chlorine has been researched along with Parkinson Disease, Secondary in 12 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Parkinson Disease, Secondary: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autopsy demonstrated gliosis primarily confined to the globus pallidus (GP) and the substantia nigra pars reticularis (SNr)." | 1.29 | Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study. ( Beal, MF; Calne, DB; Good, PF; Hewitt, KA; Olanow, CW; Perl, DP; Shinotoh, H; Snow, BJ; Vingerhoets, F, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhan, X | 1 |
| Wen, G | 1 |
| Jiang, E | 1 |
| Li, F | 1 |
| Wu, X | 1 |
| Pang, H | 1 |
| Krajnak, K | 1 |
| Sriram, K | 1 |
| Johnson, C | 1 |
| Roberts, JR | 1 |
| Mercer, R | 1 |
| Miller, GR | 1 |
| Wirth, O | 1 |
| Antonini, JM | 1 |
| Lozovaya, N | 1 |
| Eftekhari, S | 1 |
| Cloarec, R | 1 |
| Gouty-Colomer, LA | 1 |
| Dufour, A | 1 |
| Riffault, B | 1 |
| Billon-Grand, M | 1 |
| Pons-Bennaceur, A | 1 |
| Oumar, N | 1 |
| Burnashev, N | 1 |
| Ben-Ari, Y | 1 |
| Hammond, C | 1 |
| Bornhorst, J | 1 |
| Wehe, CA | 1 |
| Hüwel, S | 1 |
| Karst, U | 1 |
| Galla, HJ | 1 |
| Schwerdtle, T | 1 |
| Aboud, AA | 1 |
| Tidball, AM | 1 |
| Kumar, KK | 1 |
| Neely, MD | 1 |
| Ess, KC | 1 |
| Erikson, KM | 1 |
| Bowman, AB | 1 |
| Uversky, VN | 1 |
| Li, J | 1 |
| Bower, K | 1 |
| Fink, AL | 1 |
| Atadzhanov, M | 1 |
| Olanow, CW | 1 |
| Good, PF | 1 |
| Shinotoh, H | 1 |
| Hewitt, KA | 1 |
| Vingerhoets, F | 1 |
| Snow, BJ | 1 |
| Beal, MF | 1 |
| Calne, DB | 1 |
| Perl, DP | 1 |
| Datla, KP | 1 |
| Blunt, SB | 1 |
| Dexter, DT | 1 |
| Kosicka, B | 1 |
| Bugera, TE | 1 |
| Kittel, M | 1 |
| Smiałek, M | 1 |
| Gross, H | 1 |
| Langner, E | 1 |
| Pfolz, H | 1 |
| Samoĭlova, ZT | 1 |
| Shavolina, VA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double-blind Placebo-controlled Multicenter Proof-of-concept Trial to Assess the Efficacy and Safety of Bumetanide in Parkinson's Disease[NCT03899324] | Phase 2 | 40 participants (Anticipated) | Interventional | 2019-04-26 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for chlorine and Parkinson Disease, Secondary
| Article | Year |
|---|---|
[Modeling parkinsonism (review)].
Topics: Aluminum; Animals; Carbachol; Cats; Caudate Nucleus; Chlorides; Chlorpromazine; Disease Models, Anim | 1982 |
11 other studies available for chlorine and Parkinson Disease, Secondary
| Article | Year |
|---|---|
Secretogranin III upregulation is involved in parkinsonian toxin-mediated astroglia activation.
Topics: Astrocytes; Cell Cycle; Chlorides; Chromogranins; Dopamine; Glial Fibrillary Acidic Protein; Humans; | 2020 |
Effects of pulmonary exposure to chemically-distinct welding fumes on neuroendocrine markers of toxicity.
Topics: Air Pollutants, Occupational; Animals; Biomarkers; Chlorides; Hypothalamus; Inhalation Exposure; Mal | 2017 |
GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
Topics: Acetylcholine; Action Potentials; Animals; Bumetanide; Chlorides; Cholinergic Agents; Cholinergic Ne | 2018 |
Impact of manganese on and transfer across blood-brain and blood-cerebrospinal fluid barrier in vitro.
Topics: Animals; Blood-Brain Barrier; Calcium; Cells, Cultured; Chlorides; Ion Transport; Manganese; Mangane | 2012 |
Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.
Topics: Biosensing Techniques; Case-Control Studies; Cell Line; Cell Survival; Chlorides; Dose-Response Rela | 2012 |
Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease.
Topics: alpha-Synuclein; Aluminum Chloride; Aluminum Compounds; Chlorides; Circular Dichroism; Drug Synergis | 2002 |
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study.
Topics: Animals; Basal Ganglia; Brain; Carbidopa; Chlorides; Gliosis; Globus Pallidus; Levodopa; Macaca mula | 1996 |
Chronic L-DOPA administration is not toxic to the remaining dopaminergic nigrostriatal neurons, but instead may promote their functional recovery, in rats with partial 6-OHDA or FeCl(3) nigrostriatal lesions.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Benserazide; Chlorides; Chro | 2001 |
[Gamma-aminobutyric acid (GABA) levels and glutamate decarboxylase (GAD) activity of the brain of rats with extrapyramidal syndrome after acute manganese chloride poisoning].
Topics: Acute Disease; Brain Chemistry; Chlorides; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; | 1985 |
[Clozapine in long-term therapy of chronic schizophrenia].
Topics: Adult; Aged; Azepines; Chlorides; Chronic Disease; Drug Combinations; Drug Evaluation; Fatigue; Huma | 1974 |
[Changes of catecholamine metabolism and symptoms of parkinsonism in rats with manganotoxicosis].
Topics: Animals; Brain; Catecholamines; Chlorides; Dihydroxyphenylalanine; Dopamine; Epinephrine; Male; Mang | 1974 |