chlorine has been researched along with Colonic Inertia in 17 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Colonic Inertia: Symptom characterized by the passage of stool once a week or less.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively." | 7.76 | Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. ( An, R; Cui, B; Hu, Z; Wang, X; Wu, D; Yuan, J; Zhou, J, 2010) |
| "In January 2006 the Food and Drug Administration approved lubiprostone for the treatment of chronic constipation in men and women aged 18 and over." | 4.84 | Lubiprostone: a chloride channel activator. ( Lacy, BE; Levy, LC, 2007) |
| " Oral DRAinh-A250 and tenapanor comparably reduced signs of constipation in loperamide-treated mice, with additive effects found on coadministration." | 3.88 | SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation. ( Cil, O; Haggie, PM; Lee, S; Phuan, PW; Rivera, AA; Tan, JA; Verkman, AS, 2018) |
| "The present study was designed to evaluate the effect of LGP on Cl(-) secretion across rat distal colonic epithelium mounted in Ussing chambers, and on a rat constipation model induced by loperamide, respectively." | 3.76 | Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium. ( An, R; Cui, B; Hu, Z; Wang, X; Wu, D; Yuan, J; Zhou, J, 2010) |
| "Constipation is a common symptom frequently compromising the quality of daily life." | 1.48 | Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl ( Inoue, R; Numata, T; Okada, Y; Sato-Numata, K, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (29.41) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Cil, O | 2 |
| Anderson, MO | 1 |
| de Souza Goncalves, L | 1 |
| Tan, JA | 2 |
| Haggie, PM | 2 |
| Verkman, AS | 2 |
| Cimbalo, C | 1 |
| Tosco, A | 1 |
| Terlizzi, V | 1 |
| Sepe, A | 1 |
| Castaldo, A | 1 |
| Salvadori, L | 1 |
| Raia, V | 1 |
| Choi, YJ | 1 |
| Park, JW | 1 |
| Kim, JE | 1 |
| Lee, SJ | 1 |
| Gong, JE | 1 |
| Jung, YS | 1 |
| Seo, S | 1 |
| Hwang, DY | 1 |
| Numata, T | 1 |
| Sato-Numata, K | 1 |
| Okada, Y | 1 |
| Inoue, R | 1 |
| Lee, S | 1 |
| Rivera, AA | 1 |
| Phuan, PW | 1 |
| Camilleri, M | 1 |
| Flores, CA | 1 |
| Wu, D | 2 |
| Wang, X | 2 |
| Zhou, J | 2 |
| Yuan, J | 2 |
| Cui, B | 2 |
| An, R | 2 |
| Hu, Z | 2 |
| Shi, H | 1 |
| Bekkali, N | 1 |
| de Jonge, HR | 1 |
| van den Wijngaard, RM | 1 |
| van der Steeg, AF | 1 |
| Bijlsma, PB | 1 |
| Taminiau, JA | 1 |
| Desjeux, JF | 1 |
| Benninga, MA | 1 |
| BERTHOLD, E | 1 |
| SCHREIER, K | 1 |
| Lacy, BE | 1 |
| Levy, LC | 1 |
| Gilger, MA | 1 |
| Wagner, ML | 1 |
| Barrish, JO | 1 |
| McCarroll, LR | 1 |
| Healy, WM | 1 |
| Pokrovskiĭ, GA | 1 |
| Brandina, AM | 1 |
| Chernomordik, AE | 1 |
| Bronshteĭn, AS | 1 |
| Dubinin, AV | 1 |
| Arianoff, AA | 1 |
| Holmes, EL | 1 |
| Takagi, H | 1 |
| Kamioka, T | 1 |
| Kobayashi, S | 1 |
| Kumakura, S | 1 |
| Iizuka, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Colon Preparation With 2-Litre Polyethylene Glycol (PEG) Split-dose in Combination With Lubiprostone Versus 4-Litre Polyethylene Glycol (PEG) Split-dose: a Randomized Controlled Trial[NCT04138004] | Phase 4 | 140 participants (Actual) | Interventional | 2019-12-01 | Completed | ||
| Single Dose Lubiprostone Along With Split-dose PEG Solution Without Dietary Restrictions for Bowel Cleansing Prior to Colonoscopy, a Randomized, Double-blind, Placebo Controlled Trial[NCT00611442] | 191 participants (Actual) | Interventional | 2007-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The participants completed a survey prior to the colonoscopy that graded their overall satisfaction with the bowel preparation. The subjects rated the survey questions on a 5-point Likert scale where 1 = severely distressing, 2=distressing, 3=bothersome, 4=mild, and 5=none. (NCT00611442)
Timeframe: measured after completion of the bowel preparation and prior to the colonoscopy, completed during the course of the study (approximately 4 month period)
| Intervention | linkert scale (1-5) (Mean) |
|---|---|
| Amitiza | 3.7 |
| Placebo | 3.2 |
Procedure time refers to the total length of time required to complete the colonoscopy (NCT00611442)
Timeframe: measured upon completion of the colonoscopy, colonoscopies completed during the course of the study (approximately 4 month period)
| Intervention | minutes (Mean) |
|---|---|
| Amitiza | 17.8 |
| Placebo | 19.8 |
The number of colon polyps detected during the colonoscopy. (NCT00611442)
Timeframe: measured upon completion of the colonoscopy, colonoscopies completed during the course of the study (approximately 4 month period)
| Intervention | number of polyps (Number) |
|---|---|
| Amitiza | 48 |
| Placebo | 44 |
Bowel cleansing was evaluated with the Ottawa bowel preparation scale by each endoscopist during the endoscopy. Neither the endoscopist nor the endoscopy nurse was aware of the bowel preparation used prior to the colonoscopy. The Ottawa bowel preparation scale is a validated tool and was used in this study to provide a reliable quality assessment of the bowel preparation used for colonoscopy. This validated scale rates each section of the colon, the right, the mid, and the rectosigmoid colon, on a 5-point scale (0-4), as well as a global 3-point rating for overall colonic fluid (0-2). The total score ranges from 0 to 14. An excellent preparation with little fluid would score 0-3, a good preparation 4-6, while scores higher than 7would indicate progressively worsening bowel preparations. A completely unprepared colon would score 11-14, depending on the amount of colonic fluid (NCT00611442)
Timeframe: measured upon completion of the colonoscopy, colonoscopies completed during the course of the study (approximately 4 month period)
| Intervention | Ottawa Score (Mean) |
|---|---|
| Amitiza | 4.8 |
| Placebo | 6.2 |
1 review available for chlorine and Colonic Inertia
| Article | Year |
|---|---|
Lubiprostone: a chloride channel activator.
