Page last updated: 2024-10-24

chlordiazepoxide and Pregnancy

chlordiazepoxide has been researched along with Pregnancy in 105 studies

Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" Under conditions of such high aggression, the previously reported pro-aggressive action of a low (5 mg/kg) dosage of chlordiazepoxide (CDP) is hardly detectable."7.67Maternal aggression towards different sized male opponents: effect of chlordiazepoxide treatment of the mothers and d-amphetamine treatment of the intruders. ( Mos, J; Olivier, B; van Oorschot, R, 1987)
"Maternal weight gain was significantly reduced by THC but not by chlordiazepoxide."5.27Effects of delta-9-tetrahydrocannabinol, chlordiazepoxide (Librium), and their combination on pregnancy and offspring in mice [correction of rats]. ( Abel, EL; Tan, SE, 1987)
"The sensitivity of prenatally protein-malnourished rats to the amnestic properties of the benzodiazepine (BZ) receptor agonist, chlordiazepoxide (CDP), was studied in the male offspring of rats provided with a protein-deficient diet (6% casein) for 5 weeks prior to mating and throughout pregnancy."3.70Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition. ( Fiacco, TT; Galler, JR; Rosene, DL; Shultz, PL; Shumsky, JS; Tonkiss, J; Vincitore, M, 2000)
"Adult male and female offspring of rats injected daily with 10 mg/kg chlordiazepoxide during their pregnancy exhibited a facilitated acquisition of a two-way active avoidance response."3.67The effects of prenatal chlordiazepoxide administration on avoidance behavior and benzodiazepine receptor density in adult albino rats. ( Avnimelech-Gigus, N; Feldon, J; Gavish, M; Tanne, Z, 1986)
" Under conditions of such high aggression, the previously reported pro-aggressive action of a low (5 mg/kg) dosage of chlordiazepoxide (CDP) is hardly detectable."3.67Maternal aggression towards different sized male opponents: effect of chlordiazepoxide treatment of the mothers and d-amphetamine treatment of the intruders. ( Mos, J; Olivier, B; van Oorschot, R, 1987)
" We used a novel, potent, and selective orally bioavailable antagonist, LY2940094, to test the hypothesis that blockade of NOP receptors would induce antidepressant effects."2.82A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies. ( Barth, V; Browning, M; Dawson, GR; Harmer, CJ; Jackson, K; Kakar, R; Krikke-Workel, J; McCarthy, A; Mohs, R; Post, A; Smart, TS; Statnick, M; Wafford, K; Witkin, JM, 2016)
"Knowledge of the pharmacokinetic properties of the benzodiazepines is playing an increasingly important role in their use during pregnancy, labour and lactation."2.36Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. ( Kanto, JH, 1982)
"Three mothers of infants with holoprosencephaly consumed alcohol heavily in pregnancy."1.28Holoprosencephaly as a possible embryonic alcohol effect. ( Andrews, WL; Ronen, GM, 1991)
"Maternal weight gain was significantly reduced by THC but not by chlordiazepoxide."1.27Effects of delta-9-tetrahydrocannabinol, chlordiazepoxide (Librium), and their combination on pregnancy and offspring in mice [correction of rats]. ( Abel, EL; Tan, SE, 1987)
"Chlordiazepoxide HCl, a widely used tranquilizer, was evaluated for pre- and postnatal effects in rats by dosing orally on days 1--21 of gestation."1.26Effects of chlordiazepoxide on the pre- and postnatal development of rats. ( Buttar, HS, 1980)

Research

Studies (105)

