chlorine has been researched along with Manganese Poisoning in 95 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Manganese Poisoning: Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic manganese poisoning is characterized by mental and extrapyramidal disturbances." | 3.66 | [Histopathological alteration of the central nervous system in rats, following long-term administration of manganese chloride--relation to the activity of the brain tyrosine hydroxylase]. ( Nakashima, S, 1983) |
| "Finally, a rat model of manganese poisoning was identified with the TH expression less than 30% of the normal value." | 1.48 | Exploration of the establishment of manganese poisoning rat model and analysis of discriminant methods. ( Chen, C; Guo, S; Tian, Y; Yan, Y; Zhao, L, 2018) |
| " The aim of the present study was to assess the toxic effects of subacute exposure of Mn by measuring weight gain, motor performance, and biochemical parameters (complex I activity, lipid peroxides, and protein carbonyls) in brain mitochondria in rats." | 1.43 | Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats. ( Apaydin, M; Erbas, O; Taskiran, D, 2016) |
| " These data will be used to refine physiologically based pharmacokinetic models, extending their utility for manganese risk assessment by including multiple dietary exposures." | 1.42 | Pharmacokinetic evaluation of the equivalency of gavage, dietary, and drinking water exposure to manganese in F344 rats. ( Bartnikas, TB; Dorman, DC; Foster, ML; Herrera, C; Johnson, LC; Keene, AM; Pettiglio, MA; Taylor, MD, 2015) |
| "Manganese (Mn) can cause manganism, a neurological disorder similar to Parkinson' Disease (PD)." | 1.39 | Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese. ( Andrade, V; Aschner, M; Batoréu, MC; Camila, BM; Davis Randall, L; Dinamene, S; Edite, T; Luisa, MM; Marreilha dos Santos, AP; Mateus, ML; Michael, A; Ramos, R; Ruben, R; Santos, D; Tavares de Almeida, I; Torres, E; Vanda, A, 2013) |
| " Results of studies to evaluate the effect of Mn and DA on cell viability in control and DAT-transfected HEK cells reveal that Mn is equally toxic to both cell lines whereas DA was only toxic to cells containing DAT." | 1.39 | The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells. ( Khoshbouei, H; Li, Z; Roth, JA; Sridhar, S, 2013) |
| "Manganese (Mn) is an essential metal for biological systems; however, occupational or clinical exposure to high levels of Mn can produce a neurological disorder called manganism." | 1.39 | Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity. ( Aschner, M; Batoreu, MC; Marreilha dos Santos, AP; Santos, D, 2013) |
| "Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism." | 1.38 | Manganese alters rat brain amino acids levels. ( Almeida, I; Aschner, M; Batoreu, MC; Marreilha dos Santos, AP; Ramos, R; Santos, D; Sidoryk-Wegrzynowicz, M, 2012) |
| " Further investigation indicated that pre-treatment of pinacidil or nimodipine reversed toxic effect of MnCl(2) significantly." | 1.35 | Excitotoxicity in rat's brain induced by exposure of manganese and neuroprotective effects of pinacidil and nimodipine. ( Deng, X; Deng, Y; Gao, J; Tian, Y; Xin, X; Xu, B; Xu, Z, 2009) |
| "Chronic manganese poisoning (daily p." | 1.32 | Behavioral impairments in acute and chronic manganese poisoning in white rats. ( Lazriev, I; Mitagvariya, N; Shukakidze, A, 2003) |
| " The no observable adverse effect level (NOAEL) for maternal toxicity of MnCl2 x 4H(2)0 in mice was 4 mg/kg/day, while the NOAEL for embryo/fetal toxicity was 2 mg/kg/day." | 1.29 | Maternal and developmental toxicity of manganese in the mouse. ( Domingo, JL; Keen, CL; Llobet, JM; Sánchez, DJ, 1993) |
