Compounds > chloramphenicol
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chloramphenicol and Leukopenia

chloramphenicol has been researched along with Leukopenia in 31 studies

Amphenicol: Chloramphenicol and its derivatives.

Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).

Research Excerpts

ExcerptRelevanceReference
" Among the drugs tested chloramphenicol, thiamphenicol, and chlorpromazine were inhibitory in therapeutic concentrations, a finding consistent with the common occurrence of a dose-dependent leukopenia from these drugs."3.65Drug-induced inhibition of myeloid colony growth: protective effect of colony-stimulating factor. ( Gross, MA; Yunis, AA, 1975)
"Forty five positive blood culture acute typhoid cases were studied during a 2 years period (1997-1999) in Abbassia Fever hospital, Cairo, Egypt."1.30Comparative study on different recent diagnostic and therapeutic regimens in acute typhoid fever. ( Abdel Wahab, MF; el-Gindy, IM; el-Naby, HM; Sultan, Y, 1999)
"Typhoid was eradicated in 97% but nine children with other diagnoses died."1.30Chloramphenicol in children: dose, plasma levels and clinical effects. ( Choo, EK; Ismail, R; Teh, LK, 1998)
"Twenty eight positive blood culture paratyphoid A fever cases were studied."1.29Comparative study between paratyphoid A and typhoid fever cases. ( Abdel Wahab, MF; Awadalla, YA; Hamdy, HS; Haseeb, AN, 1996)
"Chloramphenicol therapy was effective in all patients."1.28Lack of predictability of chloramphenicol toxicity in paediatric patients. ( Nahata, MC, 1989)

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-199028 (90.32)18.7374
1990's3 (9.68)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
ROBINSON, HM1
ZELIGMAN, I1
SHAPIRO, A1
COHEN, MM1
BENINI, S1
LORENZI, C1
SUHRLAND, LG1
WEISBERGER, AS2
JIJI, RM1
GANGAROSA, EJ1
DE LA MACORRA, F1
BERNARD, J1
TIMAFFY, M1
LIBANSKY, J1
JEZKOVA, Z1
CENIC, S1
MAGAZINOVIC, V1
HUXTABLE, KA1
TUCKER, AS1
WEDGWOOD, RJ1
PAGE, AR1
ABATUROVA, EA1
SVIRIDOV, NK1
ELPATEVSKAIA, GN1
ZUIKOVA, EA1
Abdel Wahab, MF2
Haseeb, AN1
Hamdy, HS1
Awadalla, YA1
el-Gindy, IM1
Sultan, Y1
el-Naby, HM1
Fraumeni, JF1
Ismail, R1
Teh, LK1
Choo, EK1
Girdwood, RH1
Yunis, AA1
Gross, MA1
Nahata, MC1
Bogush, TA1
Varet, B1
Gluckman, E1
Reyes, F1
Basch, A1
Dreyfus, B1
Pisciotta, AV1
Armenian, HK1
Lilienfeld, AM1
VanOmmen, RA1
Cohen, HJ1
Huang, AT1
Sheehy, TW1
Hazlett, D1
Turk, RE1
Keiser, G1
Buchegger, U1
Scragg, J1
Rubidge, C1
Wallace, HL1
Deaton, JG1
Levin, WC1
Hansen, NE1
Wiontzek, H1
Wessler, S1
Avioli, LV1

Reviews

2 reviews available for chloramphenicol and Leukopenia

ArticleYear
Immune and toxic mechanisms in drug-induced agranulocytosis.
    Seminars in hematology, 1973, Volume: 10, Issue:4

    Topics: Agranulocytosis; Aminopyrine; Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Antithyroi

1973
Typhoid fever in African and Indian children in Durban.
    Archives of disease in childhood, 1969, Volume: 44, Issue:233

    Topics: Africa, Southern; Anemia, Hemolytic; Aphasia; Arthritis; Ataxia; Cardiovascular Diseases; Carrier St

1969

Trials

1 trial available for chloramphenicol and Leukopenia

ArticleYear
Scrub typhus. A comparison of chloramphenicol and tetracycline in its treatment.
    Archives of internal medicine, 1973, Volume: 132, Issue:1

    Topics: Albuminuria; Anemia; Arrhythmias, Cardiac; Aspartate Aminotransferases; Chloramphenicol; Conjunctivi

