chlorine has been researched along with ADPKD in 33 studies
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) requires the transepithelial secretion of fluid into the cyst lumen." | 5.42 | Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells. ( Blanco, G; Calvet, JP; Jansson, K; Magenheimer, BS; Reif, GA; Sánchez, G; Venugopal, J; Wallace, DP, 2015) |
| "Incubation of ADPKD cells with 10(-9) M AVP increased intracellular cAMP and stimulated ERK and cell proliferation." | 5.37 | Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. ( Fujiki, H; Nivens, E; Pinto, CS; Reif, GA; Wallace, DP; Yamaguchi, T, 2011) |
| "The focal beginning of ADPKD in a relatively few renal tubules suggests that the cells in the walls of cysts may reflect clonal growth and that this aberrant proliferation may be secondary to a somatic "second hit" process." | 2.40 | Polycystic kidney disease: huge kidneys, huge problems, huge progress. ( Grantham, JJ, 1997) |
| "ADPKD1 is an inherited disorder that has led to the discovery of a novel protein, polycystin." | 2.39 | The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances. ( Grantham, JJ, 1996) |
| "Treatment with tubacin prevented cyst formation in MDCK cells, an in vitro model of cystogenesis." | 1.43 | Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease. ( Boinot, C; Cebotaru, L; Cebotaru, V; Guggino, WB; Huso, DL; Liu, Q; Outeda, P; Watnick, T; Yanda, MK, 2016) |
| "Cyst enlargement in autosomal dominant polycystic kidney disease (ADPKD) requires the transepithelial secretion of fluid into the cyst lumen." | 1.42 | Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells. ( Blanco, G; Calvet, JP; Jansson, K; Magenheimer, BS; Reif, GA; Sánchez, G; Venugopal, J; Wallace, DP, 2015) |
| "We hypothesized that, in ADPKD epithelia, PGE(2) induces proliferation and chloride (Cl(-)) secretion, two archetypal phenotypic features of ADPKD." | 1.38 | Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia. ( Battini, L; Flores, D; Gusella, GL; Lee, K; Liu, Y; Pao, AC; Rajagopal, M; Rohatgi, R, 2012) |
| "Basal cAMP is elevated in human ADPKD cells compared with normal human kidney (NHK) cells." | 1.38 | Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells. ( Nivens, E; Pinto, CS; Reif, GA; Wallace, DP; White, C, 2012) |
| "Incubation of ADPKD cells with 10(-9) M AVP increased intracellular cAMP and stimulated ERK and cell proliferation." | 1.37 | Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin. ( Fujiki, H; Nivens, E; Pinto, CS; Reif, GA; Wallace, DP; Yamaguchi, T, 2011) |
| "Concentrations of LPA measured in human ADPKD cyst fluid and in normal serum are sufficient to maximally stimulate ion transport." | 1.37 | Lysophosphatidic acid is a modulator of cyst growth in autosomal dominant polycystic kidney disease. ( Bacallao, RL; Blacklock, BJ; Blazer-Yost, BL; Flaig, S; Gattone, VH, 2011) |
| "Net fluid secretion into renal cysts is caused by transepithelial transport mediated by the apical cystic fibrosis transmembrane conductance regulator chloride channel, which leads to cyst enlargement." | 1.35 | KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease. ( Albaqumi, M; Itani, O; Li, Z; Skolnik, EY; Srivastava, S; Wallace, DP; Wulff, H; Zhdnova, O, 2008) |
| "Cyst expansion in autosomal dominant polycystic kidney disease (ADPKD) requires accumulation of fluid into the cyst lumen, which is probably driven by aberrant chloride secretion by the cyst lining epithelium." | 1.32 | The isolated C-terminus of polycystin-1 promotes increased ATP-stimulated chloride secretion in a collecting duct cell line. ( Hooper, KM; Sutters, M; Unwin, RJ, 2003) |
