chlordiazepoxide and Alcohol Withdrawal Associated Autonomic Hyperactivity studies

Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Research Excerpts

Excerpt	Relevance	Reference
"Sedatives are important in treatment of alcohol withdrawal seizures and delirium tremens as well as in the prophylaxis of alcohol withdrawal syndrome."	2.46	[Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure]. ( Batra, A; Lutz, UC, 2010)
"Severe AWS can develop into delirium tremens (DT), which is potentially life-threatening."	1.51	Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients. ( Bergeron, JB; March, KL; Reaves, AB; Sakaan, SA; Self, TH; Slayton, MM; Twilla, JD, 2019)
"Alcohol withdrawal (especially delirium tremens) poses significant potential morbidity to postsurgical patients."	1.29	Trends in the management of alcohol withdrawal syndrome. ( Moore, M; Newman, JP; Terris, DJ, 1995)
" Finally, no significant differences were found between age groups in either the dosage or number of days of detoxification medication, although a trend was found for more days of medication in the elderly."	1.29	Severity and treatment of alcohol withdrawal in elderly versus younger patients. ( Blow, FC; Brower, KJ; Hill, EM; Mudd, S; Young, JP, 1994)

Research

Studies (49)

Authors

Clinical Trials (1)

Trial Overview

Reviews

5 reviews available for chlordiazepoxide and Alcohol Withdrawal Associated Autonomic Hyperactivity

Trials

5 trials available for chlordiazepoxide and Alcohol Withdrawal Associated Autonomic Hyperactivity

Other Studies

39 other studies available for chlordiazepoxide and Alcohol Withdrawal Associated Autonomic Hyperactivity

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (55.10)	18.7374
1990's	12 (24.49)	18.2507
2000's	6 (12.24)	29.6817
2010's	4 (8.16)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
March, KL	1
Twilla, JD	1
Reaves, AB	1
Self, TH	1
Slayton, MM	1
Bergeron, JB	1
Sakaan, SA	1
Askgaard, G	1
Pottegård, A	1
Fink-Jensen, A	1
Riddle, E	1
Bush, J	1
Tittle, M	1
Dilkhush, D	1
Lutz, UC	1
Batra, A	1
LARSEN, EF	1
MOROZ, R	1
RECHTER, E	1
LAI, G	1
SAMPAIO, BA	1
AMARO, JW	1
MEYER, L	1
Sharma, V	1
Hardern, R	1
Page, AV	1
Landers, DF	1
Targum, SD	1
Wheadon, DE	1
Chastek, CT	1
McCabe, WJ	1
Advani, MT	1
Zumbrunnen, R	1
McGovern, MP	1
Lapierre, YD	1
Bulmer, DR	1
Oyewumi, LK	1
Mauguin, ML	1
Knott, VJ	1
Lund, S	1
Starklint, JF	1
Vaag, UH	1
Wang, AG	1
Wartenberg, AA	1
Chan, AW	1
Schanley, DL	1
Leong, FW	1
Casbeer, D	1
Millman, RB	1
Mountain, R	1
Ferguson, S	1
Fowler, A	1
