chlorine and Diabetic Ketoacidosis studies

chloride : A halide anion formed when chlorine picks up an electron to form an an anion.

Diabetic Ketoacidosis: A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by KETOSIS; DEHYDRATION; and depressed consciousness leading to COMA.

Research Excerpts

Excerpt	Relevance	Reference
"Metabolic acidosis is a common occurrence in critically ill patients."	2.41	Metabolic acidosis in the intensive care unit. ( Gauthier, PM; Szerlip, HM, 2002)
"This article reviews the pathogenesis of diabetic ketoacidosis (DKA) and provides a rational approach to the management of patients with DKA."	2.39	Diabetic ketoacidosis. ( Kitabchi, AE; Wall, BM, 1995)
"Initial metabolic acidosis was due to SIG, and the treatment was associated with a significant decrease of SIG with an elevation of serum chloride above the normal range."	1.37	Evolutive physicochemical characterization of diabetic ketoacidosis in adult patients admitted to the intensive care unit. ( Lopes, AD; Maciel, AT; Park, M, 2011)
"During the acute treatment of diabetic ketoacidosis we (a) determined the temporal incidence of hyperchloraemia, and (b) quantified the influence of hyperchloraemia on interpretation of common blood gas derived acid base parameters, namely base deficit and bicarbonate."	1.33	The influence of hyperchloraemia on acid base interpretation in diabetic ketoacidosis. ( Durward, A; Holton, F; Johnstone, IC; Murdoch, IA; Taylor, D; Thorburn, K; Tibby, SM, 2006)
"Cats that had received previous treatment for diabetes mellitus, or for which medical records were incomplete, were excluded from this study."	1.29	Pretreatment clinical and laboratory evaluation of cats with diabetes mellitus: 104 cases (1992-1994). ( Crenshaw, KL; Peterson, ME, 1996)
"The occurrence of hyperchloremia during diabetic ketoacidosis (DKA) recovery and the lack of correlation between anion gap excess (delta AG) and bicarbonate deficit (delta TCO2) on admission suggest an hyperchloremic acidosis (HCLA) component."	1.28	[Hyperchloremic acidosis in metabolic acidosis with anion gap excess. Comparison with diabetic ketoacidosis]. ( Bernardin, M; Brivet, F; Dormont, J, 1991)
"Proximal renal tubular acidosis was indicated by the reduced bicarbonate threshold that persisted for approximately 7 weeks."	1.25	Renal tubular acidosis during therapy for diabetic ketoacidosis. ( Giammarco, R; Goldstein, MB; Halperin, ML; Stinebaugh, BJ, 1975)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (56.25)	18.7374
1990's	7 (14.58)	18.2507
2000's	7 (14.58)	29.6817
2010's	3 (6.25)	24.3611
2020's	4 (8.33)	2.80

