticonvulsants; Barbital; Chlorides; Dogs; Nitrogen Compounds; Seizures | 1950 |
Actions at GABA(A) receptors in the hippocampus may mediate some antiseizure effects of progestins.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Chlorides; Disease Mo | 2005 |
Differential effects of mild repeated restraint stress on behaviors and GABA(A) receptors in male and female rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Chlorides; Corticosterone; Female; | 2005 |
Extracellular chelation of zinc does not affect hippocampal excitability and seizure-induced cell death in rats.
Topics: Animals; Cell Death; Chelating Agents; Chlorides; Edetic Acid; Electrophysiology; Extracellular Spac | 2007 |
In vivo EPR estimation of bilateral hippocampal antioxidant ability of rats with epileptogenesis induced by amygdalar FeCl3 microinjection.
Topics: Amygdala; Animals; Antioxidants; Chlorides; Chronic Disease; Disease Models, Animal; Electrodes, Imp | 2007 |
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.
Topics: Animals; Anticonvulsants; Bumetanide; Chloride Channels; Chlorides; Drug Synergism; Drug Therapy, Co | 2008 |
Manganese enhanced MRI detects mossy fiber sprouting rather than neurodegeneration, gliosis or seizure-activity in the epileptic rat hippocampus.
Topics: Algorithms; Animals; Blood-Brain Barrier; Chlorides; Chronic Disease; Contrast Media; Data Interpret | 2008 |
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Chlorides; Electrophysiology; Extracellular Space; GABA | 2008 |
Cerebral composition and function in experimental brain injury in the rat.
Topics: Animals; Autoradiography; Biological Transport, Active; Brain Chemistry; Brain Edema; Brain Injuries | 1967 |
[Anxiety receptors: new pharmacological approach (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Binding, Competitive; Brain; Chlordiazepoxide; Chlo | 1982 |
Ionic and acid-base regulation of neurons and glia during seizures.
Topics: Acid-Base Equilibrium; Adenosine Triphosphatases; Animals; Anion Transport Proteins; Bicarbonates; C | 1984 |
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Topics: Animals; Atropine; Brain Chemistry; Chlorides; Drug Interactions; Humans; Inositol; Inositol Phospha | 1983 |
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.
Topics: Animals; Binding, Competitive; Carbolines; Chlorides; Diazepam; Flunitrazepam; Harmine; Indoles; Ion | 1984 |
[Comparative toxicity of various barium compounds].
Topics: Animals; Barium; Barium Compounds; Chlorides; Guinea Pigs; Humans; Mice; Muscle Spasticity; Nitrates | 1984 |
Effects of intracellular injections of chloride and EGTA on postepileptiform-burst hyperpolarizations in hippocampal neurons.
Topics: Animals; Chlorides; Egtazic Acid; Ethylene Glycols; Guinea Pigs; Hippocampus; Neurons; Penicillins; | 1981 |
Changes in [3H]lysine incorporation into protein in a seizure focus in rat isocortex.
Topics: Animals; Cerebral Cortex; Chlorides; Convulsants; Evoked Potentials; Female; Ferric Compounds; Lysin | 1981 |
Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Topics: Animals; Anticonvulsants; Chlorides; Chronic Disease; Clonazepam; Diazepam; Disease Models, Animal; | 1983 |
Chronic model of neurofibrillary changes induced in mature rabbits by metallic aluminum.
Topics: Aging; Aluminum; Aluminum Chloride; Aluminum Compounds; Animals; Brain; Chlorides; Kinetics; Models, | 1982 |
Aluminum chloride induced neurofibrillary changes in the developing rabbit a chronic animal model.
Topics: Aluminum; Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Brain; Chlorides; Femal | 1980 |
[Effect of increased partial pressure of oxygen on the regulatory function of the blood--brain barrier].
