chlordiazepoxide has been researched along with Substance Withdrawal Syndrome in 164 studies
Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal." | 9.05 | A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983) |
| "A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration." | 8.12 | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report. ( Arabadjief, MA; Bashir, S; Bergman, CL; El-Mallakh, RS; Elsayed, OH; Gundumalla, MR; Menefee, DS; Moulana, NZ, 2022) |
| ") were determined on anxiety induced in female NMRI mice by withdrawal from 21 days of chronic administration of chlordiazepoxide." | 7.71 | The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice. ( Gower, AJ; Klitgaard, H; Lamberty, Y, 2002) |
| "The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures." | 7.67 | Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987) |
| "The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied." | 7.66 | Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. ( Jacob, MS; MacLeod, SM; Sellers, EM; Ti, TY; Zilm, DH, 1980) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 7.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "Forty patients with primary chronic alcoholism took part in a randomized, double-blind, comparative group study of clobazam and chlordiazepoxide in the treatment of acute alcohol withdrawal." | 5.05 | A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism. ( Mukherjee, PK, 1983) |
| "A 27-year-old, Caucasian female with ethanol dependence who had objective symptoms of withdrawal experienced worsening of her delirium after administration of chlordiazepoxide, but improved with lorazepam and cleared with discontinuation of benzodiazepine administration." | 4.12 | Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report. ( Arabadjief, MA; Bashir, S; Bergman, CL; El-Mallakh, RS; Elsayed, OH; Gundumalla, MR; Menefee, DS; Moulana, NZ, 2022) |
| ") were determined on anxiety induced in female NMRI mice by withdrawal from 21 days of chronic administration of chlordiazepoxide." | 3.71 | The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice. ( Gower, AJ; Klitgaard, H; Lamberty, Y, 2002) |
| "6 mg/kg pentylenetetrazole and exhibited an increase in susceptibility to clonic seizures." | 3.68 | State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats. ( Gauvin, DV; Goulden, KL; Holloway, FA, 1993) |
| "Abrupt withdrawal of the centrally-acting antihypertensive agent, clonidine, is associated with a high incidence of rebound hypertension and tachycardia, with symptoms of sympathetic overactivity and increased catecholamine excretion." | 3.67 | Regimen for the control of blood pressure and symptoms during clonidine withdrawal. ( Campbell, BC; Reid, JL, 1985) |
| "The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures." | 3.67 | Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987) |
| "Rats were tested in the elevated plus-maze test of anxiety after a probe injection of chlordiazepoxide (CDP 5 mg/kg) following short-term (5 days) or long-term (20 days) pretreatment with 5 or 20 mg/kg/day." | 3.67 | Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance. ( Aranko, K; Baldwin, HA; File, SE, 1987) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 3.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "The pattern of cardiac arrhythmias and their treatment, by propranolol and chlordiazepoxide, during the first 48 hr of alcohol withdrawal has been studied." | 3.66 | Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal. ( Jacob, MS; MacLeod, SM; Sellers, EM; Ti, TY; Zilm, DH, 1980) |
| "Lorazepam was used as rescue medication." | 2.82 | A randomized, open-label, standard controlled, parallel group study of efficacy and safety of baclofen, and chlordiazepoxide in uncomplicated alcohol withdrawal syndrome. ( Girish, K; Manjunatha, R; Nagraj, M; Pandit, LV; Pundarikaksha, HP; Shruthi, R; Vasundara, K; Vijendra, R; Vikram Reddy, K, 2016) |
| "Lorazepam treated group showed a significant difference in the rate of improvement over 48 h compared to chlordiazepoxide group (70." | 2.78 | A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal. ( Mohandas, E; Rajmohan, V; Sushil, K, 2013) |
| "Phenobarbital and LZ were similarly effective in the treatment of mild/moderate alcohol withdrawal in the ED and at 48 hours." | 2.76 | A prospective, randomized, trial of phenobarbital versus benzodiazepines for acute alcohol withdrawal. ( Barnes, RL; Dery, RA; Hendey, GW; Mentler, P; Snowden, B, 2011) |
| "One hundred consecutive consenting male inpatients in a state of moderately severe, uncomplicated alcohol withdrawal at screening were randomized to receive either lorazepam (8 mg/day) or chlordiazepoxide (80 mg/day) with dosing down-titrated to zero in a fixed-dose schedule across 8 treatment days." | 2.74 | A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal. ( Andrade, C; Kumar, CN; Murthy, P, 2009) |
| "Chlordiazepoxide was administered to only 41 patients (38%), yet 92 (85%) of the 108 enrolled successfully completed outpatient detoxification without medical complications." | 2.69 | Individualized treatment for outpatients withdrawing from alcohol. ( Briggs, MJ; Henderson, KL; Wiseman, EJ, 1998) |
| "While having significant withdrawal symptoms, 50 hospitalized men were randomly assigned to receive either transdermal clonidine or chlordiazepoxide over a 4-day study period." | 2.67 | Transdermal clonidine versus chlordiazepoxide in alcohol withdrawal: a randomized, controlled clinical trial. ( Baumgartner, GR; Rowen, RC, 1991) |