Hyers, T	1
Mäthner, H	1
Gillner, M	1
Pelliccioni, R	1
Walters, L	1
Nel, P	1
Mirovsky, Y	1
Yu, YL	1
Wagner, GC	1
Sekowski, A	1
Goldberg, M	1
Fisher, H	1
Newman, JP	1
Terris, DJ	1
Moore, M	1
Sullivan, JT	2
Saitz, R	1
Mayo-Smith, MF	1
Roberts, MS	1
Redmond, HA	1
Bernard, DR	1
Calkins, DR	1
Fuller, RK	1
Gordis, E	1
Bird, RD	1
Makela, EH	1
Brower, KJ	1
Mudd, S	1
Blow, FC	1
Young, JP	1
Hill, EM	1
Monti, PM	1
Rohsenow, DJ	1
Rubonis, AV	1
Niaura, RS	1
Sirota, AD	1
Colby, SM	1
Abrams, DB	1
Prater, CD	1
Miller, KE	1
Zylstra, RG	1
Arquilla, B	1
Gupta, R	1
Gernshiemer, J	1
Fischer, M	1
Reoux, JP	1
Miller, K	1
Gossop, M	1
Keaney, F	1
Stewart, D	1
Marshall, EJ	1
Strang, J	1
Longo, LP	1
Campbell, T	1
Hubatch, S	1
Ritson, EB	1
Edwards, G	1
Beckmann, H	1
Athen, D	1
McGrath, SD	1
Richon, CA	1
Deslarzes, C	1
Fornerod, A	1
Swift, RM	1
Lewis, DC	1
Babb, D	1
Jenkins, B	1
Liskow, BI	1
Rinck, C	1
Campbell, J	1
DeSouza, C	1
Gauvin, DV	1
Harland, RD	1
Criado, JR	1
Michaelis, RC	1
Holloway, FA	1
Mitchell, TR	1
Favazza, AR	1
Martin, P	1
Helmus, C	1
Spahn, JG	1
Novotný, V	1
Kolibás, E	1
Junasová, D	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Prospective Assessment of Valproate on Ethanol Withdrawal[NCT03235531]			Phase 4	210 participants (Anticipated)	Interventional	2017-07-11	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Benzodiazepines should still be first-line treatment for alcohol withdrawal]. Ugeskrift for laeger, 2017, Jan-16, Volume: 179, Issue:3 Topics: Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Barbiturates; Benzodiazepines; Chlordiazep	2017
[Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure]. Psychiatrische Praxis, 2010, Volume: 37, Issue:6 Topics: Adrenergic beta-Antagonists; Alcohol Withdrawal Delirium; Alcohol Withdrawal Seizures; Alcoholism; A	2010
Alcohol withdrawal: what is the benzodiazepine of choice? The Annals of pharmacotherapy, 1994, Volume: 28, Issue:1 Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Chlordiazepoxide; Clinical Trials as Topic; Diazepam;	1994
Outpatient detoxification of the addicted or alcoholic patient. American family physician, 1999, Sep-15, Volume: 60, Issue:4 Topics: Alcohol Withdrawal Delirium; Alcoholic Intoxication; Ambulatory Care; Anti-Anxiety Agents; Chlordiaz	1999
The meaning and treatment of alcohol dependence. The British journal of psychiatry : the journal of mental science, 1975, Volume: Spec No 9 Topics: Alcohol Withdrawal Delirium; Alcoholic Beverages; Alcoholics Anonymous; Alcoholism; Amnesia; Aversiv	1975

