chlorine has been researched along with Critical Illness in 70 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Urine alkalinisation with sodium bicarbonate decreases renal oxidative stress and might attenuate sepsisassociated acute kidney injury (s-AKI)." | 5.17 | Safety evaluation of a trial of lipocalin-directed sodium bicarbonate infusion for renal protection in at-risk critically ill patients. ( Bellomo, R; Eastwood, GM; Garcia, M; Harley, N; Moore, E; Peck, L; Reade, M; Schneider, AG; Young, H, 2013) |
| "This prospective, open-label, clinical trial was conducted to describe the pharmacology of bumetanide in pediatric patients with edema." | 5.08 | Pharmacokinetics and pharmacodynamics of bumetanide in critically ill pediatric patients. ( Kearns, GL; Letzig, L; Marshall, JD; Wells, TG, 1998) |
| "New-onset acute kidney injury was observed in 10 patients (6." | 3.30 | Effect of Saline vs Gluconate/Acetate-Buffered Solution vs Lactate-Buffered Solution on Serum Chloride Among Children in the Pediatric Intensive Care Unit: The SPLYT-P Randomized Clinical Trial. ( Gibbons, KS; Kennedy, M; Le Marsney, R; Mattke, A; Raman, S; Schibler, A; Schlapbach, LJ; Trnka, P, 2023) |
| "AKI patients with severe critical illness were extracted from the MIMIC-IV." | 1.91 | Lower serum chloride concentrations are associated with an increased risk of death in ICU patients with acute kidney injury: an analysis of the MIMIC-IV database. ( An, S; Chen, Y; Li, R; Liang, Q; Zhou, S, 2023) |
| "Retrospective analysis of a pediatric septic shock database." | 1.48 | Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock. ( Allen, GL; Anas, N; Bigham, MT; Checchia, PA; Cvijanovich, NZ; Fitzgerald, JC; Freishtat, RJ; Gedeit, R; Gertz, S; Grunwell, JR; Hall, M; Meyer, K; Nowak, J; Quasney, M; Raj, SS; Stenson, EK; Thomas, NJ; Weiss, SL; Wong, HR, 2018) |
| "Metabolic acidosis has been implicated in the development of coagulopathy, although the specific mechanisms have not been well characterized." | 1.42 | Does saline resuscitation affect mechanisms of coagulopathy in critically ill trauma patients? An exploratory analysis. ( Galante, JM; Gosselin, RC; Scherer, LA; Schermer, CR; Smith, CA; Utter, GH; Young, JB, 2015) |
| "Hyperchloremic acidosis is frequent in critically ill patients." | 1.42 | Renal tubular acidosis is highly prevalent in critically ill patients. ( Brunner, R; Drolz, A; Fuhrmann, V; Holzinger, U; Scherzer, TM; Schneeweiß, B; Staufer, K; Zauner, C, 2015) |
| "Shock was more frequently present in the low [BE] group (46% versus 24%, P = 0." | 1.35 | Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches. ( Dubin, A; Kutscherauer, DO; Masevicius, FD; Pein, MC; Tuhay, G, 2008) |
| "We report quadriparesis as a result of severe hypokalaemia and acidosis in a 50-year-old man who had undergone ureterosigmoidostomy for bladder extrophy 48 years earlier." | 1.31 | Life-threatening hypokalaemia and quadriparesis in a patient with ureterosigmoidostomy. ( Bac, DJ; De Leeuw, PW; Dees, A; Nienhuis, IE; Van Bekkum, JW, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (7.14) | 18.2507 |
| 2000's | 8 (11.43) | 29.6817 |
| 2010's | 33 (47.14) | 24.3611 |
| 2020's | 24 (34.29) | 2.80 |
| Authors | Studies |
|---|---|
| Jin, X | 1 |
| Li, J | 1 |
| Ren, J | 1 |
| Gao, Y | 1 |
| Li, R | 2 |
| Zhang, J | 4 |
| Wang, X | 1 |
| Wang, G | 1 |
| Thongprayoon, C | 2 |
| Radhakrishnan, Y | 1 |
| Cheungpasitporn, W | 1 |
| Petnak, T | 1 |
| Zabala Genovez, J | 1 |
| Chewcharat, A | 1 |
| Qureshi, F | 1 |
| Mao, MA | 1 |
| Kashani, KB | 2 |
| Muller, L | 1 |
| Joannes-Boyau, O | 1 |
| Núñez-Martínez, FJ | 1 |
| Luna-Montalbán, R | 1 |
| Orozco-Juárez, K | 1 |
| Chávez-Lárraga, AJ | 1 |
| Velasco-Santos, JI | 1 |
| Verazaluce-Rodríguez, BE | 1 |
| Qian, J | 1 |
| Liu, L | 1 |
| Chu, F | 1 |
| Shen, Y | 2 |
| Bai, X | 1 |
| Lu, Z | 1 |
| Wang, Y | 1 |
| Zhu, X | 1 |
| Xue, J | 1 |
| Liu, Z | 1 |
| Dai, W | 1 |
| Xiang, J | 1 |
| Xu, H | 1 |
| Zhou, Q | 2 |
| Chen, W | 1 |
| Chen, Y | 1 |
| Liang, Q | 1 |
| Zhou, S | 1 |
| An, S | 1 |
| Ginter, D | 3 |
| Gilfoyle, E | 3 |
| Wade, A | 3 |
| Lethebe, BC | 3 |
| Gilad, E | 3 |
| Zhou, D | 3 |
| Jiang, J | 3 |
| Cao, F | 3 |
| Peng, Z | 3 |
| Raman, S | 1 |
| Gibbons, KS | 1 |
| Mattke, A | 1 |
| Schibler, A | 1 |