| " Skeletal malformations, identical to those seen in the previous study, were increased in a dose-dependent manner with the highest incidence occurring in fetuses from females dosed from days 15-17 of gestation." | 1.29 | Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats. ( Blazak, WF; Gray, TJ; Treinen, KA, 1995) |
| "Autopsy demonstrated gliosis primarily confined to the globus pallidus (GP) and the substantia nigra pars reticularis (SNr)." | 1.29 | Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study. ( Beal, MF; Calne, DB; Good, PF; Hewitt, KA; Olanow, CW; Perl, DP; Shinotoh, H; Snow, BJ; Vingerhoets, F, 1996) |
| " Embryotoxicity, evidenced by significant increases in number of late resorptions and in percentage of postimplantation loss, was especially relevant in groups dosed on gestational days 9 or 10." | 1.29 | Effect of day of exposure on the developmental toxicity of manganese in mice. ( Colomina, MT; Corbella, J; Domingo, JL; Llobet, JM, 1996) |
| " In one steer an infusion of manganese chloride at 529 mumol per minute was toxic and in two steers infusions at approximately 840 mumol per minute were also toxic, causing inappetence, a reduced bile flow and abdominal discomfort." | 1.27 | Acute manganese toxicity and the absorption and biliary excretion of manganese in cattle. ( Hall, ED; Symonds, HW, 1983) |
| "Manganese neurotoxicity was lowered by pretreating the animals with drugs that reduced striatal dopamine turnover rate." | 1.27 | Role of dopamine in manganese neurotoxicity. ( Cappabianca, V; Groppetti, A; Parati, EA; Parenti, M; Rusconi, L, 1988) |
| "Manganese was goitrogenic to the castrated male mouse, but it had no effect on the testosterone-treated castrated male mouse, indicating the involvement of androgen in goiter formation." | 1.27 | Manganese ion as a goitrogen in the female mouse. ( Kawada, J; Nishida, M; Yamashita, K; Yoshimura, Y, 1985) |
| " 6 days/week for a minimum for 10 weeks and until the cumulative LD50 remained constant for 3 consecutive weeks." | 1.26 | Toxicity of endosulfan and manganese chloride: cumulative toxicity rating. ( Chandra, SV; Gupta, PK; Murthy, RC, 1981) |
| " A definite dose-response relationship was, however, noticed only with the changes in the motoractivity, norepinephrine, 5-hydroxytryptamine levels and in the accumulation of lead in rats simultaneously exposed to manganese and lead." | 1.26 | Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead. ( Ali, MM; Chandra, AV; Murthy, RC; Saxena, DK, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (37.89) | 18.7374 |
| 1990's | 20 (21.05) | 18.2507 |
| 2000's | 8 (8.42) | 29.6817 |
| 2010's | 30 (31.58) | 24.3611 |
| 2020's | 1 (1.05) | 2.80 |
| Authors | Studies |
|---|---|
| Lawes, M | 1 |
| Pinkas, A | 1 |
| Frohlich, BA | 1 |
| Iroegbu, JD | 1 |
| Ijomone, OM | 1 |
| Aschner, M | 10 |
| Zhang, K | 1 |
| Zhu, Y | 1 |
| Wang, X | 1 |
| Zhao, X | 1 |
| Li, S | 1 |
| Teng, X | 1 |
| Zhang, Z | 1 |
| Guo, Z | 1 |
| Zhan, Y | 1 |
| Li, H | 1 |
| Wu, S | 2 |
| Peres, TV | 1 |
| Arantes, LP | 1 |
| Miah, MR | 1 |
| Bornhorst, J | 1 |
| Schwerdtle, T | 1 |
| Bowman, AB | 2 |
| Leal, RB | 1 |
| Tian, Y | 5 |
| Chen, C | 1 |
| Guo, S | 1 |
| Zhao, L | 1 |
| Yan, Y | 1 |
| Fernandes, J | 1 |
| Chandler, JD | 1 |
| Liu, KH | 1 |
| Uppal, K | 1 |
| Hao, L | 1 |
| Hu, X | 1 |
| Go, YM | 1 |
| Jones, DP | 1 |
| Nkpaa, KW | 1 |
| Amadi, BA | 1 |
| Wegwu, MO | 1 |
| Farombi, EO | 1 |