| " The two drugs were administered four times a day in double dummy conditions, according to a fixed-flexible decreasing dosage schedule (six days basic regimen)." | 2.66 | Double blind study on the efficacy and safety of tetrabamate and chlordiazepoxide in the treatment of the acute alcohol withdrawal syndrome. ( Chabot, F; Chawla, S; Forest, JC; Garcin, F; Guay, D; Huot, J; Marquis, PA; Martin, S; Radouco-Thomas, S; Stewart, G, 1989) |
| " A flexible dosage schedule was followed for 5 days with the objective of using the largest dose on the first day, followed by daily reductions as clinically feasible." | 2.66 | Halazepam in the management of acute alcohol withdrawal syndrome. ( Fine, EW; Mendels, J; Michals, TJ; Wasserman, TW, 1985) |
| "Clonidine was more effective than chlordiazepoxide at reducing alcohol withdrawal scale scores, systolic blood pressures, and heart rates over the entire study period." | 2.66 | Clonidine vs chlordiazepoxide in the management of acute alcohol withdrawal syndrome. ( Baumgartner, GR; Rowen, RC, 1987) |
| "Bromocriptine was ineffective in treating withdrawal symptoms, whilst chlormethiazole and chlordiazepoxide were equally effective." | 2.66 | Double-blind controlled trial of bromocriptine, chlordiazepoxide and chlormethiazole for alcohol withdrawal symptoms. ( Burroughs, AK; Morgan, MY; Sherlock, S, 1985) |
| "The chlordiazepoxide treatment produced suppression of rapid eye movement (REM) sleep lasting for about 4 days and virtually eliminated delta sleep (stages III and IV) during the recovery period." | 2.64 | Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal. ( Allen, RP; Funderburk, FR; Wagman, AM, 1978) |
| "Treatment with baclofen is easy to manage and rarely produces euphoria or other pleasant effects, or craving for the drug." | 2.55 | Baclofen for alcohol withdrawal. ( Liu, J; Wang, LN, 2017) |
| " Bases for selection include: (1) availability of other than oral dosage forms; (2) differences in additive effect with alcohol in producing central nervous system depression; (3) differences in anticonvulsant effect; and (4) differences in duration of effect in the body (ie, half-life)." | 2.36 | Selection among benzodiazepines for alcohol withdrawal. ( Keeler, MH; Miller, WC, 1977) |
| "However, withdrawal symptoms may occur in patients receiving recommended doses and/or short-term therapy." | 2.36 | Benzodiazepine withdrawal syndrome: a literature review and evaluation. ( MacKinnon, GL; Parker, WA, 1982) |
| "Severe AWS can develop into delirium tremens (DT), which is potentially life-threatening." | 1.51 | Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients. ( Bergeron, JB; March, KL; Reaves, AB; Sakaan, SA; Self, TH; Slayton, MM; Twilla, JD, 2019) |
| "Phenobarbital treatment was associated with decreased mortality, which might be confounded by somatic comorbidity among patients receiving chlordiazepoxide." | 1.43 | Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality. ( Askgaard, G; Fink-Jensen, A; Hallas, J; Madsen, KG; Molander, AC; Pottegård, A, 2016) |
| " In order to investigate the relationship between tolerance and withdrawal to the cue properties of CDP, CDP dose-response curves were determined 24 h following treatment with SAL or 10 mg/kg CDP." | 1.33 | Evidence for PTZ-like cues as a function of time following treatment with chlordiazepoxide: implications for understanding tolerance and withdrawal. ( Barrett, RJ; Smith, RL, 2005) |
| "Alcohol withdrawal (especially delirium tremens) poses significant potential morbidity to postsurgical patients." | 1.29 | Trends in the management of alcohol withdrawal syndrome. ( Moore, M; Newman, JP; Terris, DJ, 1995) |
| " Three tests were used in which the benzodiazepine antagonist flumazenil was administered to rats receiving chronic administration of chlordiazepoxide." | 1.29 | Conflicting evidence regarding the efficacy of ondansetron in benzodiazepine withdrawal. ( Emmett-Oglesby, MW; Hooper, ML; Lal, H; Lane, JD; Lytle, DA; Prather, PL; Rezazadeh, SM; Rowan, GA, 1993) |
| " That bretazenil did not produce acute physical dependence supports the findings of others (20,23) who report that chronic administration of bretazenil does not result in physical dependence." | 1.29 | Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior. ( Bronson, ME, 1994) |
| " Drug was most often given on a fixed dosing schedule with additional medication "as needed" (52% of the programs)." | 1.29 | Alcohol withdrawal: a nationwide survey of inpatient treatment practices. ( Friedman, LS; Mayo-Smith, MF; Saitz, R, 1995) |
| " Using a cumulative dosing procedure, PTZ substituted for PTZ, and MDZ, chlordiazepoxide and diazepam (DZP) substituted for MDZ, in a dose-dependent manner." | 1.28 | Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam. ( Boone, MS; Emmett-Oglesby, MW; Pugh, SL, 1992) |
| " These data support recent claims that GR38032F attenuates benzodiazepine withdrawal, and they indicate that this effect shows an inverted U-shaped dose-response curve." | 1.28 | Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats. ( Goudie, AJ; Leathley, MJ, 1990) |
| "Pre-treatment with ondansetron (0." | 1.28 | Effects of 5-HT3 receptor antagonists on behavioural measures of naloxone-precipitated opioid withdrawal. ( Higgins, GA; Joharchi, N; Nguyen, P; Sellers, EM, 1991) |
| " Based on the "chronically equivalent" dosing principle, a regimen has been devised to maintain rats in a state of quantifiable intoxication for 5 weeks." | 1.27 | Experimental induction of benzodiazepine tolerance and physical dependence. ( Boisse, NR; Ryan, GP, 1983) |