TimeframeStudies, this research(%)All Research%
pre-199091 (86.67)18.7374
1990's5 (4.76)18.2507
2000's8 (7.62)29.6817
2010's1 (0.95)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Post, A1
Smart, TS1
Krikke-Workel, J1
Dawson, GR1
Harmer, CJ1
Browning, M1
Jackson, K1
Kakar, R1
Mohs, R1
Statnick, M1
Wafford, K1
McCarthy, A1
Barth, V1
Witkin, JM1
Shultz, PL2
Galler, JR4
Tonkiss, J3
Martínez-Lage, JF1
Almagro, MJ1
López Hernández, F1
Poza, M1
Iqbal, MM1
Aneja, A1
Fremont, WP1
CASTRO, A2
MUNOZ, JL1
PEREZ, M1
STUCKI, D2
GROSS, J2
JANTZEN, H1
FROEWIS, J1
BAUMGARTEN, K1
BEUTHE, D1
BERGER, M1
NEUWEILER, W1
REIFFENSTUHL, G1
WAGNER, H1
GUZMAN, E1
ROSAS, J1
PASCUAL, C1
MOSLER, KH3
DIFRANCESCO, G1
BEGHI, Q1
FROMHAGEN, C1
LAMOUREUX, G1
SOIVA, K1
CASTREN, O1
RUPONEN, S1
BACHAND, M1
DERY, L1
YALDIZ, A1
CAREDDU, G1
LECART, C1
CAVANAGH, D2
DAFTARY, SN1
PARMAR, H1
DOSHI, NS1
DUCKMAN, S1
SPINA, T1
ATTARDI, M1
MEYER, A1
MAIER, L1
BUCOVE, A1
REIFFENSTUBL, G1
MAYER, HG1
GILBERT, JE1
Källén, B1
Robert-Gnansia, E1
Lampe, WT1
Kanto, JH1
van der Kleijn, E2
Vree, TB1
Baars, AM1
Wijsman, R1
Edmunds, LC1
Knop, HJ1
Olive, G1
Rey, E1
Saito, H1
Kobayashi, H1
Takeno, S1
Sakai, T1
Panerai, AE1
Martini, A1
De Rosa, A1
Salerno, F1
Di Giulio, AM1
Mantegazza, P1
File, SE1
Tucker, JC1
Beyer, BK1
Guram, MS3
Geber, WF3
Rodriguez-Sierra, JF1
Howard, JL1
Pollard, GT1
Hendricks, SE1
Gill, TS2
Datta, S1
Alper, MH1
Bialik, RJ1
Pappas, BA1
Pusztay, W1
Buttar, HS1
Cirulli, F1
Santucci, D1
Laviola, G1
Alleva, E1
Levine, S2
Jaiswal, AK1
Bhattacharya, SK1
Shumsky, JS1
Fiacco, TT1
Vincitore, M2
Rosene, DL1
Luebke, J1
St John, J1
Trzcińska, M1
Shultz, P1
Maciag, CM1
Dent, G1
Gilligan, P1
He, L1
Dowling, K1
Ko, T1
Smith, MA1
Fox, KA1
Guerriero, FJ1
Crombie, DL1
Pinsent, RJ1
Fleming, DM1
Rumeau-Rouquette, C1
Goujard, J1
Huel, G1
Harris, RA1
Case, J1
Rao, KP1
Rao, MS1
Parke, DV1
Rise, A1
Rosenberg, JM1
Matsuyama, SS1
Jarvik, LF1
Hartz, SC1
Heinonen, OP1
Shapiro, S1
Siskind, V1
Slone, D1
Bennett, JS1
Leathwood, PD1
Bush, MS1
Mauron, J1
Athinarayanan, P1
Pierog, SH1
Nigam, SK1
Glass, L1
Kurishingal, H1
Palanza, P1
Brain, PF2
Pankaj, V1
Ronen, GM1
Andrews, WL1
Abel, EL1
Tan, SE1
Gavish, M2
Avnimelech-Gigus, N2
Feldon, J2
Myslobodsky, M1
Fioretti, P1
Melis, GB1
Gambacciani, M1
Galbani, P1
Ronca-Testoni, S1
Tanne, Z1
Mos, J1
Olivier, B1
van Oorschot, R1
Hiranoi, N1
Greenblatt, DJ1
Shader, RI1
Browne, TR1
Penry, JK1
McDougall, IR1
Greig, WR1
Bourgoin, S1
Faivre-Bauman, A1
Benda, P1
Glowinski, J1
Hamon, M1
Walker, BE1
Patterson, A1
Milkovich, L1
van den Berg, BJ1
Sarteschi, P1
Cassano, GB2
Placidi, GF2
Farkas, G2
Simionescu, S1
Bordeianu, A1
Stancu, C1
Daniel, B1
Pintilescu, V1
Mateescu-Cantuniari, A1
Stirrat, GM1
Edington, PT1
Berry, DJ1
Dundee, JW1
Haslett, WH1
Assemany, SR1
Muzzo, S1
Gardner, LI1
Pertyński, J1
Sysa, J1
Sokól, H1
Lipecki, L1
Decancq, HG1
Bosco, JR1
Townsend, EH1
Timonen, S1
Hagner, M1
Bolesch, J1
Owen, G1
Smith, TH1
Agersborg, HP1
Beretić, T1
Rossi, T1
Lean, TH2
Ratnam, SS2
Sivasamboo, R2
Mark, PM1
Hamel, J1
Bitnun, S1
Krecek, J1
Artner, J1
Albores, EA1
Todd, J1
Samaja, BA1
Frangipani, GC1
D'Aquino, P1

Reviews

9 reviews available for chlordiazepoxide and Pregnancy

ArticleYear
Effects of chlordiazepoxide (Librium) during pregnancy and lactation.
    Connecticut medicine, 2003, Volume: 67, Issue:5

    Topics: Anti-Anxiety Agents; Anxiety Disorders; Chlordiazepoxide; Dose-Response Relationship, Drug; Female;

2003
Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations.
    Drugs, 1982, Volume: 23, Issue:5

    Topics: Anti-Anxiety Agents; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female; Flunitrazepam; Hum

1982
[Benzodiazepines and pregnancy. Transplacental passage, labor and lactation].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Biotransformation; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Female;

1983
Anesthesia for cesarean section.
    Anesthesiology, 1980, Volume: 53, Issue:2

    Topics: Anesthesia, Epidural; Anesthesia, General; Anesthesia, Intravenous; Anesthesia, Spinal; Anesthetics;

