chlordiazepoxide has been researched along with Seizures in 115 studies
Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures." | 7.67 | Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987) |
| "The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures." | 7.66 | Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, L, 1982) |
| "70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures." | 7.66 | Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures. ( Anisman, H; Hill, DA; Ings, R; Pappas, BA, 1983) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 7.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 5.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| "The running was followed by seizures and sometimes death." | 5.29 | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. ( Fuller, DJ; Gensler, HL; Gerner, EW; Gerrish, KE, 1993) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| "6 mg/kg pentylenetetrazole and exhibited an increase in susceptibility to clonic seizures." | 3.68 | State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats. ( Gauvin, DV; Goulden, KL; Holloway, FA, 1993) |
| "The authors report a case of a 55-year-old man undergoing a triazolam withdrawal syndrome that was recognized and treated with high doses of benzodiazepines, but the patient nevertheless developed seizures." | 3.67 | Seizures following triazolam withdrawal despite benzodiazepine treatment. ( Pawluczyk, S; Schneider, LS; Syapin, PJ, 1987) |
| "The anticonvulsant effects of clonazepam, nitrazepam and chlordiazepoxide alone, or combined with diphenylhydantoin, were studied on pentylenetetrazol- and bicuculline-induced seizures." | 3.66 | Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, L, 1982) |
| "70 GHz pulsed microwave radiation up to 20 mW/cm2 on pentylenetetrazol-induced seizures or on the efficacy of chlordiazepoxide for counteracting such seizures." | 3.66 | Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures. ( Anisman, H; Hill, DA; Ings, R; Pappas, BA, 1983) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 3.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| ", the maximal electroshock test (MES), and seizures induced by pentylenetetrazol, strychnine and nicotine." | 3.65 | Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs. ( Barry, H; Sofia, RD; Solomon, TA, 1976) |
| " Bases for selection include: (1) availability of other than oral dosage forms; (2) differences in additive effect with alcohol in producing central nervous system depression; (3) differences in anticonvulsant effect; and (4) differences in duration of effect in the body (ie, half-life)." | 2.36 | Selection among benzodiazepines for alcohol withdrawal. ( Keeler, MH; Miller, WC, 1977) |
| "BHF177 exhibited pro-convulsion properties only in mice, but not in rats, indicating that this effect may be species-specific." | 1.39 | Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice. ( Cates-Gatto, C; Finn, MG; Kaczanowska, K; Li, X; Markou, A; Risbrough, VB; Roberts, AJ, 2013) |
| " Usually, the slope of the dose-response lines for RWJ-51204 was more shallow than the full agonist anxiolytics but steeper than partial agonists in efficacy tests but typically shallow in tests for central nervous system side effects." | 1.31 | 5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic. ( Carter, AR; Cheo-Isaacs, CT; Crooke, JJ; DeLuca, S; DeVine, A; Dubinsky, B; Hochman, C; Jordan, AD; Reitz, AB; Rosenthal, DI; Shank, RP; Vaidya, AH, 2002) |
| "The running was followed by seizures and sometimes death." | 1.29 | Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide. ( Fuller, DJ; Gensler, HL; Gerner, EW; Gerrish, KE, 1993) |