Topics: Acid Phosphatase; Animals; Arteries; Blood Proteins; Blood-Brain Barrier; Chlorides; Female; Glucose | 1980 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Systemic administration of lithium chloride and tacrine increases nitric oxide synthase activity in the hippocampus of rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Atropine; Cerebral Cortex; Chlorides; Cyclic GMP; Hip | 1993 |
Opposite changes in GABAA receptor function in the CA1-3 area and fascia dentata of kindled rat hippocampus.
Topics: Animals; Chlorides; Hippocampus; Kindling, Neurologic; Male; Microscopy, Electron; Muscimol; Osmolar | 1995 |
Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Brain; Bridged Bicyclo Compounds; Bridged Bic | 1993 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
Extreme hypothermia induced by a synergism of acute limbic seizures, physical restraint, and acepromazine: implications for survival following brain injury.
Topics: Acepromazine; Animals; Body Temperature Regulation; Brain Injuries; Chlorides; Hypothermia; Limbic S | 1993 |
Impairment of the gustatory engram by generalised seizure activity without associated loss of conditioned taste aversion.
Topics: Animals; Association Learning; Avoidance Learning; Cerebral Cortex; Chlorides; Conditioning, Classic | 1993 |
Influence of ZnCl2 pretreatment on behavioral and histological responses to kainic acid in rats.
Topics: Animals; Chlorides; Drug Administration Schedule; Hippocampus; Kainic Acid; Male; Pyramidal Tracts; | 1993 |
Effect of metal chelating agents on the direct and seizure-related neuronal death induced by zinc and kainic acid.
Topics: Amygdala; Animals; Brain; Cell Death; Chelating Agents; Chlorides; Excitatory Amino Acid Agonists; H | 1998 |
Amygdalar injection of FeCl3 causes spontaneous recurrent seizures.
Topics: Amygdala; Animals; Behavior, Animal; Chlorides; Convulsants; Electroencephalography; Ferric Compound | 1998 |
Acute mental status changes and hyperchloremic metabolic acidosis with long-term topiramate therapy.
Topics: Acidosis; Acute Disease; Adult; Anticonvulsants; Chlorides; Confusion; Fructose; Humans; Male; Seizu | 2000 |
Behavioral effects of intra-nigral microinjections of manganese chloride: interaction with nitric oxide.
Topics: Animals; Anxiety Disorders; Chlorides; Drug Interactions; Male; Manganese Compounds; Movement Disord | 2000 |
Sequential changes in AMPA and NMDA protein levels during Fe(3+)-induced epileptogenesis.
Topics: Amygdala; Animals; Calcium; Chlorides; Convulsants; Epilepsy; Ferric Compounds; Glutamic Acid; Hippo | 2001 |
Protective effect of resveratrol against intracortical FeCl3-induced model of posttraumatic seizures in rats.
Topics: Animals; Antioxidants; Brain; Chlorides; Electroencephalography; Epilepsy, Post-Traumatic; Female; F | 2001 |
Osmolar relation between cerebrospinal fluid and serum in hyperosmolar hypernatraemic dehydration.
Topics: Blood Glucose; Blood Urea Nitrogen; Calcium; Carbon Dioxide; Child, Preschool; Chlorides; Dehydratio | 1976 |
Electrolyte changes and acid base balance after alcohol withdrawal, with special reference to rum fits and magnesium depletion.
Topics: Acid-Base Imbalance; Adult; Alcoholism; Chlorides; Electrolytes; Female; Humans; Magnesium; Magnesiu | 1977 |
Clinical biochemistry of epilepsy. II. Observations on two types of epileptiform convulsions induced in rabbits with corticotropin.
Topics: Adrenocorticotropic Hormone; Animals; Blood Chemical Analysis; Blood Pressure; Calcitonin; Calcium; | 1979 |
Epileptic-type convulsions and magnesium deficiency.
Topics: Acclimatization; Adult; Chlorides; Epilepsy; Hot Temperature; Humans; Magnesium; Magnesium Deficienc | 1979 |
Effect of elevated potassium on the ion content of mouse astrocytes and neurons.
