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chloramphenicol and Leukemia

chloramphenicol has been researched along with Leukemia in 56 studies

Amphenicol: Chloramphenicol and its derivatives.

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Treatment of drug-induced aplastic anemia requires transfusions."2.35Drug-induced anaemias. ( Girdwood, RH, 1976)
"Chloramphenicol (CAP) was an old antimicrobial agent."1.42Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug. ( Ida, N; Kawanishi, S; Murata, M; Ohnishi, S; Oikawa, S, 2015)
"Chloramphenicol is an antimicrobial agent having a very broad-spectrum of activity including Gram-positive bacteria, Gram-negative bacteria and anaerobes."1.34Chloramphenicol: screening and review to evaluate its potential beneficial effects in leukaemia. ( Juvekar, AS; Kulkarni, KP; Lokhande, J, 2007)
"A population-based case-control interview study of 309 childhood leukaemia cases and 618 age and sex matched controls showed a significant dose-response relation between chloramphenicol and risk of both acute lymphocytic leukaemia (ALL) and acute non-lymphocytic leukaemia (ANLL), treatment for more than 10 days being associated with risks of 11."1.27Chloramphenicol use and childhood leukaemia in Shanghai. ( Brinton, LA; Fraumeni, JF; Gao, RN; Gao, YT; Jin, F; Linet, MS; Shu, XO, 1987)
"Corynebacterium equi, a known cause of pneumonitis in foals, calves, and swine, was isolated from the sputum and bronchial washings of a child with pneumonitis and leukemia."1.26Pneumonitis due to Corynebacterium equi. ( Gardner, SE; Hughes, WT; Pearson, T, 1976)

Research

Studies (56)

TimeframeStudies, this research(%)All Research%
pre-199052 (92.86)18.7374
1990's2 (3.57)18.2507
2000's1 (1.79)29.6817
2010's1 (1.79)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ohnishi, S1
Murata, M1
Ida, N1
Oikawa, S1
Kawanishi, S1
LEBON, J1
MESSERSCHMITT, J1
MUKHERJI, PS1
YUNIS, AA2
HARRINGTON, WJ1
DARJA, M1
DAVY, MI1
LIBANSKY, J1
JEZKOVA, Z1
NAKAO, K1
TAKAKU, S1
UEMURA, R1
COLLIPP, PJ1
KAPLAN, SA1
PATRICK, JR1
Lokhande, J1
Juvekar, AS1
Kulkarni, KP1
Fraumeni, JF4
Baumelou, E1
Najean, Y1
Adamson, RH1
Seiber, SM1
Schmitt-Gräff, A1
Stacher, A1
Lutz, D1
Dow, LW1
Doody, MM1
Linet, MS2
Glass, AG1
Curtis, RE1
Pottern, LM1
Rush, BB1
Boice, JD1
Friedman, GD1
Hennemann, HH1
Keiser, G3
Girdwood, RH1
Aboul-Enein, M1
El-Zayat, A1
Hamza, MR1
El-Mawla, NG1
Aboul-Nasr, L1
Gardner, SE1
Pearson, T1
Hughes, WT1
Itoh, M1
Yoshida, M1
Kurata, H1
Imagawa, S1
Hoshino, M1
Tsunoda, J1
Ema, H1
Tsunoda, S1
Suzuki, T1
Komatsu, N1
Shu, XO1
Gao, YT1
Brinton, LA1
Gao, RN1
Jin, F1
Stevens, JD1
Mission, GP1
Kumana, CR1
Chau, RY1
Chan, TK1
Chaplin, S1
Corneo, G1
Cortellaro, M1
Maiolo, AT1
Bardi, U1
Shackelford, PG1
Ratzan, SA1
Shearer, WT1
Armenian, HK1
Lilienfeld, AM1
Segal, S1
Modan, B1
Shani, M1
Sheba, C1
Potolsky, A1
Creger, WP1
Gadner, H1
Gethmann, U1
Jessenberger, K1
Riehm, H1
Vince, R1
Daluge, S1
Palm, M1
Stohlman, F1
Mey, U1
Forni, A1
Vigliani, EC1
Götz, M1
Pichler, E1
Hughes, DW1
Meyer, JS1
Boxer, M1
Abrams, E1
Zierdt, CH1
Brown, JA1
Baserga, A1
Galton, DA1
Spiers, AS1
Paterni, L1
Mork, JN1
Thalhuber, WH1
Swaim, WR1
Gadrat, J1
Monnier, J1
Bourse, R1
Pris, J1
Wasi, P1
Kruetrachue, M1
Na-Nakorn, S1
Walder, HR1
Donski, S1
Bucher, U1
Naess, K1
Rowley, JD1
Blaisdell, RK1
Jacobson, LO1