Authors	Studies
Ahmed, HM	1
Elnaby, HRH	1
El Kareem, RMA	1
Hodeib, M	1
Hegab, AM	1
Khalil, FF	1
Abosedera, MM	1
Kumar, D	1
Nasim, MZ	1
Shoukat, BA	1
Shah, SSA	1
Glaser, NS	1
Stoner, MJ	1
Garro, A	1
Baird, S	1
Myers, SR	1
Rewers, A	1
Brown, KM	1
Trainor, JL	1
Quayle, KS	1
McManemy, JK	1
DePiero, AD	1
Nigrovic, LE	1
Tzimenatos, L	1
Schunk, JE	1
Olsen, CS	1
Casper, TC	1
Ghetti, S	1
Kuppermann, N	1
Toledo, I	1
Wainsztein, R	1
Mannucci, C	1
Ferraro, M	1
Ferreira, J	1
Balestracci, A	1
Handy, JM	1
Soni, N	1
Mrozik, LT	1
Yung, M	1
Lopes, AD	1
Maciel, AT	1
Park, M	1
Kimura, D	1
Raszynski, A	1
Totapally, BR	1
Funk, GC	1
Zauner, C	1
Bauer, E	1
Oschatz, E	1
Schneeweiss, B	1
SPAULDING, WB	1
SHCHEGOLEVA, GP	1
CARSON, MJ	1
IZAR, G	1
JUSTIN-BESANCON, L	1
LAMOTTE, M	1
LAMOTTE-BARRILLON, S	1
GRIVAUX, M	1
COLOMB, G	1
Taylor, D	1
Durward, A	1
Tibby, SM	1
Thorburn, K	1
Holton, F	1
Johnstone, IC	1
Murdoch, IA	1
Rosival, V	1
Shankar, PS	1
Oster, JR	1
Epstein, M	1
Gabow, PA	1
Kaehny, WD	1
Fennessey, PV	1
Goodman, SI	1
Gross, PA	1
Schrier, RW	1
Oh, MS	3
Banerji, MA	1
Carroll, HJ	3
Halperin, ML	2
Bear, RA	1
Hannaford, MC	1
Goldstein, MB	2
Adrogué, HJ	1
Wilson, H	1
Boyd, AE	1
Suki, WN	1
Eknoyan, G	1
Fudge, A	1
Rumbelow, B	1
Peake, M	1
Kitabchi, AE	2
Wall, BM	1
Crenshaw, KL	1
Peterson, ME	1
Gill, G	1
Bruskiewicz, KA	1
Nelson, RW	1
Feldman, EC	1
Griffey, SM	1
Matz, R	1
Gauthier, PM	1
Szerlip, HM	1
Goldstein, DA	1
Fein, IA	1
Carli, F	1
Clark, MM	1
Young, R	1
Sacks, H	1
Morris, L	1
Giammarco, R	1
Stinebaugh, BJ	1
Brivet, F	1
Bernardin, M	1
Dormont, J	1
Uribarri, J	1
Fulop, M	1
Luzi, L	1
Barrett, EJ	1
Groop, LC	1
Ferrannini, E	1
DeFronzo, RA	1
Joffe, BI	1
Seftel, HC	1
Goldberg, R	1
Van As, M	1
Krut, L	1
Bersohn, I	1
Misra, DP	1
Staddon, G	1
Powell, N	1
Misra, J	1
Crook, D	1
Hayat, JC	1
Bengtsson, K	1
Karlberg, B	1
Lindgren, S	1
Herbinger, W	1
Müller, WA	1
Faloona, GR	1
Unger, RH	1
Whang, R	1
Avasthi, PS	1
Cryer, PE	1
Daughaday, WH	1
Gerich, JE	1
Martin, MM	1
Recant, L	1
Benke, A	1
Hohenegger, M	1
Rudas, B	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of the Feasibility and Safety of Laryngoscopic Microsurgery Under Non-intubation Anesthesia With Combination of Superior Laryngeal Nerve Block[NCT05420649]		49 participants (Actual)	Interventional	2020-10-20	Completed
Effectiveness of the Treatment With Dapagliflozin and Metformin Compared to Metformin Monotherapy for Weight Loss on Diabetic and Prediabetic Patients With Obesity Class III[NCT03968224]	Phase 2/Phase 3	90 participants (Anticipated)	Interventional	2018-07-07	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Physiological effects of hyperchloraemia and acidosis. British journal of anaesthesia, 2008, Volume: 101, Issue:2 Topics: Acid-Base Equilibrium; Acidosis; Chlorides; Diabetic Ketoacidosis; Exercise; Fluid Therapy; Humans	2008
Acid-base aspects of ketoacidosis. American journal of nephrology, 1984, Volume: 4, Issue:3 Topics: 3-Hydroxybutyric Acid; Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Alcoholism; Alkalosis	1984
Selected aspects of the pathophysiology of metabolic acidosis in diabetes mellitus. Diabetes, 1981, Volume: 30, Issue:9 Topics: Anions; Bicarbonates; Blood; Chlorides; Diabetic Ketoacidosis; Humans; Hydrogen-Ion Concentration; K	1981
Diabetic ketoacidosis. The Medical clinics of North America, 1995, Volume: 79, Issue:1 Topics: Acidosis; Bicarbonates; Brain Edema; Chlorides; Diabetic Ketoacidosis; Emergencies; Fluid Therapy; H	1995
Metabolic acidosis in the intensive care unit. Critical care clinics, 2002, Volume: 18, Issue:2 Topics: Acid-Base Imbalance; Acidosis; Acidosis, Lactic; Chlorides; Diabetic Ketoacidosis; Ethanol; Humans;	2002
Diabetic ketoacidosis: reappraisal of therapeutic approach. Annual review of medicine, 1979, Volume: 30 Topics: Bicarbonates; Child; Chlorides; Diabetic Ketoacidosis; Fluid Therapy; Humans; Hypotonic Solutions; I	1979
Mechanism of normochloremic and hyperchloremic acidosis in diabetic ketoacidosis. Nephron, 1990, Volume: 54, Issue:1 Topics: Chlorides; Diabetic Ketoacidosis; Humans; Ketones	1990
Water and electrolyte disturbances associated with diabetic ketoacidosis. Rocky Mountain medical journal, 1967, Volume: 64, Issue:12 Topics: Bicarbonates; Blood Urea Nitrogen; Carbon Dioxide; Chlorides; Diabetic Ketoacidosis; Glucose; Humans	1967