| " Furthermore, chronic administration and withdrawal of 1,3-BD caused CNS hyperexcitability in rats that was characteristic of physical dependence." | 1.26 | Effects of acute and chronic 1,3-butanediol treatment on central nervous system function: a comparison with ethanol. ( Breese, GR; Chapin, RE; Frye, GD; Kilts, CD; Mailman, RB; Mueller, RA; Vogel, RA, 1981) |
| "Theories concerning schizophrenia and affective disease are shown to be based on the mode of action of drugs discovered in the 1950s and used in the treatment of these disorders." | 1.26 | Biology of psychoses: past research and new frontiers. ( Brodie, HK, 1977) |
| "Propranolol alone was more effective than either chlordiazepoxide or a combination of chlordiazepoxide and propranolol in alleviating the symptoms of the alcohol withdrawal syndrome." | 1.26 | Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal. ( Degani, NC; Sellers, EM; Zilm, DH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 115 (70.12) | 18.7374 |
| 1990's | 31 (18.90) | 18.2507 |
| 2000's | 6 (3.66) | 29.6817 |
| 2010's | 9 (5.49) | 24.3611 |
| 2020's | 3 (1.83) | 2.80 |
| Authors | Studies |
|---|---|
| Osler, M | 1 |
| Jørgensen, MB | 1 |
| Arabadjief, MA | 1 |
| Elsayed, OH | 1 |
| Bashir, S | 1 |
| Gundumalla, MR | 1 |
| Menefee, DS | 1 |
| Bergman, CL | 1 |
| Moulana, NZ | 1 |
| El-Mallakh, RS | 1 |
| Pedersen, SA | 1 |
| Klesse, T | 1 |
| Findal Andreasen, M | 1 |
| Dalhoff, KP | 1 |
| Andersen, CU | 1 |
| Liu, J | 1 |
| Wang, LN | 1 |
| March, KL | 1 |
| Twilla, JD | 1 |
| Reaves, AB | 1 |
| Self, TH | 1 |
| Slayton, MM | 1 |
| Bergeron, JB | 1 |
| Sakaan, SA | 1 |
| Rajmohan, V | 1 |
| Sushil, K | 1 |
| Mohandas, E | 1 |
| Prakash, S | 1 |
| Mandal, P | 1 |
| Askgaard, G | 1 |
| Hallas, J | 1 |
| Fink-Jensen, A | 1 |
| Molander, AC | 1 |
| Madsen, KG | 1 |
| Pottegård, A | 1 |
| Girish, K | 1 |
| Vikram Reddy, K | 1 |
| Pandit, LV | 1 |
| Pundarikaksha, HP | 1 |
| Vijendra, R | 1 |
| Vasundara, K | 1 |
| Manjunatha, R | 1 |
| Nagraj, M | 1 |
| Shruthi, R | 1 |
| Kumar, CN | 1 |
| Andrade, C | 1 |
| Murthy, P | 1 |
| Rothwell, PE | 1 |
| Thomas, MJ | 1 |
| Gewirtz, JC | 2 |
| Hendey, GW | 1 |
| Dery, RA | 1 |
| Barnes, RL | 1 |
| Snowden, B | 1 |
| Mentler, P | 1 |
| Keys, VA | 1 |
| Husain, OM | 1 |
| Lynas, PS | 1 |
| Totty, JP | 1 |
| Williams, K | 1 |
| Waring, WS | 1 |
| Harris, AC | 1 |
| HOLLISTER, LE | 2 |
| MOTZENBECKER, FP | 1 |
| DEGAN, RO | 1 |
| KISSEN, MD | 2 |
| KOUTSKY, CD | 1 |
| SLETEN, IW | 1 |
| SERENY, G | 1 |
| KALANT, H | 1 |
| Lelas, S | 1 |
| Wong, H | 1 |
| Li, YW | 1 |
| Heman, KL | 1 |
| Ward, KA | 1 |
| Zeller, KL | 1 |
| Sieracki, KK | 1 |
| Polino, JL | 1 |
| Godonis, HE | 1 |
| Ren, SX | 1 |
| Yan, XX | 1 |
| Arneric, SP | 1 |
| Robertson, DW | 1 |
| Hartig, PR | 1 |
| Grossman, S | 1 |
| Trainor, GL | 1 |
| Taub, RA | 1 |
| Zaczek, R | 1 |
| Gilligan, PJ | 1 |
| McElroy, JF | 1 |
| Barrett, RJ | 1 |
| Smith, RL | 1 |
| Ewing, JA | 1 |
| Bakewell, WE | 1 |
| Tucker, JF | 1 |
| Plant, NT | 1 |
| von Uexküll, A | 1 |
| Collier, HO | 1 |
| MacKinnon, GL | 1 |
| Parker, WA | 1 |
| Shader, RI | 3 |
| Greenblatt, DJ | 4 |
| Mukherjee, PK | 1 |
| Frye, GD | 2 |
| McCown, TJ | 1 |
| Breese, GR | 3 |
| Solomon, J | 1 |
| Rouck, LA | 1 |
| Koepke, HH | 1 |
| Lepola, U | 1 |
| Kokko, S | 1 |
| Nuutila, J | 1 |
| Gordin, A | 1 |
| Ryan, GP | 2 |
| Boisse, NR | 5 |
| Guarino, JJ | 3 |
| Jasinski, DR | 1 |
| Haertzen, CA | 1 |
| Henningfield, JE | 1 |
| Johnson, RE | 1 |
| Makhzoumi, HM | 1 |
| Miyasato, K | 1 |
| Lund, S | 1 |
| Starklint, JF | 1 |
| Vaag, UH | 1 |
| Wang, AG | 1 |
| Valdman, AV | 1 |
| Zvartau, EE | 1 |
| Zilm, DH | 3 |
| Jacob, MS | 1 |
| MacLeod, SM | 2 |
| Sellers, EM | 6 |
| Ti, TY | 1 |
| Petursson, H | 1 |
| Lader, MH | 1 |
| Chapin, RE | 1 |
| Vogel, RA | 1 |
| Mailman, RB | 1 |
| Kilts, CD | 1 |
| Mueller, RA | 1 |
| Chan, AW | 5 |
| Leong, FW | 4 |
| Schanley, DL | 4 |
| Howe, SM | 1 |
| Walters, L | 1 |
| Nel, P | 1 |
| Goudie, AJ | 4 |
| Leathley, MJ | 4 |
| Sala, M | 1 |
| Leone, MP | 1 |
| Lampugnani, P | 1 |
| Braida, D | 1 |
| Gori, E | 1 |
| Newman, JP | 1 |
| Terris, DJ | 1 |
| Moore, M | 1 |
| Sullivan, JT | 1 |
| Emmett-Oglesby, MW | 6 |
| Lytle, DA | 2 |
| English, SA | 1 |
| Saitz, R | 2 |
| Mayo-Smith, MF | 2 |
| Roberts, MS | 1 |
| Redmond, HA | 1 |
| Bernard, DR | 1 |
| Calkins, DR | 1 |
| Fuller, RK | 1 |
| Gordis, E | 1 |
| Bronson, ME | 1 |
| Prather, PL | 2 |
| Rezazadeh, SM | 2 |
| Lane, JD | 1 |
| Rowan, GA | 2 |
| Hooper, ML | 1 |
| Lal, H | 2 |
| Harrison, AA | 1 |
| Cannizzaro, G | 1 |
| Flugy, A | 1 |
| Cannizzaro, C | 1 |
| Gagliano, M | 1 |
| Sabatino, M | 1 |
| Gauvin, DV | 1 |
| Goulden, KL | 1 |
| Holloway, FA | 1 |
| Bird, RD | 1 |
| Makela, EH | 1 |
| Criswell, HE | 1 |
| Friedman, LS | 1 |
| Hyman, SE | 1 |
| Thomas, H | 1 |
| Mörchen, G | 1 |
| Wiseman, EJ | 1 |
| Henderson, KL | 1 |
| Briggs, MJ | 1 |
| Cao, BJ | 1 |
| Rodgers, RJ | 1 |
| Wooddell, WJ | 1 |
| Lamberty, Y | 1 |
| Gower, AJ | 1 |
| Klitgaard, H | 1 |
| Smith, RF | 1 |
| Fialkov, MJ | 1 |
| Hall, RC | 1 |
| Kirkpatrick, B | 1 |
| Baldino, F | 1 |
| Cowan, A | 1 |
| Geller, EB | 1 |
| Adler, MW | 1 |
| Edwards, G | 1 |
| Zaluzny, SG | 1 |
| Chesher, GB | 1 |
| Jackson, DM | 1 |
| Malor, R | 1 |
| Funderburk, FR | 2 |
| Allen, RP | 3 |
| Wagman, AM | 3 |
| Coleman, JH | 1 |
| Evans, WE | 1 |
| Kissin, B | 3 |
| Menken, M | 1 |
| Buonpane, N | 1 |
| Perly, R | 1 |
| Keeler, MH | 1 |
| Miller, WC | 1 |
| Brodie, HK | 1 |
| Runion, HI | 1 |
| Fowler, FN | 1 |
| Pena-Ramos, A | 2 |
| Hornberger, R | 1 |
| Degani, NC | 1 |
| Franke, K | 1 |
| Giles, HG | 1 |
| Degani, N | 1 |
| Brown, WA | 1 |
| Laughren, TP | 1 |
| Williams, BW | 1 |
| Robertson, CC | 1 |
| Palestine, ML | 1 |
| Alatorre, E | 1 |
| Rothstein, E | 2 |
| Cobble, JC | 1 |
| Sampson, N | 1 |
| Blum, K | 2 |