1980
Cytogenetic effects of psychoactive drugs.
    Modern problems of pharmacopsychiatry, 1975, Volume: 10

    Topics: Adolescent; Adult; Aged; Animals; Cannabis; Child; Child, Preschool; Chlordiazepoxide; Chlorpromazin

1975
Drug therapy. Benzodiazepines (second of two parts).
    The New England journal of medicine, 1974, Dec-05, Volume: 291, Issue:23

    Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet

1974
Benzodiazepines in the treatment of epilepsy. A review.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec

1973
Pathogenesis and treatment of thyrotoxicosis.
    Scottish medical journal, 1971, Volume: 16, Issue:12

    Topics: Adult; Child; Chlordiazepoxide; Diazepam; Eye Manifestations; Female; Glucocorticoids; Graves Diseas

1971
The benzodiazepines. A review of their actions and uses relative to anaesthetic practice.
    British journal of anaesthesia, 1970, Volume: 42, Issue:3

    Topics: Amnesia; Anesthesia; Anesthesia, Intravenous; Anesthesia, Obstetrical; Anticonvulsants; Benzazepines

1970

Trials

6 trials available for chlordiazepoxide and Pregnancy

ArticleYear
A Selective Nociceptin Receptor Antagonist to Treat Depression: Evidence from Preclinical and Clinical Studies.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:7

    Topics: Adolescent; Adult; Aged; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Depression; Disease Models,

2016
Editorial: Delaying premature labour.
    Lancet (London, England), 1974, Oct-12, Volume: 2, Issue:7885

    Topics: Administration, Oral; Adrenergic beta-Agonists; Albuterol; Chlordiazepoxide; Clinical Trials as Topi

1974
Chlordiazepoxide in labor. Its effect on the newborn infant.
    The Journal of pediatrics, 1965, Volume: 67, Issue:5

    Topics: Chlordiazepoxide; Clinical Trials as Topic; Female; Humans; Infant, Newborn; Labor, Obstetric; Pregn

1965
Triavil and Etrafon.
    The Medical letter on drugs and therapeutics, 1966, Feb-25, Volume: 8, Issue:4

    Topics: Amitriptyline; Chlordiazepoxide; Clinical Trials as Topic; Depression; Diazepam; Female; Humans; Mep

1966
Benzodiazepines in an unselected obstetrical series.
    Annales chirurgiae et gynaecologiae Fenniae, 1966, Volume: 55, Issue:1

    Topics: Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Female; Humans; Labor, Obstetric; Pregnancy

1966
Librium for patients in labor.
    Obstetrics and gynecology, 1968, Volume: 32, Issue:2

    Topics: Adolescent; Adult; Chlordiazepoxide; Female; Fetus; Humans; Infant, Newborn; Labor, Obstetric; Mater

1968

Other Studies

90 other studies available for chlordiazepoxide and Pregnancy

ArticleYear
Prenatal protein malnutrition enhances stimulus control by CDP, but not a CDP/THIP combination in rats.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:4

    Topics: Animals; Chlordiazepoxide; Dietary Proteins; Discrimination, Psychological; Dose-Response Relationsh

2002
Aplasia cutis congenita of the scalp.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2002, Volume: 18, Issue:11

    Topics: Abnormalities, Drug-Induced; Chlordiazepoxide; Female; Humans; Infant, Newborn; Lorazepam; Male; Mat

2002
["Librax" in labor (Ro-4-4395). Preliminary note].
    Medicina, 1962, May-10, Volume: 42

    Topics: Chlordiazepoxide; Drug Combinations; Female; Humans; Labor, Obstetric; Muscle Relaxants, Central; Pr

1962
[Clinical study of Librium in the course of labor].
    Praxis, 1962, Jun-14, Volume: 51

    Topics: Anesthesia; Anesthesia, Obstetrical; Chlordiazepoxide; Female; Humans; Labor, Obstetric; Pregnancy;

1962
[Contribution to the use of muscle relaxants and psychosedatives in childbirth. Clinical trail of diazepine preparations and tocographic studies].
    Munchener medizinische Wochenschrift (1950), 1963, Jul-05, Volume: 105

    Topics: Adolescent; Chlordiazepoxide; Female; Humans; Labor, Obstetric; Parturition; Pregnancy; Tranquilizin

1963
[Comparative tocometric study on inhibition of labor with adrenosan and the Librium analog Ro-4-2807 in parturients].
    Geburtshilfe und Frauenheilkunde, 1962, Volume: 22

    Topics: Chlordiazepoxide; Female; Humans; Inorganic Chemicals; Labor, Obstetric; Pregnancy; Tranquilizing Ag

1962
["Librium" and "Valium" in pregnancy and labor].
    Wiener klinische Wochenschrift, 1963, Apr-12, Volume: 75

    Topics: Chlordiazepoxide; Diazepam; Female; Humans; Labor, Obstetric; Pre-Eclampsia; Pregnancy; Pregnancy Co

