Page last updated: 2024-10-17

chlorine and Hepatocellular Carcinoma

chlorine has been researched along with Hepatocellular Carcinoma in 42 studies

chloride : A halide anion formed when chlorine picks up an electron to form an an anion.

Research Excerpts

ExcerptRelevanceReference
" Thus, in order to better comprehend the mechanism by which polyphenols regulate hTERT, the present study investigated the effects of the natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on hTERT, Nrf2, and SIRT1 expression as well as oxidative stress in HepG2 hepatocellular carcinoma."8.31The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress. ( Azadbakht, O; Behrouj, H; Ghojoghi, R; Moghadam, D; Sabaghan, M; Vakili, S; Veisi, A; Zarei, R; Zarezade, V, 2023)
" We describe a 16-year-old girl with metastatic hepatocellular carcinoma who experienced cesium-induced QT-interval prolongation after the start of a cesium chloride-based alternative treatment regimen."4.84Cesium-induced QT-interval prolongation in an adolescent. ( Harik, N; James, LP; O'Brien, CE; Seib, PM; Stowe, CD, 2008)
" Thus, in order to better comprehend the mechanism by which polyphenols regulate hTERT, the present study investigated the effects of the natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on hTERT, Nrf2, and SIRT1 expression as well as oxidative stress in HepG2 hepatocellular carcinoma."4.31The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress. ( Azadbakht, O; Behrouj, H; Ghojoghi, R; Moghadam, D; Sabaghan, M; Vakili, S; Veisi, A; Zarei, R; Zarezade, V, 2023)
"Zinc chloride is known to be effective in combatting hepatitis A virus (HAV) infection, and zinc ions seem to be especially involved in Toll-like receptor (TLR) signaling pathways."4.02Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication. ( Kanda, T; Masuzaki, R; Matsumoto, N; Moriyama, M; Okamoto, H; Sasaki-Tanaka, R, 2021)
"The most common Wilson disease (WD) mutations p."1.43Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines. ( Aggarwal, A; Bhatt, M; Chandhok, G; Horvath, J; Schmidt, HH; Zibert, A, 2016)
"The association of ClC-4 and the Wilson's disease protein (ATP7B) was determined by co-immunoprecipitation."1.32Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin. ( Wang, T; Weinman, SA, 2004)
"Whereas in both H4IIE rat hepatoma cells and primary hepatocytes TAUT mRNA levels were strongly dependent upon ambient osmolarity, mRNAs for other osmolyte transporters, i."1.30Osmoregulated taurine transport in H4IIE hepatoma cells and perfused rat liver. ( Häussinger, D; Warskulat, U; Wettstein, M, 1997)
"H4IIE hepatoma cells were inoculated directly into the liver parenchyma of ACI strain rats, and membranes were prepared from HCC livers and adjacent nonneoplastic livers 12 days following the initial inoculation."1.30Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma. ( Cahill, PA; McKillop, IH; Sitzmann, JV; Wu, Y, 1998)
"In HTC hepatoma cells, increases in volume are coupled to membrane ion permeability through a pathway involving (i) ATP efflux, (ii) autocrine stimulation of P2 receptors, and (iii) increases in anion permeability and Cl- efflux, contributing to recovery of volume toward basal values."1.30Phosphatidylinositol 3-kinase contributes to cell volume regulation through effects on ATP release. ( Feranchak, AP; Fitz, JG; Roman, RM; Schwiebert, EM, 1998)
"Studies were performed in HTC rat hepatoma and Mz-ChA-1 human cholangiocarcinoma cells, which were used as model hepatocytes and cholangiocytes, respectively."1.30Activation of protein kinase Calpha couples cell volume to membrane Cl- permeability in HTC hepatoma and Mz-ChA-1 cholangiocarcinoma cells. ( Bodily, KO; Fitz, JG; Raymond, JR; Roman, RM; Wang, Y, 1998)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199015 (35.71)18.7374
1990's10 (23.81)18.2507
2000's10 (23.81)29.6817
2010's3 (7.14)24.3611
2020's4 (9.52)2.80