Article	Year
Comparison of chlormethiazole (Heminevrin) and chlordiazepoxide (Librium) in the treatment of acute alcohol withdrawal. Neuropsychobiology, 1983, Volume: 10, Issue:2-3 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Double-Blind Meth	1983
[The addiction potential of benzodiazepines. Application of the results of treatment of alcohol withdrawal syndrome]. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1981, Jan-24, Volume: 59, Issue:4 Topics: Alcohol Withdrawal Delirium; Benzodiazepines; Chlordiazepoxide; Humans; Oxazepam; Psychoses, Alcohol	1981
Individualized treatment for alcohol withdrawal. A randomized double-blind controlled trial. JAMA, 1994, Aug-17, Volume: 272, Issue:7 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Double-Blind Method; Drug Administ	1994
Divalproex sodium (Depakote) for alcohol withdrawal and relapse prevention. Journal of addictive diseases, 2002, Volume: 21, Issue:2 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; Anticonvulsant	2002
A controlled trial of chlormethiazole and chlordiazepoxide in the treatment of the acute withdrawal phase of alcoholism. The British journal of addiction to alcohol and other drugs, 1975, Volume: 70 Suppl 1 Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Clinical Trials as Topic	1975

Article	Year
Lorazepam versus chlordiazepoxide for the treatment of alcohol withdrawal syndrome and prevention of delirium tremens in general medicine ward patients. Alcohol (Fayetteville, N.Y.), 2019, Volume: 81 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Ethanol; Female; Humans; Hypnotics and Sedatives; Inp	2019
Alcohol withdrawal: development of a standing order set. Critical care nurse, 2010, Volume: 30, Issue:3 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Chlordiazepoxide; Clinical Protocols; Critical Care; Drug	2010
[LIBRIUM TREATMENT OF DELIRIUM TREMENS]. Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry, 1963, Volume: 17 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Humans; Mental Disorders; Norway; Psychoses, Alcoholi	1963
MANAGEMENT OF PATIENTS WITH IMPENDING AND FULL-BLOWN DELIRIUM TREMENS. The Psychiatric quarterly, 1964, Volume: 38 Topics: Adrenocorticotropic Hormone; Alcohol Withdrawal Delirium; Chlordiazepoxide; Chlorpromazine; Drug The	1964
[Librium in the treatment of delirium tremens]. Praxis, 1962, Mar-01, Volume: 51 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Humans; Mental Disorders; Psychoses, Alcoholic; Psych	1962
[On the use of "chlordiazepoxide" in delirium tremens and alcoholic hallucinosis]. Hospital (Rio de Janeiro, Brazil), 1962, Volume: 62 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Humans; Mental Disorders; Psychoses, Alcoholic; Psych	1962
Delirium tremens--a case study. The Nursing journal of India, 2003, Volume: 94, Issue:3 Topics: Adult; Alcohol Withdrawal Delirium; Antihypertensive Agents; Chlordiazepoxide; Clonidine; Humans; Hy	2003
An audit of symptom triggered chlordiazepoxide treatment of alcohol withdrawal on a medical admissions unit. Emergency medicine journal : EMJ, 2005, Volume: 22, Issue:11 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Dose-Response Relationship, Drug; GABA Modulators; Ho	2005
Alcohol withdrawal syndrome. American family physician, 1983, Volume: 27, Issue:5 Topics: Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Humans; Psychoses, Alc	1983
Dysregulation of hypothalamic-pituitary-adrenal axis function in depressed alcoholic patients. Journal of affective disorders, 1982, Volume: 4, Issue:4 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Depressive Disorder; Dexamethasone	1982
[Neuropsychiatric syndromes of alcoholic origin. Diagnosis and treatment]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1984, Sep-25, Volume: 73, Issue:39 Topics: Alcohol Amnestic Disorder; Alcohol Withdrawal Delirium; Alcoholic Intoxication; Chlordiazepoxide; De	1984
Comparative evaluation of medical vs. social treatment of alcohol withdrawal syndrome. Journal of clinical psychology, 1983, Volume: 39, Issue:5 Topics: Adult; Alcohol Withdrawal Delirium; Chlordiazepoxide; Humans; Male; Motivation; Prognosis; Psycholog	1983
[Choice of drug treatment of alcohol withdrawal symptoms in Denmark]. Ugeskrift for laeger, 1983, Jan-24, Volume: 145, Issue:4 Topics: Alcohol Withdrawal Delirium; Barbital; Barbiturates; Chlordiazepoxide; Denmark; Ethanol; Humans; Sub	1983
Treatment of alcohol withdrawal syndrome. JAMA, 1983, Sep-09, Volume: 250, Issue:10 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Injections; Psychoses, Alcoholic	1983
Dissociation of tolerance and physical dependence after ethanol/chlordiazepoxide intake. Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:6 Topics: Alcohol Withdrawal Delirium; Animals; Body Temperature Regulation; Brain; Chlordiazepoxide; Drug Tol	1982
Treatment of delirium tremens. Hospital & community psychiatry, 1982, Volume: 33, Issue:5 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Psychoses, Alcoholic	1982
Noncardiac pulmonary edema following administration of parenteral paraldehyde. Chest, 1982, Volume: 82, Issue:3 Topics: Aged; Alcohol Withdrawal Delirium; Chlordiazepoxide; Humans; Injections, Intramuscular; Injections,	1982