Reviews

10 reviews available for chloramphenicol and Leukemia

ArticleYear
Chemically induced leukemia in humans.
    Environmental health perspectives, 1981, Volume: 39

    Topics: Benzene; Chlorambucil; Chloramphenicol; Cyclophosphamide; Humans; Leukemia; Melphalan; Phenylbutazon

1981
Sensitivity of normal and neoplastic cells to chemotherapeutic agents in vitro.
    Advances in internal medicine, 1980, Volume: 25

    Topics: Antineoplastic Agents; Bone Marrow; Cell Division; Cell Survival; Chloramphenicol; Hematopoietic Ste

1980
[Toxicity of chloramphenicol and thiamphenicol (CAP and TAP)].
    Haematology and blood transfusion, 1978, Volume: 21

    Topics: Anemia, Aplastic; Animals; Bacteria; Bone Marrow; Chemical Phenomena; Chemistry; Chloramphenicol; DN

1978
Drug-induced anaemias.
    Drugs, 1976, Volume: 11, Issue:5

    Topics: Anemia; Anemia, Aplastic; Anemia, Megaloblastic; Anemia, Sideroblastic; Anticonvulsants; Bone Marrow

1976
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part II.
    Adverse drug reactions and acute poisoning reviews, 1986,Autumn, Volume: 5, Issue:3

    Topics: Anemia, Aplastic; Bone Marrow; Chloramphenicol; Dose-Response Relationship, Drug; Erythropoiesis; Hu

1986
Clinical epidemiology of leukemia.
    Seminars in hematology, 1969, Volume: 6, Issue:3

    Topics: Adolescent; Age Factors; Anemia, Pernicious; Benzene; Child, Preschool; Chloramphenicol; Chromosome

1969
[Etiology of human leukemias].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1974, Jul-15, Volume: 29, Issue:14

    Topics: Age Factors; Benzene; Cell Transformation, Neoplastic; Chloramphenicol; Hematopoietic Stem Cells; Hu

1974
Chemical leukemogenesis in man.
    Series haematologica (1968), 1974, Volume: 7, Issue:2

    Topics: Anemia, Aplastic; Benzene; Benzene Derivatives; Bone Marrow; Bone Marrow Cells; Chloramphenicol; Hum

1974
Drug--induced bone marrow injury.
    Advances in internal medicine, 1969, Volume: 15

    Topics: Adult; Agranulocytosis; Anemia, Aplastic; Bone Marrow Diseases; Child, Preschool; Chloramphenicol; H

1969
Progress in the leukemias.
    Progress in hematology, 1971, Volume: 7, Issue:0

    Topics: Alkylating Agents; Androgens; Anemia, Hemolytic, Autoimmune; Benzene; Blood Transfusion; Bone Marrow

1971

Other Studies

46 other studies available for chloramphenicol and Leukemia

ArticleYear
Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug.
    Free radical research, 2015, Volume: 49, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Bacterial Agents; Cattle; Chloramphenicol; Deoxyguanosine

2015
[Drug-induced aplastic myelosis; terminal acute myeloblstosis; pathogenic reflections].
    Le Sang, 1955, Volume: 26, Issue:8

    Topics: Arsenicals; Chloramphenicol; Humans; Leukemia; Leukemia, Myeloid

1955
Acute myeloblastic leukaemia following chloramphenicol treatment.
    British medical journal, 1957, Jun-01, Volume: 1, Issue:5030

