chlordiazepoxide has been researched along with Cancer of Pituitary in 7 studies
Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of chronic administration of CDE were studied." | 1.29 | A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist. ( Gershengorn, MC; Grimberg, H; Heinflink, M; Lupu-Meiri, M; Nussenzveig, DR; Oron, Y, 1995) |
| "Chlordiazepoxide did not inhibit the small bombesin-induced rise in [3H]-InslP." | 1.27 | Chlordiazepoxide is a competitive thyrotropin-releasing hormone receptor antagonist in GH3 pituitary tumour cells. ( Drummond, AH, 1985) |
| "Chlordiazepoxide (CDE) has been shown to antagonize the effects of TRH to stimulate the hydrolysis of phosphoinositides and elevate cytoplasmic free calcium in rat pituitary tumor (GH3) cells." | 1.27 | Evidence for tight coupling of receptor occupancy by thyrotropin-releasing hormone to phospholipase C-mediated phosphoinositide hydrolysis in rat pituitary cells: use of chlordiazepoxide as a competitive antagonist. ( Gershengorn, MC; Paul, ME, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Drummond, AH | 2 |
| Hughes, PJ | 1 |
| Ruiz-Larrea, F | 1 |
| Joels, LA | 1 |
| Heinflink, M | 1 |
| Nussenzveig, DR | 2 |
| Grimberg, H | 1 |
| Lupu-Meiri, M | 1 |
| Oron, Y | 1 |
| Gershengorn, MC | 4 |
| Perlman, JH | 1 |
| Osman, R | 1 |
| de la Peña, P | 1 |
| Delgado, LM | 1 |
| del Camino, D | 1 |
| Barros, F | 1 |
| Thaw, CN | 1 |
| Geras-Raaka, E | 1 |
| Paul, ME | 1 |
1 review available for chlordiazepoxide and Cancer of Pituitary
| Article | Year |
|---|---|
Use of receptor antagonist in elucidating the mechanism of action of TRH in GH3 cells.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Line; Inositol Phosphates; Pituitary Neoplasms; | 1989 |
6 other studies available for chlordiazepoxide and Cancer of Pituitary
| Article | Year |
|---|---|
A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist.
Topics: Animals; Binding, Competitive; Chlordiazepoxide; Down-Regulation; HeLa Cells; Humans; Inositol Phosp | 1995 |
Thyrotropin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Chlordiazepoxide; GTP-Binding Protein | 1992 |
Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Chlordiazepoxide; Cloning, Molecu | 1992 |
Benzodiazepines modulate voltage-sensitive calcium channels in GH3 pituitary cells at sites distinct from thyrotropin-releasing hormone receptors.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Calcium; Cell Line; Chlordiazepoxide; Diazepam; Dil | 1988 |
Chlordiazepoxide is a competitive thyrotropin-releasing hormone receptor antagonist in GH3 pituitary tumour cells.
Topics: Animals; Bombesin; Calcium; Cell Line; Chlordiazepoxide; Diazepam; Inositol; Inositol Phosphates; Pi | 1985 |
Evidence for tight coupling of receptor occupancy by thyrotropin-releasing hormone to phospholipase C-mediated phosphoinositide hydrolysis in rat pituitary cells: use of chlordiazepoxide as a competitive antagonist.
Topics: Animals; Binding, Competitive; Cell Line; Chlordiazepoxide; Chlorides; Hydrolysis; Lithium; Lithium | 1986 |