chloramphenicol and Infections, Klebsiella studies

Research Excerpts

Excerpt	Relevance	Reference
"We have described a patient with Klebsiella pneumoniae meningitis who was treated with cefotaxime and chloramphenicol concomitantly, and whose slow initial resolution and subsequent relapse plus in vitro evidence of antagonism of cefotaxime appear to indicate that chloramphenicol interfered with the activity of the cephalosporin."	7.67	Failure of chloramphenicol and cefotaxime therapy in Klebsiella meningitis: possible role of antibiotic antagonism. ( Alford, RH; Brown, TH, 1985)
"We have described a patient with Klebsiella pneumoniae meningitis who was treated with cefotaxime and chloramphenicol concomitantly, and whose slow initial resolution and subsequent relapse plus in vitro evidence of antagonism of cefotaxime appear to indicate that chloramphenicol interfered with the activity of the cephalosporin."	3.67	Failure of chloramphenicol and cefotaxime therapy in Klebsiella meningitis: possible role of antibiotic antagonism. ( Alford, RH; Brown, TH, 1985)
"Chloramphenicol is a broad-spectrum antimicrobial widely available in sub-Saharan Africa."	1.51	ChloS-HRM, a novel assay to identify chloramphenicol-susceptible Escherichia coli and Klebsiella pneumoniae in Malawi. ( Adams, ER; Edwards, T; Feasey, NA; Musicha, P; Williams, CT, 2019)
"When chloramphenicol was added before the beta-lactams, the action of cefotaxime, moxalactam, or cefoperazone against all isolates was antagonized at all times tested."	1.27	Antagonism by chloramphenicol of broad-spectrum beta-lactam antibiotics against Klebsiella pneumoniae. ( Alford, RH; Brown, TH, 1984)
" Use of CL in neonates has been limited since the recognition that vascular collapse may occur as a consequence of dosage regimens tolerated by adults."	1.26	Disposition of chloramphenicol in low birth weight infants. ( Danish, MA; Glazer, JP; Plotkin, SA; Yaffe, SJ, 1980)
"Gentamicin in combination with cephalothin (Gent-Ceph) or with chloramphenicol (Gent-Chloro) was utilized in the treatment of 55 infections occurring in 49 cancer patients."	1.26	Therapy of infections in neutropenic patients: results with gentamicin in combination with cephalothin or chloramphenicol. ( Bodey, GP; Burgess, MA; Rodriguez, V; Valdivieso, M, 1976)

Timeframe	Studies, this research(%)	All Research%
pre-1990	47 (88.68)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (11.32)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Padilla, E	1
Llobet, E	1
Doménech-Sánchez, A	1
Martínez-Martínez, L	1
Bengoechea, JA	1
Albertí, S	1
Poirel, L	1
Revathi, G	1
Bernabeu, S	1
Nordmann, P	1
Sarciaux, M	1
Pantel, L	1
Midrier, C	1
Serri, M	1
Gerber, C	1
Marcia de Figueiredo, R	1
Campagne, JM	1
Villain-Guillot, P	1
Gualtieri, M	1
Racine, E	1
Williams, CT	1
Musicha, P	1
Feasey, NA	1
Adams, ER	1
Edwards, T	1
Battikh, H	1
Harchay, C	1
Dekhili, A	1
Khazar, K	1
Kechrid, F	1
Zribi, M	1
Masmoudi, A	1
Fendri, C	1
Srinivasan, VB	1
Vaidyanathan, V	1
Mondal, A	1
Rajamohan, G	1
CORCOS, V	1
EISENBERG, GM	2
FLIPPIN, HF	2
KAYSER, HL	2
NADEL, J	2
SATHAVARA, S	2
SPIVACK, A	2
WEISS, W	2
LOSONCZY, G	1
PETRAS, G	1
HAIDECKER, J	1
MARCUS, S	1
DONALDSON, DM	1
ESPLIN, DW	1
OLSSON, RA	1
ROMANSKY, MJ	1
Brown, TH	2
Alford, RH	3
Madhavan, T	1
Kiani, D	1
Saravolatz, L	1
Burch, K	1
Mellinger, RC	1
Glazer, JP	1
Danish, MA	1
Plotkin, SA	1
Yaffe, SJ	1
Rodríguez-Alarcón Gómez, J	1
Jaquotot, R	1
López-Chico, D	1
Gerisch, B	1
Oltmanns, G	1
Rübesamen, M	1
Anger, G	1
Vavros, B	1
Urbásková, P	1
Valdivieso, M	1
Bodey, GP	1
Burgess, MA	1
Rodriguez, V	1
Kitto, W	1
Parant, M	1
Parant, F	1
Chedid, L	1
Minor, LL	1
Waisbren, BA	1
Schwab, W	1
Hoffman, NR	1
Preston, FS	1
McHenry, MC	1
Motsay, GJ	1