| "Zaleplon was more potent than zolpidem but the maximal effect of zolpidem for increasing the latency to isoniazid-induced convulsions was greater than that of zaleplon." | 1.29 | Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem. ( Morel, E; Perrault, G; Sanger, DJ, 1996) |
| "Most electrically induced seizures involve forebrain structures, such as the amygdala or frontal cortex, but the following studies characterized a specific anatomic site in the inferior colliculus which generated seizure-like behavior after a single, low current electrical stimulation." | 1.27 | Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? ( Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ, 1984) |
| "Pretreatment with phenytoin, which is thought to bind to the inactivation gates of sodium, had no effect on the effects produced by lindane or kainic acid." | 1.27 | The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity. ( McLamb, RL; Shaw, S; Tilson, HA, 1987) |
| "In these tests latency to convulsions and lethality associated with electroshock were more sensitive to THC." | 1.26 | Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice. ( Barry, H; Sofia, RD, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 105 (91.30) | 18.7374 |
| 1990's | 5 (4.35) | 18.2507 |
| 2000's | 4 (3.48) | 29.6817 |
| 2010's | 1 (0.87) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moffett, RB | 1 |
| Kamdar, BV | 1 |
| Von Voigtlander, PF | 1 |
| Tomczuk, BE | 1 |
| Taylor, CR | 1 |
| Moses, LM | 1 |
| Sutherland, DB | 1 |
| Lo, YS | 1 |
| Johnson, DN | 1 |
| Kinnier, WB | 1 |
| Kilpatrick, BF | 1 |
| Li, X | 2 |
| Risbrough, VB | 1 |
| Cates-Gatto, C | 1 |
| Kaczanowska, K | 1 |
| Finn, MG | 1 |
| Roberts, AJ | 1 |
| Markou, A | 1 |
| Dubinsky, B | 2 |
| Vaidya, AH | 1 |
| Rosenthal, DI | 1 |
| Hochman, C | 1 |
| Crooke, JJ | 1 |
| DeLuca, S | 1 |
| DeVine, A | 1 |
| Cheo-Isaacs, CT | 1 |
| Carter, AR | 1 |
| Jordan, AD | 1 |
| Reitz, AB | 1 |
| Shank, RP | 1 |
| BARSA, JA | 2 |
| SAUNDERS, JC | 2 |
| MERLIS, S | 1 |
| TURNER, WJ | 1 |
| HALPERN, S | 1 |
| YOSHIDA, Z | 1 |
| MAKOTOI, T | 1 |
| ARMOUR, PS | 1 |
| ESPINOSA, J | 1 |
| BOGANI, E | 1 |
| GOLDMAN, D | 1 |
| SCHYNOLL, G | 1 |
| OKUDA, O | 1 |
| SHINOHARA, S | 1 |
| MIZUNO, T | 1 |
| JONGMANS, JW | 1 |
| SOULAYROL, R | 1 |
| LOB, H | 1 |
| POINSO, Y | 1 |
| MARKHAM, CH | 1 |
| FROMMEL, E | 1 |
| SEYDOUX, J | 1 |
| EIDELBERG, E | 1 |
| NEER, HM | 1 |
| MILLER, MK | 1 |
| SCHAERER, K | 1 |
| ROSENSTEIN, IN | 1 |
| MADAN, BR | 1 |
| SHARMA, JD | 1 |
| VYAS, DS | 1 |
| ROLDAN, E | 2 |
| ESCOBAR, A | 1 |
| GILBERT, JE | 1 |
| Arban, R | 1 |
| Maraia, G | 1 |
| Brackenborough, K | 1 |
| Winyard, L | 1 |
| Wilson, A | 1 |
| Gerrard, P | 1 |
| Large, C | 1 |
| Alt, A | 1 |
| Weiss, B | 1 |
| Ogden, AM | 1 |
| Gleason, SD | 1 |
| Calligaro, DO | 1 |
| Bleakman, D | 1 |
| Witkin, JM | 1 |
| Macko, E | 1 |
| Wilfon, G | 1 |
| Greene, L | 1 |
| Bender, AD | 1 |
| Tedeschi, RE | 1 |
| Golbert, TM | 1 |
| Sanz, CJ | 1 |
| Rose, HD | 1 |
| Leitschuh, TH | 1 |
| Le Fur, G | 1 |
| Czuczwar, SJ | 2 |
| Turski, L | 1 |
| Kleinrok, Z | 2 |
| Pappas, BA | 2 |
| Anisman, H | 1 |
| Ings, R | 1 |
| Hill, DA | 1 |
| Frye, GD | 2 |
| McCown, TJ | 2 |
| Breese, GR | 2 |
| Abbracchio, MP | 1 |
| Balduini, W | 1 |
| Coen, E | 1 |
| Lombardelli, G | 1 |
| Peruzzi, G | 1 |
| Cattabeni, F | 1 |
| File, SE | 1 |
| Tucker, JC | 1 |
| Shemer, A | 1 |
| Tykocinski, O | 1 |
| Feldon, J | 2 |
| Greenwood, RS | 1 |
| Bailey, DN | 1 |
| Walsh, P | 1 |
| Chmielewska, B | 1 |
| Kozicka, M | 1 |
| Chan, AW | 1 |
