Page last updated: 2024-10-17

chlorine and Nerve Pain

chlorine has been researched along with Nerve Pain in 19 studies

chloride : A halide anion formed when chlorine picks up an electron to form an an anion.

Research Excerpts

ExcerptRelevanceReference
"Various neuropathic pain models provide considerable evidence that changes in the glutamatergic, GABAergic, and monoaminergic systems."2.53The Role of Regulatory Transporters in Neuropathic Pain. ( Kerr, BJ; Yousuf, MS, 2016)
"Mechanical allodynia - the misperception of light touch as painful - occurs when inhibition is compromised."1.51Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn. ( Lee, KY; Prescott, SA; Ratté, S, 2019)
"The behavioral features of neuropathic pain are not sexually dimorphic despite sex differences in the underlying neuroimmune signaling."1.51Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes. ( De Koninck, Y; Gauthier, C; Lee, KY; Lorenzo, LE; Mapplebeck, JCS; Muley, MM; Prescott, SA; Salter, MW, 2019)
"Using the spared nerve injury model of neuropathic pain in Long-Evans rats, we first discovered a significant increase in noradrenergic innervation within the mPFC of nerve-injured compared to control animals."1.48Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex. ( Cordeiro Matos, S; Longo, G; Ribeiro-da-Silva, A; Séguéla, P; Zamfir, M, 2018)
"Chronic neuropathic pain is a debilitating condition that remains difficult to treat."1.43Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. ( Chen, H; Chen, SR; Hittelman, WN; Li, L; Pan, HL; Wen, L; Xie, JD, 2016)
"Although trigeminal neuropathic pain is one of the most common chronic pain syndromes, the etiology is still unknown."1.39Pre- and post-synaptic switches of GABA actions associated with Cl- homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain. ( Fukuda, A; Furukawa, T; Inoue, K; Kumada, T; Sato, K; Watanabe, M; Wei, B, 2013)
"The spared nerve injury (SNI) model of neuropathic pain was used for the purposes of this study."1.38Oral manganese as an MRI contrast agent for the detection of nociceptive activity. ( Behera, D; Biswal, S; Gold, G; Jacobs, KE; Moseley, M; Rosenberg, J; Yeomans, D, 2012)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.26)29.6817
2010's17 (89.47)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Lee, KY2
Ratté, S1
Prescott, SA2
Lorenzo, LE2
Godin, AG1
Ferrini, F1
Bachand, K2
Plasencia-Fernandez, I1
Labrecque, S1
Girard, AA1
Boudreau, D2
Kianicka, I2
Gagnon, M2
Doyon, N1
Ribeiro-da-Silva, A2
De Koninck, Y4
Castro, A1
Li, Y1
Raver, C1
Chandra, R1
Masri, R1
Lobo, MK1
Keller, A1
Cordeiro Matos, S1
Zamfir, M1
Longo, G1
Séguéla, P1
Tillman, L1
Zhang, J1
Mapplebeck, JCS1
Gauthier, C1
Muley, MM1
Salter, MW3
Bergeron, MJ1
Lavertu, G1
Castonguay, A1
Tripathy, S1
Bonin, RP1
Perez-Sanchez, J1
Wang, B1
Dumas, L1
Valade, I1
Jacob-Wagner, M1
Tardif, C1
Isenring, P1
Attardo, G1
Coull, JA1
Jeong, KY1
Kim, HM1
Kang, JH1
Yousuf, MS1
Kerr, BJ1
Li, L2
Chen, SR2
Chen, H2
Wen, L1
Hittelman, WN1
Xie, JD1
Pan, HL2
Tominaga, M1
Kamaleddin, MA1
Kahle, KT1
Rinehart, J1
Lifton, RP1
Beggs, S2
Jacobs, KE1
Behera, D1
Rosenberg, J1
Gold, G1
Moseley, M1
Yeomans, D1
Biswal, S1
Asiedu, MN1
Mejia, G1
Ossipov, MK1
Malan, TP1
Kaila, K1
Price, TJ1
Zhou, HY1
Byun, HS1
Han, HD1
Lopez-Berestein, G1
Sood, AK1
Wei, B1
Kumada, T1
Furukawa, T1
Inoue, K1
Watanabe, M1
Sato, K1
Fukuda, A1
Keller, AF1

Reviews

5 reviews available for chlorine and Nerve Pain

ArticleYear
Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K
    BioMed research international, 2019, Volume: 2019

    Topics: Central Nervous System; Chloride Channels; Chlorides; Epilepsy; gamma-Aminobutyric Acid; Gene Target

2019
The Role of Regulatory Transporters in Neuropathic Pain.
    Advances in pharmacology (San Diego, Calif.), 2016, Volume: 75