Topics: Animals; Animals, Newborn; Astrocytes; Body Water; Cells, Cultured; Chlorides; Cortical Spreading De | 1992 |
Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures.
Topics: Animals; Brain Mapping; Cerebral Cortex; Chlorides; Cyclic AMP; Cyclic GMP; Dose-Response Relationsh | 1992 |
Tacrine-induced seizures and brain damage in LiCl-treated rats can be prevented by N omega-nitro-L-arginine methyl ester.
Topics: Animals; Arginine; Brain; Chlorides; Lithium; Lithium Chloride; Male; NG-Nitroarginine Methyl Ester; | 1992 |
Effects of lorazepam tolerance and withdrawal on GABAA receptor operated chloride channels in mice selected for differences in ethanol withdrawal severity.
Topics: Animals; Benzodiazepines; Brain; Chloride Channels; Chlorides; Drug Tolerance; Ethanol; Infusion Pum | 1992 |
[3H]hemicholinium-3 binding in rats with status epilepticus induced by lithium chloride and pilocarpine.
Topics: Acetylcholine; Animals; Cerebral Cortex; Chlorides; Choline; Hemicholinium 3; Hippocampus; Kinetics; | 1991 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Femal | 1991 |
Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.
Topics: Animals; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitraze | 1991 |
Lithium modifies convulsions and brain phosphoinositide turnover induced by organophosphates.
Topics: Animals; Brain; Chlorides; Chromatography, Gas; Drug Synergism; Inositol Phosphates; Insecticides; I | 1991 |
Cholinergic rebound after chlorpromazine exacerbates lithium muscarinic-induced limbic seizures in rats: implications for psychiatric treatment.
Topics: Animals; Bipolar Disorder; Chlorides; Chlorpromazine; Drug Therapy, Combination; Female; Limbic Syst | 1991 |
Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndromes.
Topics: Alkalosis; Bartter Syndrome; Bicarbonates; Calcium; Child; Child, Preschool; Chlorides; Creatinine; | 1992 |
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.
Topics: 4-Aminobutyrate Transaminase; Amine Oxidase (Copper-Containing); Amino Acids; Animals; Anticonvulsan | 1991 |
Analysis of the convulsant-potentiating effects of lithium in rats.
Topics: Animals; Bicuculline; Chlorides; Convulsants; Drug Synergism; Hippocampus; Kainic Acid; Lithium; Lit | 1991 |
Effect of LiCl pretreatment on cholinomimetic-induced seizures and seizure-induced brain edema in rats.
Topics: Animals; Brain; Brain Edema; Chlorides; Isoflurophate; Lithium; Lithium Chloride; Male; Organ Specif | 1990 |
GABA-gated chloride ion influx in brains of epileptic El mice.
Topics: Animals; Brain; Chlorides; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Ion Channel Ga | 1990 |
Structural changes in astrocytes induced by seizures in a mode of temporal lobe epilepsy.
Topics: Animals; Astrocytes; Cerebral Cortex; Chlorides; Epilepsy, Temporal Lobe; Ferric Compounds; Ferrous | 1990 |
Polychlorocycloalkane insecticide-induced convulsions in mice in relation to disruption of the GABA-regulated chloride ionophore.
Topics: Animals; Binding, Competitive; Brain; Chlorides; Endosulfan; Hydrocarbons, Chlorinated; Insecticides | 1986 |
CNS biochemical and pharmacological effects of the isomers of hexachlorocyclohexane (lindane) in the mouse.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Drug | 1988 |
Antidepressants and seizure-interactions at the GABA-receptor chloride-ionophore complex.
Topics: Amitriptyline; Animals; Antidepressive Agents; Cerebral Cortex; Chlorides; Desipramine; gamma-Aminob | 1988 |
Increased sensitivity to inverse agonists and decreased GABA-stimulated chloride influx induced by chronic treatment with FG 7142.