| "The fact that most CFTR-positive ADPKD cysts also express NKCC1 suggests that transepithelial Cl(-) secretion in ADPKD involves molecular mechanisms similar to secretory epithelia." | 1.31 | Basolateral chloride transporters in autosomal dominant polycystic kidney disease. ( Beauwens, R; Devuyst, O; Guggino, WB; Hanaoka, K; Lebeau, C; Moore-Hoon, ML, 2002) |
| "Cyst growth in ADPKD is driven by cell proliferation and Cl(-) and fluid secretion." | 1.31 | Sulfonylurea-sensitive K(+) transport is involved in Cl(-) secretion and cyst trowth by cultured ADPKD cells. ( Eppler, JW; Gover, T; Grantham, JJ; Maser, R; Sullivan, LP; Wallace, DP; Welling, PA; Yamaguchi, T, 2002) |
| "Ten adult patients with ADPKD (4 men and 6 women) with initial serum creatinine levels | 1.31 | Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography. ( Cook, LT; Cowley, BD; Gordon, M; Grantham, JJ; Kusaka, M; Sise, C; Wetzel, LH; Winklhofer, F, 2000) |
| "Liver cysts, the most common extrarenal manifestation of autosomal dominant polycystic kidney disease (ADPKD), derive from the intrahepatic biliary epithelium (IBE) and are found in 60-75% of ADPKD patients on dialysis." | 1.30 | Autosomal dominant polycystic kidney disease decreases anion exchanger activity. ( Alper, SL; Grubman, SA; Jefferson, DM; Lee, DW; Murray, SL; Perrone, RD, 1997) |
| "Therefore, cyst fluids in ADPKD and GCDB share compositional characteristics, and amino acids, possibly of blood protein origin, accumulate in small but osmotically significant amounts in some, particularly low-sodium, cysts of kidney and breast." | 1.30 | Kidney and breast cysts: a comparative study of fluids. ( Bandy, SM; Gardner, KD; Glew, RH; Hurley, DK; Morris, DM, 1997) |
| "10 excised cysts bathed symmetrically in control culture medium secreted fluid at a rate of 0." | 1.29 | In vitro fluid secretion by epithelium from polycystic kidneys. ( Gattone, VH; Grantham, JJ; Sullivan, LP; Ye, M, 1995) |
| "The kidneys of patients with autosomal dominant polycystic kidney disease become massively enlarged due to the progressive expansion of myriad fluid-filled cysts." | 1.29 | Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells. ( Brill, SR; Caplan, MJ; Davidow, CJ; Grantham, JJ; Ross, KE; Ye, M, 1996) |
| "Individual cultured cysts were placed in a chamber on the stage of an inverted microscope equipped with epifluorescent and video analysis attachments." | 1.29 | Chloride and fluid secretion by cultured human polycystic kidney cells. ( Grantham, JJ; Sullivan, LP; Wallace, DP, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (33.33) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 2 (6.06) | 2.80 |
| Authors | Studies |
|---|---|
| Reif, GA | 4 |
| Wallace, DP | 8 |
| Jouret, F | 1 |
| Devuyst, O | 5 |
| Cabrita, I | 1 |
| Kraus, A | 2 |
| Scholz, JK | 1 |
| Skoczynski, K | 1 |
| Schreiber, R | 3 |
| Kunzelmann, K | 3 |
| Buchholz, B | 3 |
| Faria, D | 1 |
| Schley, G | 2 |
| Eckardt, KU | 2 |
| Tanaka, T | 1 |
| Nangaku, M | 1 |
| Jansson, K | 1 |
| Venugopal, J | 1 |
| Sánchez, G | 1 |
| Magenheimer, BS | 1 |
| Calvet, JP | 2 |
| Blanco, G | 1 |
| Peters, DJ | 1 |
| Stadler, R | 1 |
| Cebotaru, L | 1 |
| Liu, Q | 1 |
| Yanda, MK | 1 |
| Boinot, C | 1 |
| Outeda, P | 1 |
| Huso, DL | 1 |
| Watnick, T | 1 |
| Guggino, WB | 2 |
| Cebotaru, V | 1 |
| Albaqumi, M | 1 |
| Srivastava, S | 1 |
| Li, Z | 1 |
| Zhdnova, O | 1 |
| Wulff, H | 1 |
| Itani, O | 1 |
| Skolnik, EY | 1 |
| Terryn, S | 1 |
| Ho, A | 1 |
| Beauwens, R | 3 |
| Yamaguchi, T | 2 |
| Nivens, E | 2 |
| Fujiki, H | 1 |
| Pinto, CS | 2 |
| Blazer-Yost, BL | 1 |
| Blacklock, BJ | 1 |
| Flaig, S | 1 |