| Eubanks, JD | 2 |
| Wallace, JE | 2 |
| Hamilton, H | 1 |
| Schwertner, H | 1 |
| Morgan, WW | 1 |
| McGrath, SD | 1 |
| Athinarayanan, P | 1 |
| Pierog, SH | 1 |
| Nigam, SK | 1 |
| Glass, L | 1 |
| Pugh, SL | 1 |
| Boone, MS | 1 |
| Dugovic, C | 1 |
| Meert, TF | 1 |
| Ashton, D | 1 |
| Clincke, GH | 1 |
| File, SE | 7 |
| Zharkovsky, A | 1 |
| Hitchcott, PK | 2 |
| Higgins, GA | 1 |
| Nguyen, P | 1 |
| Joharchi, N | 1 |
| Baumgartner, GR | 3 |
| Rowen, RC | 2 |
| Langan, MC | 3 |
| Penetrante, ML | 3 |
| Wartenberg, AA | 1 |
| Nirenberg, TD | 1 |
| Liepman, MR | 1 |
| Silvia, LY | 1 |
| Begin, AM | 1 |
| Monti, PM | 1 |
| Baldwin, HA | 5 |
| Mathis, DA | 1 |
| Yen-Koo, HC | 1 |
| Tocus, EC | 1 |
| Balazs, T | 1 |
| Samoriski, GM | 2 |
| Xie, Y | 1 |
| Drummond, DC | 2 |
| Turkington, D | 2 |
| Rahman, MZ | 1 |
| Mullin, PJ | 1 |
| Jackson, P | 1 |
| Radouco-Thomas, S | 1 |
| Garcin, F | 1 |
| Guay, D | 1 |
| Marquis, PA | 1 |
| Chabot, F | 1 |
| Huot, J | 1 |
| Chawla, S | 1 |
| Forest, JC | 1 |
| Martin, S | 1 |
| Stewart, G | 1 |
| Mendels, J | 1 |
| Wasserman, TW | 1 |
| Michals, TJ | 1 |
| Fine, EW | 1 |
| Schneider, LS | 1 |
| Syapin, PJ | 1 |
| Pawluczyk, S | 1 |
| Gupta, AK | 1 |
| Jha, BK | 1 |
| Periana, RM | 2 |
| Kruger, HS | 2 |
| Aranko, K | 1 |
| Burroughs, AK | 1 |
| Morgan, MY | 1 |
| Sherlock, S | 1 |
| Pellow, S | 1 |
| Campbell, BC | 1 |
| Reid, JL | 1 |
| Kaim, SC | 4 |
| Whitlock, FA | 1 |
| Price, J | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Gross, MM | 2 |
| Mello, NK | 1 |
| Mendelson, JH | 1 |
| Norton, PR | 1 |
| Oge, V | 1 |
| Helmus, C | 1 |
| Spahn, JG | 1 |
| Raft, DD | 1 |
| Newmark, C | 1 |
| Toomey, T | 1 |
| Kamei, C | 1 |
| Shimomura, K | 1 |
| Ueki, S | 1 |
| Covi, L | 1 |
| Lipman, RS | 1 |
| Pattison, JH | 1 |
| Derogatis, LR | 1 |
| Uhlenhuth, EH | 1 |
| Sampliner, R | 1 |
| Iber, FL | 1 |
| Goldstein, DB | 1 |
| Overall, JE | 1 |
| Brown, D | 1 |
| Williams, JD | 1 |
| Neill, LT | 1 |
| Kaneto, H | 1 |
| Koida, M | 1 |
| Tsuchie, F | 1 |
| Miyagawa, H | 1 |
| Rickels, K | 1 |
| Klett, CJ | 2 |
| Rothfeld, B | 1 |
| Caffey, EM | 1 |
| Malmgren, G | 1 |
| Hudson, FG | 1 |
| McGowan, JM | 1 |
| Renninger, ME | 1 |
| Foster, CA | 1 |
| Kjolstad, T | 1 |
| Edgley, R | 1 |
| Victor, M | 1 |
| Smith, DE | 1 |
| Wesson, DR | 1 |
| Devenyi, P | 1 |
| Hofman, G | 1 |
| Kryspin-Exner, K | 1 |
| Ledda, F | 1 |
| Muller, DJ | 1 |
| Ideström, CM | 1 |
| Holmberg, G | 1 |
| Wegner, ME | 1 |
| Fink, DW | 1 |
| Slater, J | 1 |
| Chambers, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531] | Phase 4 | 210 participants (Anticipated) | Interventional | 2017-07-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for chlordiazepoxide and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Baclofen for alcohol withdrawal.
Topics: Alcohol-Induced Disorders; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; GABA Agonists; Humans; Ran | 2017 |
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam | 1982 |
The use of benzodiazepines in clinical practice.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Humans; Kinetics; Lorazepa | 1981 |
Benzodiazepine dependence.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Diazepam; Disease Models, Animal; Dose-Response Relation | 1981 |
Alcohol withdrawal: what is the benzodiazepine of choice?
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; | 1994 |
The meaning and treatment of alcohol dependence.
Topics: Alcohol Withdrawal Delirium; Alcoholic Beverages; Alcoholics Anonymous; Alcoholism; Amnesia; Aversiv | 1975 |
Selection among benzodiazepines for alcohol withdrawal.
Topics: Administration, Oral; Benzodiazepines; Central Nervous System; Chlordiazepoxide; Clorazepate Dipotas | 1977 |
Drug discrimination used to study drug withdrawal.
Topics: Animals; Chlordiazepoxide; Discrimination Learning; Flumazenil; Pentylenetetrazole; Substance Withdr | 1991 |
Drug therapy. Benzodiazepines (second of two parts).
Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet | 1974 |
Use of beta-adrenergic receptor blocking drugs in psychiatry.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Anxiety; Chlordiazepoxide; Di | 1974 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
Drug use in outpatient treatment.
Topics: Anxiety; Barbiturates; Chlordiazepoxide; Depression; Diazepam; Educational Status; Humans; Meprobama | 1968 |
34 trials available for chlordiazepoxide and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal.
Topics: Adult; Alcoholism; Analysis of Variance; Chlordiazepoxide; Double-Blind Method; Humans; Hypnotics an | 2013 |
A randomized, open-label, standard controlled, parallel group study of efficacy and safety of baclofen, and chlordiazepoxide in uncomplicated alcohol withdrawal syndrome.
Topics: Adult; Alcohol Drinking; Baclofen; Chlordiazepoxide; Diazepam; Humans; Lorazepam; Male; Middle Aged; | 2016 |
A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal.
Topics: Adolescent; Adult; Alcohol-Induced Disorders; Alcoholism; Chlordiazepoxide; Drug Administration Sche | 2009 |
A prospective, randomized, trial of phenobarbital versus benzodiazepines for acute alcohol withdrawal.
Topics: Administration, Oral; Alcohol-Related Disorders; Chlordiazepoxide; Female; GABA Modulators; Humans; | 2011 |
A comparison of the efficacy and tolerability of clobazam and chlordiazepoxide in the treatment of acute withdrawal from alcohol in patients with primary alcoholism.
Topics: Adolescent; Adult; Aged; Alcoholism; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Benzodiazepinone | 1983 |
Double-blind comparison of lorazepam and chlordiazepoxide in the treatment of the acute alcohol abstinence syndrome.