| Leong, FW | 1 |
| Schanley, DL | 1 |
| Howe, SM | 1 |
| Taukulis, HK | 1 |
| Gauvin, DV | 1 |
| Goulden, KL | 1 |
| Holloway, FA | 1 |
| Gerrish, KE | 1 |
| Fuller, DJ | 1 |
| Gerner, EW | 1 |
| Gensler, HL | 1 |
| Sanger, DJ | 1 |
| Morel, E | 1 |
| Perrault, G | 1 |
| Wang, HH | 1 |
| Liao, JF | 1 |
| Chen, CF | 1 |
| Smith, RF | 1 |
| Ritson, EB | 1 |
| Costa, E | 2 |
| Guidotti, A | 1 |
| Mao, CC | 1 |
| Suria, A | 1 |
| Folco, GC | 1 |
| Longiave, D | 1 |
| Berti, F | 1 |
| Fumagalli, R | 1 |
| Paoletti, R | 1 |
| Vol'f, MSh | 1 |
| Menken, M | 1 |
| Buonpane, N | 1 |
| Perly, R | 1 |
| Keeler, MH | 1 |
| Miller, WC | 1 |
| Robertson, CC | 1 |
| Sellers, EM | 1 |
| Sofia, RD | 2 |
| Barry, H | 2 |
| Blum, K | 1 |
| Eubanks, JD | 1 |
| Wallace, JE | 1 |
| Hamilton, H | 1 |
| Fernándex-Tomé, MP | 1 |
| Fuentes, JA | 1 |
| Madroñero, R | 1 |
| del Río, J | 1 |
| Solomon, TA | 1 |
| Curtis, DR | 1 |
| Game, CJ | 1 |
| Lodge, D | 1 |
| Tilson, HA | 1 |
| Shaw, S | 1 |
| McLamb, RL | 1 |
| Schneider, LS | 1 |
| Syapin, PJ | 1 |
| Pawluczyk, S | 1 |
| Gavish, M | 1 |
| Avnimelech-Gigus, N | 1 |
| Myslobodsky, M | 1 |
| Boisse, N | 1 |
| Samoriski, G | 1 |
| Guarino, J | 1 |
| Mitchell, TR | 1 |
| Helwig, H | 1 |
| Kaim, SC | 3 |
| Greenblatt, DJ | 1 |
| Shader, RI | 1 |
| Heilman, RD | 1 |
| Bauer, EW | 1 |
| Da Vanzo, JP | 1 |
| Ferrini, R | 1 |
| Miragoli, G | 1 |
| Taccardi, B | 1 |
| Baltzer, V | 1 |
| Bein, HJ | 1 |
| Browne, TR | 1 |
| Penry, JK | 1 |
| Boissier, JR | 1 |
| Simon, P | 1 |
| Villeneuve, A | 1 |
| Larousse, C | 1 |
| Millichap, JG | 1 |
| Chusid, JG | 2 |
| Kopeloff, LM | 2 |
| Chiba, S | 1 |
| Nagawa, Y | 1 |
| Yui, T | 1 |
| Norton, PR | 1 |
| Kita, T | 1 |
| Hata, T | 1 |
| Murakami, T | 1 |
| Walser, A | 1 |
| Fryer, RI | 1 |
| Sampliner, R | 1 |
| Iber, FL | 1 |
| Goldstein, DB | 1 |
| Reiter, RJ | 2 |
| Morgan, WW | 1 |
| Talbot, JA | 2 |
| Blask, DE | 1 |
| Barnett, MP | 1 |
| Doteuchi, M | 1 |
| Goldberg, ME | 1 |
| Sledge, K | 1 |
| Robichaud, RC | 2 |
| Rothstein, E | 1 |
| Klett, CJ | 2 |
| Rothfeld, B | 1 |
| Hollister, LE | 1 |
| Caffey, EM | 1 |
| Zbinden, G | 1 |
| Randall, LO | 1 |
| Takagi, H | 1 |
| Kamioka, T | 1 |
| Kobayashi, S | 1 |
| Suzuki, Y | 1 |
| Tachikawa, R | 1 |
| Gylys, JA | 1 |
| Sledge, KL | 1 |
| Hillyard, IW | 1 |
| Brune, F | 1 |
| Busch, H | 1 |
| Weissman, A | 1 |
| Koe, BK | 1 |
| Sansoy, OM | 1 |
| Whorton, D | 1 |
| Wardell, JR | 1 |
| Staples, RG | 1 |
| Yoshino, T | 1 |
| Christmas, AJ | 1 |
| Maxwell, DR | 1 |
| Weinreich, D | 1 |
| Clark, LD | 1 |
| Florescu, D | 1 |
| Tudor, S | 1 |
| Hoholova, L | 1 |
| Volanschi, D | 1 |
| Gogolák, G | 1 |
| Kolb, R | 1 |
| Stumpf, C | 1 |
| Wilson, DE | 1 |
| Chernov, HI | 1 |
| Bernard, PS | 1 |
| Partyka, DA | 1 |
| Barbaz, BS | 1 |
| DeStevens, G | 1 |
| Radil-Weiss, T | 2 |
| Chocholová, L | 2 |
| Clark, R | 1 |
| Lynes, TE | 1 |
| Price, WA | 1 |
| Smith, DH | 1 |
| Woodward, JK | 1 |
| Marvel, JP | 1 |
| Vernier, VG | 1 |
| de Carolis, AS | 1 |
| Longo, VG | 1 |
| Schreiber, MM | 1 |
| McGregor, JG | 1 |
| Straw, RN | 1 |
| Jindal, MN | 1 |
| Doctor, RB | 1 |
| Kelkar, VV | 1 |
| Choksey, HK | 1 |
| Nishie, K | 1 |
| Waiss, AC | 1 |
| Keyl, AC | 1 |
| Pifferi, G | 1 |
| Consonni, P | 1 |
| Banfi, S | 1 |
| Diena, A | 1 |
| Gupta, SK | 1 |
| Kulkarni, HJ | 1 |
| Arrigo, A | 1 |
| Jann, G | 1 |
| Tonali, P | 1 |
| Winter, D | 1 |
| Sauvard, S | 1 |
| Lieberman, M | 1 |
| Pollikoff, R | 1 |
| Pascale, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for chlordiazepoxide and Seizures
| Article | Year |
|---|---|
New concepts on the mechanism of action of benzodiazepines.