Topics: Alprostadil; Cathartics; Chloride Channels; Chlorides; Chronic Disease; Constipation; Fatty Acids; F | 2007 |
Lubiprostone: a chloride channel activator.
Topics: Alprostadil; Cathartics; Chloride Channels; Chlorides; Chronic Disease; Constipation; Fatty Acids; F | 2007 |
Lubiprostone: a chloride channel activator.
Topics: Alprostadil; Cathartics; Chloride Channels; Chlorides; Chronic Disease; Constipation; Fatty Acids; F | 2007 |
Lubiprostone: a chloride channel activator.
Topics: Alprostadil; Cathartics; Chloride Channels; Chlorides; Chronic Disease; Constipation; Fatty Acids; F | 2007 |
2 trials available for chlorine and Colonic Inertia
| Article | Year |
|---|---|
New treatment for rectal impaction in children: an efficacy, comfort, and safety trial of the pulsed-irrigation enhanced-evacuation procedure.
Topics: Adolescent; Bicarbonates; Child; Child, Preschool; Chlorides; Chronic Disease; Constipation; Enema; | 1994 |
Experimental observations on flufenamic, mefenamic, and meclofenamic acids. IV. Toleration by normal human subjects.
Topics: Adult; Anti-Inflammatory Agents; Aspirin; Biphenyl Compounds; Blood Coagulation; Blood Urea Nitrogen | 1966 |
14 other studies available for chlorine and Colonic Inertia
| Article | Year |
|---|---|
Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action.
Topics: Animals; Anions; Antiporters; Biological Transport; Chlorides; Constipation; Mice; Molecular Docking | 2023 |
Elevated sweat chloride test: is it always cystic fibrosis?
Topics: Celiac Disease; Chlorides; Constipation; Cystic Fibrosis; Diagnosis, Differential; Female; Humans; I | 2021 |
Novel Characterization of Constipation Phenotypes in ICR Mice Orally Administrated with Polystyrene Microplastics.
Topics: Animals; Behavior, Animal; Biomarkers; Chemical Phenomena; Chlorides; Colon; Constipation; Disease M | 2021 |
Cellular mechanism for herbal medicine Junchoto to facilitate intestinal Cl
Topics: Animals; Caco-2 Cells; Chlorides; Constipation; Cystic Fibrosis Transmembrane Conductance Regulator; | 2018 |
SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation.
Topics: Animals; Antiporters; Chloride-Bicarbonate Antiporters; Chlorides; Constipation; Cystic Fibrosis; Di | 2018 |
Guanylate cyclase C agonists: emerging gastrointestinal therapies and actions.
Topics: Apoptosis; Chlorides; Colon; Constipation; Gastrointestinal Agents; Humans; Intestinal Mucosa; Irrit | 2015 |
ClC-2 and intestinal chloride secretion.
Topics: Animals; Chloride Channel Agonists; Chloride Channels; Chlorides; CLC-2 Chloride Channels; Constipat | 2016 |
Traditional Chinese formula, lubricating gut pill, improves loperamide-induced rat constipation involved in enhance of Cl- secretion across distal colonic epithelium.
Topics: Animals; Chlorides; Cholinergic Antagonists; Colon; Constipation; Cyclic AMP; Cyclooxygenase Inhibit | 2010 |
Traditional Chinese formula, lubricating gut pill, stimulates cAMP-dependent CI(−) secretion across rat distal colonic mucosa.
Topics: Animals; Anions; Benzoates; Cell Membrane; Chloride Channel Agonists; Chlorides; Colon; Constipation | 2011 |
The role of rectal chloride secretion in childhood constipation.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Biopsy; Carbachol; Child; Chlorides; Cholinergic Agonists; C | 2011 |
[TRANSITORY HYPERCHLOREMIC ACIDOSIS IN 2 FULL-TERM INFANTS IN FEEDING WITH ACID MILK].
Topics: Acidosis; Blood; Chlorides; Constipation; Humans; Infant; Infant Nutrition Disorders; Milk; Vomiting | 1963 |
[Pathologic mineral metabolism in patients with post-dysentery lesions of the gastrointestinal tract].
Topics: Adolescent; Adult; Calcium; Chlorides; Constipation; Diarrhea; Dysentery, Bacillary; Female; Gastroi | 1974 |
[Cholecystoses. Apropos of 679 operated cases].
Topics: Amylases; Bile; Bile Acids and Salts; Calcium; Chlorides; Cholecystectomy; Cholesterol; Constipation | 1972 |
[Pharmacological studies of oxazoleazepam, a new psychotropic agent. II. General pharmacology and subacute toxicity].
Topics: Animals; Benzazepines; Blood Pressure; Body Temperature; Body Weight; Cats; Chlordiazepoxide; Chlori | 1970 |