    Topics: Chloramphenicol; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute

1957
Patterns of inhibition by chloramphenicol of nucleic acid synthesis in human bone marrow and leukemic cells.
    The Journal of laboratory and clinical medicine, 1960, Volume: 56

    Topics: Bone Marrow; Chloramphenicol; Humans; Leukemia; Nucleic Acids; Vegetables

1960
PULMONARY MUCORMYCOSIS WITH CULTURAL IDENTIFICATION.
    Canadian Medical Association journal, 1963, Dec-14, Volume: 89

    Topics: Anti-Bacterial Agents; Canada; Chloramphenicol; Cortisone; Erythromycin; Geriatrics; Humans; Leukemi

1963
INVESTIGATIONS OF THE IMMUNOLOGICAL REACTIVITY IN HAEMOBLASTOSES. IV. THE BACTERICIDAL PROPERTIES OF THE SERUM AGAINST GRAM-POSITIVE MICROBES IN PATIENTS SUFFERING FROM LEUKAEMIA, MALIGNANT LYMPHOMA, MYELOMA, AND MYELOFIBROSIS.
    Neoplasma, 1964, Volume: 11

    Topics: Aged; Agranulocytosis; Anti-Bacterial Agents; Bacteroides; Brucella; Chloramphenicol; Complement Sys

1964
[BLOOD DISEASES].
    Naika. Internal medicine, 1964, Volume: 13

    Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Pernicious; Blood Coagulation; Blood Protein

1964
BACTERIOSTATIC CHEMOTHERAPEUTIC AGENTS AND THE GROWTH OF MALIGNANT TUMOR.
    The Journal of the International College of Surgeons, 1964, Volume: 41

    Topics: Adenoma; Aminosalicylic Acid; Aminosalicylic Acids; Animals; Anti-Bacterial Agents; Antineoplastic A

1964
REDUCED LIVER GLUCOSE-6-PHOSPHATASE IN HUMAN LEUKEMIA.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1965, Volume: 118

    Topics: Antineoplastic Agents; Child; Chloramphenicol; Clinical Enzyme Tests; Dactinomycin; Drug Therapy; Gl

1965
Chloramphenicol: screening and review to evaluate its potential beneficial effects in leukaemia.
    Journal of the Indian Medical Association, 2007, Volume: 105, Issue:4

    Topics: Anti-Infective Agents; Antineoplastic Agents; Chloramphenicol; Humans; In Vitro Techniques; Leukemia

2007
Bone marrow depression induced by chloramphenicol or phenylbutazone. Leukemia and other sequelae.
    JAMA, 1967, Sep-11, Volume: 201, Issue:11

    Topics: Anemia, Aplastic; Bone Marrow Diseases; Chloramphenicol; Follow-Up Studies; Hemorrhage; Humans; Infe

1967
Why still prescribe chloramphenicol in 1983? Comparison of the clinical and biological hematologic effects of chloramphenicol and thiamphenicol.
    Blut, 1983, Volume: 47, Issue:6

    Topics: Acute Disease; Anemia; Anemia, Aplastic; Bone Marrow; Chloramphenicol; Dose-Response Relationship, D

1983
Fever and chloramphenicol in leukemic patients.
    Acta haematologica, 1980, Volume: 64, Issue:5

    Topics: Chloramphenicol; Fever of Unknown Origin; Humans; Leukemia

1980
Chloramphenicol-induced aplastic anemia terminating with acute nonlymphocytic leukemia.
    Acta haematologica, 1981, Volume: 66, Issue:4

    Topics: Acute Disease; Adult; Anemia, Aplastic; Chloramphenicol; Humans; Leukemia; Male

1981
[Drug-induced leukemia].
    Acta medica Austriaca. Supplement, 1982, Volume: 25

    Topics: Antineoplastic Agents; Chloramphenicol; Drug-Related Side Effects and Adverse Reactions; Humans; Imm

1982
Risks of non-Hodgkin's lymphoma, multiple myeloma, and leukemia associated with common medications.
    Epidemiology (Cambridge, Mass.), 1996, Volume: 7, Issue:2

    Topics: Adult; Aged; Amphetamines; California; Case-Control Studies; Chloramphenicol; Confidence Intervals;