1963
[Experiences with the parenteral use of Librium in obstetrics and gynecology].
    Munchener medizinische Wochenschrift (1950), 1963, May-24, Volume: 105

    Topics: Chlordiazepoxide; Female; Gynecology; Humans; Obstetrics; Pregnancy

1963
[Relaxation and sedation of the human uterus].
    Geburtshilfe und Frauenheilkunde, 1962, Volume: 22

    Topics: Abortion, Induced; Chlordiazepoxide; Female; Humans; Labor, Obstetric; Placenta Previa; Pre-Eclampsi

1962
[Extended 1st aid in obstetrics].
    Wiener medizinische Wochenschrift (1946), 1963, Jan-26, Volume: 113

    Topics: Chlordiazepoxide; Female; Humans; Labor, Obstetric; Obstetrics; Pregnancy; Pregnancy Complications

1963
[Apropos of Librium during the course of labor].
    Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie, 1963, Volume: 155

    Topics: Chlordiazepoxide; Female; Humans; Labor, Obstetric; Pregnancy; Work

1963
[Significance of the limbic system in obstetrics].
    Medizinische Monatsschrift, 1962, Volume: 16

    Topics: Anesthesia; Anesthesia, Obstetrical; Anesthesiology; Chlordiazepoxide; Female; Humans; Limbic System

1962
[Methaminodiazepoxide in the first stage of labor].
    Medicina, 1963, May-25, Volume: 43

    Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Obstetrical; Chlordiazepoxide; Female; Humans; Labor,

1963
[ON THE MECHANICAL AND ELECTRICAL BEHAVIOF OR ANNULAR AND LONGITUDINAL MUSCLE FIBERS OF THE UTERUS IN RATS].
    Zeitschrift fur die gesamte experimentelle Medizin, 1963, Jun-21, Volume: 137

    Topics: Chlordiazepoxide; Electromyography; Female; Humans; Labor, Obstetric; Muscle, Smooth; Muscles; Pregn

1963
[USE OF LIBRIUM IN GESTOSIS. CLINICAL OBSERVATIONS].
    Annali di ostetricia e ginecologia, 1963, Volume: 85

    Topics: Chlordiazepoxide; Female; Humans; Pre-Eclampsia; Pregnancy

1963
[PSYCHIATRIC USE OF SOME PSYCHOPHARMACOLOGICAL DRUGS IN PREGNANCY].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1963, Jun-30, Volume: 87

    Topics: Chlordiazepoxide; Chlorpromazine; Fetus; Haloperidol; Imipramine; Isocarboxazid; Meprobamate; Nialam

1963
MANAGEMENT OF EMOTIONAL DISTURBANCES IN OBSTETRICAL AND GYNECOLOGICAL PATIENTS.
    American journal of obstetrics and gynecology, 1963, Sep-15, Volume: 87

    Topics: Affective Symptoms; Anxiety; Chlordiazepoxide; Female; Gynecology; Humans; Labor, Obstetric; Obstetr

1963
[USE OF A NEW ANXIOLYTIC AGENT IN OBSTETRICAL ANALGESIA. PRELIMINARY REPORT].
    Laval medical, 1964, Volume: 35

    Topics: Adjuvants, Anesthesia; Analgesia, Obstetrical; Anesthesia; Anesthesia, Obstetrical; Anesthesiology;

1964
TOCOGRAPHIC STUDIES WITH LIBRIUM AND VALIUM.
    Annales chirurgiae et gynaecologiae Fenniae, 1964, Volume: 53

    Topics: Adolescent; Chlordiazepoxide; Diazepam; Ergotamine; Female; Humans; Labor, Induced; Labor, Obstetric

1964
[USE OF LIBRIUM DURING LABOR].
    L'union medicale du Canada, 1964, Volume: 93

    Topics: Adjuvants, Anesthesia; Adolescent; Anesthesia; Anesthesia, Obstetrical; Chlordiazepoxide; Female; Hu

1964
[OBSERVATIONS ON THE USE OF A PSYCHOPLEGIC IN LABOR: LIBRIUM].
    La Clinica ostetrica e ginecologica, 1964, Volume: 66

    Topics: Anesthesia; Anesthesia, Obstetrical; Chlordiazepoxide; Female; Humans; Labor, Obstetric; Obstetrics;

1964
A CLINICAL EVALUATION OF BENZODIAZEPINES IN THE MANAGEMENT OF TOXEMIA OF PREGNANCY.
    Current therapeutic research, clinical and experimental, 1964, Volume: 6

    Topics: Benzodiazepines; Biomedical Research; Chlordiazepoxide; Diazepam; Disease Management; Drug Therapy;

1964
EFFECT OF CHLORDIAZEPOXIDE (LIBRIUM) ON CERVICAL DILATATION IN LABOUR.
    Journal of postgraduate medicine, 1964, Volume: 10

    Topics: Cervix Uteri; Chlordiazepoxide; Female; Humans; Labor Stage, First; Labor, Obstetric; Natural Childb