Authors

AuthorsStudies
Huang, JJ1
Lin, J1
Chen, X1
Zhu, W1
Moghadam, D1
Zarei, R1
Vakili, S1
Ghojoghi, R1
Zarezade, V1
Veisi, A1
Sabaghan, M1
Azadbakht, O1
Behrouj, H1
Tang, H1
Chen, D1
Li, C1
Zheng, C1
Wu, X1
Zhang, Y1
Song, Q1
Fei, W1
Hassan, SA1
Schmithals, C1
von Harten, M1
Piiper, A1
Korf, HW1
von Gall, C1
Kanda, T1
Sasaki-Tanaka, R1
Masuzaki, R1
Matsumoto, N1
Okamoto, H1
Moriyama, M1
Lam, KH1
Lee, KK1
Gambari, R1
Kok, SH1
Kok, TW1
Chan, AS1
Bian, ZX1
Wong, WY1
Wong, RS1
Lau, FY1
Tong, SW1
Chan, KW1
Cheng, CH1
Chui, CH1
Tang, JC1
Chandhok, G1
Horvath, J1
Aggarwal, A1
Bhatt, M1
Zibert, A1
Schmidt, HH1
O'Brien, CE1
Harik, N1
James, LP1
Seib, PM1
Stowe, CD1
Haas, MJ1
Sawaf, R1
Horani, MH1
Gobal, F1
Wong, NC1
Mooradian, AD1
ATCHLEY, WA1
BHAGAVAN, NV1
Wang, T2
Weinman, SA2
Hwang, DR1
Lin, RK1
Leu, GZ1
Lin, TY1
Lien, TW1
Yu, MC1
Yeh, CT1
Hsu, JT1
Dalton, T1
Palmiter, RD1
Andrews, GK1
Hiranuma, K1
Hirata, K1
Abe, T1
Hirano, T1
Matsuno, K1
Hirano, H1
Suzuki, K1
Higashi, K1
Bergelson, S1
Pinkus, R1
Daniel, V1
Yang, MS1
Tang, MK1
Wong, RN1
Warskulat, U1
Wettstein, M1
Häussinger, D1
Cao, D1
Fan, ST1
Chung, SS1
McKillop, IH1
Wu, Y1
Cahill, PA1
Sitzmann, JV1
Feranchak, AP3
Roman, RM4
Schwiebert, EM2
Fitz, JG4
Bodily, KO1
Wang, Y1
Raymond, JR1
Panara, F1
Guiderdone, S1
Pellegrini, M1
Zuccaccia, C1
Contenti, S1
Imakita, M1
Yamanaka, N1
Kuroda, N1
Kitayama, Y1
Okamoto, E1
Smith, RL1
Clayton, GH1
Doctor, RB1
Kim, JA2
Kang, YS1
Lee, YS2
Lomri, N1
Braunstein, G1
Simeoni, LA1
Davison, AK1
Mechetner, E1
Li, X1
Zhao, Z1
Abdel-Dayam, HM1
Elkousy, AM1
Leslie, EV1
Panaro, VA1
Alekhina, RP1
Likhtenshteĭn, AV1
Shapot, VS1
Chan, CH1
Steer, CJ1
Vergalla, J1
Jones, EA1
Noll, F1
Bielka, H3
Egan, BZ1
Caton, JE1
Kelmers, AD1
Wilhelm, JA1
Hnilica, LS1
Adamson, RH1
Levinson, BB1
Baxter, JD1
Rousseau, GG1
Tomkins, GM1
Tsuruo, T1
Satoh, H1
Ukita, T1
Van Rossum, GD2
Galeotti, T1
Morris, HP2
Smith, KP1
Jackson, V1
Chalkley, R1
Lutsch, G1
Welfle, H1

Reviews

1 review available for chlorine and Hepatocellular Carcinoma

ArticleYear
Cesium-induced QT-interval prolongation in an adolescent.
    Pharmacotherapy, 2008, Volume: 28, Issue:8

    Topics: Adolescent; Carcinoma, Hepatocellular; Cesium; Chlorides; Electrocardiography; Female; Humans; Liver