Topics: Acute Disease; Adult; Aged; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Drug Ad | 1983 |
Tiapride and chlordiazepoxide in acute alcohol withdrawal. A controlled clinical trial.
Topics: Adult; Benzamides; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Ethanol; Female; | 1984 |
[The addiction potential of benzodiazepines. Application of the results of treatment of alcohol withdrawal syndrome].
Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Chlordiazepoxide; Humans; Oxazepam; Psychoses, Alcohol | 1981 |
Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial.
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Administ | 1994 |
Individualized treatment for outpatients withdrawing from alcohol.
Topics: Adult; Age Factors; Aged; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Aspartate Aminotransfera | 1998 |
Residual effects of ethanol and chlordiazepoxide treatments for alcohol withdrawal.
Topics: Adult; Alcoholism; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Male; Middle Aged; Psy | 1978 |
A double blind study of chlordiazepoxide and hydroxyzine HC1 therapy in acute alcohol withdrawal utilizing chronic electromyography for tremor assessment.
Topics: Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Electromyography; Human | 1978 |
MMPI and drug treatment in alcohol withdrawal.
Topics: Adult; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Mid | 1979 |
Control of acute alcoholic withdrawal symptoms: a comparative study of haloperidol and chlordiazepoxide.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Female; Haloperidol; Humans; In | 1976 |
Slow wave sleep changes: alcohol tolerance and treatment implications.
Topics: Adult; Alcoholism; Chlordiazepoxide; Drug Tolerance; Ethanol; Humans; Male; Middle Aged; Sleep Stage | 1977 |
A controlled trial of chlormethiazole and chlordiazepoxide in the treatment of the acute withdrawal phase of alcoholism.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Clinical Trials as Topic | 1975 |
Transdermal clonidine versus chlordiazepoxide in alcohol withdrawal: a randomized, controlled clinical trial.
Topics: Administration, Cutaneous; Adult; Anxiety; Chlordiazepoxide; Clonidine; Double-Blind Method; Ethanol | 1991 |
Chlordiazepoxide vs. methadone in opiate withdrawal: a preliminary double blind trial.
Topics: Adult; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Female; Heroin Dependence; H | 1989 |
Double blind study on the efficacy and safety of tetrabamate and chlordiazepoxide in the treatment of the acute alcohol withdrawal syndrome.
Topics: Adult; Barbiturates; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Drug Combinati | 1989 |
How should opiate withdrawal be measured?
Topics: Arousal; Chlordiazepoxide; Clinical Trials as Topic; Double-Blind Method; Humans; Methadone; Nursing | 1989 |
Halazepam in the management of acute alcohol withdrawal syndrome.
Topics: Acute Disease; Adult; Alcoholism; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiaz | 1985 |
Clonidine in heroin withdrawal syndrome: a controlled study in India.
Topics: Adolescent; Adult; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Clonidine; Drug Thera | 1988 |
Clonidine versus chlordiazepoxide in acute alcohol withdrawal: a preliminary report.
Topics: Acute Disease; Adolescent; Adult; Aged; Chlordiazepoxide; Clinical Trials as Topic; Clonidine; Doubl | 1988 |
Clonidine vs chlordiazepoxide in the management of acute alcohol withdrawal syndrome.
Topics: Acute Disease; Adolescent; Adult; Aged; Blood Pressure; Chlordiazepoxide; Clinical Trials as Topic; | 1987 |
Double-blind controlled trial of bromocriptine, chlordiazepoxide and chlormethiazole for alcohol withdrawal symptoms.
Topics: Adult; Bromocriptine; Chlordiazepoxide; Chlormethiazole; Clinical Trials as Topic; Ethanol; Female; | 1985 |
Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.
Topics: Antipsychotic Agents; Biogenic Amines; Brain Chemistry; Chlordiazepoxide; Chlorpromazine; Drug Toler | 1974 |
Length of treatment with anxiolytic sedatives and response to their sudden withdrawal.
Topics: Adolescent; Adult; Aged; Anxiety; Chlordiazepoxide; Clinical Trials as Topic; Drug Tolerance; Female | 1973 |
Diphenylhydantoin control of alcohol withdrawal seizures. Results of a controlled study.
Topics: Administration, Oral; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Drug Evaluation; Elect | 1974 |
Drug treatment of anxiety and depression in detoxified alcoholic patients.
Topics: Alcoholism; Amitriptyline; Analysis of Variance; Anxiety; Ascorbic Acid; Chlordiazepoxide; Depressio | 1973 |
Drug therapy in alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Amitriptyline; Antidepressive Agents; Benactyzine; Carbamates; C | 1968 |
Treatment of the acute alcohol withdrawal state: a comparison of four drugs.
Topics: Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Humans; Hydroxyzine; Middle Aged; Placeb | 1969 |
Evaluating changes in symptoms during acute alcohol withdrawal.
Topics: Affect; Alcoholism; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hydr | 1971 |
Treatment of alcohol withdrawal syndromes.
Topics: Chloral Hydrate; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Drug Synergism; Ethanol; Huma | 1971 |
Comparative investigation of the effects of dixyrazine, placebo and chlordiazepoxide on alcoholics during hospital care.
Topics: Adult; Aged; Alcoholism; Chemical Phenomena; Chemistry; Chlordiazepoxide; Chronic Disease; Clinical | 1967 |
118 other studies available for chlordiazepoxide and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Association of benzodiazepines, Z-drugs, pregabalin, and melatonin with traffic accidents: A nationwide cohort and case-crossover study in Danish adults.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort S | 2022 |
Chlordiazepoxide-induced delirium in a patient undergoing alcohol withdrawal: a case report.
Topics: Adult; Alcoholism; Chlordiazepoxide; Delirium; Ethanol; Female; Humans; Substance Withdrawal Syndrom | 2022 |
Active chlordiazepoxide metabolites in a patient needing life support after treatment of alcohol abstinence.
Topics: Alcohol Abstinence; Alcoholism; Benzodiazepines; Chlordiazepoxide; Female; Humans; Male; Middle Aged | 2020 |
Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients.
Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Ethanol; Female; Humans; Hypnotics and Sedatives; Inp | 2019 |
Drug trials in psychiatry: methodological issues.
Topics: Alcoholism; Chlordiazepoxide; Citalopram; Depressive Disorder; Diabetes Mellitus; Female; Humans; Hy | 2014 |
Phenobarbital compared to benzodiazepines in alcohol withdrawal treatment: A register-based cohort study of subsequent benzodiazepine use, alcohol recidivism and mortality.
Topics: Adult; Alcoholism; Benzodiazepines; Chlordiazepoxide; Cohort Studies; Ethanol; Female; GABA Modulato | 2016 |
Distinct profiles of anxiety and dysphoria during spontaneous withdrawal from acute morphine exposure.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; | 2009 |
Alcohol withdrawal during hospitalization.
Topics: Central Nervous System Depressants; Chlordiazepoxide; Diazepam; Early Diagnosis; Ethanol; Humans; In | 2011 |
Unplanned alcohol withdrawal: a survey of consecutive admissions to an acute medical unit in 2010 and 2011.