Martin, WJ	1
Yu, PK	1
Washington, JA	1
Tauchnitz, C	1
Rahal, JJ	1
Boxerbaum, B	1
Terman, JW	1
Bryant, RE	1
Lorian, V	1
Topf, B	1
Eisenach, KD	1
Reber, RM	1
Eitzman, DV	1
Baer, H	1
Schlenker, JD	1
Barrios, R	1
Trolin, C	1
Schoutens, E	1
Yourassowsky, E	2
Squire, RA	1
Bush, M	1
Curry, N	1
McCallum, RW	1
Guth, PH	1
Tong, MJ	1
Barenholtz, L	1
Kaminsky, NI	1
Palmer, DL	1
Sivasamboo, R	1
Lean, TH	1
Goon, SM	1
Rubbo, SD	1
Gardner, P	1
Smith, DH	1
Baker, GL	1
Josey, WE	1
Farrar, WE	1
Elder, HA	1
Santamarina, BA	1
Smith, S	1
Kass, EH	1
Biró, L	1
Iván, E	1
Lévai, O	1
Siegenthaler, W	1
Vetter, H	1
Lüthy, R	1
Siegenthaler, G	1
Wehr, KL	1
McCall, CE	1
Marca, G	1
Codazza, D	1
Brincourt, J	1
Ward, JD	1
Münter, W	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Wound Bacterial Microbiota and Their Antibiotic Resistance: a Prospective Cohort Study of Hospitalized Patients Originating From the Syrian Armed Conflict[NCT02744144]				457 participants (Actual)	Observational	2014-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Antibiotics in the treatment of burns. The Surgical clinics of North America, 1970, Volume: 50, Issue:6 Topics: Adult; Anti-Bacterial Agents; Burns; Child; Chloramphenicol; Clostridium Infections; Enterobacter; g	1970
[Sulfonamide and antibiotic usage in otolaryngology (author's transl)]. HNO, 1974, Volume: 22, Issue:6 Topics: Adult; Anti-Bacterial Agents; Cephalosporins; Child; Chloramphenicol; Erythromycin; Escherichia coli	1974
Bacteremic shock due to gram-negative bacilli. Some concepts of pathogenesis and management based on recent developments. Geriatrics, 1969, Volume: 24, Issue:4 Topics: Animals; Bacteroides Infections; Chloramphenicol; Enterobacter; Escherichia coli Infections; Gentami	1969
Treatment of gram-negative bacillary meningitis in adults. Annals of internal medicine, 1972, Volume: 77, Issue:2 Topics: Adult; Alcaligenes; Ampicillin; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Carbenicillin	1972
Management of neonatal bacterial infections. Rx: continual alertness, specific treatment, and ampicillin with kanamycin until the culture reports are back. Clinical pediatrics, 1969, Volume: 8, Issue:10 Topics: Ampicillin; Anti-Bacterial Agents; Chloramphenicol; Cross Infection; Escherichia coli Infections; Hu	1969
[Clinical picture and antibiotic therapy of bacterial septicemias in internal medicine]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1971, Volume: 77 Topics: Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Chloramphenicol; Drug Combinations; End	1971

Article	Year
Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:1 Topics: Animals; Anti-Bacterial Agents; Bronchoalveolar Lavage Fluid; Culture Media; Defensins; DNA, Bacteri	2010
Detection of NDM-1-producing Klebsiella pneumoniae in Kenya. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:2 Topics: Adult; Aged; Anti-Bacterial Agents; beta-Lactamases; Carbapenems; Cross Infection; DNA, Bacterial; D	2011
Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17 Topics: Animals; Anti-Bacterial Agents; Humans; Klebsiella Infections; Klebsiella pneumoniae; Mice; Microbia	2018
ChloS-HRM, a novel assay to identify chloramphenicol-susceptible Escherichia coli and Klebsiella pneumoniae in Malawi. The Journal of antimicrobial chemotherapy, 2019, 05-01, Volume: 74, Issue:5 Topics: Chloramphenicol; Escherichia coli; Escherichia coli Infections; Genes, Bacterial; Humans; Klebsiella	2019
Clonal Spread of Colistin-Resistant Klebsiella pneumoniae Coproducing KPC and VIM Carbapenemases in Neonates at a Tunisian University Hospital. Microbial drug resistance (Larchmont, N.Y.), 2017, Volume: 23, Issue:4 Topics: Adult; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Typing Techniques; beta-Lactamases; beta	2017
Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044. PloS one, 2012, Volume: 7, Issue:4 Topics: Amino Acid Sequence; Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; B	2012
[Meningitis due to Friedlander's pneumobacillus (Klebsiella pneumoniae) in an eight month old infant; sensitivity of the bacteria to chloromycetin; recovery]. Archives francaises de pediatrie, 1953, Volume: 10, Issue:6 Topics: Bacteriology; Chloramphenicol; Infections; Klebsiella Infections; Klebsiella pneumoniae; Meningitis;	1953
Klebsiella in respiratory disease. Annals of internal medicine, 1956, Volume: 45, Issue:6 Topics: Chloramphenicol; Klebsiella; Klebsiella Infections; Respiratory System; Respiratory Tract Diseases;	1956
Klebsiella in respiratory disease. Annals of internal medicine, 1956, Volume: 45, Issue:6 Topics: Chloramphenicol; Klebsiella; Klebsiella Infections; Respiratory System; Respiratory Tract Diseases;	1956
Klebsiella in respiratory disease. Annals of internal medicine, 1956, Volume: 45, Issue:6 Topics: Chloramphenicol; Klebsiella; Klebsiella Infections; Respiratory System; Respiratory Tract Diseases;	1956
Klebsiella in respiratory disease. Annals of internal medicine, 1956, Volume: 45, Issue:6 Topics: Chloramphenicol; Klebsiella; Klebsiella Infections; Respiratory System; Respiratory Tract Diseases;	1956
[DIAGNOSTIC AND EPIDEMIOLOGICAL DATA ON KLEBSIELLA INFECTIONS]. Orvosi hetilap, 1964, Mar-10, Volume: 105 Topics: Adolescent; Child; Chloramphenicol; Chlortetracycline; Drug Resistance; Drug Resistance, Microbial;	1964
Role of host defenses in systemic Klebsiella pneumoniae infection: effect of antibiotics in normal and x-irradiated mice. Journal of immunology (Baltimore, Md. : 1950), 1955, Volume: 74, Issue:6 Topics: Animals; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Infections; Klebsiella Infections; Kleb	1955
Clinical findings and results of a therapeutic regimen in acute Friedlander's pneumonia. Annals of internal medicine, 1962, Volume: 56 Topics: Anti-Bacterial Agents; Chloramphenicol; Humans; Klebsiella; Klebsiella Infections; Pneumonia; Strept	1962
Antagonism by chloramphenicol of broad-spectrum beta-lactam antibiotics against Klebsiella pneumoniae. Antimicrobial agents and chemotherapy, 1984, Volume: 25, Issue:4 Topics: Anti-Bacterial Agents; Aztreonam; Cephalosporins; Chloramphenicol; Humans; Imipenem; Klebsiella Infe	1984
Recurrent Klebsiella meningitis following trans-sphenoidal hypophysectomy for Nelson's syndrome. Chloramphenicol resistance during relapse. Henry Ford Hospital medical journal, 1980, Volume: 28, Issue:2-3 Topics: Adenoma, Chromophobe; Adult; Cerebrospinal Fluid Rhinorrhea; Chloramphenicol; Drug Resistance, Micro	1980
Disposition of chloramphenicol in low birth weight infants. Pediatrics, 1980, Volume: 66, Issue:4 Topics: Chloramphenicol; Enterobacteriaceae Infections; Half-Life; Humans; Infant; Infant, Low Birth Weight;	1980
[Treatment with Chloranphenicol of neonatal sepsis-meningitis by gram-negative bacteria (author's transl)]. Anales espanoles de pediatria, 1977, Volume: 10, Issue:4 Topics: Chloramphenicol; Drug Evaluation; Female; Humans; Injections, Intravenous; Klebsiella Infections; Kl	1977
[Severe Klebsiella serogenes infections]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1978, Apr-15, Volume: 33, Issue:8 Topics: Aged; Bronchopneumonia; Candida albicans; Carbenicillin; Cephalothin; Chloramphenicol; Drug Therapy,	1978
[Pneumococci resistant to tetracycline and chloramphenicol as a cause of fatal pleuropneumonia]. Vnitrni lekarstvi, 1976, Volume: 22, Issue:4 Topics: Aged; Chloramphenicol; Drug Resistance, Microbial; Humans; Klebsiella Infections; Klebsiella pneumon	1976