[Treatment of an alcoholic pre-delirium syndrome with chlormethiazol, methophenazin and chlordiazepoxide]. Psychiatrie, Neurologie, und medizinische Psychologie, 1980, Volume: 32, Issue:2 Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Chlormethiazole; Drug Therapy, Com	1980
Novel synergistic treatment of ethanol withdrawal seizures in rats with dopamine and serotonin agonists. Alcoholism, clinical and experimental research, 1995, Volume: 19, Issue:1 Topics: Alcohol Withdrawal Delirium; Amantadine; Amphetamine; Animals; Chlordiazepoxide; Dopamine Agonists;	1995
Trends in the management of alcohol withdrawal syndrome. The Laryngoscope, 1995, Volume: 105, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide;	1995
Individualized treatment of alcohol withdrawal. JAMA, 1995, Jan-18, Volume: 273, Issue:3 Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Drug Administration Schedule; Ethanol; Hu	1995
Refining the treatment of alcohol withdrawal. JAMA, 1994, Aug-17, Volume: 272, Issue:7 Topics: Alcohol Withdrawal Delirium; Alcoholism; Benzodiazepines; Chlordiazepoxide; Drug Administration Sche	1994
Severity and treatment of alcohol withdrawal in elderly versus younger patients. Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:1 Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Dose-Response R	1994
Alcohol cue reactivity: effects of detoxification and extended exposure. Journal of studies on alcohol, 1993, Volume: 54, Issue:2 Topics: Adaptation, Psychological; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Arousal	1993
Acute arterial spasm in an extremity caused by inadvertent intra-arterial injection successfully treated in the emergency department. The Journal of emergency medicine, 2000, Volume: 19, Issue:2 Topics: Adult; Alcohol Withdrawal Delirium; Angiography; Anti-Anxiety Agents; Arm; Brachial Artery; Chlordia	2000
Routine hospital alcohol detoxification practice compared to symptom triggered management with an Objective Withdrawal Scale (CIWA-Ar). The American journal on addictions, 2000,Spring, Volume: 9, Issue:2 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Hospitalization; Hos	2000
A Short Alcohol Withdrawal Scale (SAWS): development and psychometric properties. Addiction biology, 2002, Volume: 7, Issue:1 Topics: Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Humans; Neurologic Examination; Neuropsyc	2002
Psychological medicine. Treatment of alcoholism. British medical journal, 1975, Apr-19, Volume: 2, Issue:5963 Topics: Adolescent; Adult; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholics Anonymous; Alcoholism;	1975
[Therapy of delirium tremens]. Deutsche medizinische Wochenschrift (1946), 1978, Sep-15, Volume: 103, Issue:37 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Chlormethiazole; Diazepam; Haloperidol; Humans; Inten	1978
[The prevention of postoperative delirium tremens (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1976, Jan-13, Volume: 65, Issue:2 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Drug Combinations; Esophagogastric Junction; Esophagu	1976
Benzodiazepine requirements during alcohol withdrawal syndrome: clinical implications of using a standardized withdrawal scale. Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:5 Topics: Administration, Oral; Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Chlordiazepoxide; Dia	1991
Action stat! Alcohol withdrawal syndrome. Nursing, 1990, Volume: 20, Issue:10 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Emergencies; Ethanol; Humans; Male; Middle Aged; Nurs	1990
Comment: I.v. alcohol in prevention of delirium tremens. DICP : the annals of pharmacotherapy, 1990, Volume: 24, Issue:11 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Ethanol; Humans; Injections, Intramuscular; Injection	1990
Alcohol withdrawal in the elderly. Journal of studies on alcohol, 1989, Volume: 50, Issue:5 Topics: Adult; Age Factors; Aged; Alcohol Withdrawal Delirium; Alcoholism; Chlordiazepoxide; Female; Humans;	1989
The discriminative stimulus properties of ethanol and acute ethanol withdrawal states in rats. Drug and alcohol dependence, 1989, Volume: 24, Issue:2 Topics: Affect; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholic Intoxication; Animals; Arousal; Chl	1989
Alcohol withdrawal. Journal of the Tennessee Medical Association, 1988, Volume: 81, Issue:2 Topics: Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Male; Middle Aged; Psychoses, Alcoh	1988
Chemotherapy of delirium tremens: a survey of physicians' preferences. The American journal of psychiatry, 1974, Volume: 131, Issue:9 Topics: Alcohol Withdrawal Delirium; Antipsychotic Agents; Attitude of Health Personnel; Barbiturates; Chlor	1974
Delirium tremens in head and neck surgery. The Laryngoscope, 1974, Volume: 84, Issue:9 Topics: Aged; Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Laryngeal Neoplasms; Male; Mi	1974
Our experience with the treatment of delirium tremens with diazepam. Activitas nervosa superior, 1974, Volume: 16, Issue:3 Topics: Adult; Aged; Alcohol Withdrawal Delirium; Chlordiazepoxide; Diazepam; Humans; Hypnotics and Sedative	1974