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chlordiazepoxide and Cancer of Pituitary

chlordiazepoxide has been researched along with Cancer of Pituitary in 7 studies

Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Research Excerpts

ExcerptRelevanceReference
" The effects of chronic administration of CDE were studied."1.29A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist. ( Gershengorn, MC; Grimberg, H; Heinflink, M; Lupu-Meiri, M; Nussenzveig, DR; Oron, Y, 1995)
"Chlordiazepoxide did not inhibit the small bombesin-induced rise in [3H]-InslP."1.27Chlordiazepoxide is a competitive thyrotropin-releasing hormone receptor antagonist in GH3 pituitary tumour cells. ( Drummond, AH, 1985)
"Chlordiazepoxide (CDE) has been shown to antagonize the effects of TRH to stimulate the hydrolysis of phosphoinositides and elevate cytoplasmic free calcium in rat pituitary tumor (GH3) cells."1.27Evidence for tight coupling of receptor occupancy by thyrotropin-releasing hormone to phospholipase C-mediated phosphoinositide hydrolysis in rat pituitary cells: use of chlordiazepoxide as a competitive antagonist. ( Gershengorn, MC; Paul, ME, 1986)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Drummond, AH2
Hughes, PJ1
Ruiz-Larrea, F1
Joels, LA1
Heinflink, M1
Nussenzveig, DR2
Grimberg, H1
Lupu-Meiri, M1
Oron, Y1
Gershengorn, MC4
Perlman, JH1
Osman, R1
de la Peña, P1
Delgado, LM1
del Camino, D1
Barros, F1
Thaw, CN1
Geras-Raaka, E1
Paul, ME1

Reviews

1 review available for chlordiazepoxide and Cancer of Pituitary

ArticleYear
Use of receptor antagonist in elucidating the mechanism of action of TRH in GH3 cells.
    Annals of the New York Academy of Sciences, 1989, Volume: 553

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Line; Inositol Phosphates; Pituitary Neoplasms;

1989

Other Studies

6 other studies available for chlordiazepoxide and Cancer of Pituitary

ArticleYear
A constitutively active mutant thyrotropin-releasing hormone receptor is chronically down-regulated in pituitary cells: evidence using chlordiazepoxide as a negative antagonist.
    Molecular endocrinology (Baltimore, Md.), 1995, Volume: 9, Issue:11

    Topics: Animals; Binding, Competitive; Chlordiazepoxide; Down-Regulation; HeLa Cells; Humans; Inositol Phosp

1995
Thyrotropin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors.
    The Journal of biological chemistry, 1992, Dec-05, Volume: 267, Issue:34

    Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Chlordiazepoxide; GTP-Binding Protein

1992
Two isoforms of the thyrotropin-releasing hormone receptor generated by alternative splicing have indistinguishable functional properties.
    The Journal of biological chemistry, 1992, Dec-25, Volume: 267, Issue:36

    Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Chlordiazepoxide; Cloning, Molecu

1992
Benzodiazepines modulate voltage-sensitive calcium channels in GH3 pituitary cells at sites distinct from thyrotropin-releasing hormone receptors.
    Endocrinology, 1988, Volume: 123, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Calcium; Cell Line; Chlordiazepoxide; Diazepam; Dil

1988
Chlordiazepoxide is a competitive thyrotropin-releasing hormone receptor antagonist in GH3 pituitary tumour cells.
    Biochemical and biophysical research communications, 1985, Feb-28, Volume: 127, Issue:1

    Topics: Animals; Bombesin; Calcium; Cell Line; Chlordiazepoxide; Diazepam; Inositol; Inositol Phosphates; Pi

1985
Evidence for tight coupling of receptor occupancy by thyrotropin-releasing hormone to phospholipase C-mediated phosphoinositide hydrolysis in rat pituitary cells: use of chlordiazepoxide as a competitive antagonist.
    Endocrinology, 1986, Volume: 119, Issue:2

    Topics: Animals; Binding, Competitive; Cell Line; Chlordiazepoxide; Chlorides; Hydrolysis; Lithium; Lithium

1986