| Wang, L | 2 |
| Shiraki, A | 1 |
| Itahashi, M | 1 |
| Akane, H | 1 |
| Abe, H | 2 |
| Mitsumori, K | 1 |
| Shibutani, M | 2 |
| Santos, D | 3 |
| Dinamene, S | 1 |
| Batoréu, MC | 3 |
| Camila, BM | 1 |
| Tavares de Almeida, I | 1 |
| Davis Randall, L | 1 |
| Mateus, ML | 1 |
| Luisa, MM | 1 |
| Andrade, V | 1 |
| Vanda, A | 1 |
| Ramos, R | 2 |
| Ruben, R | 1 |
| Torres, E | 1 |
| Edite, T | 1 |
| Michael, A | 1 |
| Marreilha dos Santos, AP | 4 |
| Harischandra, DS | 1 |
| Jin, H | 1 |
| Anantharam, V | 1 |
| Kanthasamy, A | 1 |
| Kanthasamy, AG | 1 |
| Kikuchihara, Y | 1 |
| Tanaka, T | 1 |
| Kato, M | 1 |
| Ikarashi, Y | 1 |
| Yoshida, T | 1 |
| Foster, ML | 1 |
| Bartnikas, TB | 1 |
| Johnson, LC | 1 |
| Herrera, C | 1 |
| Pettiglio, MA | 1 |
| Keene, AM | 1 |
| Taylor, MD | 1 |
| Dorman, DC | 1 |
| Wang, T | 1 |
| Li, X | 1 |
| Yang, D | 1 |
| Zhang, H | 1 |
| Zhao, P | 1 |
| Fu, J | 1 |
| Yao, B | 1 |
| Zhou, Z | 1 |
| Ma, X | 1 |
| Han, J | 1 |
| Wu, Q | 1 |
| Liu, H | 1 |
| Shi, S | 1 |
| Wang, C | 1 |
| Wang, Y | 2 |
| Xiao, J | 1 |
| Zhao, J | 1 |
| Jiang, J | 1 |
| Wan, C | 1 |
| Apaydin, M | 1 |
| Erbas, O | 1 |
| Taskiran, D | 1 |
| Saputra, D | 1 |
| Chang, J | 1 |
| Lee, BJ | 1 |
| Yoon, JH | 1 |
| Kim, J | 1 |
| Lee, K | 1 |
| Li, SJ | 1 |
| Luo, YN | 1 |
| Li, Y | 1 |
| Chen, JW | 1 |
| Mo, YH | 1 |
| Yuan, ZX | 1 |
| Ou, SY | 1 |
| Ou, CY | 1 |
| Jiang, YM | 1 |
| Deng, XF | 1 |
| Liapi, C | 1 |
| Zarros, A | 1 |
| Galanopoulou, P | 1 |
| Theocharis, S | 1 |
| Skandali, N | 1 |
| Al-Humadi, H | 1 |
| Anifantaki, F | 1 |
| Gkrouzman, E | 1 |
| Mellios, Z | 1 |
| Tsakiris, S | 1 |
| Lazrishvili, IL | 2 |
| Shukakidze, AA | 2 |
| Chkhartishvili, NN | 2 |
| Bikashvili, TZ | 2 |
| Deng, Y | 5 |
| Xu, Z | 5 |
| Xu, B | 5 |
| Deng, X | 2 |
| Xin, X | 2 |
| Gao, J | 2 |
| Milatovic, D | 1 |
| Zaja-Milatovic, S | 1 |
| Gupta, RC | 1 |
| Yu, Y | 1 |
| Jia, K | 1 |
| He, A | 1 |
| Li, J | 1 |
| Zhang, F | 1 |
| Avila, DS | 1 |
| Colle, D | 1 |
| Gubert, P | 1 |
| Palma, AS | 1 |
| Puntel, G | 1 |
| Manarin, F | 1 |
| Noremberg, S | 1 |
| Nascimento, PC | 1 |
| Rocha, JB | 1 |
| Soares, FA | 1 |
| Just, N | 1 |
| Cudalbu, C | 1 |
| Lei, H | 1 |
| Gruetter, R | 1 |
| Yang, Y | 1 |
| An, J | 1 |
| Luo, W | 1 |
| Wang, W | 1 |
| Mei, X | 1 |
| Chen, J | 1 |
| Sidoryk-Wegrzynowicz, M | 2 |
| Lee, E | 1 |
| Mingwei, N | 1 |
| Streifel, KM | 1 |
| Moreno, JA | 1 |
| Hanneman, WH | 1 |
| Legare, ME | 1 |
| Tjalkens, RB | 1 |
| Xu, D | 2 |
| Feng, W | 2 |
| Liu, W | 1 |
| Yang, H | 1 |
| Mokgobu, MI | 1 |
| Anderson, R | 1 |
| Steel, HC | 1 |
| Cholo, MC | 1 |
| Tintinger, GR | 1 |
| Theron, AJ | 1 |
| Almeida, I | 1 |
| Aboud, AA | 1 |
| Tidball, AM | 1 |
| Kumar, KK | 1 |
| Neely, MD | 1 |
| Ess, KC | 1 |
| Erikson, KM | 1 |
| Stephenson, AP | 1 |
| Schneider, JA | 1 |
| Nelson, BC | 1 |
| Atha, DH | 1 |
| Jain, A | 1 |
| Soliman, KF | 1 |
| Mazzio, E | 1 |
| Renee Reams, R | 1 |
| Roth, JA | 1 |
| Li, Z | 1 |
| Sridhar, S | 1 |
| Khoshbouei, H | 1 |
| Ponzoni, S | 1 |
| Gaziri, LC | 1 |
| Britto, LR | 1 |
| Barreto, WJ | 1 |
| Blum, D | 1 |
| Shukakidze, A | 1 |
| Lazriev, I | 1 |
| Mitagvariya, N | 1 |
| LA TORRACA, F | 1 |
| Bonilla, E | 3 |
| Nakashima, S | 1 |
| Wolf, GL | 1 |
| Baum, L | 1 |
| Gajkowska, B | 3 |
| Kraśnicka, Z | 1 |
| Smiałek, M | 6 |
| Dydyk, L | 3 |
| Mossakowski, MJ | 5 |
| Zareba-Kowalska, A | 1 |
| Skreb, Y | 2 |
| Nagy, B | 1 |
| Kojima, S | 1 |
| Hirai, M | 1 |
| Kiyozumi, M | 1 |
| Sasawa, Y | 1 |
| Nakagawa, M | 1 |
| Shin-o, T | 1 |
| Symonds, HW | 1 |
| Hall, ED | 1 |