    Topics: Animals; Biogenic Monoamines; Chlorides; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Membrane Tr

2016
[Thermosensitive TRP channels and brain function].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2016, Volume: 36, Issue:2

    Topics: Animals; Anoctamin-1; Calcium; Calcium Channels; Chloride Channels; Chlorides; Drug Discovery; Human

2016
Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels.
    Journal of cellular physiology, 2018, Volume: 233, Issue:2

    Topics: Animals; Asthma; Calcium; Chloride Channels; Chlorides; Cystic Fibrosis; Humans; Ion Channel Gating;

2018
Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases.
    Biochimica et biophysica acta, 2010, Volume: 1802, Issue:12

    Topics: Anemia, Sickle Cell; Animals; Caenorhabditis; Chlorides; Enzyme Activation; Epilepsy; Humans; Hypert

2010

Other Studies

14 other studies available for chlorine and Nerve Pain

ArticleYear
Excitatory neurons are more disinhibited than inhibitory neurons by chloride dysregulation in the spinal dorsal horn.
    eLife, 2019, 11-19, Volume: 8

    Topics: Animals; Chlorides; Female; Hyperalgesia; K Cl- Cotransporters; Male; Models, Animal; Models, Biolog

2019
Enhancing neuronal chloride extrusion rescues α2/α3 GABA
    Nature communications, 2020, 02-13, Volume: 11, Issue:1

    Topics: Analgesia; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Chlorides; Disease Models, Animal

2020
Neuropathic pain after chronic nerve constriction may not correlate with chloride dysregulation in mouse trigeminal nucleus caudalis neurons.
    Pain, 2017, Volume: 158, Issue:7

    Topics: Animals; Chlorides; Disease Models, Animal; Female; K Cl- Cotransporters; Male; Mice; Neuralgia; Neu

2017
Noradrenergic fiber sprouting and altered transduction in neuropathic prefrontal cortex.
    Brain structure & function, 2018, Volume: 223, Issue:3

    Topics: Adrenergic Agents; Animals; Barium Compounds; Chlorides; Disease Models, Animal; Dopamine beta-Hydro

2018
Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.
    Cell reports, 2019, 07-16, Volume: 28, Issue:3

    Topics: Acetazolamide; Animals; Brain-Derived Neurotrophic Factor; Carbonic Anhydrase Inhibitors; Chlorides;

2019
Chloride extrusion enhancers as novel therapeutics for neurological diseases.
    Nature medicine, 2013, Volume: 19, Issue:11

    Topics: Analgesics; Animals; Chlorides; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; HEK293 Ce

2013
Investigation of the functional difference between the pathological itching and neuropathic pain-induced rat brain using manganese-enhanced MRI.
    Acta radiologica (Stockholm, Sweden : 1987), 2016, Volume: 57, Issue:7

    Topics: Animals; Brain; Chlorides; Contrast Media; Magnetic Resonance Imaging; Male; Manganese Compounds; Ne

2016
Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain.
    Cell reports, 2016, 05-17, Volume: 15, Issue:7

    Topics: Animals; Chlorides; gamma-Aminobutyric Acid; Ganglia, Spinal; Homeostasis; Injections, Spinal; K Cl-

2016
Microglia-neuronal signalling in neuropathic pain hypersensitivity 2.0.
    Current opinion in neurobiology, 2010, Volume: 20, Issue:4

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Communication; Chlorides; Humans; Microglia; Models

2010
Oral manganese as an MRI contrast agent for the detection of nociceptive activity.
    NMR in biomedicine, 2012, Volume: 25, Issue:4

    Topics: Administration, Oral; Animals; Chlorides; Contrast Media; Magnetic Resonance Imaging; Male; Manganes

2012
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
    The journal of pain, 2012, Volume: 13, Issue:6

    Topics: Analgesia; Analgesics; Animals; Benzodiazepines; Chlorides; GABA-A Receptor Agonists; Isoxazoles; K

2012
N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain.
    The Journal of biological chemistry, 2012, Sep-28, Volume: 287, Issue:40

    Topics: Animals; Biological Transport; Calpain; Chlorides; Electrophysiology; Glutamic Acid; Homeostasis; K

2012
Pre- and post-synaptic switches of GABA actions associated with Cl- homeostatic changes are induced in the spinal nucleus of the trigeminal nerve in a rat model of trigeminal neuropathic pain.
    Neuroscience, 2013, Jan-03, Volume: 228

    Topics: Animals; Chlorides; Disease Models, Animal; gamma-Aminobutyric Acid; HEK293 Cells; Homeostasis; Huma

2013
Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain.
    Molecular pain, 2007, Sep-27, Volume: 3

    Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Communication; Cells, Cultured; Chlorides;

2007