| Trnka, P | 1 |
| Kennedy, M | 1 |
| Le Marsney, R | 1 |
| Schlapbach, LJ | 1 |
| Hellman, T | 1 |
| Uusalo, P | 1 |
| Järvisalo, MJ | 1 |
| Semmler, G | 1 |
| Scheiner, B | 1 |
| Balcar, L | 1 |
| Paternostro, R | 1 |
| Simbrunner, B | 1 |
| Pinter, M | 1 |
| Trauner, M | 1 |
| Bofill Roig, M | 1 |
| Meyer, EL | 1 |
| Hofer, BS | 1 |
| Mandorfer, M | 1 |
| Pinato, DJ | 1 |
| Zauner, C | 2 |
| Reiberger, T | 1 |
| Funk, GC | 2 |
| Luglio, M | 1 |
| de Carvalho, WB | 1 |
| Tannuri, U | 1 |
| Tannuri, ACA | 1 |
| Matsura, RH | 1 |
| Morais França, G | 1 |
| Delgado, AF | 1 |
| Bihari, S | 2 |
| Galluccio, S | 1 |
| Komaru, Y | 1 |
| Doi, K | 1 |
| Matsuura, R | 1 |
| Yoshida, T | 1 |
| Miyamoto, Y | 1 |
| Yoshimoto, K | 1 |
| Nangaku, M | 1 |
| Li, Z | 1 |
| Xing, C | 1 |
| Li, T | 1 |
| Du, L | 1 |
| Wang, N | 1 |
| Langer, T | 1 |
| D'Oria, V | 1 |
| Spolidoro, GCI | 1 |
| Chidini, G | 1 |
| Scalia Catenacci, S | 1 |
| Marchesi, T | 1 |
| Guerrini, M | 1 |
| Cislaghi, A | 1 |
| Agostoni, C | 1 |
| Pesenti, A | 1 |
| Calderini, E | 1 |
| Sumarsono, A | 1 |
| Wang, J | 1 |
| Xie, L | 1 |
| Chiang, GC | 1 |
| Tielleman, T | 1 |
| Messiah, SE | 1 |
| Singal, AG | 1 |
| Mufti, A | 1 |
| Chen, C | 1 |
| Leveno, M | 1 |
| Kee, YK | 1 |
| Jeon, HJ | 1 |
| Oh, J | 1 |
| Shin, DH | 1 |
| Huang, L | 1 |
| Hu, Y | 1 |
| Jia, L | 1 |
| Pang, M | 1 |
| Huang, C | 1 |
| Zhao, Z | 1 |
| Li, L | 2 |
| Breen, TJ | 1 |
| Brueske, B | 1 |
| Sidhu, MS | 1 |
| Anavekar, NS | 1 |
| Barsness, GW | 1 |
| Jentzer, JC | 1 |
| Gucyetmez, B | 2 |
| Tuzuner, F | 1 |
| Atalan, HK | 2 |
| Sezerman, U | 1 |
| Gucyetmez, K | 1 |
| Telci, L | 1 |
| Ji, Y | 1 |
| Tehranian, S | 1 |
| Shawwa, K | 1 |
| Barreto, EF | 1 |
| Clements, CM | 1 |
| Kashani, K | 2 |
| Masevicius, FD | 3 |
| Rubatto Birri, PN | 1 |
| Risso Vazquez, A | 1 |
| Zechner, FE | 1 |
| Motta, MF | 1 |
| Valenzuela Espinoza, ED | 1 |
| Welsh, S | 1 |
| Guerra Arias, EF | 1 |
| Furche, MA | 1 |
| Berdaguer, FD | 1 |
| Dubin, A | 3 |
| Stenson, EK | 1 |
| Cvijanovich, NZ | 1 |
| Anas, N | 1 |
| Allen, GL | 1 |
| Thomas, NJ | 1 |
| Bigham, MT | 1 |
| Weiss, SL | 2 |
| Fitzgerald, JC | 1 |
| Checchia, PA | 1 |
| Meyer, K | 1 |
| Quasney, M | 1 |
| Hall, M | 1 |
| Gedeit, R | 1 |
| Freishtat, RJ | 1 |
| Nowak, J | 1 |
| Raj, SS | 1 |
| Gertz, S | 1 |
| Grunwell, JR | 1 |
| Wong, HR | 1 |
| Barhight, MF | 3 |
| Lusk, J | 1 |
| Brinton, J | 3 |
| Stidham, T | 2 |
| Soranno, DE | 2 |
| Faubel, S | 2 |
| Goebel, J | 2 |
| Mourani, PM | 2 |
| Gist, KM | 2 |
| Van Regenmortel, N | 1 |
| Verbrugghe, W | 1 |
| Roelant, E | 1 |
| Van den Wyngaert, T | 1 |
| Jorens, PG | 1 |
| Priebe, HJ | 1 |
| Zampieri, FG | 1 |
| Kawano-Dourado, L | 1 |
| Azevedo, LCP | 1 |
| Corrêa, TD | 1 |
| Cavalcanti, AB | 1 |
| Burns, AR | 1 |
| Ho, KM | 1 |
| Griffin, BR | 1 |
| Prakash, S | 1 |
| Potts, S | 1 |
| Matheson, E | 1 |
| Bersten, AD | 1 |
| Babl, FE | 1 |
| Dalziel, SR | 1 |
| Balamuth, F | 1 |
| Yan, J | 1 |
| Cai, G | 1 |
| Constable, P | 1 |
| Trefz, FM | 1 |
| Stämpfli, H | 1 |
| Kim, HJ | 1 |
| Oh, TK | 1 |
| Song, IA | 1 |
| Lee, JH | 1 |
| Saito, D | 1 |
| Fujimaru, T | 1 |
| Inoue, Y | 1 |
| Hirayama, T | 1 |
| Ezaki, I | 1 |
| Kin, H | 1 |
| Shuo, T | 1 |
| Nakayama, M | 1 |
| Komatsu, Y | 1 |
| Mallat, J | 1 |
| Barrailler, S | 1 |
| Lemyze, M | 1 |
| Pepy, F | 1 |
| Gasan, G | 1 |
| Tronchon, L | 1 |
| Thevenin, D | 1 |
| Schneider, AG | 1 |
| Bellomo, R | 8 |
| Reade, M | 1 |
| Peck, L | 1 |
| Young, H | 1 |
| Eastwood, GM | 1 |
| Garcia, M | 1 |
| Moore, E | 1 |
| Harley, N | 1 |
| Zhang, Z | 1 |
| Xu, X | 1 |
| Fan, H | 1 |
| Li, D | 1 |
| Deng, H | 1 |
| Shaw, AD | 1 |
| Raghunathan, K | 1 |
| Peyerl, FW | 1 |
| Munson, SH | 1 |
| Paluszkiewicz, SM | 1 |
| Schermer, CR | 2 |
| Smith, CA | 1 |
| Gosselin, RC | 1 |
| Utter, GH | 1 |
| Galante, JM | 1 |
| Young, JB | 1 |
| Scherer, LA | 1 |
| Brunner, R | 1 |
| Drolz, A | 1 |
| Scherzer, TM | 1 |
| Staufer, K | 1 |
| Fuhrmann, V | 1 |
| Holzinger, U | 2 |
| Schneeweiß, B | 1 |
| Balsorano, P | 1 |
| Romagnoli, S | 1 |
| Evans, SK | 1 |
| Ricci, Z | 1 |
| De Gaudio, AR | 1 |
| Soussi, S | 1 |
| Ferry, A | 1 |
| Chaussard, M | 1 |
| Legrand, M | 1 |
| Shao, M | 1 |
| Li, G | 1 |
| Sarvottam, K | 1 |
| Wang, S | 1 |
| Dong, Y | 1 |
| Gajic, O | 1 |
| Nagaoka, D | 1 |