| Khandelwal, S | 2 |
| Kachru, DN | 1 |
| Tandon, SK | 2 |
| Gupta, PK | 1 |
| Murthy, RC | 2 |
| Chandra, SV | 1 |
| Lai, JC | 2 |
| Leung, TK | 2 |
| Lim, L | 2 |
| Chandra, AV | 1 |
| Ali, MM | 1 |
| Saxena, DK | 1 |
| Ogawa, HI | 1 |
| Shibahara, T | 1 |
| Iwata, H | 1 |
| Okada, T | 1 |
| Tsuruta, S | 1 |
| Kakimoto, K | 1 |
| Sakata, K | 1 |
| Kato, Y | 1 |
| Ryo, H | 1 |
| Itoh, T | 1 |
| Ingersoll, RT | 1 |
| Montgomery, EB | 1 |
| Aposhian, HV | 1 |
| Desole, MS | 2 |
| Miele, M | 2 |
| Esposito, G | 2 |
| Migheli, R | 2 |
| Fresu, L | 2 |
| Enrico, P | 1 |
| De Natale, G | 2 |
| Miele, E | 2 |
| Villalobos, V | 1 |
| Castro, F | 1 |
| Estévez, J | 1 |
| Dávila, JO | 1 |
| Unger, E | 1 |
| Fritz, T | 1 |
| Shen, DK | 1 |
| Wu, G | 1 |
| Sánchez, DJ | 1 |
| Domingo, JL | 2 |
| Llobet, JM | 2 |
| Keen, CL | 1 |
| Treinen, KA | 1 |
| Gray, TJ | 1 |
| Blazak, WF | 1 |
| Olanow, CW | 1 |
| Good, PF | 1 |
| Shinotoh, H | 1 |
| Hewitt, KA | 1 |
| Vingerhoets, F | 1 |
| Snow, BJ | 1 |
| Beal, MF | 1 |
| Calne, DB | 1 |
| Perl, DP | 1 |
| Galvani, P | 1 |
| Fumagalli, P | 1 |
| Santagostino, A | 1 |
| Colomina, MT | 1 |
| Corbella, J | 1 |
| Kumar, R | 1 |
| Srivastava, S | 1 |
| Agrawal, AK | 1 |
| Seth, PK | 1 |
| Fox, RM | 1 |
| Jones, JD | 1 |
| Baker, J | 1 |
| Pullen, RG | 1 |
| Jynge, P | 1 |
| Brurok, H | 1 |
| Asplund, A | 1 |
| Towart, R | 1 |
| Refsum, H | 1 |
| Karlsson, JO | 1 |
| Sircana, S | 1 |
| Delogu, MR | 1 |
| Thongphasuk, J | 1 |
| Oberley, LW | 1 |
| Oberley, TD | 1 |
| Gadzikiewicz, I | 1 |
| Grobelna, M | 1 |
| Mikulski, T | 1 |
| Campbell, KI | 1 |
| George, EL | 1 |
| Hall, LL | 1 |
| Stara, JF | 1 |
| Waters, MD | 1 |
| Gardner, DE | 1 |
| Aranyi, C | 1 |
| Coffin, DL | 1 |
| Vescovi, A | 1 |
| Facheris, L | 1 |
| Zaffaroni, A | 1 |
| Malanca, G | 1 |
| Parati, EA | 2 |
| Ghanmi, Z | 1 |
| Rouabhia, M | 1 |
| Alifuddin, M | 1 |
| Troutaud, D | 1 |
| Deschaux, P | 1 |
| Eberle, NB | 1 |
| Miller, K | 1 |
| Kimelberg, HK | 1 |
| Niesman, MR | 1 |
| Bacic, GG | 1 |
| Wright, SM | 1 |
| Swartz, HJ | 1 |
| Magin, RL | 1 |
| Fleet, JC | 1 |
| Golemboski, KA | 1 |
| Dietert, RR | 1 |
| Andrews, GK | 1 |
| McCormick, CC | 1 |
| Parenti, M | 1 |
| Rusconi, L | 1 |
| Cappabianca, V | 1 |
| Groppetti, A | 1 |
| Kosicka, B | 3 |
| Kittel, M | 2 |
| Srisuchart, B | 1 |
| Taylor, MJ | 1 |
| Sharma, RP | 1 |
| Rossman, TG | 1 |
| Molina, M | 1 |
| Kristensson, K | 1 |
| Eriksson, H | 1 |
| Lundh, B | 1 |
| Plantin, LO | 1 |
| Wachtmeister, L | 1 |
| el Azazi, M | 1 |
| Morath, C | 1 |
| Heilbronn, E | 1 |
| Bugera, TE | 1 |
| Camner, P | 1 |
| Curstedt, T | 1 |
| Jarstrand, C | 1 |
| Johannsson, A | 1 |
| Robertson, B | 1 |
| Wiernik, A | 1 |
| Szumańska, G | 1 |
| Kawada, J | 1 |
| Nishida, M | 1 |
| Yoshimura, Y | 1 |
| Yamashita, K | 1 |
| Diez-Ewald, M | 1 |
| Levina, EN | 1 |
| Królewski, J | 1 |
| Bogutyn, W | 1 |
| Samoĭlova, ZT | 1 |
| Shavolina, VA | 1 |
2 reviews available for chlorine and Manganese Poisoning
| Article | Year |
|---|---|
Cardiovascular safety of MnDPDP and MnCl2.
Topics: Animals; Cardiovascular System; Chlorides; Contrast Media; Dose-Response Relationship, Drug; Edetic | 1997 |
[Correlations between solubility of metal compounds and their toxicity, distribution and elimination from the body (review)].
Topics: Animals; Brain; Chlorides; Kidney; Liver; Lung; Manganese; Manganese Poisoning; Mercury; Myocardium; | 1972 |
93 other studies available for chlorine and Manganese Poisoning
| Article | Year |
|---|---|
Metal-induced neurotoxicity in a RAGE-expressing C. elegans model.
