chlorine has been researched along with Parkinson Disease in 28 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One hundred and two patients with Parkinson's disease were enrolled in this study." | 1.46 | Serum sodium and chloride are inversely associated with dyskinesia in Parkinson's disease patients. ( Chen, J; Huang, JY; Jin, H; Liu, CF; Mao, CJ; Wang, F; Xu, LL; Yang, Y; Yang, YP; Zhang, HJ; Zhang, JR; Zhong, CK, 2017) |
| "The neuropathological hallmark of Parkinson's disease is the loss of dopaminergic neurons in the pars compacta of the substantia nigra (SNc)." | 1.37 | In vivo magnetic resonance imaging characterization of bilateral structural changes in experimental Parkinson's disease: a T2 relaxometry study combined with longitudinal diffusion tensor imaging and manganese-enhanced magnetic resonance imaging in the 6- ( Aguilar, E; Marin, C; Mullol, J; Planas, AM; Soria, G; Tudela, R, 2011) |
| "Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders." | 1.36 | Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. ( Antonini, JM; Castranova, V; Ghio, AJ; Hayashi, Y; Jefferson, AM; Krajnak, KM; Lin, GX; Munson, AE; Reynolds, SH; Roberts, JR; Soukup, JM; Sriram, K; Wirth, O, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Viegas, MPC | 1 |
| Santos, LEC | 1 |
| Aarão, MC | 1 |
| Cecilio, SG | 1 |
| Medrado, JM | 1 |
| Pires, AC | 1 |
| Rodrigues, AM | 1 |
| Scorza, CA | 1 |
| Moret, MA | 1 |
| Finsterer, J | 1 |
| Scorza, FA | 1 |
| Almeida, AG | 1 |
| Menzikov, SA | 1 |
| Morozov, SG | 1 |
| Kubatiev, AA | 1 |
| Li, C | 1 |
| Zhuo, Y | 1 |
| Xiao, X | 1 |
| Li, S | 1 |
| Han, K | 1 |
| Lu, M | 1 |
| Zhang, J | 1 |
| Chen, S | 1 |
| Gu, H | 1 |
| Mao, CJ | 1 |
| Zhong, CK | 1 |
| Yang, Y | 1 |
| Yang, YP | 1 |
| Wang, F | 1 |
| Chen, J | 1 |
| Zhang, JR | 1 |
| Zhang, HJ | 1 |
| Jin, H | 2 |
| Xu, LL | 1 |
| Huang, JY | 1 |
| Liu, CF | 1 |
| Park, JS | 1 |
| Koentjoro, B | 1 |
| Klein, C | 1 |
| Sue, CM | 1 |
| Harischandra, DS | 1 |
| Anantharam, V | 1 |
| Kanthasamy, A | 1 |
| Kanthasamy, AG | 1 |
| Yang, N | 1 |
| Wei, Y | 1 |
| Wang, T | 1 |
| Guo, J | 1 |
| Sun, Q | 1 |
| Hu, Y | 1 |
| Yan, X | 1 |
| Zhu, X | 1 |
| Tang, B | 1 |
| Xu, Q | 1 |
| He, R | 1 |
| Xie, X | 1 |
| Lv, L | 1 |
| Huang, Y | 1 |
| Xia, X | 1 |
| Chen, X | 2 |
| Zhang, L | 1 |
| Ordoñez-Librado, JL | 2 |
| Gutierrez-Valdez, AL | 2 |
| Colín-Barenque, L | 1 |
| Anaya-Martínez, V | 2 |
| Díaz-Bech, P | 1 |
| Avila-Costa, MR | 2 |
| Tong, M | 1 |
| Dong, M | 1 |
| de la Monte, SM | 1 |
| Montiel-Flores, E | 1 |
| Corona, DR | 1 |
| Martinez-Fong, D | 1 |
| Roth, JA | 1 |
| Singleton, S | 1 |
| Feng, J | 1 |
| Garrick, M | 1 |
| Paradkar, PN | 1 |
| Sriram, K | 1 |
| Lin, GX | 1 |
| Jefferson, AM | 1 |
| Roberts, JR | 1 |
| Wirth, O | 1 |
| Hayashi, Y | 1 |
| Krajnak, KM | 1 |
| Soukup, JM | 1 |
| Ghio, AJ | 1 |
| Reynolds, SH | 1 |
| Castranova, V | 1 |
| Munson, AE | 1 |
| Antonini, JM | 1 |
| Soria, G | 1 |