| Nassar Junior, AP | 1 |
| Maciel, AT | 1 |
| Taniguchi, LU | 1 |
| Noritomi, DT | 1 |
| Azevedo, LC | 1 |
| Neto, LM | 1 |
| Park, M | 1 |
| Yunos, NM | 3 |
| Story, D | 3 |
| Kellum, J | 1 |
| Berend, K | 1 |
| Tuhay, G | 2 |
| Pein, MC | 2 |
| Ventrice, E | 1 |
| Kim, IB | 1 |
| Bailey, M | 2 |
| Ho, L | 2 |
| Gutteridge, GA | 1 |
| Hart, GK | 1 |
| Ioannou, N | 1 |
| Terblanche, M | 1 |
| Kurt, A | 1 |
| Ecevit, A | 1 |
| Ozkiraz, S | 1 |
| Ince, DA | 1 |
| Akcan, AB | 1 |
| Tarcan, A | 1 |
| Gueret, G | 1 |
| Airiau, S | 1 |
| Khalifa, A | 1 |
| Lozachmeur, D | 1 |
| Carre, JL | 1 |
| Ozier, Y | 1 |
| Hegarty, C | 1 |
| Story, DA | 4 |
| Poustie, S | 1 |
| Morimatsu, H | 3 |
| Doberer, D | 1 |
| Heinze, G | 1 |
| Madl, C | 1 |
| Schneeweiss, B | 1 |
| Kaplan, LJ | 1 |
| Frangos, S | 1 |
| Egi, M | 1 |
| Kutscherauer, DO | 1 |
| Dolník, V | 1 |
| Dolníková, J | 1 |
| Jabor, A | 1 |
| Kazda, A | 1 |
| Levraut, J | 1 |
| Bounatirou, T | 1 |
| Ichai, C | 1 |
| Ciais, JF | 1 |
| Jambou, P | 1 |
| Hechema, R | 1 |
| Grimaud, D | 1 |
| Wilkes, P | 1 |
| Marshall, JD | 1 |
| Wells, TG | 1 |
| Letzig, L | 1 |
| Kearns, GL | 1 |
| Van Bekkum, JW | 1 |
| Bac, DJ | 1 |
| Nienhuis, IE | 1 |
| De Leeuw, PW | 1 |
| Dees, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Incidence of Acute Kidney Injury and Risk Factors in Newborns With Congenital Diaphragmatic Hernia[NCT06050525] | 118 participants (Anticipated) | Observational | 2023-02-01 | Recruiting | |||
| Renal Effects of Fluid Resuscitation With Plasmalyte Viaflo Versus Saline in Trauma Patients (the ASTRAU Study)[NCT03630224] | Phase 3 | 622 participants (Anticipated) | Interventional | 2019-06-24 | Recruiting | ||
| Renal Tubular Acidosis is Highly Prevalent in Critically Ill Patients[NCT02392091] | 100 participants (Actual) | Observational | 2011-04-30 | Completed | |||
| Incidence of Acute Kidney Injury and Mortality in Critically Ill Patients: Urinary Chloride as a Prognostic Marker[NCT05542927] | 90 participants (Anticipated) | Observational [Patient Registry] | 2022-09-01 | Recruiting | |||
| Isotonic Solutions and Major Adverse Renal Events Trial in Non-Medical Intensive Care Units[NCT02547779] | 10,421 participants (Actual) | Interventional | 2015-10-01 | Completed | |||
| Isotonic Solution Administration Logistical Testing: Pilot Study for the Isotonic Solutions and Major Adverse Renal Events Trial[NCT02345486] | 974 participants (Actual) | Interventional | 2015-02-28 | Completed | |||
| Acetated Ringer's Solution Versus Saline in Patients With Septic Shock[NCT04507672] | 2,000 participants (Anticipated) | Interventional | 2020-09-01 | Not yet recruiting | |||
| A Prospective, Before and After Study of the Impact of Lower Chloride Intravenous Fluid Management on Patients' Acid-base Status, Renal Profile,Length of Stay and Mortality.[NCT00885404] | Phase 4 | 7,000 participants (Anticipated) | Interventional | 2009-02-28 | Active, not recruiting | ||
| Isotonic Solutions and Major Adverse Renal Events Trial in the Medical Intensive Care Unit[NCT02444988] | 5,381 participants (Actual) | Interventional | 2015-06-01 | Completed | |||
| Change in Serum Chloride Level After Loading Dose of Sterofundin Solution Compared With Normal Saline Solution[NCT02950974] | 20 participants (Actual) | Interventional | 2014-11-30 | Completed | |||
| Saline Against Lactated Ringers or Plasmalyte in the Emergency Department (SaLt-ED)[NCT02614040] | 14,000 participants (Actual) | Interventional | 2016-01-01 | Completed | |||
| Effect of Normal Saline Versus Balance Salt Solution Resuscitation on Kidney Function; A Randomized Open Label Controlled Study[NCT02520804] | 107 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Death before hospital discharge, censored at 30 days after enrollment (NCT02547779)
Timeframe: 30 days after enrollment censored at hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 408 |
| Balanced Crystalloids | 400 |
The primary outcome was the proportion of patients who met one or more criteria for a major adverse kidney event within 30 days - the composite of death, new receipt of renal-replacement therapy, or persistent renal dysfunction (defined as a final inpatient creatinine value ≥200% of the baseline value) - all censored at hospital discharge or 30 days after enrollment, whichever came first. (NCT02547779)