1973

Other Studies

28 other studies available for chloramphenicol and Leukopenia

ArticleYear
Leukopenia, a complication of chloromycetin therapy of chronic discoid lupus erythematosus.
    The Journal of investigative dermatology, 1952, Volume: 19, Issue:3

    Topics: Chloramphenicol; Humans; Leukocytes; Leukopenia; Lupus Erythematosus, Discoid; Lupus Erythematosus,

1952
[The presumed leukopenic action of chloramphenicol].
    Il Policlinico. Sezione pratica, 1953, Jul-13, Volume: 60, Issue:28

    Topics: Chloramphenicol; Hyperthermia, Induced; Leukocyte Count; Leukopenia; Typhoid Fever; Typhoid-Paratyph

1953
Hematologic toxicity of a chloramphenicol analogue.
    The American journal of the medical sciences, 1962, Volume: 244

    Topics: Chloramphenicol; Erythrocytes; Leukopenia

1962
Chlorampehnicol and its sulfamoyl analogue. Report of reversible erythropoietic toxicity in healthy volunteers.
    Archives of internal medicine, 1963, Volume: 111

    Topics: Bone Marrow Diseases; Chloramphenicol; Erythropoiesis; Healthy Volunteers; Humans; Leukopenia; Throm

1963
[Blood complications induced by chloramphenicol].
    La Revue du praticien, 1962, Nov-21, Volume: 12

    Topics: Anemia; Anemia, Aplastic; Chloramphenicol; Humans; Leukopenia; Thrombocytopenia

1962
[ON CHLORAMPHENICOL-RELATED CASES OF PANCYTOPENIA].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1963, Aug-01, Volume: 18

    Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Bone Marrow Transplantation; Chloramphenicol; Erythropoie

1963
INVESTIGATIONS OF THE IMMUNOLOGICAL REACTIVITY IN HAEMOBLASTOSES. IV. THE BACTERICIDAL PROPERTIES OF THE SERUM AGAINST GRAM-POSITIVE MICROBES IN PATIENTS SUFFERING FROM LEUKAEMIA, MALIGNANT LYMPHOMA, MYELOMA, AND MYELOFIBROSIS.
    Neoplasma, 1964, Volume: 11

    Topics: Aged; Agranulocytosis; Anti-Bacterial Agents; Bacteroides; Brucella; Chloramphenicol; Complement Sys

1964
ACTION OF ANTIBIOTICS ON ERYTHRO- AND LEUCOPOIESIS IN HEALTHY DOGS. III. ACTION OF CHLORAMPHENICOL AND COMBINED ANTIBIOTICS.
    Folia haematologica (Leipzig, Germany : 1928), 1963, Volume: 80

    Topics: Agranulocytosis; Anemia; Anti-Bacterial Agents; Bone Marrow Diseases; Bone Marrow Examination; Chlor

1963
STAPHYLOCOCCAL PNEUMONIA IN CHILDHOOD; LONG-TERM FOLLOW-UP.
    American journal of diseases of children (1960), 1964, Volume: 108

    Topics: Adolescent; Aerosols; Anti-Bacterial Agents; Candidiasis; Child; Chloramphenicol; Drug Therapy; Eryt

1964
STUDIES ON THE LYMPHOCYTE RESPONSE TO INFLAMMATION.
    Annals of the New York Academy of Sciences, 1964, Aug-27, Volume: 116

    Topics: Agranulocytosis; Aminopterin; Animals; Azaguanine; Biopsy; Chloramphenicol; Connective Tissue; Cyclo

1964
[CLINICO-HEMATOLOGICAL, BIOCHEMICAL AND MORPHOLOGICAL CHANGES IN THE RECOVERY PERIOD DURING THERAPY OF RADIATION SICKNESS].
    Biulleten' eksperimental'noi biologii i meditsiny, 1964, Volume: 57

    Topics: Alcohols; Animals; Blood; Body Temperature; Body Weight; Chloramphenicol; Chlortetracycline; Creatin

1964
Comparative study between paratyphoid A and typhoid fever cases.
    The Journal of the Egyptian Public Health Association, 1996, Volume: 71, Issue:5-6

    Topics: Acute Disease; Adolescent; Adult; Agglutination Tests; Anti-Bacterial Agents; Bronchitis; Case-Contr