| Bacallao, RL | 1 |
| Gattone, VH | 2 |
| Liu, Y | 1 |
| Rajagopal, M | 1 |
| Lee, K | 1 |
| Battini, L | 1 |
| Flores, D | 1 |
| Gusella, GL | 1 |
| Pao, AC | 1 |
| Rohatgi, R | 1 |
| White, C | 1 |
| Lebeau, C | 1 |
| Hanaoka, K | 1 |
| Moore-Hoon, ML | 1 |
| Sullivan, LP | 4 |
| Gover, T | 1 |
| Welling, PA | 1 |
| Maser, R | 1 |
| Eppler, JW | 1 |
| Grantham, JJ | 10 |
| Hooper, KM | 2 |
| Unwin, RJ | 2 |
| Sutters, M | 2 |
| Wildman, SS | 1 |
| Turner, CM | 1 |
| Sham, JS | 1 |
| Lakatta, EG | 1 |
| King, BF | 1 |
| Humphreys, BD | 1 |
| Forman, JP | 1 |
| Zandi-Nejad, K | 1 |
| Bazari, H | 1 |
| Seifter, J | 1 |
| Magee, CC | 1 |
| Chernova, MN | 1 |
| Vandorpe, DH | 1 |
| Clark, JS | 1 |
| Alper, SL | 2 |
| Ye, M | 2 |
| Davidow, CJ | 2 |
| Maser, RL | 1 |
| Rome, LA | 1 |
| Brill, SR | 1 |
| Ross, KE | 1 |
| Caplan, MJ | 1 |
| Perrone, RD | 1 |
| Grubman, SA | 1 |
| Murray, SL | 1 |
| Lee, DW | 1 |
| Jefferson, DM | 1 |
| Hurley, DK | 1 |
| Bandy, SM | 1 |
| Glew, RH | 1 |
| Morris, DM | 1 |
| Gardner, KD | 1 |
| Persu, A | 1 |
| Sise, C | 1 |
| Kusaka, M | 1 |
| Wetzel, LH | 1 |
| Winklhofer, F | 1 |
| Cowley, BD | 1 |
| Cook, LT | 1 |
| Gordon, M | 1 |
8 reviews available for chlorine and ADPKD
| Article | Year |
|---|---|
Targeting chloride transport in autosomal dominant polycystic kidney disease.
Topics: Animals; Cells, Cultured; Chlorides; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator | 2020 |
Fluid transport and cystogenesis in autosomal dominant polycystic kidney disease.
Topics: Animals; Aquaporins; Biological Transport, Active; Chlorides; Cyclic AMP; Cystic Fibrosis Transmembr | 2011 |
The inscrutable renal cyst in ADPKD.
Topics: Body Fluids; Chlorides; Humans; Polycystic Kidney, Autosomal Dominant; Sodium | 1995 |
The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances.
Topics: Animals; Body Fluids; Chlorides; Extracellular Matrix; Humans; Kidney Tubules; Mutation; Polycystic | 1996 |
Polycystic kidney disease: huge kidneys, huge problems, huge progress.
Topics: Body Fluids; Chlorides; Cyclic AMP; Extracellular Matrix; Genotype; Humans; Kidney Failure, Chronic; | 1997 |
Chloride and fluid secretion in polycystic kidney disease.
Topics: Animals; Body Fluids; Chlorides; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Hu | 1998 |
Ion transport and cystogenesis: the paradigm of autosomal dominant polycystic kidney disease.
Topics: Aquaporin 1; Aquaporin 2; Aquaporin 6; Aquaporins; Blood Group Antigens; Chlorides; Cystic Fibrosis | 1998 |
Transepithelial chloride secretion and cystogenesis in autosomal dominant polycystic kidney disease.
Topics: Chloride Channels; Chlorides; Genetic Linkage; Humans; Membrane Proteins; Polycystic Kidney, Autosom | 2000 |
25 other studies available for chlorine and ADPKD
| Article | Year |
|---|---|
ADPKD cell proliferation and Cl
Topics: Biological Transport; Cell Count; Cell Proliferation; Chlorides; Epithelial Cells; Humans; Kidney; P | 2019 |
Cyst growth in ADPKD is prevented by pharmacological and genetic inhibition of TMEM16A in vivo.
Topics: Animals; Anoctamin-1; Benzbromarone; Calcium Channels; Cell Proliferation; Chlorides; Cystic Fibrosi | 2020 |
Anoctamin 1 induces calcium-activated chloride secretion and proliferation of renal cyst-forming epithelial cells.
Topics: Animals; Anoctamin-1; Cell Proliferation; Chloride Channels; Chlorides; Disease Progression; Dogs; E | 2014 |
ANO1: an additional key player in cyst growth.
Topics: Animals; Anoctamin-1; Cell Proliferation; Chloride Channels; Chlorides; Epithelial Cells; Female; Hu | 2014 |
Ouabain Regulates CFTR-Mediated Anion Secretion and Na,K-ATPase Transport in ADPKD Cells.