1964
DOUBLE-BLIND STUDY OF CHLORDIAZEPOXIDE IN OBSTETRICS.
    Obstetrics and gynecology, 1964, Volume: 24

    Topics: Adjuvants, Anesthesia; Anesthesia; Anesthesia, Obstetrical; Biomedical Research; Blood Coagulation T

1964
[RELAXATION AND SHORTENING THE PERIOD OF LABOR WITH BENZODIAZEPINE DERIVATIVES].
    Wiener medizinische Wochenschrift (1946), 1964, May-16, Volume: 114

    Topics: Anti-Anxiety Agents; Cardiovascular Agents; Chlordiazepoxide; Diazepam; Drug Therapy; Female; Humans

1964
POSTPARTUM PSYCHOSES IN THE MALE.
    Bulletin of the New York Academy of Medicine, 1964, Volume: 40

    Topics: Chlordiazepoxide; Chlorpromazine; Drug Therapy; Female; Humans; Paranoid Disorders; Paternity; Postp

1964
[The importance of Librium for relaxation of the human uterus].
    Wiener medizinische Wochenschrift (1946), 1962, Aug-04, Volume: 112

    Topics: Abortion, Induced; Biomedical Research; Chlordiazepoxide; Female; Humans; Pre-Eclampsia; Pregnancy;

1962
Relief of eclamptic convulsions with chlordiazepoxide.
    Clinical medicine (Northfield, Ill.), 1961, Volume: 8

    Topics: Chlordiazepoxide; Eclampsia; Female; Pregnancy; Seizures; Tranquilizing Agents

1961
Maternal drug use, fertility problems, and infant craniostenosis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2005, Volume: 42, Issue:6

    Topics: Adult; Anti-Allergic Agents; Anti-Anxiety Agents; Anti-Infective Agents, Urinary; Anticonvulsants; C

2005
Tocolysis.
    Bibliotheca gynaecologica, 1966, Volume: 42

    Topics: Animals; Chlordiazepoxide; Diazepam; Female; Guinea Pigs; Humans; In Vitro Techniques; Muscle Contra

1966
Lactation following psychotropic agents.
    Metabolism: clinical and experimental, 1967, Volume: 16, Issue:3

    Topics: Adult; Chlordiazepoxide; Female; Humans; Hypothalamo-Hypophyseal System; Hypothalamus; Lactation; Pi

1967
Factors influencing the activity and fate of benzodiazepines in the body.
    British journal of clinical pharmacology, 1981, Volume: 11 Suppl 1

    Topics: Anti-Anxiety Agents; Brain; Catecholamines; Chlordiazepoxide; Diazepam; Drug Interactions; Ethanol;

1981
Fetal toxicity of benzodiazepines in rats.
    Research communications in chemical pathology and pharmacology, 1984, Volume: 46, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Clonazepam; Diazepam; F

1984
Plasma beta-endorphin and met-enkephalin in physiological and pathological conditions.
    Advances in biochemical psychopharmacology, 1982, Volume: 33

    Topics: Alcoholism; beta-Endorphin; Brain; Chlordiazepoxide; Circadian Rhythm; Endorphins; Enkephalin, Methi

1982
Chronic neonatal treatment with CGS 8216: effects on the behaviour of adolescent rats.
    Behavioural brain research, 1984, Volume: 11, Issue:3

    Topics: Animals; Animals, Newborn; Behavior, Animal; Benzodiazepinones; Brain; Chlordiazepoxide; Dose-Respon

1984
Incidence and potentiation of external and internal fetal anomalies resulting from chlordiazepoxide and amitriptyline alone and in combination.
    Teratology, 1984, Volume: 30, Issue:1

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Animals; Chlordiazepoxide; Cricetinae; Drug Synergism; E

1984
Effect of ovarian hormones on conflict behavior.
    Psychoneuroendocrinology, 1984, Volume: 9, Issue:3

    Topics: Animals; Anxiety; Castration; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Elec

1984
Comparative teratogenicity of chlordiazepoxide, amitriptyline, and a combination of the two compounds in the fetal hamster.
    Neurotoxicology, 1982, Volume: 3, Issue:3

    Topics: Abnormalities, Drug-Induced; Amitriptyline; Animals; Chlordiazepoxide; Cricetinae; Dose-Response Rel

1982
Chlordiazepoxide-induced released responding in extinction and punishment-conflict procedures is not altered by neonatal forebrain norepinephrine depletion.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:2

    Topics: Animals; Animals, Newborn; Brain; Chlordiazepoxide; Conflict, Psychological; Dopamine; Extinction, P

1982
Effects of chlordiazepoxide on the pre- and postnatal development of rats.
    Toxicology, 1980, Volume: 17, Issue:3

    Topics: Animals; Animals, Newborn; Body Weight; Chlordiazepoxide; Female; Fetus; Hexobarbital; Male; Pregnan

1980
Comparative study of the teratogenic effects of chlordiazepoxide and diazepam in the fetal hamster.
    Life sciences, 1981, Nov-23, Volume: 29, Issue:21