Timeframe: 30 days after enrollment censored at hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 551 |
| Balanced Crystalloids | 524 |
Dialysis free survival to day 28 will be defined as the number of days alive and without dialysis receipt to day 28 after enrollment, assuming a patient survives for at least two consecutive calendar days after last receipt of dialysis and remains free of dialysis. If the patient is receiving dialysis at day 28 or dies prior to day 28, VFD will be 0. (NCT02345486)
Timeframe: 28 days
| Intervention | days (Median) |
|---|---|
| 0.9% Sodium Chloride | 28.0 |
| Physiologically Balanced Fluid | 28.0 |
highest serum chloride (mmol/L) during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | mmol/L (Median) |
|---|---|
| 0.9% Sodium Chloride | 109 |
| Physiologically Balanced Fluid | 108 |
Highest serum sodium concentration (mmol/L) during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | mmol/L (Median) |
|---|---|
| 0.9% Sodium Chloride | 141 |
| Physiologically Balanced Fluid | 141 |
Death prior to the earlier of hospital discharge or day 30 (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 68 |
| Physiologically Balanced Fluid | 72 |
Incidence of stage II or III acute kidney injury by Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury criteria, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 129 |
| Physiologically Balanced Fluid | 135 |
Incidence of hyperchloremia defined as a serum chloride greater than or equal to 110 mmol/L (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 171 |
| Physiologically Balanced Fluid | 171 |
Incidence of severe hypochloremia defined as a serum chloride less than 90mmol/L (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 34 |
| Physiologically Balanced Fluid | 32 |
Increase in serum creatinine during hospitalization, censored at 30 days Change from baseline to highest value, median (IQR), mg/dl (NCT02345486)
Timeframe: 30 days
| Intervention | mg/dL (Median) |
|---|---|
| 0.9% Sodium Chloride | 0.07 |
| Physiologically Balanced Fluid | 0.07 |
ICU-free days to 28 days after enrollment will be defined as the number of days alive and not admitted to an intensive care unit service after the patient's final discharge from the intensive care unit before 28 days. If the patient is admitted to an intensive care unit service at day 28 or dies prior to day 28, ICU-free days will be 0. (NCT02345486)
Timeframe: 28 days
| Intervention | days (Median) |
|---|---|
| 0.9% Sodium Chloride | 25.1 |
| Physiologically Balanced Fluid | 25.2 |
Lowest serum bicarbonate concentration (mmol/L) during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | mmol/L (Median) |
|---|---|
| 0.9% Sodium Chloride | 19 |
| Physiologically Balanced Fluid | 19 |
Receipt of new renal replacement therapy after the first study day, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 14 |
| Physiologically Balanced Fluid | 24 |
Number of contraindications to assigned study fluid identified by providers, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | Orders for intravenous crystalloid (Count of Units) |
|---|---|
| 0.9% Sodium Chloride | 28 |
| Physiologically Balanced Fluid | 66 |
Incidence of Major Adverse Kidney Events by 30 days -- a composite outcome defined as one or more of the following: death, new use of renal replacement therapy, or persistence of renal dysfunction at hospital discharge or at 30 days (defined as an increase in serum creatinine ≥ 200% from baseline) (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 112 |
| Physiologically Balanced Fluid | 128 |
Highest creatinine value in the first 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | mg/dL (Median) |
|---|---|
| 0.9% Sodium Chloride | 1.19 |
| Physiologically Balanced Fluid | 1.19 |
Persistence of renal dysfunction at hospital discharge or at 30 days (defined as an increase in serum creatinine ≥ 200% from baseline) (NCT02345486)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride | 59 |
| Physiologically Balanced Fluid | 76 |