Topics: Animals; Anti-Anxiety Agents; Appetite Depressants; Benzodiazepines; Carbolines; Chlorides; gamma-Am | 1988 |
Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Respons | 1989 |
Behavioral and functional studies indicate a role for GABAAergic transmission in the actions of ethanol.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; C | 1987 |
Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.
Topics: Androstane-3,17-diol; Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Comp | 1988 |
Characteristics of limbic seizures evoked by peripheral injections of lithium and pilocarpine.
Topics: Animals; Anticonvulsants; Brain Mapping; Chlorides; Dose-Response Relationship, Drug; Drug Synergism | 1988 |
Lithium suppresses seizure susceptibility in pentylenetetrazol-kindled rats.
Topics: Animals; Chlorides; Disease Susceptibility; Female; Kindling, Neurologic; Lithium; Lithium Chloride; | 1986 |
Synaptic and non-synaptic mechanisms underlying low calcium bursts in the in vitro hippocampal slice.
Topics: Action Potentials; Animals; Bicuculline; Calcium; Chlorides; Electric Stimulation; Hippocampus; In V | 1988 |
Serum chemistry abnormalities in adult patients with seizures.
Topics: Adolescent; Adult; Aged; Alcoholism; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Calcium; Chlo | 1985 |
Dopaminergic supersensitivity follows ferric chloride-induced limbic seizures.
Topics: Aggression; Amygdala; Animals; Apomorphine; Behavior, Animal; Chlorides; Ferric Compounds; Humans; I | 1985 |
Metabolic alkalosis with hypertonic dehydration in a patient with diarrhoea and magnesium oxide ingestion.
Topics: Alkalosis; Chlorides; Dehydration; Diagnosis, Differential; Diarrhea, Infantile; Feces; Female; Gast | 1985 |
The role of astroglia as modulators of neuronal function in cerebral cortex: comparative data, and observations in vivo and in vitro in fluid, electrolyte and amino acid interrelationships.
Topics: Acetylcholinesterase; Animals; Astrocytes; Biological Transport, Active; Carbonic Anhydrases; Carbox | 1973 |
Inhibition in focal epileptogenesis.
Topics: Animals; Cats; Cerebral Cortex; Chlorides; Electroencephalography; Evoked Potentials; Penicillins; S | 1968 |
Some age-dependent biochemical changes in mice susceptible to seizures.
Topics: Adenosine Triphosphatases; Age Factors; Aminobutyrates; Animals; Brain; Carbon Radioisotopes; Chlori | 1974 |
Propagation of afterdischarges elicited in thin brain sections in artificial media.
Topics: Action Potentials; Animals; Brain; Calcium; Chlorides; Electric Stimulation; Evoked Potentials; Guin | 1973 |
[Vincristine-induced encephalopathies during treatment of childhood leukemias].
Topics: Albuminuria; Central Nervous System; Child; Chlorides; Electroencephalography; Female; Humans; Leuke | 1972 |
Localized ECS impedes tast aversion learning.
Topics: Animals; Avoidance Learning; Brain; Brain Mapping; Chlorides; Conditioning, Classical; Drinking Beha | 1972 |
[Several biochemical indices in convulsive conditions in children in the 1st months of life].
Topics: Acid-Base Equilibrium; Acidosis; Adenosine Triphosphate; Asphyxia Neonatorum; Chlorides; Humans; Inf | 1972 |
Symptomatology, pathophysiology and treatment of the transurethral resection of the prostate syndrome.
Topics: Aged; Bicarbonates; Chlorides; Extracellular Space; Headache; Humans; Male; Mannitol; Nausea; Osmola | 1973 |
Electroconvulsive shock impedes association formation: conditioned taste aversion paradigm.
Topics: Amnesia; Animals; Association; Avoidance Learning; Chlorides; Conditioning, Classical; Drinking Beha | 1973 |
Mortality in systemic lupus erythematosus: a 10-year review.