Topics: Animals; Benzodiazepines; Cerebellum; Chlordiazepoxide; Cyclic AMP; Diazepam; gamma-Aminobutyric Aci | 1975 |
Selection among benzodiazepines for alcohol withdrawal.
Topics: Administration, Oral; Benzodiazepines; Central Nervous System; Chlordiazepoxide; Clorazepate Dipotas | 1977 |
[Psychopharmacological agents in children].
Topics: Acetylcholine; Aminobutyrates; Antipsychotic Agents; Cerebral Palsy; Child; Chlordiazepoxide; Diazep | 1973 |
Drug therapy. Benzodiazepines (second of two parts).
Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet | 1974 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
Pharmacology of benzodiazepines: laboratory and clinical correlations.
Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn | 1967 |
7 trials available for chlordiazepoxide and Seizures
| Article | Year |
|---|---|
Comparative evaluation of treatments of alcohol withdrawal syndromes.
Topics: Alcoholism; Chloral Hydrate; Chlordiazepoxide; Drug Synergism; Ethanol; Fever; Humans; Male; Middle | 1967 |
Prevention of delirium tremens: use of phenothiazines versus drugs cross-dependent with alcohol.
Topics: Antipsychotic Agents; Biogenic Amines; Brain Chemistry; Chlordiazepoxide; Chlorpromazine; Drug Toler | 1974 |
Diphenylhydantoin control of alcohol withdrawal seizures. Results of a controlled study.
Topics: Administration, Oral; Alcoholism; Chlordiazepoxide; Clinical Trials as Topic; Drug Evaluation; Elect | 1974 |
Treatment of the acute alcohol withdrawal state: a comparison of four drugs.
Topics: Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Humans; Hydroxyzine; Middle Aged; Placeb | 1969 |
Evaluating changes in symptoms during acute alcohol withdrawal.
Topics: Affect; Alcoholism; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Hydr | 1971 |
Treatment of alcohol withdrawal syndromes.
Topics: Chloral Hydrate; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Drug Synergism; Ethanol; Huma | 1971 |
Chlordiazepoxide hydrochloride in treatment of convulsive disorders. A three-year retrospective study.
Topics: Adolescent; Adult; Anticonvulsants; Chlordiazepoxide; Clinical Trials as Topic; Epilepsy; Female; Hu | 1966 |
102 other studies available for chlordiazepoxide and Seizures
| Article | Year |
|---|---|
Central nervous system depressants. 13. s-Triazolo-1,5-benzodiazepin-5-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Depression, Chemical; Male; Mice; Nicotine; Pent | 1976 |
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cereb | 1991 |
Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior, learning, and memory in mice.
Topics: Animals; Anxiety; Baclofen; Chlordiazepoxide; Dose-Response Relationship, Drug; GABA-B Receptor Agon | 2013 |
5-ethoxymethyl-7-fluoro-3-oxo-1,2,3,5-tetrahydrobenzo[4,5]imidazo[1,2a]pyridine-4-N-(2-fluorophenyl)carboxamide (RWJ-51204), a new nonbenzodiazepine anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Central Nervous System Depressants; Chlordiazepoxide | 2002 |
Chlordiazepoxide in the treatment of psychotics with convulsive disorders.
Topics: Chlordiazepoxide; Mental Disorders; Psychosurgery; Psychotic Disorders; Seizures; Tranquilizing Agen | 1962 |
Chlordiazepoxide as adjunctive therapy in convulsive disorders.
Topics: Chlordiazepoxide; Combined Modality Therapy; Epilepsy; Humans; Seizures | 1962 |
[On the anti-convulsion action of chlordiazepoxide].
Topics: Chlordiazepoxide; Seizures; Tranquilizing Agents | 1962 |
MANAGEMENT OF ACUTE ALCOHOL BARBITURATE WITHDRAWAL STATES.
Topics: Alcoholism; Alcohols; Barbiturates; Chlordiazepoxide; Coma; Humans; Psychoses, Alcoholic; Psychotic | 1963 |
[EPILEPTIC STATES AND THEIR CONTROL WITH INJECTABLE LIBRIUM].
Topics: Barbiturates; Chlordiazepoxide; Epilepsy; Epilepsy, Tonic-Clonic; Injections, Intravenous; Paraldehy | 1963 |
THE EFFECT OF CHLORDIAZEPOXIDE ON CONVULSIVE DISORDER.
Topics: Alcoholism; Anticonvulsants; Brain Diseases; Chlordiazepoxide; Electroencephalography; Epilepsy; Hyd | 1964 |
COMPARATIVE STUDY OF CHLORDIAZEPOXIDE AND DIAZEPAM.