| Aguilar, E | 1 |
| Tudela, R | 1 |
| Mullol, J | 1 |
| Planas, AM | 1 |
| Marin, C | 1 |
| Aboud, AA | 1 |
| Tidball, AM | 1 |
| Kumar, KK | 1 |
| Neely, MD | 1 |
| Ess, KC | 1 |
| Erikson, KM | 1 |
| Bowman, AB | 1 |
| Uversky, VN | 1 |
| Li, J | 1 |
| Bower, K | 1 |
| Fink, AL | 1 |
| Zhang, GH | 1 |
| Zhu, JX | 1 |
| Xue, H | 1 |
| Fan, J | 1 |
| Tsang, LL | 1 |
| Chung, YW | 1 |
| Xing, Y | 1 |
| Chan, HC | 1 |
| Atadzhanov, M | 1 |
| Serra, PA | 1 |
| Esposito, G | 1 |
| Enrico, P | 1 |
| Mura, MA | 1 |
| Migheli, R | 1 |
| Delogu, MR | 1 |
| Miele, M | 1 |
| Desole, MS | 1 |
| Grella, G | 1 |
| Miele, E | 1 |
| Datla, KP | 1 |
| Blunt, SB | 1 |
| Dexter, DT | 1 |
| Eisenlohr, JJ | 1 |
| Gehlen, W | 1 |
| Parkes, JD | 1 |
| Calver, DM | 1 |
| Zilkha, KJ | 1 |
| Knill-Jones, RP | 1 |
| Hunter, KR | 1 |
| Stern, GM | 1 |
| Laurence, DR | 1 |
| Armitage, P | 1 |
| Bettag, W | 1 |
| Fünfgeld, EW | 1 |
| Reveno, WS | 1 |
| Bauer, RB | 1 |
| Rosenbaum, H | 1 |
| Cooperman, LH | 1 |
| Fine, W | 1 |
2 reviews available for chlorine and Parkinson Disease
| Article | Year |
|---|---|
Intricacies of GABA
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Alzheimer Disease; Animals; Anion Transport Prote | 2021 |
[Modeling parkinsonism (review)].
Topics: Aluminum; Animals; Carbachol; Cats; Caudate Nucleus; Chlorides; Chlorpromazine; Disease Models, Anim | 1982 |
2 trials available for chlorine and Parkinson Disease
| Article | Year |
|---|---|
Controlled trial of amantadine hydrochloride in Parkinson's disease.
Topics: Aged; Amantadine; Chlorides; Clinical Trials as Topic; Humans; Middle Aged; Motor Activity; Movement | 1970 |
Amantadine in parkinsonism.
Topics: Aged; Amantadine; Chlorides; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Parkinson | 1970 |
24 other studies available for chlorine and Parkinson Disease
| Article | Year |
|---|---|
The nonsynaptic plasticity in Parkinson's disease: Insights from an animal model.
Topics: Adenosine Triphosphatases; Animals; Chlorides; Disease Models, Animal; Male; Oxidopamine; Parkinson | 2023 |
Facile Electrochemical Microbiosensor Based on
Topics: Animals; Brain; Chlorides; Electrochemical Techniques; Metal Nanoparticles; Mice; Parkinson Disease; | 2021 |
Serum sodium and chloride are inversely associated with dyskinesia in Parkinson's disease patients.
Topics: Age of Onset; Aged; Antiparkinson Agents; Chlorides; Dyskinesias; Female; Humans; Levodopa; Male; Mi | 2017 |
Single Heterozygous ATP13A2 Mutations Cause Cellular Dysfunction Associated with Parkinson's Disease.
Topics: Adenosine Triphosphate; Benzimidazoles; Carbocyanines; Chlorides; Dose-Response Relationship, Drug; | 2018 |
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apoptosis; Binding Sites; Blotting, Western; Cell Culture Techniques; Cell | 2015 |
Genome-wide analysis of DNA methylation during antagonism of DMOG to MnCl2-induced cytotoxicity in the mouse substantia nigra.