Article	Year
The relationship between hyperchloremia and acute kidney injury in pediatric diabetic ketoacidosis and its impact on clinical outcomes. Pediatric nephrology (Berlin, Germany), 2022, Volume: 37, Issue:6 Topics: Acid-Base Imbalance; Acute Kidney Injury; Child; Chlorides; Creatinine; Cross-Sectional Studies; Dia	2022
Incidence and factors associated with acute kidney injury among children with type 1 diabetes hospitalized with diabetic ketoacidosis: A prospective study. Pediatric diabetes, 2022, Volume: 23, Issue:6 Topics: Acute Kidney Injury; Child; Chlorides; Creatinine; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis;	2022
Presentation of mixed diabetic ketoacidosis and metabolic acidosis due to ileal neobladder reconstruction. BMJ case reports, 2021, Feb-23, Volume: 14, Issue:2 Topics: Acidosis; Adult; Bicarbonates; Chlorides; Diabetic Ketoacidosis; Humans; Male; Water-Electrolyte Imb	2021
Impact of the hyperchloremic component of metabolic acidosis on the patient's hydration status and the treatment of diabetic ketoacidosis. Archivos argentinos de pediatria, 2018, 06-01, Volume: 116, Issue:3 Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Child; Child, Preschool; Chlorides; Cross-Sectional Stu	2018
Hyperchloraemic metabolic acidosis slows recovery in children with diabetic ketoacidosis: a retrospective audit. Australian critical care : official journal of the Confederation of Australian Critical Care Nurses, 2009, Volume: 22, Issue:4 Topics: Acid-Base Equilibrium; Adolescent; Bicarbonates; Child; Chlorides; Diabetic Ketoacidosis; Female; Hu	2009
Evolutive physicochemical characterization of diabetic ketoacidosis in adult patients admitted to the intensive care unit. Journal of critical care, 2011, Volume: 26, Issue:3 Topics: Acid-Base Imbalance; Acidosis; Adult; Anions; Chlorides; Diabetic Ketoacidosis; Female; Humans; Inte	2011
Admission and treatment factors associated with the duration of acidosis in children with diabetic ketoacidosis. Pediatric emergency care, 2012, Volume: 28, Issue:12 Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Bicarbonates; Brain Edema; Child; Child, Preschool; Chl	2012
Compensatory hypochloraemic alkalosis in diabetic ketoacidosis. Diabetologia, 2003, Volume: 46, Issue:6 Topics: Acid-Base Equilibrium; Bicarbonates; Chlorides; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Fe	2003
DIABETIC ACIDOSIS. Applied therapeutics, 1963, Volume: 5 Topics: Acidosis; Carbohydrates; Chlorides; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Insulin; Ions;	1963
[WATER-SALT METABOLISM IN DIABETES MELLITUS IN CHILDREN]. Pediatriia, 1963, Volume: 42 Topics: Acidosis; Adolescent; Blood Chemical Analysis; Child; Chlorides; Diabetes Mellitus, Type 1; Diabetic	1963
DIABETES MELLITUS IN INFANTS AND CHILDREN. L. MANAGEMENT OF ACIDOSIS DURING THE FIRST 24 HOURS. Postgraduate medicine, 1964, Volume: 36 Topics: Acidosis; Adolescent; Carbohydrate Metabolism; Child; Chlorides; Diabetes Mellitus, Type 1; Diabetic	1964
[GRAVE KETOACIDOSIS AND DIABETIC COMA: ITS THERAPY]. Minerva medica, 1964, Sep-29, Volume: 55 Topics: Acidosis; Chlorides; Diabetes Mellitus; Diabetic Coma; Diabetic Ketoacidosis; Humans; Insulin; Ions;	1964