Topics: Acute Disease; Adult; Anti-Anxiety Agents; Chlordiazepoxide; Drug Administration Schedule; England; | 2013 |
Elevated startle during withdrawal from acute morphine: a model of opiate withdrawal and anxiety.
Topics: Acoustic Stimulation; Acute Disease; Animals; Chlordiazepoxide; Clonidine; Disease Models, Animal; I | 2004 |
Withdrawal reactions from chlordiazepoxide ("Librium").
Topics: Behavior, Addictive; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome; Substance-Related Diso | 1961 |
The management of acute withdrawal symptoms of alcoholism.
Topics: Alcoholism; Chlordiazepoxide; Disease Management; Humans; Substance Withdrawal Syndrome | 1962 |
Chlordiazepoxide in alcohol withdrawal-intramuscular effects.
Topics: Alcoholism; Alcohols; Chlordiazepoxide; Conduct Disorder; Humans; Minnesota; Psychoses, Substance-In | 1963 |
COMPARATIVE CLINICAL EVALUATION OF CHLORDIAZEPOXIDE AND PROMAZINE IN TREATMENT OF ALCOHOL-WITHDRAWAL SYNDROME.
Topics: Alcohol-Induced Disorders; Alcoholism; Alcohols; Biomedical Research; Blood Pressure Determination; | 1965 |
MANAGEMENT OF PSYCHOMOTOR AGITATION IN ACUTE ALCOHOLISM: A DOUBLE-BLIND STUDY USING CHLORDIAZEPOXIDE.
Topics: Alcoholism; Biomedical Research; Chlordiazepoxide; Depression; Depressive Disorder; Double-Blind Met | 1965 |
Anxiolytic-like effects of the corticotropin-releasing factor1 (CRF1) antagonist DMP904 [4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine] administered acutely or chronically at doses occupying central CRF1 receptors
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Corticosterone; Discrimination Learning; Ma | 2004 |
Evidence for PTZ-like cues as a function of time following treatment with chlordiazepoxide: implications for understanding tolerance and withdrawal.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Discrimination Learning; GABA Agonists; Male; Motiva | 2005 |
Diagnosis and management of depressant drug dependence.
Topics: Adult; Aged; Analgesics; Barbiturates; Chlordiazepoxide; Drug Tolerance; Female; Humans; Hypnotics a | 1967 |
Inhibition by adenosine analogs of opiate withdrawal effects.
Topics: 2-Chloroadenosine; Adenosine; Animals; Behavior, Animal; Chlordiazepoxide; Guinea Pigs; Humans; Ileu | 1984 |
Choice of benzodiazepines.
Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Flurazepam; Half-Life; Humans; Liver | 1981 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea | 1983 |
Experimental induction of benzodiazepine tolerance and physical dependence.
Topics: Animals; Benzodiazepines; Central Nervous System; Chlordiazepoxide; Depression, Chemical; Dose-Respo | 1983 |
Experimental induction of benzodiazepine physical dependence in rodents.
Topics: Animals; Chlordiazepoxide; Humans; Male; Mice; Rats; Rats, Inbred Strains; Substance Withdrawal Synd | 1982 |
Progress report of the NIDA Addiction Research Center.
Topics: Analgesics; Buprenorphine; Chlordiazepoxide; Clonidine; Diazepam; Humans; Morphine; National Institu | 1982 |
[Choice of drug treatment of alcohol withdrawal symptoms in Denmark].
Topics: Alcohol Withdrawal Delirium; Barbital; Barbiturates; Chlordiazepoxide; Denmark; Ethanol; Humans; Sub | 1983 |
Systems of reinforcement and drug dependence.
Topics: Amphetamines; Animals; Cats; Chlordiazepoxide; Cocaine; Diazepam; Drug Tolerance; Escape Reaction; E | 1982 |
Propranolol and chlordiazepoxide effects on cardiac arrhythmias during alcohol withdrawal.
Topics: Alcoholism; Arrhythmias, Cardiac; Chlordiazepoxide; Electroencephalography; Humans; Male; Propranolo | 1980 |
Effects of acute and chronic 1,3-butanediol treatment on central nervous system function: a comparison with ethanol.
Topics: Animals; Behavior, Animal; Blood Pressure; Brain; Butylene Glycols; Cerebellum; Chlordiazepoxide; Do | 1981 |
Alcohol withdrawal reactions after chronic intake of chlordiazepoxide and ethanol.
Topics: Alcoholism; Animals; Body Temperature; Chlordiazepoxide; Diet; Drug Interactions; Ethanol; Half-Life | 1981 |
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam; | 1980 |
Effects of the CCKB antagonist L-365, 260 on benzodiazepine withdrawal-induced hypophagia in rats.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Eating; Female; Phenylurea Compounds; Rats; Rats, Wist | 1995 |
Different kinetics of tolerance to behavioral and electroencephalographic effects of chlordiazepoxide in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Weight; Chlordiazepoxide; Drug Tolerance; Electroen | 1995 |
Trends in the management of alcohol withdrawal syndrome.
Topics: Adult; Aged; Aged, 80 and over; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; | 1995 |
Individualized treatment of alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Drug Administration Schedule; Ethanol; Hu | 1995 |
Abecarnil used to treat benzodiazepine withdrawal.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Chlordiazepoxide; Cues; Discrimination Learning; Flumazeni | 1993 |
Refining the treatment of alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Chlordiazepoxide; Drug Administration Sche | 1994 |
Chlordiazepoxide, but not bretazenil, produces acute dependence, as evidenced by disruptions in schedule-controlled behavior.
Topics: Animals; Benzodiazepinones; Chlordiazepoxide; Conditioning, Operant; Flumazenil; Male; Rats; Reinfor | 1994 |
Conflicting evidence regarding the efficacy of ondansetron in benzodiazepine withdrawal.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Psychological; Discrimination Learning | 1993 |
Evidence for a dissociation between benzodiazepine withdrawal signs.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Body Weight; Chlordiazepoxide; Male; Rats; Rats, W | 1993 |
Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol.
Topics: Alprazolam; Animals; Chlordiazepoxide; Desipramine; GABA-A Receptor Antagonists; Male; Motor Activit | 1993 |
State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats.
Topics: Animals; Arousal; Association Learning; Avoidance Learning; Chlordiazepoxide; Conditioning, Classica | 1993 |
Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Chlordiazepoxide; Conflict, Psychological; Dos | 1993 |
Alcohol withdrawal: a nationwide survey of inpatient treatment practices.
Topics: Adrenergic beta-Antagonists; Alcoholism; Barbiturates; Benzodiazepines; Chlordiazepoxide; Clonidine; | 1995 |
Current treatment for alcohol withdrawal.
Topics: Alcoholism; Benzodiazepines; Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome | 1995 |
[Benzodiazepine withdrawal syndrome in low dose dependency].