Topics: Animals; Anions; Biological Transport; Cell Membrane; Chlorides; Colforsin; Cystic Fibrosis Transmem | 2015 |
Glucose promotes secretion-dependent renal cyst growth.
Topics: Animals; Anoctamin-1; Calcium; Cell Line; Cell Proliferation; Chloride Channels; Chlorides; Cyclic A | 2016 |
Inhibition of histone deacetylase 6 activity reduces cyst growth in polycystic kidney disease.
Topics: Anilides; Animals; Cell Proliferation; Chlorides; Cyclic AMP; Cystic Fibrosis Transmembrane Conducta | 2016 |
KCa3.1 potassium channels are critical for cAMP-dependent chloride secretion and cyst growth in autosomal-dominant polycystic kidney disease.
Topics: Animals; Biological Transport; Cells, Cultured; Chlorides; Cyclic AMP; Cyst Fluid; Cysts; Dogs; Huma | 2008 |
Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.
Topics: Adult; Aged; Amiloride; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blotting, Western; | 2011 |
Lysophosphatidic acid is a modulator of cyst growth in autosomal dominant polycystic kidney disease.
Topics: Amiloride; Cell Line; Chlorides; Cyst Fluid; Epithelial Cells; Humans; Ion Transport; Lysophospholip | 2011 |
Prostaglandin E(2) mediates proliferation and chloride secretion in ADPKD cystic renal epithelia.
Topics: Animals; Cell Line; Cell Proliferation; Cells, Cultured; Chlorides; Dinoprostone; Epithelial Cells; | 2012 |
Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells.
Topics: Adenylyl Cyclases; Aquaporin 2; Arginine Vasopressin; Calmodulin; Cell Proliferation; Cells, Culture | 2012 |
Basolateral chloride transporters in autosomal dominant polycystic kidney disease.
Topics: Anion Exchange Protein 1, Erythrocyte; Chlorides; Colonic Neoplasms; Cystic Fibrosis Transmembrane C | 2002 |
Sulfonylurea-sensitive K(+) transport is involved in Cl(-) secretion and cyst trowth by cultured ADPKD cells.
Topics: Barium; Cell Division; Cells, Cultured; Charybdotoxin; Chlorides; Disease Progression; Glyburide; Hu | 2002 |
The isolated C-terminus of polycystin-1 promotes increased ATP-stimulated chloride secretion in a collecting duct cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line; Chloride Channels; Chlorides; Culture Techniques; Exudat | 2003 |
The isolated polycystin-1 cytoplasmic COOH terminus prolongs ATP-stimulated Cl- conductance through increased Ca2+ entry.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Chlorides; Cytoplasm; Kidney Tubules, Col | 2003 |
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.
Topics: Acetaminophen; Acid-Base Equilibrium; Acidosis; Adult; Analgesics, Non-Narcotic; Antineoplastic Comb | 2005 |
Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes.
Topics: Animals; Calcium; Cations; Cell Membrane; Chloride Channels; Chlorides; Cytoplasm; Membrane Proteins | 2005 |
In vitro fluid secretion by epithelium from polycystic kidneys.
Topics: Biological Transport; Cell Polarity; Cells, Cultured; Chlorides; Cyclic AMP; Cysts; Epithelium; Huma | 1995 |
The cystic fibrosis transmembrane conductance regulator mediates transepithelial fluid secretion by human autosomal dominant polycystic kidney disease epithelium in vitro.
Topics: Cells, Cultured; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Kidney; Pol | 1996 |
Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cells.
Topics: Antibodies, Monoclonal; Cell Membrane; Cells, Cultured; Chlorides; Colforsin; Cystic Fibrosis Transm | 1996 |
Chloride and fluid secretion by cultured human polycystic kidney cells.
Topics: Bumetanide; Cells, Cultured; Chlorides; Colforsin; Cysts; Electric Conductivity; Epidermal Growth Fa | 1996 |
Autosomal dominant polycystic kidney disease decreases anion exchanger activity.
Topics: Alkalies; Antiporters; Bile Ducts, Intrahepatic; Blotting, Western; Buffers; Cell Line, Transformed; | 1997 |
Kidney and breast cysts: a comparative study of fluids.
Topics: Amino Acids; Body Fluids; Chlorides; Female; Fibrocystic Breast Disease; Humans; Male; Osmolar Conce | 1997 |
Volumetric determination of progression in autosomal dominant polycystic kidney disease by computed tomography.
Topics: Adult; Age Factors; Body Fluids; Chlorides; Disease Progression; Female; Humans; Kidney; Kidney Fail | 2000 |