1996
Comparative study on different recent diagnostic and therapeutic regimens in acute typhoid fever.
    The Journal of the Egyptian Public Health Association, 1999, Volume: 74, Issue:1-2

    Topics: Acute Disease; Adolescent; Adult; Agglutination Tests; Anti-Bacterial Agents; Case-Control Studies;

1999
Bone marrow depression induced by chloramphenicol or phenylbutazone. Leukemia and other sequelae.
    JAMA, 1967, Sep-11, Volume: 201, Issue:11

    Topics: Anemia, Aplastic; Bone Marrow Diseases; Chloramphenicol; Follow-Up Studies; Hemorrhage; Humans; Infe

1967
Chloramphenicol in children: dose, plasma levels and clinical effects.
    Annals of tropical paediatrics, 1998, Volume: 18, Issue:2

    Topics: Anemia; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Drug Monitoring; Humans; In

1998
Haematological side-effects of drugs.
    The Practitioner, 1976, Volume: 216, Issue:1291

    Topics: Ampicillin; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Megaloblastic; Anti-Inflammatory Agents, No

1976
Drug-induced inhibition of myeloid colony growth: protective effect of colony-stimulating factor.
    The Journal of laboratory and clinical medicine, 1975, Volume: 86, Issue:3

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Chloramphenicol; Chlorpromazine; Clone Cells

1975
Lack of predictability of chloramphenicol toxicity in paediatric patients.
    Journal of clinical pharmacy and therapeutics, 1989, Volume: 14, Issue:4

    Topics: Anemia; Child; Child, Preschool; Chloramphenicol; Eosinophilia; Hematologic Diseases; Humans; Infant

1989
[Effect of chloramphenicol on the toxic and therapeutic actions of cyclophosphane].
    Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 1986, Volume: 31, Issue:3

    Topics: Animals; Chloramphenicol; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation, Precl

1986
[Acute drug cytopenia. Apropos of 11 cases].
    Annales de medecine interne, 1971, Volume: 122, Issue:4

    Topics: Adult; Aged; Agranulocytosis; Aminopyrine; Anemia; Antithyroid Agents; Blood Transfusion; Bone Marro

1971
The distribution of incubation periods of neoplastic diseases.
    American journal of epidemiology, 1974, Volume: 99, Issue:2

    Topics: Adenoma; Adolescent; Adult; Burkitt Lymphoma; Carcinoma, Bronchogenic; Child; Child, Preschool; Chlo

1974
Untoward effects of antimicrobial agents on major organ systems.
    The Medical clinics of North America, 1974, Volume: 58, Issue:3

    Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia;

1974
A marker chromosome abnormality. Occurrence in chloramphenicol-associated acute leukemia.
    Archives of internal medicine, 1973, Volume: 132, Issue:3

    Topics: Aged; Anemia, Aplastic; Bone Marrow Examination; Chloramphenicol; Chromosome Aberrations; Chromosome

1973
Hematological side effects of chloramphenicol and thiamphenicol.
    Helvetica medica acta, 1973, Volume: 37, Issue:4

    Topics: Acetamides; Adolescent; Adult; Aged; Anemia, Aplastic; Bone Marrow; Bronchitis; Child; Child, Presch

1973
Systemic lupus erythematosus and acute myeloblastic leukemia. Report of their coexistence and a survey of possible associating features.
    Archives of internal medicine, 1967, Volume: 120, Issue:3

    Topics: Bone Marrow; Chloramphenicol; Female; Hematocrit; Hemoglobinometry; Humans; Leukemia, Myeloid, Acute

1967
[Leukopenia].
    Tandlaegebladet, 1969, Volume: 73, Issue:4

    Topics: Agranulocytosis; Anti-Bacterial Agents; Antineoplastic Agents; Cachexia; Chloramphenicol; Collagen D

1969
[Bone marrow lesions caused by chloramphenicol. Case report].
    Munchener medizinische Wochenschrift (1950), 1969, Oct-31, Volume: 111, Issue:44

    Topics: Anemia, Aplastic; Asthma; Blood Transfusion; Bone Marrow Diseases; Chloramphenicol; Erythrocytes; He

1969
Mechanisms of action of chloramphenicol.
    JAMA, 1969, Jul-07, Volume: 209, Issue:1

    Topics: Antibody Formation; Blood Proteins; Chloramphenicol; Female; Hematocrit; Humans; Immunosuppressive A

1969