Topics: Adolescent; Adult; Aged; Bronchopneumonia; Cerebrospinal Fluid Proteins; Child; Chlorides; Coma; Cyc | 1973 |
Case report: diuretics and non-respiratory alkalosis.
Topics: Alkalosis; Chlorides; Dehydration; Female; Furosemide; Hemiplegia; Humans; Infusions, Parenteral; Mi | 1973 |
[Osmotic shifts in the blood and cerebrospinal fluid of the newborn following asphyxia and intrauterine trauma].
Topics: Acid-Base Equilibrium; Asphyxia Neonatorum; Birth Injuries; Blood; Blood Glucose; Brain Injuries; Ca | 1973 |
The behavior of presumed glial cells during seizure discharge in cat cerebral cortex.
Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Chlorides; Disease Models, Animal; Electric Stimu | 1974 |
Mechanisms of seizures and coma in hypoglycemia. Evidence for a direct effect of insulin on electrolyte transport in brain.
Topics: Animals; Biological Transport, Active; Brain; Brain Edema; Chlorides; Coma; Disease Models, Animal; | 1974 |
Cerebral spinal fluid studies in eclampsia.
Topics: Bicarbonates; Cerebrospinal Fluid; Chlorides; Eclampsia; Female; Hematocrit; Humans; Hypertension; N | 1972 |
Electrophysiological response of the rabbit brain to chronic hypernatremic dehydration and rehydration.
Topics: Administration, Oral; Animals; Brain; Chlorides; Dehydration; Electrodes, Implanted; Electroencephal | 1972 |
Hypochloremic alkalosis with symptoms of seizure disorder.
Topics: Aged; Alkalosis; Chlorides; Female; Humans; Middle Aged; Seizures | 1970 |
Generation of the seizure discharge in thin sections from the guinea pig brain in chloride-free medium in vitro.
Topics: Animals; Chlorides; Electric Stimulation; Evoked Potentials; Guinea Pigs; Hippocampus; Phenobarbital | 1968 |
Acute toxicity of propoxyphene salts.
Topics: Administration, Oral; Animals; Ataxia; Chlorides; Dextropropoxyphene; Dogs; Female; Injections, Intr | 1971 |
Therapy of infants with hypertonic dehydration due to diarrhea. A controlled study of clinical, chemical, and pathophysiological response to two types of therapeutic fluid regimen, with evaluation of late sequelae.
Topics: Blood Chemical Analysis; Blood Gas Analysis; Blood Urea Nitrogen; Chlorides; Dehydration; Diarrhea, | 1968 |
Inhibition in "epileptic" neurons.
Topics: Action Potentials; Animals; Cats; Cerebral Cortex; Chlorides; Electric Stimulation; Electrophysiolog | 1968 |
The effect of selected neuromuscular blocking agents on the duration of pentylenetetrazol-induced sezures.
Topics: Animals; Bromides; Cats; Chlorides; Decamethonium Compounds; Female; Gallamine Triethiodide; Male; P | 1968 |
Pathogenesis of seizures occurring during restoration of plasma tonicity to normal in animals previously chronically hypernatremic.
Topics: Animals; Brain Chemistry; Chlorides; Dehydration; Diarrhea; Glucose; Hypernatremia; Potassium; Rabbi | 1969 |
Cerebral metabolism during electrically induced seizures in man.
Topics: Adolescent; Adult; Anesthesia, General; Bicarbonates; Blood Glucose; Blood Pressure; Brain; Carbon D | 1969 |
Responses of flexor alpha-motoneurones in cats anaesthetised with chloralose.
Topics: Animals; Cats; Chloralose; Chlorides; Electric Stimulation; Electrophysiology; Evoked Potentials; In | 1969 |
Responses of extensor alpha-motoneurones in cats anaesthetised with chloralose.
Topics: Anesthesia; Animals; Cats; Chloralose; Chlorides; Electric Stimulation; Electrophysiology; Evoked Po | 1969 |