Proportion of total intravenous isotonic crystalloid administered during admission to the intensive care unit that is 0.9% sodium chloride, censored at 30 days. The primary outcome was the proportion of intravenous isotonic crystalloid administered in the ICU that was saline. This was a continuous variable calculated for each patient as the volume of saline received divided by volume of saline received plus volume of balanced crystalloids received with a range from 0.0 (no saline received) to 1.0 (only saline received). (NCT02345486)
Timeframe: 30 days
| Intervention | Percentage of fluid that was saline (Mean) |
|---|---|
| 0.9% Sodium Chloride | 91.2 |
| Physiologically Balanced Fluid | 21.0 |
Proportion of total intravenous isotonic crystalloid administered during admission to the intensive care unit that is either Lactated ringers or Plasmalyte-A, censored at 30 days. (NCT02345486)
Timeframe: 30 days
| Intervention | Percentage of fluid that was balanced (Mean) |
|---|---|
| 0.9% Sodium Chloride | 8.8 |
| Physiologically Balanced Fluid | 78.8 |
Total volume of packed red blood cells, platelets, and fresh frozen plasma administered during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | milliliters (Median) |
|---|---|
| 0.9% Sodium Chloride | 0 |
| Physiologically Balanced Fluid | 0 |
Total volume of intravenous colloid administration (excluding blood products) during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | milliliters (Median) |
|---|---|
| 0.9% Sodium Chloride | 0 |
| Physiologically Balanced Fluid | 0 |
Total volume of intravenous fluid administration during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | milliliters (Median) |
|---|---|
| 0.9% Sodium Chloride | 2000 |
| Physiologically Balanced Fluid | 2125 |
Total volume of intravenous isotonic crystalloid administration during admission to the intensive care unit, censored at 30 days (NCT02345486)
Timeframe: 30 days
| Intervention | mL (Median) |
|---|---|
| 0.9% Sodium Chloride | 1424 |
| Physiologically Balanced Fluid | 1617 |
Ventilator-free days to day 28 will be defined as the number of days alive and with unassisted breathing to day 28 after enrollment, assuming a patient survives for at least two consecutive calendar days after initiating unassisted breathing and remains free of assisted breathing. If a patient returns to assisted breathing and subsequently achieves unassisted breathing prior to day 28, VFD will be counted from the end of the last period of assisted breathing to day 28. If the patient is receiving assisted ventilation at day 28 or dies prior to day 28, VFD will be 0. (NCT02345486)
Timeframe: 28 days
| Intervention | days (Median) |
|---|---|
| 0.9% Sodium Chloride | 28.0 |
| Physiologically Balanced Fluid | 28.0 |
Death before hospital discharge, censored at 30 days after enrollment (NCT02444988)
Timeframe: 30 days after enrollment censored at hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride (Saline) | 467 |
| Balanced Crystalloid | 418 |
The primary outcome was the proportion of patients who met one or more criteria for a major adverse kidney event within 30 days - the composite of death, new receipt of renal-replacement therapy, or persistent renal dysfunction (defined as a final inpatient creatinine value ≥200% of the baseline value) - all censored at hospital discharge or 30 days after enrollment, whichever came first. (NCT02444988)
Timeframe: 30 days after enrollment censored at hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| 0.9% Sodium Chloride (Saline) | 659 |
| Balanced Crystalloid | 615 |
3 reviews available for chlorine and Critical Illness
| Article | Year |
|---|---|
Chloride toxicity in critically ill patients: What's the evidence?
Topics: Acid-Base Imbalance; Chlorides; Critical Illness; Crystalloid Solutions; Humans; Isotonic Solutions; | 2017 |
Bench-to-bedside review: Chloride in critical illness.
Topics: Acid-Base Equilibrium; Animals; Chloride Channels; Chlorides; Critical Care; Critical Illness; Fluid | 2010 |
Clinical review: Acid-base abnormalities in the intensive care unit -- part II.
Topics: Acid-Base Imbalance; Acidosis; Acidosis, Lactic; Adult; Animals; Child; Chlorides; Cohort Studies; C | 2005 |
5 trials available for chlorine and Critical Illness
| Article | Year |
|---|---|
Effect of Saline vs Gluconate/Acetate-Buffered Solution vs Lactate-Buffered Solution on Serum Chloride Among Children in the Pediatric Intensive Care Unit: The SPLYT-P Randomized Clinical Trial.