[Hypochloremic and hypokalemic alkalosis, atypical hypoglycemia in a case of diabetic acidosis]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1960, Mar-12, Volume: 36 Topics: Acid-Base Imbalance; Alkalosis; Bartter Syndrome; Chlorides; Diabetes Complications; Diabetic Ketoac	1960
The influence of hyperchloraemia on acid base interpretation in diabetic ketoacidosis. Intensive care medicine, 2006, Volume: 32, Issue:2 Topics: Acid-Base Imbalance; Acute Disease; Child; Chlorides; Diabetic Ketoacidosis; Female; Humans; Male; R	2006
Comment on "The influence of hyperchloraemia on acid--base interpretation in diabetic ketoacidosis" by Taylor et al. Intensive care medicine, 2006, Volume: 32, Issue:9 Topics: Acid-Base Imbalance; Chlorides; Diabetic Ketoacidosis; Humans	2006
Hyperchloraemic metabolic acidosis in diabetes. The Journal of the Association of Physicians of India, 1983, Volume: 31, Issue:9 Topics: Adult; Chlorides; Diabetic Ketoacidosis; Female; Humans; Kidney	1983
Diagnostic importance of an increased serum anion gap. The New England journal of medicine, 1980, Oct-09, Volume: 303, Issue:15 Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Adult; Aged; Anions; Bicarbonates; Chlorides; Diabetic	1980
The mechanism of hyperchloremic acidosis during the recovery phase of diabetic ketoacidosis. Diabetes, 1981, Volume: 30, Issue:4 Topics: Acidosis; Carbon Dioxide; Chlorides; Diabetes Mellitus; Diabetic Ketoacidosis; Humans; Water-Electro	1981
Plasma acid-base patterns in diabetic ketoacidosis. The New England journal of medicine, 1982, Dec-23, Volume: 307, Issue:26 Topics: Acid-Base Equilibrium; Adolescent; Adult; Bicarbonates; Carbon Dioxide; Chlorides; Diabetic Ketoacid	1982
Specificity problems with Hitachi chloride electrodes. Clinical chemistry, 1994, Volume: 40, Issue:10 Topics: Bicarbonates; Chlorides; Diabetic Ketoacidosis; Electrodes; False Negative Reactions; Humans; Hydrog	1994
Pretreatment clinical and laboratory evaluation of cats with diabetes mellitus: 104 cases (1992-1994). Journal of the American Veterinary Medical Association, 1996, Sep-01, Volume: 209, Issue:5 Topics: Animals; Cat Diseases; Cats; Chlorides; Diabetes Complications; Diabetes Mellitus; Diabetic Ketoacid	1996
Hyperchloraemic acidosis during recovery from hyperglycaemic diabetic emergencies. Journal of the Royal Society of Medicine, 1996, Volume: 89, Issue:8 Topics: Chlorides; Diabetic Ketoacidosis; Humans; Hyperglycemia	1996
Diabetic ketosis and ketoacidosis in cats: 42 cases (1980-1995). Journal of the American Veterinary Medical Association, 1997, Jul-15, Volume: 211, Issue:2 Topics: Alanine Transaminase; Animals; Bicarbonates; Calcium; Cat Diseases; Cats; Chlorides; Diabetic Ketoac	1997
Severe diabetic ketoacidosis. Diabetic medicine : a journal of the British Diabetic Association, 2000, Volume: 17, Issue:4 Topics: Bicarbonates; Chlorides; Diabetic Ketoacidosis; Fluid Therapy; Humans	2000
Hyperchloremic acidosis during the recovery phase of diabetic ketosis. Annals of internal medicine, 1978, Volume: 89, Issue:6 Topics: Adolescent; Adult; Aged; Bicarbonates; Chlorides; Diabetic Ketoacidosis; Female; Humans; Ketones; Ma	1978
The anion gap-a diagnostic tool. Anaesthesia, 1979, Volume: 34, Issue:9 Topics: Bicarbonates; Chlorides; Diabetic Ketoacidosis; Female; Humans; Lactates; Middle Aged; Potassium; So	1979
