Page last updated: 2024-10-17

chlorine and Familial Hypokalemia-Hypomagnesemia

chlorine has been researched along with Familial Hypokalemia-Hypomagnesemia in 12 studies

chloride : A halide anion formed when chlorine picks up an electron to form an an anion.

Research Excerpts

Excerpt	Relevance	Reference
"Gitelman syndrome is the most common inherited tubular disease resulting from mutations of the SLC12A3 gene that encodes the thiazide-sensitive sodium-chloride cotransporter in the early distal convoluted tubules."	2.58	Gitelman syndrome: an analysis of the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities. ( Elisaf, MS; Filippatos, TD; Rizos, CV; Tzavella, E, 2018)
"Diagnosis of Gitelman's syndrome is usually made incidentally during adolescence or early adulthood based on clinical and biochemical findings."	1.42	Gitelman's syndrome as a cause of poorly controlled hypokalemia. ( Dimitrijevic, Z; Mitic, B; Nikolic, V; Salinger-Martinovic, S, 2015)

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	11 (91.67)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Zhang, L	1
Peng, X	2
Zhao, B	1
Zhu, Z	1
Wang, Y	2
Tian, D	1
Yan, Z	1
Yao, L	1
Liu, J	1
Qiu, L	1
Xing, X	2
Chen, L	2
Filippatos, TD	1
Rizos, CV	1
Tzavella, E	1
Elisaf, MS	1
Oba, T	1
Kobayashi, S	1
Nakamura, Y	1
Nagao, M	1
Nozu, K	2
Fukuda, I	1
Iijima, K	2
Sugihara, H	1
Chew, TA	1
Orlando, BJ	1
Zhang, J	1
Latorraca, NR	1
Wang, A	1
Hollingsworth, SA	1
Chen, DH	1
Dror, RO	1
Liao, M	1
Feng, L	1
Matsunoshita, N	1
Shono, A	1
Nozu, Y	1
Fu, XJ	1
Morisada, N	1
Kamiyoshi, N	1
Ohtsubo, H	1
Ninchoji, T	1
Minamikawa, S	1
Yamamura, T	1
Nakanishi, K	1
Yoshikawa, N	1
Shima, Y	1
Kaito, H	1
Knepper, MA	1
Grimm, PR	1
Lazo-Fernandez, Y	1
Delpire, E	1
Wall, SM	1
Dorsey, SG	1
Weinman, EJ	1
Coleman, R	1
Wade, JB	1
Welling, PA	1
Jiang, L	1
Ma, J	1
Yuan, T	2
Qin, Y	1
Wang, O	2
Wang, H	1
Chen, G	1
Yue, C	2
Li, C	1
Nie, M	1
Li, X	1
Lee, X	1
Dimitrijevic, Z	1
Salinger-Martinovic, S	1
Mitic, B	1
Nikolic, V	1
Peng, XY	1
Jiang, LP	1
Zheng, K	1
Li, NS	1
Li, W	1
Tong, AL	1
Xing, XP	1
Li, XM	1
Li, XW	1
Chen, LM	1
Ehren, K	1
Marx, A	1
Wasmuth, JC	1
Ueda, K	1
Makita, N	1
Kawarazaki, H	1
Fujiwara, T	1
Unuma, S	1
Monkawa, T	1
Hayashi, M	1
Fujita, T	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial[NCT03923933]			Phase 2	34 participants (Actual)	Interventional	2019-06-18	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-3.4
Treatment Grup	-13.5

Change in Extracellular Water

Decrease in extracellular water measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	litres (Mean)
Placebo	-0.15
Treatment Grup	2.55

Change in Extracellular Water / Total Body Water Ratio

Decrease in extracellular water / total body water ratio measured by bioelectrical impedance analysis (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	percentage of ECW/TBW (Mean)
Placebo	-0.24
Treatment Grup	-2.92

Change in Mean Arterial Pressure

decrease in blood pressure compared wit baseline measure (mmhg) (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-5.4
Treatment Grup	-18.1

Change in Systolic Blood Pressure

(NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	mmHg (Mean)
Placebo	-10
Treatment Grup	-26.1

Change in the Fractional Excretion of Sodium

Increase in the fractional excretion of sodium compared with the baseline measure (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	percentage of sodium excreted (Mean)
Placebo	-0.348
Treatment Grup	0.598