Topics: Animals; Animals, Genetically Modified; Cadmium Chloride; Cadmium Poisoning; Caenorhabditis elegans; | 2020 |
Excess Manganese-Induced Apoptosis in Chicken Cerebrums and Embryonic Neurocytes.
Topics: Administration, Oral; Animals; Animals, Inbred Strains; Apoptosis; Apoptosis Regulatory Proteins; Av | 2017 |
Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2/heme oxygenase 1 pathway by manganese chloride.
Topics: Acetylation; Active Transport, Cell Nucleus; Anacardic Acids; Animals; Chlorides; Glutathione; Heme | 2017 |
Role of Caenorhabditis elegans AKT-1/2 and SGK-1 in Manganese Toxicity.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Genetically Modified; Behavior, Animal; Caenorhabd | 2018 |
Exploration of the establishment of manganese poisoning rat model and analysis of discriminant methods.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Chlorides; Discriminant Analysis; Disease Models, Ani | 2018 |
Metabolomic Responses to Manganese Dose in SH-SY5Y Human Neuroblastoma Cells.
Topics: Cell Death; Cell Line, Tumor; Chlorides; Dose-Response Relationship, Drug; Energy Metabolism; Humans | 2019 |
Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Behavior, Animal; Chlorides; Disease Models, Anim | 2019 |
Aberration in epigenetic gene regulation in hippocampal neurogenesis by developmental exposure to manganese chloride in mice.
Topics: Age Factors; Animals; Animals, Newborn; Chlorides; COUP Transcription Factor I; CpG Islands; Dentate | 2013 |
Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Chlorides; Dose-Response Relationship, Drug; Endp | 2013 |
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Apoptosis; Binding Sites; Blotting, Western; Cell Culture Techniques; Cell | 2015 |
Relationship between brain accumulation of manganese and aberration of hippocampal adult neurogenesis after oral exposure to manganese chloride in mice.
Topics: Administration, Oral; Animals; Biomarkers; Brain-Derived Neurotrophic Factor; Chlorides; GABAergic N | 2015 |
Pharmacokinetic evaluation of the equivalency of gavage, dietary, and drinking water exposure to manganese in F344 rats.
Topics: Administration, Oral; Animals; Body Burden; Chlorides; Diet; Food Contamination; Male; Manganese Com | 2015 |
ER stress and ER stress-mediated apoptosis are involved in manganese-induced neurotoxicity in the rat striatum in vivo.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Chlorides; Corpus Striatum; Dose-Response Relatio | 2015 |
Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.
Topics: Animals; Apoptosis; Basal Ganglia; bcl-2-Associated X Protein; bcl-X Protein; Chlorides; Disease Mod | 2015 |
Protection by Edaravone, a Radical Scavenger, against Manganese-Induced Neurotoxicity in Rats.
Topics: Animals; Antipyrine; Brain; Chlorides; Edaravone; Electron Transport Complex I; Free Radical Scaveng | 2016 |
Short-term manganese inhalation decreases brain dopamine transporter levels without disrupting motor skills in rats.
Topics: Animals; Behavior, Animal; Brain; Chlorides; Dopamine Plasma Membrane Transport Proteins; Inhalation | 2016 |
Sodium para-aminosalicylate protected cultured basal ganglia astrocytes from manganese-induced DNA damages and alteration of amino acid neurotransmitter levels.
Topics: Aminosalicylic Acid; Animals; Animals, Newborn; Astrocytes; Basal Ganglia; Cells, Cultured; Chloride | 2016 |
Effects of short-term exposure to manganese on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na,K)-ATPase and Mg-ATPase: modulation by L-cysteine.
Topics: Acetylcholinesterase; Animals; Antioxidants; Brain; Ca(2+) Mg(2+)-ATPase; Chlorides; Cysteine; Male; | 2008 |
[Morphological changes and manganese level in the brain of rat pups subjected to subchronic manganese chloride intoxication].
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Chlorides; Female; Gliosis; Manganese Compounds; | 2008 |
Morphological changes and manganese content in the brains of rat pups subjected to subchronic poisoning with manganese chloride.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Chlorides; Female; Gliosis; Manganese Compounds; | 2009 |
Excitotoxicity in rat's brain induced by exposure of manganese and neuroprotective effects of pinacidil and nimodipine.
Topics: Animals; Chlorides; Corpus Striatum; Dose-Response Relationship, Drug; Female; Male; Manganese Compo | 2009 |
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity.
Topics: Adenosine Triphosphate; Animals; Basal Ganglia; Biomarkers; Cells, Cultured; Cerebral Cortex; Chlori | 2009 |
The protective effect of riluzole on manganese caused disruption of glutamate-glutamine cycle in rats.
Topics: Animals; Blotting, Western; Chlorides; Corpus Striatum; Excitatory Amino Acid Transporter 1; Excitat | 2009 |
Effects of MK-801, taurine and dextromethorphan on neurotoxicity caused by manganese in rats.
Topics: Animals; Cerebral Cortex; Chlorides; Corpus Striatum; Dextromethorphan; Dizocilpine Maleate; Dose-Re | 2010 |
A possible neuroprotective action of a vinylic telluride against Mn-induced neurotoxicity.