    Topics: Animals; Chlordiazepoxide; Cricetinae; Diazepam; Female; Fetal Resorption; Fetus; Food Deprivation;

1981
Behavioral and hormonal responses to stress in the newborn mouse: effects of maternal deprivation and chlordiazepoxide.
    Developmental psychobiology, 1994, Volume: 27, Issue:5

    Topics: Animals; Animals, Newborn; Arousal; Chlordiazepoxide; Corticosterone; Female; Male; Maternal Depriva

1994
Effect of gestational undernutrition and chlordiazepoxide treatment on black/white discrimination learning and retention in young rats.
    Indian journal of experimental biology, 1994, Volume: 32, Issue:3

    Topics: Animals; Birth Weight; Chlordiazepoxide; Color; Conditioning, Operant; Discrimination Learning; Fema

1994
Chlordiazepoxide-induced spatial learning deficits: dose-dependent differences following prenatal malnutrition.
    Pharmacology, biochemistry, and behavior, 2000, Jan-01, Volume: 65, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Body Weight; Chlordiazepoxide; Chlorides; Dose-Response Relationship,

2000
Prenatal protein malnutrition results in increased frequency of miniature inhibitory synaptic currents in rat CA1 pyramidal cells.
    Synapse (New York, N.Y.), 2000, Volume: 37, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animal Nutritional Physiological

2000
Prenatally protein-malnourished rats are less sensitive to the amnestic effects of medial septal infusions of chlordiazepoxide.
    Behavioural pharmacology, 2000, Volume: 11, Issue:6

    Topics: Animals; Animals, Newborn; Chlordiazepoxide; Female; GABA Modulators; Male; Maze Learning; Memory; P

2000
Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2002, Volume: 26, Issue:5

    Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Behavior, Animal; Chlordiazepoxide; Femal

2002
Effect of benzodiazepines on age of vaginal perforation and first estrus in mice.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 21, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Estrus; Female; Mice; Nitrazepam; Prazepam

1978
Letter: Fetal effects of tranquilizers in pregnancy.
    The New England journal of medicine, 1975, Jul-24, Volume: 293, Issue:4

    Topics: Abnormalities, Drug-Induced; Anti-Anxiety Agents; Carbamates; Chlordiazepoxide; Diazepam; Female; He

1975
Effects of maternal consumption of ethanol, barbital, or chlordiazepoxide on the behavior of the offspring.
    Behavioral and neural biology, 1979, Volume: 26, Issue:2

    Topics: Alcohol Drinking; Animals; Animals, Newborn; Avoidance Learning; Barbital; Barbiturates; Behavior, A

1979
Induction of dominant lethal mutations in mice with chlordiazepoxide hydrochloride.
    The Indian journal of medical research, 1977, Volume: 66, Issue:5

    Topics: Animals; Chlordiazepoxide; Female; Fetal Death; Genes, Dominant; Genes, Lethal; Male; Mice; Mice, In

1977
The effects of nutrition and enzyme induction in toxicology.
    World review of nutrition and dietetics, 1978, Volume: 29

    Topics: Animals; Anticonvulsants; Ascorbic Acid; Chlordiazepoxide; Enzyme Induction; Female; Folic Acid; Gui

1978
[Drugs and the fetus. Anxiolytic agents. Meprobamate and chlordiazepoxide].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Jun-20, Volume: 96, Issue:17-18

    Topics: Abnormalities, Drug-Induced; Chlordiazepoxide; Female; Humans; Meprobamate; Pregnancy; Teratogens

1976
Is it safe to utilize minor tranquilizers such as Librium, Valium, and meprobamate during pregnancy?
    New York state journal of medicine, 1975, Volume: 75, Issue:8

    Topics: Abnormalities, Drug-Induced; Chlordiazepoxide; Diazepam; Female; Humans; Meprobamate; Pregnancy

1975
Antenatal exposure to meprobamate and chlordiazepoxide in relation to malformations, mental development, and childhood mortality.
    The New England journal of medicine, 1975, Apr-03, Volume: 292, Issue:14

    Topics: Abnormalities, Drug-Induced; Child Development; Child, Preschool; Chlordiazepoxide; Congenital Abnor

1975
Letter: Drugs in pregnancy.
    Canadian Medical Association journal, 1975, Jul-12, Volume: 113, Issue:1

    Topics: Abnormalities, Drug-Induced; Chlordiazepoxide; Female; Fetal Death; Humans; Meprobamate; Pregnancy;

1975
The effects of chloridazepoxide on avoidance performance of mice subjected to undernutrition or handling stress in early life.
    Psychopharmacologia, 1975, Volume: 41, Issue:2

    Topics: Animals; Animals, Newborn; Avoidance Learning; Chlordiazepoxide; Conditioning, Psychological; Crowdi

1975
Chloriazepoxide withdrawal in the neonate.
    American journal of obstetrics and gynecology, 1976, Jan-15, Volume: 124, Issue:2

