chlordecone has been researched along with Lupus Erythematosus, Systemic in 3 studies
Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In murine models of systemic lupus erythematosus (SLE), administration of either prolactin or estradiol (E2) increases autoimmunity, and there is evidence that elevated prolactin in response to E2 administration may contribute substantially to E2 effects." | 1.34 | Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice. ( Butfiloski, EJ; Roberts, SM; Sobel, ES; Wang, F, 2007) |
| "Chlordecone treatment in (NZBxNZW) F(1) mice shortened significantly the time to onset of elevated autoantibody titers and renal disease in a dose-related manner." | 1.33 | Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice. ( Butfiloski, E; Croker, B; Roberts, SM; Sobel, ES; Wang, F, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sobel, ES | 3 |
| Wang, F | 3 |
| Butfiloski, E | 1 |
| Croker, B | 1 |
| Roberts, SM | 3 |
| Butfiloski, EJ | 2 |
| Morel, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Organochlorine Pesticide Exposure in Residents Near Lake Apopka[NCT02530814] | 20 participants (Actual) | Observational | 2015-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for chlordecone and Lupus Erythematosus, Systemic
| Article | Year |
|---|---|
Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice.
Topics: Animals; Antibodies, Antinuclear; Autoimmunity; Chlordecone; Chromatin; Delayed-Action Preparations; | 2006 |
Acceleration of autoimmunity by organochlorine pesticides: a comparison of splenic B-cell effects of chlordecone and estradiol in (NZBxNZW)F1 mice.
Topics: Animals; Antigens, Differentiation; Apoptosis; Autoimmunity; B-Lymphocytes; Cell Proliferation; Chlo | 2007 |
Diminished prolactin from chlordecone treatment in ovariectomized (NZBxNZW)F(1) mice.
Topics: Animals; Autoimmunity; Chlordecone; Dose-Response Relationship, Drug; Estradiol; Female; Insecticide | 2007 |