Renal tubular acidosis during therapy for diabetic ketoacidosis. Canadian Medical Association journal, 1975, Feb-22, Volume: 112, Issue:4 Topics: Acid-Base Equilibrium; Acidosis, Renal Tubular; Adult; Bicarbonates; Carbon Dioxide; Chlorides; Diab	1975
[Hyperchloremic acidosis in metabolic acidosis with anion gap excess. Comparison with diabetic ketoacidosis]. Presse medicale (Paris, France : 1983), 1991, Mar-09, Volume: 20, Issue:9 Topics: Acid-Base Equilibrium; Acidosis, Lactic; Bicarbonates; Chlorides; Diabetic Ketoacidosis; Humans; Pre	1991
Pretreatment hyperchloremia in diabetic ketoacidosis. Critical care medicine, 1986, Volume: 14, Issue:9 Topics: Chlorides; Diabetic Ketoacidosis; Humans	1986
Metabolic effects of low-dose insulin therapy on glucose metabolism in diabetic ketoacidosis. Diabetes, 1988, Volume: 37, Issue:11 Topics: 3-Hydroxybutyric Acid; Adult; Bicarbonates; Blood; Blood Glucose; Chlorides; Diabetes Mellitus, Type	1988
Factors in the pathogenesis of experimental nonketotic and ketoacidotic diabetic stupor. Diabetes, 1973, Volume: 22, Issue:9 Topics: Animals; Antigens; Blood Glucose; Carbon Dioxide; Chlorides; Diabetes Mellitus, Experimental; Diabet	1973
Lecithin-cholesterol acyltransferase activity in diabetes mellitus and the effect of insulin on these cases. Clinica chimica acta; international journal of clinical chemistry, 1974, Oct-15, Volume: 56, Issue:1 Topics: Acidosis; Acute Kidney Injury; Acyltransferases; Adult; Aged; Bicarbonates; Carbon Radioisotopes; Ch	1974
The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases. Diabetologia, 1974, Volume: 10, Issue:5 Topics: Acetates; Acute Kidney Injury; Aged; Bicarbonates; Blood Glucose; Carbon Dioxide; Chlorides; Diabeti	1974
Lactic acidosis in phenformin-treated diabetics. A clinical and laboratory study. Acta medica Scandinavica, 1972, Volume: 191, Issue:3 Topics: Adult; Aged; Bicarbonates; Blood; Blood Glucose; Chlorides; Creatinine; Diabetes Mellitus; Diabetes	1972
[Therapy of ketoacidotic diabetic coma]. Wiener medizinische Wochenschrift (1946), 1972, Jun-17, Volume: 122, Issue:25 Topics: Adolescent; Adult; Age Factors; Bicarbonates; Chlorides; Diabetic Coma; Diabetic Ketoacidosis; Human	1972
Hyperglucagonemia in diabetic ketoacidosis. Its prevalence and significance. The American journal of medicine, 1973, Volume: 54, Issue:1 Topics: Acetone; Adolescent; Adult; Aged; Blood Glucose; Blood Urea Nitrogen; Carbon Dioxide; Child; Chlorid	1973
Diabetic ketosis: elevated serum glutamic-oxaloacetic transaminase (SGOT) and other findings determined by multi-channel chemical analysis. Diabetes, 1969, Volume: 18, Issue:11 Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Glucose; B	1969
Clinical and metabolic characteristics of hyperosmolar nonketotic coma. Diabetes, 1971, Volume: 20, Issue:4 Topics: Adolescent; Adult; Aged; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Carbon Dioxide; Chlorides	1971
[Behavior of serum electrolytes in alloxan diabetes in rats]. Wiener klinische Wochenschrift, 1971, Mar-12, Volume: 83, Issue:10 Topics: Acid-Base Equilibrium; Animals; Bicarbonates; Blood Glucose; Blood Urea Nitrogen; Chlorides; Chronic	1971

chlorine and Diabetic Ketoacidosis

Research Excerpts

Research

Studies (48)

Authors

Clinical Trials (2)

Trial Overview

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