Topics: Anti-Anxiety Agents; Anxiety Disorders; Chlordiazepoxide; Depressive Disorder; Diazepam; Dose-Respon | 1996 |
Tolerance to acute anxiolysis but no withdrawal anxiogenesis in mice treated chronically with 5-HT1A receptor antagonist, WAY 100635.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Drug Tolerance; Exploratory Behavior; Male; Mice; Pi | 1998 |
The alcohol withdrawal syndrome.
Topics: Alcoholism; Chlordiazepoxide; Diazepam; Drug Tolerance; Ethanol; Hospitalization; Humans; Substance | 1979 |
The new antiepileptic drug levetiracetam normalises chlordiazepoxide withdrawal-induced anxiety in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Chlordiazepoxide; Dose | 2002 |
Relative effectiveness of primidone (Mysoline) and diphenylhydantoin (Dilantin) in the management of sedative withdrawal seizures.
Topics: Antipsychotic Agents; Chlordiazepoxide; Drug Evaluation; Humans; Phenothiazines; Phenytoin; Primidon | 1976 |
Recent advances in alcohol withdrawal states.
Topics: Adrenergic beta-Antagonists; Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hum | 1977 |
The benzodiazepines.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Re | 1978 |
Effects of antipsychotic and antianxiety drugs on the morphine abstinence syndrome in rats.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Body Weight; Chlordiazepoxide; | 1979 |
The attenuation of delta 9-tetrahydrocannabinol and morphine of the quasi-morphine withdrawal syndrome in rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Behavior, Animal; Chlordiazepoxide; Dronabinol; Haloperidol; H | 1979 |
Pharmacotherapy of the acute alcohol withdrawal syndrome.
Topics: Alcoholism; Anti-Anxiety Agents; Barbiturates; Chemical and Drug Induced Liver Injury; Chloral Hydra | 1975 |
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch | 1975 |
Alcoholic epilepsy. Effects of treatment on convulsions following the cessation of drinking.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Female; Humans; Male; Middle Aged; Seizures; Substance Wi | 1977 |
Biology of psychoses: past research and new frontiers.
Topics: Antidepressive Agents; beta-Lipotropin; Chemistry; Chlordiazepoxide; Depression; Endorphins; History | 1977 |
Comparative efficacy of propranolol and chlordiazepoxide in alcohol withdrawal.
Topics: Adult; Alcoholism; Catecholamines; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Evaluati | 1977 |
Absorption of oral and intramuscular chlordiazepoxide.
Topics: Absorption; Administration, Oral; Adult; Alcoholism; Biological Availability; Chlordiazepoxide; Deal | 1978 |
Decline in chlordiazepoxide plasma levels during fixed-dose therapy of alcohol withdrawal.
Topics: Alcoholism; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome; Time Factors | 1978 |
Neuroendocrine correlates of clinical response during withdrawal from chlordiazepoxide.
Topics: Anxiety Disorders; Chlordiazepoxide; Growth Hormone; Humans; Hydrocortisone; Male; Middle Aged; Prol | 1978 |
Alcohol intoxication and the alcohol withdrawal syndrome.
Topics: Alcoholic Intoxication; Alcoholism; Benzodiazepines; Chlordiazepoxide; Hallucinations; Humans; Pheny | 1978 |
Chlordiazepoxide: long-term use in alcoholism.
Topics: Alcoholism; Chlordiazepoxide; Drug Evaluation; Humans; Long-Term Care; Substance Withdrawal Syndrome | 1976 |
Thioridazine HC1 Vs. chlordiazepoxide HC1 in controlling symptoms attributable to alcohol withdrawal.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Drug Evaluation; Female; Humans; Male; Middle Aged; Psych | 1977 |
Enhancement of alcohol withdrawal convulsions in mice by haloperidol.
Topics: Animals; Chlordiazepoxide; Ethanol; Haloperidol; Humans; Mice; Seizures; Substance Withdrawal Syndro | 1976 |
Possible role of tetrahydroisoquinoline alkaloids in postalcohol intoxication states.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Brain; Catecholamines; Chlordiazepoxide; Dopamine; Huma | 1976 |
Effects of alcohol ingestion and abstinence on slow wave sleep of alcoholics.
Topics: Adult; Alcoholism; Analysis of Variance; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; | 1975 |
Chloriazepoxide withdrawal in the neonate.
Topics: Adult; Affective Symptoms; Chlordiazepoxide; Diseases in Twins; Female; Humans; Infant, Newborn; Inf | 1976 |
Evaluation of anxiolytic action of ondansetron in rats during withdrawal from chronic chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Flumazenil; Imidazoles; Learning; Male; Ondansetron; | 1992 |
Effects of the 5-HT3 antagonist ondansetron on benzodiazepine-induced operant behavioural dependence in rats.
Topics: Animals; Chlordiazepoxide; Conditioning, Operant; Female; Ondansetron; Rats; Rats, Wistar; Reinforce | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug | 1992 |
Effects of ritanserin and chlordiazepoxide on sleep-wakefulness alterations in rats following chronic cocaine treatment.
Topics: Animals; Chlordiazepoxide; Cocaine; Male; Rats; Rats, Inbred Strains; Ritanserin; Sleep; Sleep, REM; | 1992 |
Effects of nitrendipine, chlordiazepoxide, flumazenil and baclofen on the increased anxiety resulting from alcohol withdrawal.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Diazepam; Ethanol; Flumazenil; Interpersonal Relations | 1992 |
Effects of 5-HT3 receptor antagonists on behavioural measures of naloxone-precipitated opioid withdrawal.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Drug Implants; Imidazoles; Male; | 1991 |
Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Chlordiazepoxide; Dose-Response Relationship, Drug; Eatin | 1990 |
The ability of chlordiazepoxide to maintain ethanol tolerance and dependence.
Topics: Animals; Body Temperature; Body Weight; Chlordiazepoxide; Diet; Drug Tolerance; Ethanol; Flumazenil; | 1991 |
Partial cross-dependence on ethanol in mice dependent on chlordiazepoxide.
Topics: Animals; Chlordiazepoxide; Ethanol; Flumazenil; Generalization, Stimulus; Male; Mice; Mice, Inbred C | 1990 |
Detoxification of alcoholics: improving care by symptom-triggered sedation.
Topics: Alcoholism; Chlordiazepoxide; Humans; Male; Substance Withdrawal Syndrome | 1990 |
Flumazenil prevents the development of chlordiazepoxide withdrawal in rats tested in the social interaction test of anxiety.
Topics: Animals; Anxiety; Chlordiazepoxide; Flumazenil; Interpersonal Relations; Male; Motor Activity; Rats; | 1989 |
A liquid diet model of chlordiazepoxide dependence in mice.
Topics: Animals; Chlordiazepoxide; Diet; Disease Models, Animal; Drinking; Flumazenil; Male; Mice; Mice, Inb | 1989 |
Withdrawal from benzodiazepine dependence as a discriminative stimulus.