Topics: Animals; Antioxidants; Behavior, Animal; Chlorides; Corpus Striatum; Environmental Exposure; Male; M | 2010 |
Effect of manganese chloride on the neurochemical profile of the rat hypothalamus.
Topics: Amino Acids; Animals; Anorexia; Chlorides; Dehydration; Energy Metabolism; Female; gamma-Aminobutyri | 2011 |
Intrastriatal manganese chloride exposure causes acute locomotor impairment as well as partial activation of substantia nigra GABAergic neurons.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Chlorides; Corpus Striatum; Dopamine; Fluo | 2011 |
Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway.
Topics: Amino Acid Transport System ASC; Amino Acid Transport Systems, Neutral; Animals; Astrocytes; Biotiny | 2011 |
Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice.
Topics: Animals; Apoptosis; Astrocytes; Basal Ganglia; Behavior, Animal; Cell Communication; Cells, Cultured | 2012 |
G0/G1 phase arrest and apoptosis induced by manganese chloride on cultured rat astrocytes and protective effects of riluzole.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Cycle; Cell Cycle Checkpoints; Cell Survival; | 2011 |
The protective effects of riluzole on manganese-induced disruption of glutamate transporters and glutamine synthetase in the cultured astrocytes.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Astrocytes; Biological Transport; Blott | 2012 |
Manganese promotes increased formation of hydrogen peroxide by activated human macrophages and neutrophils in vitro.
Topics: Air Pollutants, Occupational; Catalysis; Cells, Cultured; Chlorides; Free Radical Scavengers; Humans | 2012 |
Manganese alters rat brain amino acids levels.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Chlorides; Dose-Response Relationship, Drug; Extrapyra | 2012 |
Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.
Topics: Biosensing Techniques; Case-Control Studies; Cell Line; Cell Survival; Chlorides; Dose-Response Rela | 2012 |
Manganese-induced oxidative DNA damage in neuronal SH-SY5Y cells: attenuation of thymine base lesions by glutathione and N-acetylcysteine.
Topics: Acetylcysteine; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Survival; Chlorides; Comet Assay; DN | 2013 |
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.
Topics: Amphetamine; Cell Survival; Chlorides; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-R | 2013 |
Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity.
Topics: Aminosalicylic Acid; Analysis of Variance; Animals; Brain; Cell Line; Cell Survival; Chlorides; Dose | 2013 |
Clearance of manganese from the rat substantia nigra following intra-nigral microinjections.
Topics: Animals; Apomorphine; Cell Death; Chlorides; Dopamine; Dopamine Agonists; Gliosis; Immunohistochemis | 2002 |
Behavioral impairments in acute and chronic manganese poisoning in white rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Chlorides; Conditioning, Classical; Manganese Compoun | 2003 |
[Experimental research on the action of liver-protective treatment in acute manganese chloride poisoning].
Topics: Chlorides; Ions; Liver; Manganese; Manganese Compounds; Manganese Poisoning | 1962 |
L-tyrosine hydroxylase activity in the rat brain after chronic oral administration of manganese chloride.
Topics: Administration, Oral; Animals; Brain; Chlorides; Corpus Striatum; Dopamine; GABA Antagonists; Male; | 1980 |
[Histopathological alteration of the central nervous system in rats, following long-term administration of manganese chloride--relation to the activity of the brain tyrosine hydroxylase].
Topics: Animals; Brain; Central Nervous System; Chlorides; Female; Hypothalamus; Manganese; Manganese Compou | 1983 |
Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit.
Topics: Animals; Blood Pressure; Chlorides; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Magn | 1983 |
[Effect of manganese ions (Mn++) on the morphological picture of cultured nerve tissue].
Topics: Animals; Chlorides; Corpus Striatum; Inclusion Bodies; Manganese Compounds; Manganese Poisoning; Mic | 1983 |
Ultrastructural alterations of the grey matter structures of the brain due to experimental manganese intoxication.
Topics: Animals; Brain; Chlorides; Male; Manganese Compounds; Manganese Poisoning; Microscopy, Electron; Mit | 1984 |
The effect of manganese on the ultrastructure of pituicytes in vitro.
Topics: Animals; Chlorides; Culture Media; Manganese Compounds; Manganese Poisoning; Microscopy, Electron; N | 1984 |
Cell survival after the combined action of manganese (MnCl2) and X-rays in synchronized Chinese hamster cells.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chlorides; Cricetinae; Cricetulus; DNA; Fibroblasts; | 1984 |
Studies on poisonous metals. X. Metabolic fate of manganese after oral administration of excessive manganese chloride in rats.
Topics: Administration, Oral; Animals; Chlorides; Male; Manganese; Manganese Compounds; Manganese Poisoning; | 1983 |
[Early damage of the central nervous system in experimental poisoning with manganese compounds].
Topics: Animals; Brain; Brain Edema; Chlorides; Male; Manganese Compounds; Manganese Poisoning; Microscopy, | 1983 |
Selective white matter damage due to manganese intoxication.
Topics: Animals; Brain; Brain Edema; Chlorides; Male; Manganese Compounds; Manganese Poisoning; Microscopy, | 1983 |
Acute manganese toxicity and the absorption and biliary excretion of manganese in cattle.