Topics: Cerebral Palsy; Chlordiazepoxide; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Int | 1964 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
[DIAGNOSIS AND THERAPY OF CONVULSIVE DISEASES IN CHILDHOOD].
Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Amino Acids; Barbiturates; Brain Diseases; C | 1964 |
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox | 1964 |
[TRIAL OF TREATMENT OF PSYCHO-AFFECTIVE DISORDERS OF EPILEPTIC AND NON-EPILEPTIC CHILDREN WITH CHLORDIAZEPOXIDE OR "LIBRIUM"].
Topics: Adolescent; Child; Child Behavior Disorders; Chlordiazepoxide; Epilepsy; Humans; Mood Disorders; Sei | 1964 |
THE TREATMENT OF MYOCLONIC SEIZURES OF INFANCY AND CHILDHOOD WITH LA-1.
Topics: Adolescent; Child; Chlordiazepoxide; Drug Therapy; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absenc | 1964 |
STUDY OF THE EFFECTS OF MORPHINE AND NALORPHINE.
Topics: Animals; Body Temperature Regulation; Chlordiazepoxide; Chlorpromazine; Electroshock; Ether; Guinea | 1964 |
ANTICONVULSANT PROPERTIES OF SOME BENZODIAZEPINE DERIVATIVES. POSSIBLE USE AGAINST PSYCHOMOTOR SEIZURES.
Topics: Amygdala; Anticonvulsants; Cats; Caudate Nucleus; Cerebral Cortex; Chlordiazepoxide; Cocaine; Diazep | 1965 |
[TOXICITY STUDIES WITH AMITRIPTYLINE. THERAPEUTIC GUIDE LINES FROM EXPERIMENTAL STUDIES].
Topics: Amitriptyline; Chlordiazepoxide; Dogs; Electrocardiography; Mice; Parasympathomimetics; Pharmacology | 1965 |
A new psychosedative (librium) as an anticonvulsant in grand mal type convulsive seizures.
Topics: Anticonvulsants; Chlordiazepoxide; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Seizures | 1960 |
Some neuropharmacological actions of Librium.
Topics: Chlordiazepoxide; Humans; Neuropharmacology; Seizures; Sleep; Tranquilizing Agents | 1962 |
[Control of convulsive activity and the effects on afferent transmission produced by methaminodiazepoxide. Experimental study in the cat].
Topics: Animals; Brain Stem; Cats; Chlordiazepoxide; Felis; Seizures; Tranquilizing Agents | 1961 |
Relief of eclamptic convulsions with chlordiazepoxide.
Topics: Chlordiazepoxide; Eclampsia; Female; Pregnancy; Seizures; Tranquilizing Agents | 1961 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders.
Topics: Animals; Anti-Anxiety Agents; Carboxylic Acids; Cells, Cultured; Chlordiazepoxide; Conditioning, Ope | 2006 |
Pharmacological properties of the isopropyl ester of o-sulfamoyl-benzoic acid.
Topics: Animals; Behavior, Animal; Benzoates; Carbamates; Carisoprodol; Chlordiazepoxide; Chlormezanone; Chl | 1967 |
[Anxiety receptors: new pharmacological approach (author's transl)].
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Binding, Competitive; Brain; Chlordiazepoxide; Chlo | 1982 |
Effects of combined treatment with diphenylhydantoin and different benzodiazepines on pentylenetetrazol- and bicuculline-induced seizures in mice.
Topics: Animals; Anti-Anxiety Agents; Bicuculline; Chlordiazepoxide; Clonazepam; Dose-Response Relationship, | 1982 |
Acute exposure to pulsed microwaves affects neither pentylenetetrazol seizures in the rat nor chlordiazepoxide protection against such seizures.
Topics: Animals; Body Temperature; Chlordiazepoxide; Dose-Response Relationship, Drug; Dose-Response Relatio | 1983 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea | 1983 |
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid; | 1983 |
Chronic neonatal treatment with CGS 8216: effects on the behaviour of adolescent rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Benzodiazepinones; Brain; Chlordiazepoxide; Dose-Respon | 1984 |
Long term effects of chronic chlordiazepoxide (CDP) administration.
Topics: Animals; Behavior, Animal; Chlordiazepoxide; Electroshock; Extinction, Psychological; Male; Punishme | 1984 |
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Ma | 1984 |
Blood concentrations and clinical findings following overdose of chlordiazepoxide alone and chlordiazepoxide plus ethanol.