1996
[Septicaemia in leukaemia (author's transl)].
    Medizinische Klinik, 1977, Apr-15, Volume: 72, Issue:15

    Topics: Adult; Amikacin; Ampicillin; Chloramphenicol; Female; Gentamicins; Humans; Immunity, Cellular; Immun

1977
Chloramphenicol as a possible leukaemogenic agent.
    The Journal of the Egyptian Public Health Association, 1977, Volume: 52, Issue:1

    Topics: Acute Disease; Adult; Anemia, Aplastic; Child; Chloramphenicol; Female; Humans; Leukemia; Male; Midd

1977
Pneumonitis due to Corynebacterium equi.
    Chest, 1976, Volume: 70, Issue:1

    Topics: Adolescent; Chloramphenicol; Corynebacterium; Corynebacterium Infections; Humans; Immunosuppression

1976
[Staphylococcus aureus sepsis in patients with hematological malignancies: increase in MRSA sepsis].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1991, Volume: 32, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Chloramphenicol; Female; Humans; Leukemia; Male; Methicillin Resista

1991
Chloramphenicol use and childhood leukaemia in Shanghai.
    Lancet (London, England), 1987, Oct-24, Volume: 2, Issue:8565

    Topics: Child; Child, Preschool; China; Chloramphenicol; Dose-Response Relationship, Drug; Humans; Interview

1987
Ophthalmic use of chloramphenicol.
    Lancet (London, England), 1987, Dec-19, Volume: 2, Issue:8573

    Topics: Administration, Topical; Child; Chloramphenicol; Eye Diseases; Humans; Leukemia

1987
Chloramphenicol use and childhood leukaemia.
    Lancet (London, England), 1988, Feb-27, Volume: 1, Issue:8583

    Topics: Child; China; Chloramphenicol; Humans; Leukemia

1988
[Etiopathogenetic, clinical and therapeutic aspects of involutive myelopathies].
    Recenti progressi in medicina, 1973, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anabolic Agents; Anemia, Aplastic; Bone Marrow Diseas

1973
Ecthyma gangrenosum produced by Aeromonas hydrophilia.
    The Journal of pediatrics, 1973, Volume: 83, Issue:1

    Topics: Adolescent; Aeromonas; Carbenicillin; Cephalothin; Chloramphenicol; Ecthyma; Enterobacteriaceae Infe

1973
The distribution of incubation periods of neoplastic diseases.
    American journal of epidemiology, 1974, Volume: 99, Issue:2

    Topics: Adenoma; Adolescent; Adult; Burkitt Lymphoma; Carcinoma, Bronchogenic; Child; Child, Preschool; Chlo

1974
[Chloramphenicol in the etiology of aplastic anemia].
    Harefuah, 1974, Sep-01, Volume: 87, Issue:5

    Topics: Acute Disease; Adolescent; Adult; Anemia, Aplastic; Child; Child, Preschool; Chloramphenicol; Female

1974
Radiation and drug therapies, and leukemia.
    Annual review of medicine, 1973, Volume: 24

    Topics: Antineoplastic Agents; Benzene; Bone Marrow Diseases; Chloramphenicol; Cyclophosphamide; Dose-Respon

1973
[Acute leukemia following exposure to chloramphenicol? Three case reports and review of the literature (author's transl)].
    Monatsschrift fur Kinderheilkunde, 1973, Volume: 121, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Aged; Anemia, Aplastic; Child; Child, Preschool; Chloramphenicol;

1973
Inhibition of in vitro protein synthesis by a carbocyclic puromycin analog.
    Biochemical and biophysical research communications, 1972, Jan-31, Volume: 46, Issue:2

    Topics: Animals; Antineoplastic Agents; Bacterial Proteins; Carbon Isotopes; Carcinoma; Cell Line; Chloramph

1972
Aplastic anemia.
    Blood, 1972, Volume: 40, Issue:2

    Topics: Androgens; Anemia, Aplastic; Blood Transfusion; Bone Marrow Transplantation; Chloramphenicol; Hemato

1972
[Aplastic anaemia in childhood].
    Klinische Padiatrie, 1972, Volume: 184, Issue:5

