chlorine has been researched along with Amyotrophic Lateral Sclerosis in 9 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, E | 1 |
| Cazenave, W | 2 |
| Allain, AE | 2 |
| Cattaert, D | 1 |
| Branchereau, P | 2 |
| Miller, RG | 1 |
| Zhang, R | 1 |
| Block, G | 1 |
| Katz, J | 1 |
| Barohn, R | 1 |
| Kasarskis, E | 1 |
| Forshew, D | 1 |
| Gopalakrishnan, V | 1 |
| McGrath, MS | 1 |
| Watanabe, S | 1 |
| Kimura, T | 1 |
| Suenaga, K | 1 |
| Wada, S | 1 |
| Tsuda, K | 1 |
| Kasama, S | 1 |
| Takaoka, T | 1 |
| Kajiyama, K | 1 |
| Takeda, M | 1 |
| Yoshikawa, H | 1 |
| Le Corronc, H | 1 |
| Delpy, A | 1 |
| Meyrand, P | 1 |
| Legendre, P | 1 |
| Boswell, CA | 1 |
| Mundo, EE | 1 |
| Johnstone, B | 1 |
| Ulufatu, S | 1 |
| Schweiger, MG | 1 |
| Bumbaca, D | 1 |
| Fielder, PJ | 1 |
| Prabhu, S | 1 |
| Khawli, LA | 1 |
| Turner, BJ | 1 |
| Lopes, EC | 1 |
| Cheema, SS | 1 |
| Taylor, DM | 1 |
| Minotti, S | 1 |
| Agar, JN | 1 |
| Durham, HD | 1 |
| He, BP | 1 |
| Strong, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Single Dose NP001 on Blood Markers of Inflammation in Individuals With Mild-to-Moderate Alzheimer's Disease[NCT03179501] | Phase 1 | 4 participants (Actual) | Interventional | 2017-09-01 | Terminated (stopped due to Poor recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for chlorine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
ALSUntangled No. 19: Sodium chlorite.
Topics: Administration, Oral; Amyotrophic Lateral Sclerosis; Animals; Chemistry, Pharmaceutical; Chlorides; | 2013 |
Maturation of the GABAergic transmission in normal and pathologic motoneurons.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Central Nervous System; Chlorides; gamma-Aminobutyric | 2011 |
1 trial available for chlorine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
NP001 regulation of macrophage activation markers in ALS: a phase I clinical and biomarker study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Analysis of Variance; Anti-Inflammatory Agents; Biomarke | 2014 |
6 other studies available for chlorine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Implication of 5-HT in the Dysregulation of Chloride Homeostasis in Prenatal Spinal Motoneurons from the G93A Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Action Potentials; Amyotrophic Lateral Sclerosis; Animals; Chlorides; Female; gamma-Aminobutyric Aci | 2020 |
Decreased chloride levels of cerebrospinal fluid in patients with amyotrophic lateral sclerosis.
Topics: Age Factors; Aged; Amyotrophic Lateral Sclerosis; Chlorides; Female; Humans; Male; Middle Aged; Nerv | 2009 |
Vascular physiology and protein disposition in a preclinical model of neurodegeneration.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blood Volume; Blood-Brain Barrier; Cerebrovascular Circulati | 2013 |
Inducible superoxide dismutase 1 aggregation in transgenic amyotrophic lateral sclerosis mouse fibroblasts.
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Animals, Newborn; Blotting, Western; Cell Su | 2004 |
Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Chlorides | 2004 |
Motor neuronal death in sporadic amyotrophic lateral sclerosis (ALS) is not apoptotic. A comparative study of ALS and chronic aluminium chloride neurotoxicity in New Zealand white rabbits.
Topics: Adult; Aged; Aluminum Chloride; Aluminum Compounds; Amyotrophic Lateral Sclerosis; Animals; Antibodi | 2000 |