Topics: Animals; Bile; Cattle; Cattle Diseases; Chlorides; Copper; Intestinal Absorption; Liver; Male; Manga | 1983 |
Effect of manganese on certain enzymes and constituents of blood and serum in rabbits. I.
Topics: Adenosine Deaminase; Alkaline Phosphatase; Animals; Chlorides; Cholesterol; Cholinesterases; Hemoglo | 1981 |
Effect of manganese on certain enzymes and constituents of blood and serum in rabbits. II.
Topics: Administration, Oral; Animals; Chlorides; Erythrocytes; Intubation, Intratracheal; Male; Manganese C | 1981 |
Toxicity of endosulfan and manganese chloride: cumulative toxicity rating.
Topics: Animals; Chlorides; Drug Synergism; Endosulfan; Lethal Dose 50; Male; Manganese Compounds; Manganese | 1981 |
Brain regional distribution of glutamic acid decarboxylase, choline acetyltransferase, and acetylcholinesterase in the rat: effects of chronic manganese chloride administration after two years.
Topics: Acetylcholinesterase; Aging; Animals; Brain; Carboxy-Lyases; Chlorides; Choline O-Acetyltransferase; | 1981 |
Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead.
Topics: Agonistic Behavior; Animals; Brain; Brain Chemistry; Chlorides; Dopamine; Drug Synergism; Lead Poiso | 1981 |
The response of mammalian cells in the plateau phase to treatment with manganese.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Chlorides; Cricetinae; Cricetulus; Manganese Compound | 1981 |
Genotoxic activities in vivo of cobaltous chloride and other metal chlorides as assayed in the Drosophila wing spot test.
Topics: Animals; Chlorides; Cobalt; Crossing Over, Genetic; Drosophila melanogaster; Larva; Manganese Compou | 1994 |
Central nervous system toxicity of manganese. I. Inhibition of spontaneous motor activity in rats after intrathecal administration of manganese chloride.
Topics: Animals; Brain Chemistry; Central Nervous System; Chlorides; Choroid Plexus; Dopamine; Injections, S | 1995 |
Monoaminergic systems activity and cellular defense mechanisms in the brainstem of young and aged rats subchronically exposed to manganese.
Topics: Aging; Animals; Biogenic Monoamines; Biomarkers; Brain Stem; Chlorides; Dehydroascorbic Acid; Drug A | 1994 |
Manganese toxicity: muscarinic receptor binding in the mouse brain.
Topics: Animals; Binding Sites; Brain; Chlorides; Corpus Striatum; Dose-Response Relationship, Drug; Frontal | 1994 |
Manganese-based liposomes. Comparative approaches.
Topics: Animals; Chlorides; Contrast Media; Liposomes; Liver Neoplasms, Experimental; Magnetic Resonance Ima | 1993 |
Maternal and developmental toxicity of manganese in the mouse.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Chlorides; Dose-Response Relationship, Drug; Embr | 1993 |
Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chlorides; Contrast Media; Dose-Response Relat | 1995 |
Manganese intoxication in the rhesus monkey: a clinical, imaging, pathologic, and biochemical study.
Topics: Animals; Basal Ganglia; Brain; Carbidopa; Chlorides; Gliosis; Globus Pallidus; Levodopa; Macaca mula | 1996 |
Vulnerability of mitochondrial complex I in PC12 cells exposed to manganese.
Topics: Animals; Cells, Cultured; Chlorides; Manganese Compounds; Manganese Poisoning; Mitochondria; NAD(P)H | 1995 |
Effect of day of exposure on the developmental toxicity of manganese in mice.
Topics: Analysis of Variance; Animals; Chlorides; Dose-Response Relationship, Drug; Embryonic and Fetal Deve | 1996 |
Alteration in some membrane properties in rat brain following exposure to manganese.
Topics: Animals; Chlorides; Cholesterol; Corpus Striatum; Frontal Lobe; Hypothalamus; Injections, Intraperit | 1996 |
Measurement of glutathione as a marker of oxidative stress in CNS reaggregate cultures.
Topics: Animals; Brain; Cell Aggregation; Cells, Cultured; Chlorides; Ferrous Compounds; Glutathione; In Vit | 1996 |
Glutathione deficiency potentiates manganese toxicity in rat striatum and brainstem and in PC12 cells.
Topics: Animals; Ascorbic Acid; Brain Stem; Chlorides; Dopamine; Glutathione; Male; Manganese Compounds; Man | 1997 |
Induction of superoxide dismutase and cytotoxicity by manganese in human breast cancer cells.
Topics: Acetylcysteine; Breast Neoplasms; Cell Survival; Chlorides; Citrate (si)-Synthase; Cyclic N-Oxides; | 1999 |
[Experimental studies of chronic manganese poisoning in guinea pigs].
Topics: Animals; Chlorides; Guinea Pigs; Manganese; Manganese Poisoning; Time Factors | 1975 |
Dermal irritancy of metal compounds. Studies with palladium, platinum, lead, and manganese compounds.