Change in Total Body Water

Measured by bioelectrical impedance analysis, compared to the initial measurement (NCT03923933)
Timeframe: Change from Basal to day 28

Intervention	litres (Mean)
Placebo	-0.075
Treatment Grup	-4.36

Reviews

1 review available for chlorine and Familial Hypokalemia-Hypomagnesemia

Article	Year
Gitelman syndrome: an analysis of the underlying pathophysiologic mechanisms of acid-base and electrolyte abnormalities. International urology and nephrology, 2018, Volume: 50, Issue:1 Topics: Acidosis; Calcium; Chlorides; Gitelman Syndrome; Humans; Hypokalemia; Hyponatremia; Potassium	2018

Other Studies

11 other studies available for chlorine and Familial Hypokalemia-Hypomagnesemia

Article	Year
Clinical and laboratory features of female Gitelman syndrome and the pregnancy outcomes in a Chinese cohort. Nephrology (Carlton, Vic.), 2020, Volume: 25, Issue:10 Topics: Adult; China; Chlorides; Delivery, Obstetric; Female; Gitelman Syndrome; Humans; Infant, Newborn; Ma	2020
A Case of Gitelman Syndrome that Was Difficult to Distinguish from Hypokalemic Periodic Paralysis Caused by Graves' Disease. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2019, Dec-03, Volume: 86, Issue:5 Topics: Base Sequence; Chlorides; Diagnosis, Differential; Gitelman Syndrome; Graves Disease; Humans; Hypoka	2019
Structure and mechanism of the cation-chloride cotransporter NKCC1. Nature, 2019, Volume: 572, Issue:7770 Topics: Amino Acid Sequence; Animals; Binding Sites; Cations, Monovalent; Chlorides; Cryoelectron Microscopy	2019
Differential diagnosis of Bartter syndrome, Gitelman syndrome, and pseudo-Bartter/Gitelman syndrome based on clinical characteristics. Genetics in medicine : official journal of the American College of Medical Genetics, 2016, Volume: 18, Issue:2 Topics: Adolescent; Adult; Bartter Syndrome; Child, Preschool; Chlorides; Diagnosis, Differential; DNA Mutat	2016
Systems biology of diuretic resistance. The Journal of clinical investigation, 2015, Volume: 125, Issue:5 Topics: Animals; Blood Pressure; Chlorides; Gitelman Syndrome; Male; Natriuresis; Nephrons; Renal Reabsorpti	2015
Integrated compensatory network is activated in the absence of NCC phosphorylation. The Journal of clinical investigation, 2015, Volume: 125, Issue:5 Topics: Amiloride; Ammonia; Animals; Biological Transport; Blood Pressure; Carbonic Anhydrases; Chlorides; D	2015
NORMOMAGNESEMIC GITELMAN SYNDROME PATIENTS EXHIBIT A STRONGER REACTION TO THIAZIDE THAN HYPOMAGNESEMIC PATIENTS. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2015, Volume: 21, Issue:9 Topics: Adolescent; Adult; Aged; Child; Chlorides; Female; Genotype; Gitelman Syndrome; Humans; Hydrochlorot	2015
Gitelman's syndrome as a cause of poorly controlled hypokalemia. La Clinica terapeutica, 2015, Volume: 166, Issue:3 Topics: Alkalosis; Calcium; Chlorides; Diagnosis, Differential; Female; Gitelman Syndrome; Humans; Hypokalem	2015
Value of Chloride Clearance Test in Differential Diagnosis of Gitelman Syndrome. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2016, 06-10, Volume: 38, Issue:3 Topics: Case-Control Studies; Chlorides; Diagnosis, Differential; Gitelman Syndrome; Humans; Hydrochlorothia	2016
[Unexplained chronic hypokalaemia in a young woman]. Deutsche medizinische Wochenschrift (1946), 2010, Volume: 135, Issue:41 Topics: Adult; Chlorides; Chronic Disease; Diagnosis, Differential; Diarrhea; Female; Gitelman Syndrome; Hum	2010
A novel compound heterozygous mutation of Gitelman's syndrome in Japan, as diagnosed by an extraordinary response of the fractional excretion rate of chloride in the trichlormethiazide loading test. Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:12 Topics: Adult; Asian People; Base Sequence; Chlorides; DNA Mutational Analysis; Female; Gitelman Syndrome; H	2012