Therapy of infections in neutropenic patients: results with gentamicin in combination with cephalothin or chloramphenicol. Medical and pediatric oncology, 1976, Volume: 2, Issue:1 Topics: Agranulocytosis; Bacterial Infections; Cephalothin; Chloramphenicol; Drug Therapy, Combination; Ente	1976
Chloramphenicol today. JAMA, 1975, Jul-28, Volume: 233, Issue:4 Topics: Bacteroides Infections; Bone Marrow; Chloramphenicol; Drug Resistance, Microbial; Haemophilus Infect	1975
[Protective effects of bacterial immunostimulants in mice infected by "Klebsiella pneumoniae" resistant to antibiotics after mutation or by plasmid transfer]. Annales d'immunologie, 1975, Volume: 126, Issue:3 Topics: Ampicillin; Animals; Antigens, Bacterial; BCG Vaccine; Chloramphenicol; Corynebacterium; Endotoxins;	1975
Failure of chloramphenicol and cefotaxime therapy in Klebsiella meningitis: possible role of antibiotic antagonism. Southern medical journal, 1985, Volume: 78, Issue:7 Topics: Brain Diseases; Cefotaxime; Chloramphenicol; Creutzfeldt-Jakob Syndrome; Cysts; Drug Therapy, Combin	1985
Friedlander's pneumonia. A report of 11 cases and appraisal of antibiotic therapy. Diseases of the chest, 1968, Volume: 53, Issue:4 Topics: Adult; Aged; Alcoholism; Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Colistin; Female; Huma	1968
Gram negative septic shock. Experimental and clinical studies. International surgery, 1970, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Ampicillin; Animals; Arteriovenous Anastomosis; Blood Pressure; Capillary P	1970
Epidemiologic significance of Klebsiella pneumoniae. A 3-month study. Mayo Clinic proceedings, 1971, Volume: 46, Issue:12 Topics: Adolescent; Adult; Aged; Cephalothin; Child; Child, Preschool; Chloramphenicol; Cross Infection; Fem	1971
[Expedient therapy of chronic pyelonephritis]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Mar-01, Volume: 25, Issue:5 Topics: Adult; Aged; Ampicillin; Anti-Bacterial Agents; Chloramphenicol; Chronic Disease; Colistin; Depressi	1970
Antimicrobial drugs for treatment of infections caused by aerobic gram-negative bacilli. The Medical clinics of North America, 1974, Volume: 58, Issue:3 Topics: Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Carbenicillin; C	1974
Hospital-acquired Klebsiella bacteremia. The American journal of the medical sciences, 1972, Volume: 264, Issue:3 Topics: Ampicillin; Cephalothin; Chloramphenicol; Colistin; Cross Infection; Gentamicins; Humans; Kanamycin;	1972
Microbiology of nosocomial infections. Archives of internal medicine, 1972, Volume: 130, Issue:1 Topics: Adult; Ampicillin; Anti-Bacterial Agents; Bacteria; Cephalothin; Chloramphenicol; Cross Infection; E	1972
Nosocomial infections due to kanamycin-resistant, (R)-factor carrying enteric organisms in an intensive care nursery. Pediatrics, 1972, Volume: 50, Issue:3 Topics: Ampicillin; Bacterial Infections; Carrier State; Chloramphenicol; Cross Infection; Drug Synergism; E	1972
Gram-negative pneumonias in surgical patients. Complication of antibiotic treatment. Archives of surgery (Chicago, Ill. : 1960), 1973, Volume: 106, Issue:3 Topics: Aged; Ampicillin; Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Erythromycin; Escherichia col	1973
[Sensitivity of Klebsiella to antibiotics. Study of 50 strains from cases of "extra" and "intrahospital" septicemia]. Pathologie-biologie, 1973, Volume: 21, Issue:6 Topics: Anti-Bacterial Agents; Cephalothin; Chloramphenicol; Cross Infection; Drug Resistance, Microbial; Dr	1973
The therapy of canine and feline lymphosarcoma. Bibliotheca haematologica, 1973, Volume: 39 Topics: Ampicillin; Animals; BCG Vaccine; Cat Diseases; Cats; Chloramphenicol; Cyclophosphamide; Dog Disease	1973