2008

Trials

1 trial available for chlorine and Hepatocellular Carcinoma

ArticleYear
Does topical cooling alleviate ischemia/reperfusion injury during inflow occlusion in hepatectomy? Results of an experimental and clinical study.
    Surgery today, 2000, Volume: 30, Issue:9

    Topics: Aged; Animals; Calcium; Carcinoma, Hepatocellular; Cell Nucleus; Chlorides; Dogs; Electron Probe Mic

2000

Other Studies

40 other studies available for chlorine and Hepatocellular Carcinoma

ArticleYear
Identification of chloride intracellular channels as prognostic factors correlated with immune infiltration in hepatocellular carcinoma using bioinformatics analysis.
    Medicine, 2021, Nov-12, Volume: 100, Issue:45

    Topics: Carcinoma, Hepatocellular; Chloride Channels; Chlorides; Computational Biology; Humans; Liver Neopla

2021
The effect of natural polyphenols Resveratrol, Gallic acid, and Kuromanin chloride on human telomerase reverse transcriptase (hTERT) expression in HepG2 hepatocellular carcinoma: role of SIRT1/Nrf2 signaling pathway and oxidative stress.
    Molecular biology reports, 2023, Volume: 50, Issue:1

    Topics: Carcinoma, Hepatocellular; Chlorides; Gallic Acid; Humans; Liver Neoplasms; NF-E2-Related Factor 2;

2023
Dual GSH-exhausting sorafenib loaded manganese-silica nanodrugs for inducing the ferroptosis of hepatocellular carcinoma cells.
    International journal of pharmaceutics, 2019, Dec-15, Volume: 572

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Chlorides; Drug Carriers; Drug Compounding; Drug L

2019
Time-dependent changes in proliferation, DNA damage and clock gene expression in hepatocellular carcinoma and healthy liver of a transgenic mouse model.
    International journal of cancer, 2021, 01-01, Volume: 148, Issue:1

    Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Chlorides; Chronotherapy; DNA Damage; Gene E

2021
Knockdown of Mitogen-Activated Protein Kinase Kinase 3 Negatively Regulates Hepatitis A Virus Replication.
    International journal of molecular sciences, 2021, Jul-10, Volume: 22, Issue:14

    Topics: Carcinoma, Hepatocellular; Chlorides; Hepatitis A; Hepatitis A virus; Hepatocytes; Host-Pathogen Int

2021
Anti-tumour and pharmacokinetics study of 2-Formyl-8-hydroxy-quinolinium chloride as Galipea longiflora alkaloid analogue.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2014, May-15, Volume: 21, Issue:6

    Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Chlorides; Hepatoc

2014
Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines.
    World journal of gastroenterology, 2016, Apr-28, Volume: 22, Issue:16

    Topics: Adenosine Triphosphatases; Apoptosis; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Sur

2016
Effect of chromium on apolipoprotein A-I expression in HepG2 cells.
    Nutrition (Burbank, Los Angeles County, Calif.), 2003, Volume: 19, Issue:4

    Topics: Antioxidants; Apolipoprotein A-I; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular;

2003
SALINE-SOLUBLE PREPARATIONS OF DEOXYRIBONUCLEOPROTEINS.
    Archives of biochemistry and biophysics, 1964, Jul-20, Volume: 106

    Topics: Acetates; Alanine; Aminobutyrates; Aminocaproates; Aminocaproic Acid; Animals; Cadmium; Caprylates;

1964
Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes copper incorporation into ceruloplasmin.
    Gastroenterology, 2004, Volume: 126, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Biological Transport; Carcinoma, Hepatocellular; Cation Transpor

2004
Inhibition of hepatitis C virus replication by antimonial compounds.
    Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:10

    Topics: Antimony; Antimony Sodium Gluconate; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line, Tumor;

2005
Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxide-treated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements.
    Nucleic acids research, 1994, Nov-25, Volume: 22, Issue:23

    Topics: Animals; Antioxidants; Base Sequence; Carcinoma, Hepatocellular; Chlorides; Consensus Sequence; DNA-

1994
Induction of mitochondrial chaperonin, hsp60, by cadmium in human hepatoma cells.
    Biochemical and biophysical research communications, 1993, Jul-15, Volume: 194, Issue:1