Topics: Acute Kidney Injury; Adult; Child; Child, Preschool; Chlorides; Critical Illness; Fluid Therapy; Glu | 2023 |
Safety evaluation of a trial of lipocalin-directed sodium bicarbonate infusion for renal protection in at-risk critically ill patients.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Aged; Bicarbonates; Chlorides; Critical Illness; Double-B | 2013 |
Dyschloremia Is a Risk Factor for the Development of Acute Kidney Injury in Critically Ill Patients.
Topics: Acute Kidney Injury; Adult; Aged; Chlorides; Critical Illness; Female; Humans; Male; Middle Aged; Re | 2016 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Female; Fluid Therapy; Hospital Mortality; Hospita | 2012 |
Pharmacokinetics and pharmacodynamics of bumetanide in critically ill pediatric patients.
Topics: Adult; Alkalosis; Area Under Curve; Bumetanide; Child; Child, Preschool; Chlorides; Creatine; Critic | 1998 |
62 other studies available for chlorine and Critical Illness
| Article | Year |
|---|---|
Effect of initial serum chloride level on the association between intravenous chloride load and mortality in critically ill patients: A retrospective cohort study.
Topics: Chlorides; Critical Illness; Hospital Mortality; Humans; Intensive Care Units; Retrospective Studies | 2022 |
Association of hypochloremia with mortality among patients requiring continuous renal replacement therapy.
Topics: Acute Kidney Injury; Chlorides; Continuous Renal Replacement Therapy; Critical Illness; Humans; Logi | 2023 |
Isotonic saline, balanced fluids, and chloride toxicity in ICU: Lessons from the PLUS trial.
Topics: Chlorides; Critical Illness; Crystalloid Solutions; Fluid Therapy; Humans; Intensive Care Units; Iso | 2022 |
[Sodium-chlorine difference as a prognostic predictor in adult patients diagnosed with COVID-19].
Topics: Acute Kidney Injury; Adult; Chlorides; Chlorine; COVID-19; Critical Illness; Hospital Mortality; Hum | 2022 |
Association between C-reactive protein and all-cause mortality among critically ill patients with acute kidney injury.
Topics: Acute Kidney Injury; C-Reactive Protein; Chlorides; Critical Illness; Hospital Mortality; Humans; In | 2022 |
Association between serum chloride levels with mortality in critically ill patients with acute kidney injury: An observational multicenter study employing the eICU database.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Chlorides; Critical Illness; Humans; Intensive Care Units; | 2022 |
Lower serum chloride concentrations are associated with an increased risk of death in ICU patients with acute kidney injury: an analysis of the MIMIC-IV database.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Hospitalization; Humans; Intensive Care Units; Ret | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
Hyperchloremia and association with acute kidney injury in critically ill children.
Topics: Acid-Base Imbalance; Acute Kidney Injury; Adult; Child; Chlorides; Critical Illness; Hospitalization | 2023 |
INCREASE IN CHLORIDE IS ASSOCIATED WITH MAJOR ADVERSE KIDNEY EVENTS IN CRITICALLY ILL PATIENTS.
Topics: Acute Kidney Injury; Adult; Aged; Chlorides; Critical Illness; Hospital Mortality; Humans; Intensive | 2023 |
INCREASE IN CHLORIDE IS ASSOCIATED WITH MAJOR ADVERSE KIDNEY EVENTS IN CRITICALLY ILL PATIENTS.
Topics: Acute Kidney Injury; Adult; Aged; Chlorides; Critical Illness; Hospital Mortality; Humans; Intensive | 2023 |
INCREASE IN CHLORIDE IS ASSOCIATED WITH MAJOR ADVERSE KIDNEY EVENTS IN CRITICALLY ILL PATIENTS.
Topics: Acute Kidney Injury; Adult; Aged; Chlorides; Critical Illness; Hospital Mortality; Humans; Intensive | 2023 |
INCREASE IN CHLORIDE IS ASSOCIATED WITH MAJOR ADVERSE KIDNEY EVENTS IN CRITICALLY ILL PATIENTS.
Topics: Acute Kidney Injury; Adult; Aged; Chlorides; Critical Illness; Hospital Mortality; Humans; Intensive | 2023 |
Chloride, Sodium and Calcium Intake Are Associated with Mortality and Follow-Up Kidney Function in Critically Ill Patients Receiving Continuous Veno-Venous Hemodialysis-A Retrospective Study.
Topics: Acute Kidney Injury; Aged; Calcium; Chlorides; Continuous Renal Replacement Therapy; Critical Illnes | 2023 |
Disturbances in sodium and chloride homeostasis predict outcome in stable and critically ill patients with cirrhosis.
Topics: Chlorides; Critical Illness; Female; Homeostasis; Humans; Hypernatremia; Liver Cirrhosis; Male; Prog | 2023 |
Effects of serum sodium and chloride levels in the outcome of critically ill pediatric patients in the post-operative period of liver transplantation.
Topics: Acute Kidney Injury; Brazil; Child; Chlorides; Critical Illness; Humans; Liver Transplantation; Post | 2023 |
Discrepancy in Chloride Measurement with Decreasing Bicarbonate Concentrations.
