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chlordiazepoxide and Aging

chlordiazepoxide has been researched along with Aging in 13 studies

Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.
chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Absolute bioavailability of oral chlordiazepoxide was not less than 100%, and was unrelated to age or sex."1.28Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition. ( Abernethy, DR; Divoll, MK; Greenblatt, DJ; Harmatz, JS; Ochs, HR; Shader, RI, 1989)
"The diazepam stimuli were dose-dependent in each group."1.27A comparison of diazepam stimuli in aged and adult rats. ( Amrick, CL; Bennett, DA, 1987)
"The elimination half-life of chlordiazepoxide and diazepam increases with age, and this may cause prolongation of action after a single dose and delayed accumulation on multiple dosing in elderly patients."1.26[Pharmacokinetic of benzodiazepines in old age]. ( Vozeh, S, 1981)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19909 (69.23)18.7374
1990's4 (30.77)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vozeh, S1
Abbracchio, MP1
Balduini, W1
Coen, E1
Lombardelli, G1
Peruzzi, G1
Cattabeni, F1
McGaughy, J2
Sarter, M4
Turchi, J1
Holley, LA1
Hoyumpa, AM1
Schenker, S1
Wilkinson, GR1
Moore, H1
Bruno, JP1
Greenblatt, DJ1
Divoll, MK1
Abernethy, DR1
Ochs, HR1
Harmatz, JS1
Shader, RI1
Amrick, CL1
Bennett, DA1
Bourgoin, S1
Faivre-Bauman, A1
Benda, P1
Glowinski, J1
Hamon, M1
Sainz, A1

Other Studies

13 other studies available for chlordiazepoxide and Aging

ArticleYear
[Pharmacokinetic of benzodiazepines in old age].
    Schweizerische medizinische Wochenschrift, 1981, Nov-21, Volume: 111, Issue:47

    Topics: Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Half-Life; Humans; Lorazepam; M

1981
Chronic chlordiazepoxide treatment on adult and newborn rats: effect on the GABA-benzodiazepine receptor complex.
    Advances in biochemical psychopharmacology, 1983, Volume: 38

    Topics: Aging; Animals; Animals, Newborn; Chlordiazepoxide; Female; Flunitrazepam; gamma-Aminobutyric Acid;

1983
Behavioral vigilance in rats: task validation and effects of age, amphetamine, and benzodiazepine receptor ligands.
    Psychopharmacology, 1995, Volume: 117, Issue:3

    Topics: Aging; Amphetamine; Animals; Arousal; Attention; Behavior, Animal; Carbolines; Chlordiazepoxide; Con

1995
Effects of chlordiazepoxide and scopolamine, but not aging, on the detection and identification of conditional visual stimuli.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1995, Volume: 50, Issue:2

    Topics: Aging; Animals; Arousal; Attention; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relations

1995
Effects of benzodiazepine receptor inverse agonists and nicotine on behavioral vigilance in senescent rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1996, Volume: 51, Issue:3

    Topics: Aging; Animals; Attention; Behavior, Animal; Carbolines; Chlordiazepoxide; Discrimination, Psycholog

1996
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
    Southern medical journal, 1978, Volume: 71 Suppl 2

    Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li

1978
Effects of liver disease and of aging on the disposition and elimination of sedatives.
    Transactions of the American Clinical and Climatological Association, 1978, Volume: 89

    Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral,

1978
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
    Acta psychiatrica Scandinavica. Supplementum, 1978, Issue:274

    Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H

1978
Age-dependent modulation of in vivo cortical acetylcholine release by benzodiazepine receptor ligands.
    Brain research, 1992, Nov-20, Volume: 596, Issue:1-2

    Topics: Acetylcholine; Aging; Animals; Carbolines; Cerebral Cortex; Chlordiazepoxide; Darkness; Dialysis; GA

1992
Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition.
    Pharmacology, 1989, Volume: 38, Issue:5

    Topics: Adult; Aging; Antipyrine; Body Weight; Chlordiazepoxide; Female; Half-Life; Humans; Injections, Intr

1989
A comparison of diazepam stimuli in aged and adult rats.
    Psychopharmacology, 1987, Volume: 93, Issue:3

    Topics: Aging; Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Dru

1987
Plasma tryptophan and 5-HT metabolism in the CNS of the newborn rat.
    Journal of neurochemistry, 1974, Volume: 23, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Biological Transport; Blood-Brain Barrier; Brain; Bra

1974
Hyperkinetic disease of children: diagnosis and therapy.
    Diseases of the nervous system, 1966, Volume: 7 Suppl, Issue:7

    Topics: Adolescent; Adult; Aging; Brain Damage, Chronic; Child; Chlordiazepoxide; Dextroamphetamine; Humans;

1966