Spontaneous peritonitis in cirrhotic ascites. A decade of experience. The American journal of digestive diseases, 1974, Volume: 19, Issue:8 Topics: Adult; Alcoholism; Ampicillin; Cephalothin; Chloramphenicol; Escherichia coli Infections; Fatty Live	1974
Septic complications of war wounds. JAMA, 1972, Feb-21, Volume: 219, Issue:8 Topics: Acinetobacter; Adolescent; Adult; Alcaligenes; Arm Injuries; Bacillus subtilis; Blast Injuries; Bloo	1972
Venous intramural microabscess. A cause of protracted sepsis with intravenous cannulas. The American journal of the medical sciences, 1973, Volume: 265, Issue:4 Topics: Abscess; Adolescent; Catheterization; Chloramphenicol; Drug Resistance, Microbial; Gentamicins; Huma	1973
Ampicillin in septic abortion. The Journal of obstetrics and gynaecology of the British Commonwealth, 1968, Volume: 75, Issue:3 Topics: Abortion, Septic; Ampicillin; Chloramphenicol; Clostridium; Clostridium Infections; Escherichia coli	1968
Common sense in chemotherapy. The Medical journal of Australia, 1969, Mar-01, Volume: 1, Issue:9 Topics: Adult; Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents; Australia; Bacteria; Brucellosis; C	1969
Studies on the epidemiology of resistance (R) factors. I. Analysis of Klebsiella isolates in a general hospital. II. A prospective study of R factor transfer in the host. Annals of internal medicine, 1969, Volume: 71, Issue:1 Topics: Aged; Anti-Bacterial Agents; Bacteriological Techniques; Bacteriuria; Chloramphenicol; Cross Infecti	1969
Cephaloridine in septic abortion. Comparison with a conventional combined antibiotic regimen in a conservative program of management. American journal of obstetrics and gynecology, 1970, Jan-15, Volume: 106, Issue:2 Topics: Abortion, Septic; Adolescent; Adult; Cephaloridine; Chloramphenicol; Escherichia coli Infections; Fe	1970
Intravenous use of chlorocide (chloramphenicol) succinate sodium. Clinical observations and laboratory assays. Therapia Hungarica (English edition), 1971, Volume: 19, Issue:4 Topics: Administration, Oral; Chloramphenicol; Escherichia coli Infections; Evaluation Studies as Topic; Hae	1971
[Synthetic material and infection]. Acta chirurgica Belgica, 1971, Volume: 70, Issue:3 Topics: Antisepsis; Carbenicillin; Chloramphenicol; Cloxacillin; Drug Synergism; Foreign-Body Reaction; Gent	1971
Infection of prosthetic valves: successful therapy with antibiotics. Southern medical journal, 1972, Volume: 65, Issue:10 Topics: Adult; Ampicillin; Anti-Bacterial Agents; Aortic Valve Stenosis; Cephalothin; Chloramphenicol; Endoc	1972
[On the mechanism of antibiotic-resistance in Klebsiella associated with genital infections in horses]. Archivio veterinario italiano, 1971, Jun-30, Volume: 22, Issue:2 Topics: Animals; Anti-Bacterial Agents; Chloramphenicol; Drug Resistance, Microbial; Endometritis; Female; H	1971
[Liquefying effect on suppurations of an oral dose of calciferol]. La Presse medicale, 1969, Mar-15, Volume: 77, Issue:13 Topics: Abscess; Adrenal Insufficiency; Adult; Calcium; Chloramphenicol; Citrates; Citric Acid Cycle; Empyem	1969
Gram-negative septicaemia during haemorrhage from an anastomotic ulcer. Journal of clinical pathology, 1969, Volume: 22, Issue:6 Topics: Aged; Cephaloridine; Chloramphenicol; Gastroenterostomy; Humans; Jejunum; Klebsiella; Klebsiella Inf	1969
[Capsule types and resistance to antibiotics in strains of Klebsiella from clinical examination material]. Pathologia et microbiologia, 1968, Volume: 32, Issue:6 Topics: Bacteriuria; Chloramphenicol; Drug Resistance, Microbial; Humans; Klebsiella; Klebsiella Infections;	1968

chloramphenicol and Infections, Klebsiella

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