    Topics: Abnormalities, Multiple; Acute Disease; Anemia, Aplastic; Bone Marrow Examination; Child; Child, Pre

1972
Bone-marrow depression in childhood.
    The Medical journal of Australia, 1973, Feb-17, Volume: 1, Issue:7

    Topics: Androgens; Anemia, Aplastic; Child; Chloramphenicol; Diagnosis, Differential; Erythrocytes, Abnormal

1973
Leukemic cellular thrombi in pulmonary blood vessels. Subleukemic myelogenous leukemia following chloramphenicol-induced aplastic anemia.
    Cancer, 1973, Volume: 32, Issue:3

    Topics: Adult; Anemia, Aplastic; Autopsy; Chloramphenicol; Esterases; Female; Hemosiderosis; Histiocytes; Hi

1973
Observations on Aeromonas hydrophila septicaemia in a patient with leukaemia.
    Journal of clinical pathology, 1971, Volume: 24, Issue:6

    Topics: Adolescent; Aeromonas; Chloramphenicol; Enterobacteriaceae; Escherichia coli; Humans; Leukemia; Male

1971
[Karyotype in preleukemic and preneoplastic conditions].
    Haematologica, 1970, Volume: 55, Issue:3

    Topics: Anemia; Antineoplastic Agents; Benzene; Chloramphenicol; Chromosome Aberrations; Humans; Karyotyping

1970
[General pathology of blood diseases due to non-hemolytic chemical agents. Special reference to myelopathies and cryptogenetic leukemia].
    Minerva medica, 1972, Feb-14, Volume: 63, Issue:11

    Topics: Acute Disease; Benzene; Bone Marrow Diseases; Chloramphenicol; Hematologic Diseases; Hemoglobinuria,

1972
Hematologic toxicity of chloramphenicol.
    Minnesota medicine, 1969, Volume: 52, Issue:10

    Topics: Aged; Anemia, Aplastic; Chloramphenicol; Female; Hematologic Diseases; Humans; Leukemia; Male; Middl

1969
[Regressive bone marrow aplasia and terminal acute leukosis after chloramphenicol treatment].
    Annales de medecine interne, 1969, Volume: 120, Issue:10

    Topics: Acute Disease; Adult; Anemia, Aplastic; Chloramphenicol; Humans; Leukemia; Male

1969
[Chloramphenicol therapy].
    Blut, 1970, Volume: 20, Issue:2

    Topics: Agranulocytosis; Anemia, Aplastic; Biliary Tract Diseases; Bronchitis; Chlamydia Infections; Chloram

1970
Aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome-acute leukemia in the same patient. The first record of such occurrence.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1970, Volume: 53, Issue:9

    Topics: Adolescent; Anemia, Aplastic; Chloramphenicol; Hemoglobinuria, Paroxysmal; Humans; Leukemia; Male

1970
[Acquired panmyelopathies].
    Schweizerische medizinische Wochenschrift, 1970, Nov-14, Volume: 100, Issue:46

    Topics: Anemia, Aplastic; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Chloramphenicol; Deficiency

1970
[Idiopathic and drug-induced acquired aplastic anemia].
    Schweizerische medizinische Wochenschrift, 1970, Apr-18, Volume: 100, Issue:16

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Androgens; Anemia, Aplastic; Blood Transfusion; Chloramp

1970
Increase of the number of pancytopenias between 1954 and 1964.
    Helvetica medica acta, 1968, Volume: 34, Issue:4

    Topics: Adult; Aged; Anemia, Aplastic; Bone Marrow; Chloramphenicol; Collagen Diseases; Communicable Disease

1968
[Leukemia as a reaction to poisons and drugs? Discussion of a hypothesis].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1969, Jul-15, Volume: 89, Issue:14

    Topics: Analgesics; Benzene; Chloramphenicol; Leukemia

1969
Chromosome studies in preleukemia. I. Aneuploidy of group C chromosomes in three patients.
    Blood, 1966, Volume: 27, Issue:6

    Topics: Adult; Anemia; Anemia, Aplastic; Anemia, Sideroblastic; Chloramphenicol; Chromosome Aberrations; Chr

1966