    Topics: Adult; Affective Symptoms; Chlordiazepoxide; Diseases in Twins; Female; Humans; Infant, Newborn; Inf

1976
Effects of exposure of pregnant mice to chlordiazepoxide (CDP) on the development and ultrasound production of their offspring.
    General pharmacology, 1992, Volume: 23, Issue:1

    Topics: Analysis of Variance; Animals; Behavior, Animal; Body Height; Body Weight; Chlordiazepoxide; Female;

1992
Effects of prenatal exposure to benzodiazepine-related drugs on early development and adult social behaviour in Swiss mice--I. Agonists.
    General pharmacology, 1991, Volume: 22, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Body Weight; Chlordiazepoxide; Female; Growth; Mice;

1991
Holoprosencephaly as a possible embryonic alcohol effect.
    American journal of medical genetics, 1991, Aug-01, Volume: 40, Issue:2

    Topics: Abnormalities, Drug-Induced; Alcohol Drinking; Chlordiazepoxide; Female; Holoprosencephaly; Humans;

1991
Effects of delta-9-tetrahydrocannabinol, chlordiazepoxide (Librium), and their combination on pregnancy and offspring in mice [correction of rats].
    Reproductive toxicology (Elmsford, N.Y.), 1987, Volume: 1, Issue:1

    Topics: Animals; Chlordiazepoxide; Drinking; Dronabinol; Drug Synergism; Eating; Embryo Implantation; Embryo

1987
Prenatal chlordiazepoxide effects on metrazol seizures and benzodiazepine receptors density in adult albino rats.
    Life sciences, 1985, May-06, Volume: 36, Issue:18

    Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Chlordiazepoxide; Drug Resistance; Female; Flunitrazepa

1985
Evidence of specific benzodiazepine binding to myometrial membrane preparations from human pregnant uterus.
    Acta obstetricia et gynecologica Scandinavica, 1986, Volume: 65, Issue:4

    Topics: Adult; Benzodiazepines; Benzodiazepinones; Cell Membrane; Chlordiazepoxide; Diazepam; Female; Flunit

1986
The effects of prenatal chlordiazepoxide administration on avoidance behavior and benzodiazepine receptor density in adult albino rats.
    European journal of pharmacology, 1986, Sep-23, Volume: 129, Issue:1-2

    Topics: Animals; Avoidance Learning; Brain Chemistry; Chlordiazepoxide; Female; Male; Pregnancy; Prenatal Ex

1986
Maternal aggression towards different sized male opponents: effect of chlordiazepoxide treatment of the mothers and d-amphetamine treatment of the intruders.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:3

    Topics: Aggression; Animals; Body Constitution; Chlordiazepoxide; Dextroamphetamine; Exploratory Behavior; F

1987
[Significance of the determination of a protein-bound iodine (PBI) in thyroid function tests: interpretation of the test results].
    Nihon rinsho. Japanese journal of clinical medicine, 1969

    Topics: Adult; Age Factors; Antithyroid Agents; Chlordiazepoxide; Chronic Disease; Diet; Female; Humans; Hyp

1969
Plasma tryptophan and 5-HT metabolism in the CNS of the newborn rat.
    Journal of neurochemistry, 1974, Volume: 23, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Blood-Brain Barrier; Brain; Bra

1974
Induction of cleft palate in mice by tranquilizers and barbiturates.
    Teratology, 1974, Volume: 10, Issue:2

    Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Cleft Palate; Diazepam; Female; Hydroxyzine

1974
Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development.
    The New England journal of medicine, 1974, Dec-12, Volume: 291, Issue:24

    Topics: Abnormalities, Drug-Induced; Aluminum; Anxiety; Child, Preschool; Chlordiazepoxide; Embryo, Mammalia

1974
Placental penetration and foetal uptake of neuropharmacological agents.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1973, Volume: 6, Issue:1

    Topics: Amitriptyline; Animals; Animals, Newborn; Autoradiography; Carbon Radioisotopes; Chlordiazepoxide; C

1973
[Proceedings: Is hemorrhage in early pregnancy and its drug therapy an increased risk of teratogenesis?].
    Archiv fur Gynakologie, 1973, Sep-28, Volume: 214, Issue:1

    Topics: Abnormalities, Drug-Induced; Abortion, Threatened; Allyl Compounds; Aminopyrine; Chlordiazepoxide; C

1973
[The nonspecific pharmacodynamic action of certain psychotropic drugs of different structure and classification on the equilibrium of sexual function].
    Revue roumaine de physiologie, 1974, Volume: 11, Issue:3

    Topics: Animals; Antidepressive Agents; Chlordiazepoxide; Estrus; Female; Hydroxyzine; Meprobamate; Ovary; P

1974
Letter: Transplacental passage of chlordiazepoxide.
    British medical journal, 1974, Jun-29, Volume: 2, Issue:5921

    Topics: Apgar Score; Chlordiazepoxide; Eclampsia; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases

1974
Syndrome of phocomelic diabetic embryopathy (caudal dysplasia).
    American journal of diseases of children (1960), 1972, Volume: 123, Issue:5