Topics: Amino Acids, Dicarboxylic; Animals; Behavior, Animal; Brain; Cell Line, Tumor; Cell Survival; Chlori | 2016 |
Comprehensive investigation of aberrant microRNAs expression in cells culture model of MnCl2-induced neurodegenerative disease.
Topics: Base Sequence; Cell Line, Tumor; Cell Survival; Chlorides; Dose-Response Relationship, Drug; Gene Ex | 2017 |
Inhalation of divalent and trivalent manganese mixture induces a Parkinson's disease model: immunocytochemical and behavioral evidences.
Topics: Acetates; Animals; Behavior, Animal; Chlorides; Disease Models, Animal; Dose-Response Relationship, | 2008 |
Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity.
Topics: Aged; Aged, 80 and over; Animals; Brain; Cells, Cultured; Chlorides; Female; Gene Expression Regulat | 2009 |
L-DOPA treatment reverses the motor alterations induced by manganese exposure as a Parkinson disease experimental model.
Topics: Acetates; Administration, Inhalation; Animals; Antiparkinson Agents; Chlorides; Corpus Striatum; Dis | 2010 |
Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.
Topics: Adult; Animals; B-Lymphocytes; Cation Transport Proteins; Cell Death; Cells, Cultured; Chlorides; Cy | 2010 |
Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes.
Topics: Air Pollutants, Occupational; Animals; Blotting, Western; Chlorides; Inhalation Exposure; Male; Mang | 2010 |
In vivo magnetic resonance imaging characterization of bilateral structural changes in experimental Parkinson's disease: a T2 relaxometry study combined with longitudinal diffusion tensor imaging and manganese-enhanced magnetic resonance imaging in the 6-
Topics: Animals; Basal Ganglia; Behavior, Animal; Chlorides; Diffusion Tensor Imaging; Dopamine Plasma Membr | 2011 |
Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.
Topics: Biosensing Techniques; Case-Control Studies; Cell Line; Cell Survival; Chlorides; Dose-Response Rela | 2012 |
Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease.
Topics: alpha-Synuclein; Aluminum Chloride; Aluminum Compounds; Chlorides; Circular Dichroism; Drug Synergis | 2002 |
Dopamine stimulates Cl(-) absorption coupled with HCO(3)(-) secretion in rat late distal colon.
Topics: Animals; Antiporters; Bicarbonates; Chlorides; Colon; Dopamine; In Vitro Techniques; Intestinal Abso | 2007 |
Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Ascorbic Acid; Chlorides; Chromatography, H | 2000 |
Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Benserazide; Chlorides; Chro | 2001 |
[Changes of blood pressure, pulse and electrolytes following long-term treatment of Parkinsonism using Ro 8-0576 (L-Dopa and decarboxylase inhibitor)].
Topics: Aged; Antiparkinson Agents; Arrhythmias, Cardiac; Blood Pressure; Blood Pressure Determination; Calc | 1975 |
[Effect of basal ganglia on the central nervous regulation of the blood picture and electrolyte balance].
Topics: Athetosis; Basal Ganglia; Brain Diseases; Calcium; Central Nervous System; Chlorides; Chorea; Dience | 1968 |
[Long-time therapy of Parkinsonism with amantadine sulfate. Reply to L.W. Diehl: "Nil nocere. Adverse effects of amantadine therapy of parkinsonism"].
Topics: Amantadine; Chlorides; Humans; Intestinal Absorption; Lethal Dose 50; Parkinson Disease; Solubility; | 1972 |
L-dopa treatment of parkinsonism. Clinical observations on the use of amantadine hydrochloride.
Topics: Aged; Amantadine; Chlorides; Depression; Dihydroxyphenylalanine; Drug Hypersensitivity; Female; Foll | 1971 |
Succinylcholine-induced hyperkalemia in neuromuscular disease.
Topics: Anesthesia, General; Arrhythmias, Cardiac; Central Nervous System Diseases; Chlorides; Chronic Disea | 1970 |
Some common factors in the causation of postural hypotension.
Topics: 17-Ketosteroids; Aged; Arrhythmias, Cardiac; Asthenia; Blood Pressure; Blood Volume; Chlorides; Crea | 1969 |