Topics: Adolescent; Adult; Alcoholism; Blood Pressure; Chlordiazepoxide; Consciousness; Drug Interactions; F | 1984 |
Behavioral comparison of pentylenetetrazol, clonidine, chlordiazepoxide and diazepam in infant rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Chlordiazepoxide; Clonidine; Diazepam; Mot | 1983 |
Effect of combined treatment of diphenylhydantoin with clonazepam and chlordiazepoxide on the threshold for maximal electroconvulsions in mice.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Chlordiazepoxide; Clonazepam; Drug Interactions; Electr | 1983 |
Alcohol withdrawal reactions after chronic intake of chlordiazepoxide and ethanol.
Topics: Alcoholism; Animals; Body Temperature; Chlordiazepoxide; Diet; Drug Interactions; Ethanol; Half-Life | 1981 |
Conditional attenuation of the antipentylenetetrazol activity of chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Chlordiazepoxide; Chlorpromazine; Conditioning, Operant; | 1993 |
State-dependent stimulus control: cueing attributes of ethanol "hangover" in rats.
Topics: Animals; Arousal; Association Learning; Avoidance Learning; Chlordiazepoxide; Conditioning, Classica | 1993 |
Inhibition of DFMO-induced audiogenic seizures by chlordiazepoxide.
Topics: Acoustic Stimulation; Animals; Brain; Chlordiazepoxide; Eflornithine; Female; gamma-Aminobutyric Aci | 1993 |
Comparison of the pharmacological profiles of the hypnotic drugs, zaleplon and zolpidem.
Topics: Acetamides; Analysis of Variance; Animals; Chlordiazepoxide; Convulsants; Discrimination Learning; E | 1996 |
Anticonvulsant effect of water extract of Scutellariae radix in mice.
Topics: Animals; Anticonvulsants; Binding Sites; Cerebral Cortex; Chlordiazepoxide; Convulsants; Electroshoc | 2000 |
Relative effectiveness of primidone (Mysoline) and diphenylhydantoin (Dilantin) in the management of sedative withdrawal seizures.
Topics: Antipsychotic Agents; Chlordiazepoxide; Drug Evaluation; Humans; Phenothiazines; Phenytoin; Primidon | 1976 |
Psychological medicine. Treatment of alcoholism.
Topics: Adolescent; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholics Anonymous; Alcoholism; | 1975 |
Prostaglandin E2 and central cyclic nucleotides.
Topics: Cerebellum; Cerebral Cortex; Chlordiazepoxide; Convulsants; Cyclic AMP; Cyclic GMP; Dose-Response Re | 1976 |
[Psychotropic drugs in the clinical picture of epilepsy (review of the literature)].
Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Anticonvulsants; Antipsychotic Agents; Carbamazepine; C | 1975 |
Alcoholic epilepsy. Effects of treatment on convulsions following the cessation of drinking.
Topics: Adult; Aged; Alcoholism; Chlordiazepoxide; Female; Humans; Male; Middle Aged; Seizures; Substance Wi | 1977 |
Alcohol intoxication and the alcohol withdrawal syndrome.
Topics: Alcoholic Intoxication; Alcoholism; Benzodiazepines; Chlordiazepoxide; Hallucinations; Humans; Pheny | 1978 |
Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice.
Topics: Animals; Body Weight; Chlordiazepoxide; Dronabinol; Electroshock; Glucose; Male; Mice; Phenobarbital | 1977 |
Enhancement of alcohol withdrawal convulsions in mice by haloperidol.
Topics: Animals; Chlordiazepoxide; Ethanol; Haloperidol; Humans; Mice; Seizures; Substance Withdrawal Syndro | 1976 |
Pharmacological properties of 6,7-tetramethylene-5-phenyl-1,2-dihydro-3H-thieno[2,3-e](1,4)-diazepin-2-one (QM-6008, thiadipone), a new psychotropic drug.
Topics: Aggression; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepinones; Cats; | 1975 |
Anticonvulsant activity of delta9-tetrahydrocannabinol compared with three other drugs.
Topics: Animals; Anticonvulsants; Cannabis; Chlordiazepoxide; Dronabinol; Electroshock; Male; Mice; Nicotine | 1976 |
Benzodiazepines and central glycine receptors.
Topics: Action Potentials; Animals; Bicuculline; Cats; Chlordiazepoxide; Diazepam; Glycine; Mice; Receptors, | 1976 |
The effects of lindane, DDT, and chlordecone on avoidance responding and seizure activity.
Topics: Animals; Avoidance Learning; Chlordecone; Chlordiazepoxide; DDT; Dose-Response Relationship, Drug; H | 1987 |
Seizures following triazolam withdrawal despite benzodiazepine treatment.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Recep | 1987 |
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa | 1985 |
Flurothyl seizure thresholds associated with acute and chronic chlordiazepoxide dependence and withdrawal.
Topics: Animals; Chlordiazepoxide; Dose-Response Relationship, Drug; Flumazenil; Flurothyl; Male; Rats; Rats | 1988 |
Alcohol withdrawal.
Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Psychoses, Alcoh | 1988 |
Pharmacologic studies with triflubazam (ORF 8063): a new psychotherapeutic agent.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Appetite Depressants; Behavi | 1974 |
Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.
Topics: Aggression; Amphetamine; Animals; Anti-Anxiety Agents; Avoidance Learning; Carbamates; Chlordiazepox | 1974 |
Pharmacological investigations with benzoctamine (Tacitin), a new psycho-active agent.
Topics: Adjuvants, Anesthesia; Aggression; Animals; Anthracenes; Cats; Central Nervous System; Chlordiazepox | 1973 |
Flurothyl in mice: seizure, post-convulsive behavior, and interactions with psychotropic drugs.
Topics: Amphetamine; Animals; Atropine; Behavior, Animal; Biperiden; Caffeine; Catalepsy; Central Nervous Sy | 1968 |
Drugs in management of hyperkinetic and perceptually handicapped children.
Topics: Anticonvulsants; Central Nervous System Stimulants; Child; Child, Preschool; Chlordiazepoxide; Chlor | 1968 |
Use of chronic irritative foci in laboratory evaluation of antiepileptic drugs.
Topics: Aluminum; Aminobutyrates; Animals; Bemegride; Central Nervous System Stimulants; Chlordiazepoxide; C | 1969 |
[Pharmacological studies on 2-methyl-4-amino-6-methoxy-s-triazine (CV399); with special reference to its central effects].
Topics: Amphetamine; Analgesics; Animals; Avoidance Learning; Behavior, Animal; Blood Pressure; Body Tempera | 1970 |
The effects of drugs on barbiturate withdrawal convulsions in the rat.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Ethanol; Ethosuximide; Female; Humans; Hydr | 1970 |
[Introduction of mass psychology in animals to pharmacology. 6. Mutural relation in simultaneity convulsion and non-convulsin in E1-mice].
Topics: Amphetamine; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Camphor; Central Nervous Sy | 1970 |
Quinazolines and 1,4-benzodiazepines. 69. 1-Vinyl-1,4-benzodiazepin-2-ones and 1-vinylquinazolin-2(1H)-ones.
Topics: Animals; Benzodiazepinones; Central Nervous System; Chlordiazepoxide; Depression, Chemical; Diazepam | 1974 |
An animal model for testing effects of drugs on alcohol withdrawal reactions.
Topics: Animals; Ataxia; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Ethanol; Humans; Male; M | 1972 |
Seizures in rats induced by pinealectomy: influence of diazepam, chlordiazepoxide, diphenylhydantoin and pineal substances.
Topics: Animals; Calcium; Chlordiazepoxide; Diazepam; Gluconates; Indoles; Male; Melatonin; Parathyroid Glan | 1973 |
Nature and the time course of seizures associated with surgical removal of the pineal gland from parathyroidectomized rats.
Topics: Animals; Chlordiazepoxide; Chlorpromazine; Diazepam; Haloperidol; Male; Parathyroid Glands; Phenytoi | 1973 |
Chlorpromazine contraindicated in delirium tremens.
Topics: Chlordiazepoxide; Chlorpromazine; Cholestasis; Diazepam; Humans; Psychoses, Alcoholic; Seizures | 1973 |
Pentylenetetrazol convulsions and brain catecholamine turnover rate in rats and mice receiving diphenylhydantoin or benzodiazepines.
Topics: Animals; Benzazepines; Body Temperature; Brain; Brain Chemistry; Catecholamines; Cerebellum; Chlordi | 1973 |
The influence of SKF-525A on the acute pharmacological properties of chlordiazepoxide.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Brain; Chlordiazepoxide; Conflict, Psycho | 1973 |
Prevention of alcohol withdrawal seizures: the roles of diphenylhydantoin and chlordiazepoxide.
Topics: Alcoholism; Anticonvulsants; Chlordiazepoxide; Electroencephalography; Ethanol; Humans; Neurons; Phe | 1973 |
Diazepam as anticonvulsant in epileptic and normal monkeys.
Topics: Animals; Chlordiazepoxide; Diazepam; Electroencephalography; Haplorhini; Injections, Intramuscular; | 1967 |
[Pharmacological studies of oxazolazepam, a new psychotropic agent. I. Actions on the central nervous system, especially on the behavioral aspect].
Topics: Adaptation, Biological; Analgesics; Anesthesia; Animals; Anticonvulsants; Apomorphine; Avoidance Lea | 1970 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Dia | 1970 |
Anticonvulsive-sedative treatment of delirium alcoholicum.
Topics: Adult; Carbamazepine; Chlordiazepoxide; Chlormethiazole; Diazepam; Dibenzazepines; Drug Synergism; F | 1971 |
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxid | 1967 |
Librium and valium.
Topics: Alcoholism; Anxiety; Chlordiazepoxide; Diazepam; Humans; Mental Disorders; Seizures; Suicide | 1969 |
Animal studies comparing the neuropharmacological profile of a trifluoperazine HCl-amobarbital combination with that of the individual components.