    Topics: Abnormalities, Multiple; Adolescent; Chlordiazepoxide; Chlorpropamide; Ectromelia; Female; Humans; I

1972
[Effects of benzodiazepine compounds on the isolated myometrium in pregnant and nonpregnant women].
    Ginekologia polska, 1971, Volume: 42, Issue:10

    Topics: Chlordiazepoxide; Diazepam; Female; Humans; Muscle Contraction; Muscles; Pregnancy; Uterus

1971
Kinetics of distribution and metabolism of diazepam and chlordiazepoxide in mice.
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 178, Issue:1

    Topics: Adipose Tissue; Animals; Autoradiography; Brain Chemistry; Chlordiazepoxide; Diazepam; Endocrine Gla

1969
[Treatment of imminent abortion, threatened premature birth and placenta praevia with Librium and Valium "Roche"].
    Therapie der Gegenwart, 1969, Volume: 108, Issue:7

    Topics: Abortion, Threatened; Chlordiazepoxide; Diazepam; Female; Humans; Obstetric Labor, Premature; Placen

1969
Toxicity of some benzodiazepine compounds with CNS activity.
    Toxicology and applied pharmacology, 1970, Volume: 16, Issue:2

    Topics: Alkaline Phosphatase; Animals; Benzazepines; Blood Chemical Analysis; Blood Glucose; Breeding; Centr

1970
[Teratogenesis and drug control].
    Lijecnicki vjesnik, 1967, Volume: 89, Issue:8

    Topics: Abnormalities, Drug-Induced; Aminosalicylic Acids; Androgens; Animals; Chlordiazepoxide; Drug and Na

1967
[Observations on the use of librium in obstetric practice].
    Quaderni di clinica ostetrica e ginecologica, 1967, Volume: 22, Issue:2

    Topics: Adult; Anesthesia, Obstetrical; Anxiety; Cesarean Section; Chlordiazepoxide; Female; Humans; Preanes

1967
The use of chlordiazepoxide in patients with severe pregnancy toxaemia. (A preliminary study of effects on the newborn infants).
    The Journal of obstetrics and gynaecology of the British Commonwealth, 1968, Volume: 75, Issue:8

    Topics: Chlordiazepoxide; Delivery, Obstetric; Eclampsia; Female; Fetus; Humans; Infant, Newborn; Maternal W

1968
Use of benzodiazepines in the management of eclampsia.
    The Journal of obstetrics and gynaecology of the British Commonwealth, 1968, Volume: 75, Issue:8

    Topics: Birth Weight; Cesarean Section; Chlordiazepoxide; Diazepam; Eclampsia; Female; Fetal Death; Humans;

1968
Distribution and metabolism of 14C-labelled-chlordiazepoxide in mice.
    International journal of neuropharmacology, 1968, Volume: 7, Issue:4

    Topics: Animals; Autoradiography; Brain; Brain Chemistry; Carbon Isotopes; Chlordiazepoxide; Chromatography,

1968
Possible effect of chlordiazepoxide on the fetus.
    Canadian Medical Association journal, 1969, Feb-15, Volume: 100, Issue:7

    Topics: Anxiety; Chlordiazepoxide; Depression, Chemical; Female; Humans; Infant, Newborn; Infant, Premature,

1969
[Problems of labor pain inhibition by pharmacological agents].
    Medizinische Klinik, 1969, Jan-24, Volume: 64, Issue:4

    Topics: Bronchodilator Agents; Chlordiazepoxide; Diazepam; Female; Halothane; Humans; Infant Mortality; Isop

1969
[Librium and Valium in the treatment of threatened abortion].
    Ceskoslovenska gynekologie, 1969, Volume: 34, Issue:7

    Topics: Abortion, Threatened; Chlordiazepoxide; Diazepam; Female; Humans; Pregnancy; Tranquilizing Agents

1969
[Use of psychopharmacologic drugs in gynecology and obstetrics].
    Geburtshilfe und Frauenheilkunde, 1966, Volume: 26, Issue:5

    Topics: Amitriptyline; Chlordiazepoxide; Diazepam; Female; Genital Diseases, Female; Humans; Hypnotics and S

1966
Comparative effects of two benzodiazepine compounds on isolated human myometrium.
    American journal of obstetrics and gynecology, 1966, Jan-01, Volume: 94, Issue:1

    Topics: Animals; Chlordiazepoxide; Diazepam; Female; Humans; In Vitro Techniques; Muscles; Pregnancy; Rabbit

1966
[Clinical trial of a new analgesic-spasmolytic-tranquilizing association (D-propoxyphene; dimethyl-n-octyl benzylate of ethyl ammonium bromide; chlordiazepoxide) in labor].
    Minerva ginecologica, 1966, Oct-31, Volume: 18, Issue:20

    Topics: Anesthesia, Obstetrical; Chlordiazepoxide; Dextropropoxyphene; Female; Humans; Muscles; Pregnancy

1966