Page last updated: 2024-10-17

chlorine and Hepatolenticular Degeneration

chlorine has been researched along with Hepatolenticular Degeneration in 6 studies

chloride : A halide anion formed when chlorine picks up an electron to form an an anion.

Hepatolenticular Degeneration: A rare autosomal recessive disease characterized by the deposition of copper in the BRAIN; LIVER; CORNEA; and other organs. It is caused by defects in the ATP7B gene encoding copper-transporting ATPase 2 (EC 3.6.3.4), also known as the Wilson disease protein. The overload of copper inevitably leads to progressive liver and neurological dysfunction such as LIVER CIRRHOSIS; TREMOR; ATAXIA and intellectual deterioration. Hepatic dysfunction may precede neurologic dysfunction by several years.

Research Excerpts

ExcerptRelevanceReference
"The most common Wilson disease (WD) mutations p."1.43Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines. ( Aggarwal, A; Bhatt, M; Chandhok, G; Horvath, J; Schmidt, HH; Zibert, A, 2016)
"The association of ClC-4 and the Wilson's disease protein (ATP7B) was determined by co-immunoprecipitation."1.32Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin. ( Wang, T; Weinman, SA, 2004)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chandhok, G1
Horvath, J1
Aggarwal, A1
Bhatt, M1
Zibert, A1
Schmidt, HH1
Wang, T1
Weinman, SA1
Walshe, JM1
Koutenský, J1
Eybl, V1
Koutenská, M1
Sýkora, J1
Mertl, F1
Sunderman, FW1
Nomoto, S1
Wysocki, K1
Owczarek, L1
Górski, S1
Kurnatowska, A1

Other Studies

6 other studies available for chlorine and Hepatolenticular Degeneration

ArticleYear
Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.
    World journal of gastroenterology, 2016, Apr-28, Volume: 22, Issue:16

    Topics: Adenosine Triphosphatases; Apoptosis; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Sur

2016
Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin.
    Gastroenterology, 2004, Volume: 126, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Biological Transport; Carcinoma, Hepatocellular; Cation Transpor

2004
Management of penicillamine nephropathy in Wilson's disease: a new chelating agent.
    Lancet (London, England), 1969, Dec-27, Volume: 2, Issue:7635

    Topics: Adolescent; Chelating Agents; Chlorides; Copper; Ethylenediamines; Hepatolenticular Degeneration; Hu

1969
Influence of sodium diethyldithiocarbamate on the toxicity and distribution of copper in mice.
    European journal of pharmacology, 1971, Volume: 14, Issue:4

    Topics: Animals; Biotransformation; Bone and Bones; Brain; Chelating Agents; Chlorides; Copper; Digestive Sy

1971
Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity.
    Clinical chemistry, 1970, Volume: 16, Issue:11

    Topics: Adult; Aniline Compounds; Animals; Bilirubin; Buffers; Ceruloplasmin; Chlorides; Copper; Female; Hem

1970
Investigations by the use of radioactive copper (64Cu) in chronic liver diseases.
    Polish medical journal, 1969, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Aged; Chlorides; Chronic Disease; Copper; Female; Hepatitis; Hepatolenticular Deg

1969