Topics: Bicarbonates; Blood Gas Analysis; Chlorides; Critical Illness; Electrodes; Humans; Hydrogen-Ion Conc | 2019 |
Urinary chloride concentration as a prognostic marker in critically ill patients.
Topics: Acute Kidney Injury; Aged; Biomarkers; Chlorides; Critical Illness; Down-Regulation; Female; Hospita | 2020 |
Hypochloremia is associated with increased risk of all-cause mortality in patients in the coronary care unit: A cohort study.
Topics: Aged; Aged, 80 and over; Chlorides; Coronary Care Units; Critical Illness; Female; Hospital Mortalit | 2020 |
Fluid therapy in mechanically ventilated critically ill children: the sodium, chloride and water burden of fluid creep.
Topics: Child; Child, Preschool; Chlorides; Critical Illness; Fluid Therapy; Humans; Intensive Care Units, P | 2020 |
Prognostic Value of Hypochloremia in Critically Ill Patients With Decompensated Cirrhosis.
Topics: Acute Disease; Chlorides; Critical Illness; Female; Humans; Kaplan-Meier Estimate; Liver Cirrhosis; | 2020 |
Dyschloremia is associated with failure to restore renal function in survivors with acute kidney injury: an observation retrospective study.
Topics: Acute Kidney Injury; Aged; Chlorides; Continuous Renal Replacement Therapy; Critical Illness; Female | 2020 |
Safety analysis regarding acute kidney injuries for chloride-restrictive intravenous fluid administration against that of chloride-liberal for patients admitted in the medical intensive care unit: A non-randomised retrospective (chrachl-mic) study.
Topics: Acute Kidney Injury; Chlorides; Critical Illness; Hospitalization; Humans; Intensive Care Units; Ret | 2021 |
Abnormal serum chloride is associated with increased mortality among unselected cardiac intensive care unit patients.
Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Chlorides; Coronary Care Units; Critical Care; Cri | 2021 |
Base-excess chloride; the best approach to evaluate the effect of chloride on the acid-base status: A retrospective study.
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Aged; APACHE; Chlorides; Critical Illness; Female; Human | 2021 |
Lower serum chloride concentrations are associated with increased risk of mortality in critically ill cirrhotic patients: an analysis of the MIMIC-III database.
Topics: Chlorides; Critical Illness; End Stage Liver Disease; Humans; Intensive Care Units; Liver Cirrhosis; | 2021 |
Impact of chloride-rich crystalloids on sepsis-associated community-acquired acute kidney injury recovery in critically ill patients.
Topics: Acute Kidney Injury; Adult; Aged; Aged, 80 and over; Chlorides; Cohort Studies; Critical Illness; Cr | 2022 |
Relationship of at Admission Lactate, Unmeasured Anions, and Chloride to the Outcome of Critically Ill Patients.
Topics: Acidosis; Aged; Aged, 80 and over; Anions; Blood Gas Analysis; Chlorides; Critical Illness; Female; | 2017 |
Hyperchloremia Is Associated With Complicated Course and Mortality in Pediatric Patients With Septic Shock.
Topics: Child; Child, Preschool; Chlorides; Critical Illness; Female; Humans; Infant; Intensive Care Units, | 2018 |
Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy.
Topics: Adolescent; Child; Child, Preschool; Chlorides; Cohort Studies; Critical Illness; Female; Hospital M | 2018 |
Maintenance fluid therapy and fluid creep impose more significant fluid, sodium, and chloride burdens than resuscitation fluids in critically ill patients: a retrospective study in a tertiary mixed ICU population.
Topics: Adult; Aged; Chlorides; Critical Illness; Female; Fluid Therapy; Humans; Intensive Care Units; Male; | 2018 |
Hyperchloremic Intravenous Fluids Should Be Abandoned.
Topics: Adult; Chlorides; Critical Illness; Fluid Therapy; Humans | 2018 |
In Response.
Topics: Chlorides; Critical Illness; Humans | 2018 |
Urinary potassium excretion and its association with acute kidney injury in the intensive care unit.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Area Under Curve; Biomarkers; Chlor | 2018 |
Increase in chloride from baseline is independently associated with mortality in critically ill children.
Topics: Acute Kidney Injury; Adolescent; Age Factors; Child; Child, Preschool; Chlorides; Critical Illness; | 2018 |
Addressing the inadvertent sodium and chloride burden in critically ill patients: a prospective before-and-after study in a tertiary mixed intensive care unit population.
Topics: Aged; Chlorides; Critical Care; Critical Illness; Female; Fluid Therapy; Humans; Intensive Care Unit | 2018 |
Is chloride worth its salt?
Topics: Child; Chlorides; Critical Illness; Humans; Sodium Chloride; Sodium Chloride, Dietary | 2019 |
Interaction between serum chloride increase and baseline chloride level.
Topics: Child; Chlorides; Critical Illness; Humans; Sodium | 2019 |
Effects of pH and the plasma or serum concentrations of total calcium, chloride, magnesium, l-lactate, and albumin on the plasma ionized calcium concentration in calves.
Topics: Animals; Calcium; Carbon Dioxide; Cattle; Cattle Diseases; Chlorides; Critical Illness; Female; Hydr | 2019 |
Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis.
Topics: Aged; Aged, 80 and over; Biomarkers; Chlorides; Cohort Studies; Critical Illness; Female; Hospital M | 2019 |
Serial measurement of electrolyte and citrate concentrations in blood-primed continuous hemodialysis circuits during closed-circuit dialysis.