    Topics: Biological Transport; Blotting, Northern; Cadmium; Cadmium Chloride; Carcinoma, Hepatocellular; Chap

1993
Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.
    Oncogene, 1994, Volume: 9, Issue:2

    Topics: Arsenates; Arsenites; Base Sequence; Binding Sites; Carcinoma, Embryonal; Carcinoma, Hepatocellular;

1994
Induction of metallothionein in the Reuber H-35 rat hepatoma cell.
    Toxicology, 1995, Dec-15, Volume: 104, Issue:1-3

    Topics: Animals; Blotting, Northern; Cadmium; Cadmium Chloride; Carcinogens; Carcinoma, Hepatocellular; Cell

1995
Osmoregulated taurine transport in H4IIE hepatoma cells and perfused rat liver.
    The Biochemical journal, 1997, Feb-01, Volume: 321 ( Pt 3)

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Betaine; Biological Transport; Blotting,

1997
Identification and characterization of a novel human aldose reductase-like gene.
    The Journal of biological chemistry, 1998, May-08, Volume: 273, Issue:19

    Topics: Adult; Aldehyde Reductase; Aldo-Keto Reductases; Amino Acid Sequence; Carcinoma, Hepatocellular; Chl

1998
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi-proteins) in experimental hepatocellular carcinoma.
    Journal of cellular physiology, 1998, Volume: 175, Issue:3

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Carcino

1998
Phosphatidylinositol 3-kinase contributes to cell volume regulation through effects on ATP release.
    The Journal of biological chemistry, 1998, Jun-12, Volume: 273, Issue:24

    Topics: Adenosine Triphosphate; Androstadienes; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Membran

1998
Activation of protein kinase Calpha couples cell volume to membrane Cl- permeability in HTC hepatoma and Mz-ChA-1 cholangiocarcinoma cells.
    Hepatology (Baltimore, Md.), 1998, Volume: 28, Issue:4

    Topics: Alkaloids; Animals; Benzophenanthridines; Bile Duct Neoplasms; Carcinoma, Hepatocellular; Catalytic

1998
Acid phosphatase and zinc ion-dependent acid phosphatase expression in normal human liver and in Hep G2 (human hepatocellular carcinoma) cell line.
    Cytobios, 1998, Volume: 94, Issue:376

    Topics: Acid Phosphatase; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Fractionation; Chlorid

1998
ClC-2 chloride channels contribute to HTC cell volume homeostasis.
    American journal of physiology. Gastrointestinal and liver physiology, 2001, Volume: 280, Issue:3

    Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Antibodies; Carcinoma, Hepatocellular; Ce

2001
Involvement of K(+)-Cl(-)-cotransport in the apoptosis induced by N-ethylmaleimide in HepG2 human hepatoblastoma cells.
    European journal of pharmacology, 2001, Apr-20, Volume: 418, Issue:1-2

    Topics: Apoptosis; Carcinoma, Hepatocellular; Carrier Proteins; Chlorides; Ethylmaleimide; Flow Cytometry; G

2001
Evidence for multidrug resistance-1 P-glycoprotein-dependent regulation of cellular ATP permeability.
    The Journal of membrane biology, 2001, Oct-01, Volume: 183, Issue:3

    Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Antibodies; ATP Binding Cassette Transporter, Subfamily

2001
Role of reactive oxygen species generated by NADPH oxidase in the mechanism of activation of K(+)-Cl(-)-cotransport by N-ethylmaleimide in HepG2 human hepatoma cells.
    Free radical research, 2001, Volume: 35, Issue:1

    Topics: Carcinoma, Hepatocellular; Chlorides; Enzyme Inhibitors; Ethylmaleimide; Genistein; Humans; K Cl- Co

2001
The ClC-3 chloride channel promotes acidification of lysosomes in CHO-K1 and Huh-7 cells.
    American journal of physiology. Cell physiology, 2002, Volume: 282, Issue:6

    Topics: Acids; Animals; Carcinoma, Hepatocellular; Chloride Channels; Chlorides; CHO Cells; Cricetinae; Fema