Topics: Animals; Chlordiazepoxide; Cocaine; Discrimination Learning; Flumazenil; Pentylenetetrazole; Rats; S | 1989 |
The effects of chronic treatment and withdrawal of CNS depressants on aggressive behavior.
Topics: Aggression; Animals; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Dronabino | 1989 |
Effects of buspirone in the benzodiazepine dependent rat.
Topics: Animals; Anti-Anxiety Agents; Arousal; Buspirone; Chlordiazepoxide; Dose-Response Relationship, Drug | 1989 |
Evidence that the increased anxiety detected in the elevated plus-maze during chlordiazepoxide withdrawal is not due to enhanced noradrenergic activity.
Topics: Animals; Anxiety; Chlordiazepoxide; Clonidine; Learning; Male; Norepinephrine; Propranolol; Rats; Ra | 1989 |
Reversal of increased anxiety during benzodiazepine withdrawal: evidence for an anxiogenic endogenous ligand for the benzodiazepine receptor.
Topics: Animals; Anxiety; Behavior, Animal; Chlordiazepoxide; Flumazenil; Male; Rats; Receptors, GABA-A; Sub | 1988 |
Flumazenil: a possible treatment for benzodiazepine withdrawal anxiety.
Topics: Animals; Anxiety; Benzodiazepines; Chlordiazepoxide; Flumazenil; Rats; Substance Withdrawal Syndrome | 1987 |
Seizures following triazolam withdrawal despite benzodiazepine treatment.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Recep | 1987 |
Acute chlordiazepoxide dependence in the rat: comparisons to chronic.
Topics: Animals; Chlordiazepoxide; Drug Administration Schedule; Male; Rats; Rats, Inbred Strains; Substance | 1986 |
Pharmacologic characterization of acute chlordiazepoxide dependence in the rat.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Dose-Response Relationship, Drug; Drug Interactions; Dr | 1986 |
Ethanol and chlordiazepoxide cross-dependence.
Topics: Alcoholism; Animals; Chlordiazepoxide; Flumazenil; Male; Mice; Mice, Inbred C57BL; Substance Withdra | 1987 |
Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance.
Topics: Animals; Anxiety; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Drug Tolerance; Injections, I | 1987 |
Chlordiazepoxide enhances the anxiogenic action of CGS 8216 in the social interaction test: evidence for benzodiazepine withdrawal?
Topics: Animals; Anxiety; Benzodiazepinones; Carbolines; Chlordiazepoxide; Flumazenil; Humans; Male; Pyrazol | 1985 |
Regimen for the control of blood pressure and symptoms during clonidine withdrawal.
Topics: Adult; Aged; Atenolol; Blood Pressure; Chlordiazepoxide; Clonidine; Female; Heart Rate; Humans; Hype | 1985 |
Drug therapy in alcoholism.
Topics: Adult; Alcoholic Intoxication; Alcoholism; Antidepressive Agents; Anxiety; Carbamates; Chlordiazepox | 1970 |
Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal.
Topics: Adult; Alcohol Drinking; Alcoholism; Chlordiazepoxide; Ethanol; Hallucinations; Humans; Hypnotics an | 1970 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydr | 1970 |
Drug therapy in alcoholism. It is especially important in the prevention of such complications as seizures, DT's, Wernicke's encephalopathy, or polyneuritis.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Chlorpromazine; Diazepam; Disulfiram; Humans; Hydroxy | 1971 |
Delirium tremens in head and neck surgery.
Topics: Aged; Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Laryngeal Neoplasms; Male; Mi | 1974 |
The organic brain syndrome.
Topics: Alcoholic Intoxication; Attention; Chlordiazepoxide; Delirium; Haloperidol; Humans; Hydrocephalus; M | 1974 |
Significance of withdrawal jumping response in predicting physical dependence in mice.
Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip | 1973 |
An animal model for testing effects of drugs on alcohol withdrawal reactions.
Topics: Animals; Ataxia; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Ethanol; Humans; Male; M | 1972 |
Prevention of alcohol withdrawal seizures: the roles of diphenylhydantoin and chlordiazepoxide.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Neurons; Phe | 1973 |
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice].
Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight | 1973 |
Grand-mal seizures in two patients in acute alcohol withdrawal after treatment with hydroxyzine.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Epilepsy, Tonic-Clonic; Humans; Hydroxyzine; Injectio | 1967 |
Experience with chlormethiazole.
Topics: Chlordiazepoxide; Chlormethiazole; Humans; Hypnotics and Sedatives; Male; Psychoses, Alcoholic; Subs | 1966 |
Diazepam, nitrazepam and the N.H.S.
Topics: Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
The alcohol withdrawal syndrome: theory and practice.
Topics: Alcoholism; Chlordiazepoxide; Humans; Psychoses, Alcoholic; Substance Withdrawal Syndrome | 1970 |
A new method for treatment of barbiturate dependence.
Topics: Barbiturates; Chlordiazepoxide; Diazepam; Heroin; Humans; Meprobamate; Pentobarbital; Phenobarbital; | 1970 |
The treatment of acute alcohol intoxication and withdrawal.
Topics: Acute Disease; Adult; Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Chlormethiazole; Ethanol | 1970 |
Optimal therapy of the alcohol withdrawal state.
Topics: Adult; Chlordiazepoxide; Chlorpromazine; Electrolytes; Female; Humans; Hydroxyzine; Male; Paraldehyd | 1970 |
[Drug dependence and addiction among patients of the Vienna Psychiatric-Neurological University Hospital with special reference to psychotropic drugs].
Topics: Analgesics; Antidepressive Agents; Antitussive Agents; Austria; Barbiturates; Cannabis; Chlordiazepo | 1970 |
[Acute chlordiazepoxide poisoning in a drug addict, followed by withdrawal syndrome].
Topics: Adult; Chlordiazepoxide; Humans; Male; Morphine Dependence; Substance Withdrawal Syndrome | 1968 |
A comparison of three approaches to alcohol-withdrawal states.
Topics: Adult; Alcoholism; Chloral Hydrate; Chlordiazepoxide; Chlorpromazine; Female; Humans; Male; Paraldeh | 1969 |
[Therapy of anxiety, mental anguish and sleeplessness. 4. Drug abuse and accidents].
Topics: Accidents, Traffic; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Drug Synergism; Ethan | 1969 |
[Therapy of anxiety, mental anguish and sleeplessness. 5. Abuse of diazepam?].
Topics: Chlordiazepoxide; Diazepam; Humans; Meprobamate; Substance Withdrawal Syndrome; Substance-Related Di | 1969 |
Chlordiazepoxide (librium) compared with meprobamate and promazine (prozine) for the withdrawal symptoms of acute alcoholism.
Topics: Alcoholic Intoxication; Alcoholism; Chlordiazepoxide; Humans; Male; Meprobamate; Promazine; Substanc | 1965 |
Suspected dependence on chlordiazepoxide hydrochloride (Librium).
Topics: Adult; Chlordiazepoxide; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1966 |
Management of acute alcohol withdrawal symptoms.
Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Humans; Substance Withdrawal Syndrome | 1966 |