Topics: Calcium; Chlorides; Citric Acid; Critical Illness; Dialysis Solutions; Electrolytes; Erythrocyte Tra | 2020 |
Use of sodium-chloride difference and corrected anion gap as surrogates of Stewart variables in critically ill patients.
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Aged; Biomarkers; Chlorides; Critical Illness; Female; H | 2013 |
Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients.
Topics: Acute Kidney Injury; Biomarkers; China; Chlorides; Critical Illness; Female; Humans; Male; Middle Ag | 2013 |
Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS.
Topics: Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Chlorides; Colloids; Critic | 2014 |
Does saline resuscitation affect mechanisms of coagulopathy in critically ill trauma patients? An exploratory analysis.
Topics: Acidosis; Blood Coagulation Tests; Chlorides; Critical Illness; Crystalloid Solutions; Double-Blind | 2015 |
Renal tubular acidosis is highly prevalent in critically ill patients.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Renal Tubular; Adult; Aged; Bicarbonates; Chlorides; Crit | 2015 |
Non-lactate strong ion difference: a clearer picture.
Topics: Acid-Base Imbalance; Adult; Aged; Aged, 80 and over; APACHE; Chlorides; Critical Care; Critical Illn | 2016 |
Urinary Strong Ion Difference as a Marker of Renal Dysfunction. A Retrospective Analysis.
Topics: Acute Kidney Injury; Aged; Biomarkers; Calcium; Chlorides; Creatinine; Critical Illness; Female; Hum | 2016 |
The use of sodium-chloride difference and chloride-sodium ratio as strong ion difference surrogates in the evaluation of metabolic acidosis in critically ill patients.
Topics: Acid-Base Equilibrium; Acidosis; Adult; Aged; Chlorides; Critical Illness; Female; Humans; Male; Mid | 2010 |
Misconceptions about hyperchloremic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Chlorides; Critical Illness; Humans; Sodium; Terminology as Topic | 2010 |
Alterations in urinary strong ion difference in critically ill patients with metabolic acidosis: a prospective observational study.
Topics: Acidosis; Aged; Aged, 80 and over; Case-Control Studies; Chlorides; Critical Care; Critical Illness; | 2010 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
The biochemical effects of restricting chloride-rich fluids in intensive care.
Topics: Adult; Aged; Alkalosis; Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Mid | 2011 |
Surrogate end points in critical illness research: some way to go yet.
Topics: Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Plasma Substitutes; Solutio | 2011 |
The use of chloride-sodium ratio in the evaluation of metabolic acidosis in critically ill neonates.
Topics: Acidosis; Anions; Biomarkers; Blood Gas Analysis; Chlorides; Critical Illness; Electrolytes; Female; | 2012 |
Modern medicine is a good goal to seek.
Topics: Chlorides; Critical Illness; Female; Humans; Intensive Care Units; Male; Plasma Substitutes; Solutio | 2012 |
Estimating unmeasured anions in critically ill patients: anion-gap, base-deficit, and strong-ion-gap.
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Chlorides; Critical Illness; Humans; Hydrogen- | 2002 |
Strong ions, weak acids and base excess: a simplified Fencl-Stewart approach to clinical acid-base disorders.
Topics: Acid-Base Imbalance; Adolescent; Adult; Aged; Aged, 80 and over; Child; Chlorides; Critical Care; Cr | 2004 |
Changes of serum chloride and metabolic acid-base state in critical illness.
Topics: Acid-Base Imbalance; Alkalosis; Chlorides; Critical Illness; Female; Humans; Linear Models; Male; Pr | 2004 |
Hyperchloremic acidosis in the critically ill: one of the strong-ion acidoses?
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Chlorides; Critical Illness; Humans | 2006 |
The effect of albumin concentration on plasma sodium and chloride measurements in critically ill patients.
Topics: Bicarbonates; Blood Chemical Analysis; Chlorides; Critical Illness; Humans; Hypoalbuminemia; Intensi | 2007 |
Severe hyperlactatemia with normal base excess: a quantitative analysis using conventional and Stewart approaches.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Aged; Bicarbonates; Blood Gas Analysis; Carbon Dioxide; Chl | 2008 |
Capillary zone electrophoresis of organic acids in serum of critically ill children.
Topics: Acids; Child; Chlorides; Critical Illness; Electrolytes; Electrophoresis, Capillary; Humans; Hydroge | 1995 |
Modelling of acid-base equilibria.
Topics: Acid-Base Equilibrium; Acid-Base Imbalance; Acidosis; Acidosis, Lactic; Algorithms; Alkalosis; Anion | 1995 |
Reliability of anion gap as an indicator of blood lactate in critically ill patients.
Topics: Acid-Base Equilibrium; Adult; Carbon Dioxide; Chlorides; Confidence Intervals; Critical Illness; Hum | 1997 |
Hypoproteinemia, strong-ion difference, and acid-base status in critically ill patients.
Topics: Acid-Base Equilibrium; Adult; Aged; Carbon Dioxide; Chlorides; Critical Illness; Electrolytes; Human | 1998 |
Life-threatening hypokalaemia and quadriparesis in a patient with ureterosigmoidostomy.
Topics: Acidosis, Renal Tubular; Anastomosis, Surgical; Bicarbonates; Bladder Exstrophy; Chlorides; Colon, S | 2002 |