Topics: Amobarbital; Animals; Central Nervous System; Chlordiazepoxide; Drug Synergism; Female; Hypnosis; Ma | 1969 |
[Action of diazepam on the spinal cord reflex, with special reference to dorsal root reflex].
Topics: Animals; Cats; Chlordiazepoxide; Denervation; Diazepam; Electric Stimulation; Evoked Potentials; Fem | 1969 |
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.
Topics: Aggression; Animals; Chlordiazepoxide; Diazepam; Electroshock; Exploratory Behavior; Humans; Locomot | 1970 |
Anticonvulsant drugs and self-stimulation rates in rats.
Topics: Acetazolamide; Animals; Chlordiazepoxide; Electrodes; Male; Meprobamate; Pentobarbital; Pentylenetet | 1970 |
[Action of several benzodiazepine derivatives (chlordiazepoxide, diazepam, nitrazepam) on audiogenic seizures in mice].
Topics: Animals; Benzazepines; Chlordiazepoxide; Diazepam; Mice; Seizures | 1970 |
[Experimental examinations on the convulsive effect of benzyl penicillin, ampicillin and oxacillin].
Topics: Ampicillin; Animals; Chlordiazepoxide; Diazepam; Electroencephalography; Oxacillin; Penicillin G; Ra | 1970 |
Neuropharmacological properties of Su17595A a chlorpromazine-like central nervous system depressant.
Topics: Animals; Blood Pressure; Brain Stem; Caffeine; Cats; Chlordiazepoxide; Chlorpromazine; Cocaine; Depr | 1971 |
Influence of chlordiazepoxide on paroxysmal EEG activity induced by hippocampal and-or thalamic cobalt foci.
Topics: Animals; Chlordiazepoxide; Cobalt; Electrodes; Electroencephalography; Gelatin; Hippocampus; Methods | 1971 |
The pharmacology and toxicology of midaflur.
Topics: Analgesics; Animals; Appetite; Avoidance Learning; Benzimidazoles; Body Temperature; Body Weight; Ca | 1971 |
Studies on the anticonvulsant properties of some benzodiazepines. (Chlordiazepoxide, diazepam, oxazepam).
Topics: Action Potentials; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Electroencephalography; Fem | 1967 |
Pseudolymphoma syndrome. A sensitivity to anticonvulsant drugs.
Topics: Biopsy; Blood Cell Count; Blood Chemical Analysis; Chlordiazepoxide; Drug Hypersensitivity; Female; | 1968 |
The effect of certain benzodaizepines on the threshold for pentylenetetrazol-induced seizures in the cat.
Topics: Animals; Benzazepines; Cats; Chlordiazepoxide; Diazepam; Pentylenetetrazole; Seizures; Time Factors | 1968 |
Certain aspects of pharmacological profiles of chlordiazepoxide and diazepam.
Topics: Analgesics; Animals; Benzazepines; Chlordiazepoxide; Diazepam; Drug Antagonism; Drug Synergism; Elec | 1968 |
Toxicity of methylimidazoles.
Topics: Animals; Anticonvulsants; Chickens; Chlordiazepoxide; Electroencephalography; Heart Rate; Imidazoles | 1969 |
2,3-benzoxazines. IX. Synthesis and central nervous system depressant activity of some 3,6- and 3,7-disubstituted 1H-3,4-dihydro-2,3-benzoxazines.
Topics: Analgesia; Animals; Aspirin; Ataxia; Barbiturates; Central Nervous System; Chlordiazepoxide; Chlorpr | 1969 |
Focal epileptoid EEG activity in rats in relationship to the level of vigilance.
Topics: Animals; Arousal; Chlordiazepoxide; Cobalt; Electroencephalography; Rats; Seizures; Sleep; Sleep Sta | 1969 |
Convulsant action of Ro-4-1778 and its modification by barbiturates and tranquillisers.
Topics: Analgesics; Animals; Chlordiazepoxide; Phenobarbital; Quinolines; Rats; Reserpine; Seizures | 1964 |
Some aspects of the action of valium and of librium on the electrical activity of the rabbit brain.
Topics: Animals; Anticonvulsants; Brain; Chlordiazepoxide; Diazepam; Electroconvulsive Therapy; Electroencep | 1965 |
[Contribution to the pharmacodynamic study of chlordiazepoxide].
Topics: Animals; Body Temperature; Chlordiazepoxide; Conditioning, Classical; Mice; Seizures | 1965 |
Effect of N-ethylisatin beta-thiosemicarbazone and anticonvulsant drugs on tonic convulsions in neurovaccinia-infected mice.
Topics: Animals; Anticonvulsants; Chlordiazepoxide; Mice; Seizures; Thiosemicarbazones; Vaccinia virus | 1966 |