2002
Experience with 111-In-chloride scanning in patients with focal defects on 99-mTc-sulfur colloid liver scans.
    Radiology, 1975, Volume: 114, Issue:2

    Topics: Adolescent; Alcoholism; Carcinoma, Hepatocellular; Chlorides; Diagnosis, Differential; Fatty Liver;

1975
[Fractional composition of cytoplasmic RNP-particles in the cells of Zajdela ascitic hepatoma and the liver of a tumor-bearing animal].
    Biulleten' eksperimental'noi biologii i meditsiny, 1976, Volume: 82, Issue:11

    Topics: Animals; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Cesium; Chlorides; Liver; Live

1976
Alpha1-antitrypsin deficiency with cirrhosis associated with the protease inhibitor phenotype SZ.
    The American journal of medicine, 1978, Volume: 65, Issue:6

    Topics: alpha 1-Antitrypsin Deficiency; Biopsy; Carcinoma, Hepatocellular; Chlorides; Copper; Hepatitis; Hep

1978
[Proteins of animal ribosomes. IV. Antigenic properties of ribosomes and ribosomal proteins from liver and hepatoma].
    Archiv fur Geschwulstforschung, 1970, Volume: 35, Issue:4

    Topics: Animals; Carcinoma, Hepatocellular; Cattle; Centrifugation; Chemical Precipitation; Chlorides; Compl

1970
Separation of Escherichia coli ribosomal ribonucleic acids by reversed-phase chromatography.
    Biochemistry, 1971, May-11, Volume: 10, Issue:10

    Topics: Alkaline Phosphatase; Animals; Carcinoma, Hepatocellular; Cell Fractionation; Chlorides; Chromatogra

1971
Nucleolar and extranucleolar chromatin of rat Novikoff hepatoma cells. Separation and partial characterization of RNA polymerase activities.
    Biochimica et biophysica acta, 1971, May-13, Volume: 238, Issue:2

    Topics: Animals; Ascitic Fluid; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Nucleolus; Cell Nucleus; Ch

1971
Antitumor activity of tilorone hydrochloride against some rodent tumors: preliminary report.
    Journal of the National Cancer Institute, 1971, Volume: 46, Issue:2

    Topics: Animals; Antiviral Agents; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Chlorides; Culture Tech

1971
Cellular site of glucocorticoid-receptor complex formation.
    Science (New York, N.Y.), 1972, Jan-14, Volume: 175, Issue:4018

    Topics: Animals; Autoradiography; Binding Sites; Carcinoma, Hepatocellular; Cell-Free System; Cells, Culture

1972
DNA polymerases of ascites hepatoma cells. I. Purification and properties of a DNA polymerase from soluble fraction.
    Biochemical and biophysical research communications, 1972, Aug-21, Volume: 48, Issue:4

    Topics: Animals; Ascitic Fluid; Carcinoma, Hepatocellular; Cell Line; Centrifugation, Density Gradient; Chlo

1972
The mineral content and water compartments of liver and of Morris hepatomata 5123tc and 3924A and the changes of composition occurring during necrosis in hepatoma 3924A.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Animals; Biological Transport, Active; Calcium; Carcinoma, Hepatocellular; Chlorides; Female; Liver;

1973
The net extrusion of calcium and its temporal relation to the accumulation of potassium in slices of rat liver and of Morris hepatomata 5123tc and 3924A.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Animals; Biological Transport, Active; Calcium; Carcinoma, Hepatocellular; Chlorides; Female; Geese;

1973
Separation of newly synthesized nucleohistone by equilibrium centrifugation in cesium chloride.
    Biochemistry, 1974, Sep-10, Volume: 13, Issue:19

    Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Cesi

1974
Studies on the structure of ribosomal ribonucleic acid from normal and tumour tissues.
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1967, Volume: 22, Issue:10

    Topics: Animals; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry, Physical; Chlorides; Electrochemi

1967
[Characterization of proteins from liver and hepatoma ribosomes by polyacrylamide gel electrophoresis].
    Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete, 1968, Volume: 23, Issue:5

    Topics: Animals; Bacterial Proteins; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Chlorides;

1968