chlorcyclizine has been researched along with Chronic Hepatitis C in 3 studies
chlorcyclizine: was heading 1964-94 (Prov 1964-73); CHLOROCYCLIZINE & HISTACHLORAZINE were see CHLORCYCLIZINE 1977-94; use PIPERAZINES to search CHLORCYCLIZINE 1966-94; histamine H1-blocker used both orally and topically in allergies and also for the prevention of motion sickness
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorcyclizine HCl (CCZ) is a piperazine-class antihistamine with anti-hepatitis C virus (HCV) activity in vitro and in vivo." | 6.90 | A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C. ( Borochov, N; Cotler, SJ; Dahari, H; Dubey, P; Etzion, O; Garraffo, HM; Han, MAT; Heller, T; Koh, C; Liang, TJ; Southall, NT; Surana, P; Uprichard, SL; Walter, PJ, 2019) |
| "Chlorcyclizine HCl (CCZ) is a piperazine-class antihistamine with anti-hepatitis C virus (HCV) activity in vitro and in vivo." | 2.90 | A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C. ( Borochov, N; Cotler, SJ; Dahari, H; Dubey, P; Etzion, O; Garraffo, HM; Han, MAT; Heller, T; Koh, C; Liang, TJ; Southall, NT; Surana, P; Uprichard, SL; Walter, PJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rolt, A | 1 |
| Le, D | 1 |
| Hu, Z | 2 |
| Wang, AQ | 2 |
| Shah, P | 1 |
| Singleton, M | 1 |
| Hughes, E | 1 |
| Dulcey, AE | 1 |
| He, S | 2 |
| Imamura, M | 2 |
| Uchida, T | 1 |
| Chayama, K | 2 |
| Xu, X | 1 |
| Marugan, JJ | 2 |
| Liang, TJ | 3 |
| Koh, C | 1 |
| Dubey, P | 1 |
| Han, MAT | 1 |
| Walter, PJ | 1 |
| Garraffo, HM | 1 |
| Surana, P | 1 |
| Southall, NT | 1 |
| Borochov, N | 1 |
| Uprichard, SL | 1 |
| Cotler, SJ | 1 |
| Etzion, O | 1 |
| Heller, T | 1 |
| Dahari, H | 1 |
| Lin, B | 1 |
| Chu, V | 1 |
| Hu, X | 1 |
| Xiao, J | 1 |
| Schweitzer, CJ | 1 |
| Li, Q | 1 |
| Hiraga, N | 1 |
| Southall, N | 1 |
| Ferrer, M | 1 |
| Zheng, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Safety, Tolerability, and Antiviral Activity of Chlorcyclizine HCl Alone or in Combination With Ribavirin in Patients With Chronic Hepatitis C[NCT02118012] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-03-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT02118012)
Timeframe: Baseline and 28 days
| Intervention | U/L (Median) |
|---|---|
| Chlorcyclizine and RBV | 26 |
| Chlorcyclizine HCl Only | 6 |
(NCT02118012)
Timeframe: Baseline and 28 days
| Intervention | log IU/ml (Median) |
|---|---|
| Chlorcyclizine and RBV | -0.46 |
| Chlorcyclizine HCl Only | -0.11 |
Chlorcyclizine HCL concentration was measured once a week in the morning. This outcome is the maximum over the four weeks. (NCT02118012)
Timeframe: Weeks 1-4
| Intervention | ng/ml (Median) |
|---|---|
| Chlorcyclizine and RBV | 211 |
| Chlorcyclizine HCl Only | 251 |
(NCT02118012)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Chlorcyclizine and RBV | 12 |
| Chlorcyclizine HCl Only | 11 |
1 trial available for chlorcyclizine and Chronic Hepatitis C
| Article | Year |
|---|---|
A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.
Topics: Antiviral Agents; Drug Repositioning; Female; Genotype; Hepatitis C, Chronic; Humans; Kinetics; Male | 2019 |
2 other studies available for chlorcyclizine and Chronic Hepatitis C
| Article | Year |
|---|---|
Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.
Topics: Animals; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line; Genotype; Hepacivirus; Hepatitis C, | 2018 |
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.
Topics: Animals; Antiviral Agents; Drug Resistance, Viral; Genotype; Hepacivirus; Hepatitis C, Chronic; High | 2015 |