Topics: Acetates; Allyl Compounds; Animals; Chlorides; Dermatitis, Contact; Environmental Exposure; Environm | 1975 |
Metal toxicity for rabbit alveolar macrophages in vitro.
Topics: Acid Phosphatase; Animals; Cadmium; Cell Count; Cell Membrane; Cell Survival; Cells, Cultured; Chlor | 1975 |
Dopamine metabolism alterations in a manganese-treated pheochromocytoma cell line (PC12).
Topics: Adrenal Gland Neoplasms; Animals; Ascorbic Acid; Cell Survival; Chlorides; Culture Media; Dopamine; | 1991 |
Modulatory effect of metal ions on the immune response of fish: in vivo and in vitro influence of MnCl2 on NK activity of carp pronephros cells.
Topics: Animals; Antibody Formation; Carps; Cell Line; Chlorides; Chromium Radioisotopes; Injections, Intrap | 1990 |
Interactions of methylmercury with rat primary astrocyte cultures: inhibition of rubidium and glutamate uptake and induction of swelling.
Topics: 3-O-Methylglucose; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Chloride | 1990 |
Liposome encapsulated MnCl2 as a liver specific contrast agent for magnetic resonance imaging.
Topics: Animals; Chlorides; Contrast Media; Drug Carriers; Female; Liposomes; Liver Neoplasms, Experimental; | 1990 |
Induction of hepatic metallothionein by intraperitoneal metal injection: an associated inflammatory response.
Topics: Animals; Cells, Cultured; Chick Embryo; Chickens; Chlorides; Chromium; Chromium Compounds; Cobalt; F | 1990 |
Role of dopamine in manganese neurotoxicity.
Topics: alpha-Methyltyrosine; Animals; Catalase; Cell Survival; Chlorides; Corpus Striatum; Dopamine; Fibrob | 1988 |
[Effect of manganese chloride poisoning during pregnancy and lactation on the levels and synthesis of gamma-aminobutyric acid (GABA) in the rat brain].
Topics: Animals; Brain Chemistry; Chlorides; Female; gamma-Aminobutyric Acid; Lactation; Male; Manganese Com | 1985 |
Alteration of humoral and cellular immunity in manganese chloride-treated mice.
Topics: Animals; Antibody Formation; Chlorides; Erythrocytes; Immunity, Cellular; Lymphocyte Activation; Lym | 1987 |
[Structural changes in the central nervous system of rats in manganese chloride (MnCl2) poisoning].
Topics: Animals; Brain; Cerebral Cortex; Chlorides; Corpus Striatum; Hippocampus; Male; Manganese Compounds; | 1987 |
The genetic toxicology of metal compounds: II. Enhancement of ultraviolet light-induced mutagenesis in Escherichia coli WP2.
Topics: Chlorides; Copper; DNA Repair; Escherichia coli; Manganese Compounds; Manganese Poisoning; Metals; M | 1986 |
Effects of manganese chloride on the rat developing nervous system.
Topics: Animals; Brain; Chlorides; Electroretinography; Homovanillic Acid; Manganese; Manganese Compounds; M | 1986 |
[3H]spiperone and [3H]quinuclidinyl benzilate binding in striatal membranes from rats chronically treated with manganese chloride throughout development and for over two years.
Topics: Age Factors; Animals; Chlorides; Corpus Striatum; In Vitro Techniques; Male; Manganese Compounds; Ma | 1986 |
[Gamma-aminobutyric acid (GABA) levels and glutamate decarboxylase (GAD) activity of the brain of rats with extrapyramidal syndrome after acute manganese chloride poisoning].
Topics: Acute Disease; Brain Chemistry; Chlorides; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; | 1985 |
Rabbit lung after inhalation of manganese chloride: a comparison with the effects of chlorides of nickel, cadmium, cobalt, and copper.
Topics: Animals; Cadmium; Cadmium Chloride; Chlorides; Cobalt; Copper; Lung; Macrophages; Male; Manganese Co | 1985 |
[Adenyl cyclase and alkaline phosphatase activities in the cerebral blood vessels of rats in experimental manganese chloride poisoning].
Topics: Adenylyl Cyclases; Alkaline Phosphatase; Animals; Capillaries; Cerebral Arteries; Chlorides; Male; M | 1985 |
Manganese ion as a goitrogen in the female mouse.
Topics: Animals; Chlorides; Female; Goiter; Male; Manganese; Manganese Compounds; Manganese Poisoning; Mice; | 1985 |
Effect of L-DOPA on brain concentration of dopamine and homovanillic acid in rats after chronic manganese chloride administration.
Topics: Administration, Oral; Animals; Brain; Chlorides; Dihydroxyphenylalanine; Dopamine; Female; Homovanil | 1974 |
[Effect of manganese on the physical properties of bones in guinea pigs poisoned with MnCl 2 ].
Topics: Animals; Bone and Bones; Chlorides; Guinea Pigs; Manganese; Manganese Poisoning; Time Factors | 1972 |
[Changes of catecholamine metabolism and symptoms of parkinsonism in rats with manganotoxicosis].
Topics: Animals; Brain; Catecholamines; Chlorides; Dihydroxyphenylalanine; Dopamine; Epinephrine; Male; Mang | 1974 |