chloramphenicol and Agranulocytosis studies

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

Excerpt	Relevance	Reference
"Hematologic abnormalities associated with penicillin compounds are uncommon, and neutropenia associated with ampicillin is reported even less frequently."	7.66	Reversible neutropenia associated with ampicillin therapy in pediatric patients. ( Kumar, A; Kumar, K, 1981)
"In 520 consecutive cataract extractions, 1 gm chloramphenicol has been given intravenously immediately before entering the anterior chamber of the eye with no known resultant blood dyscrasias and no bacterial endophthalmitis."	7.66	Intravenous chloramphenicol to prevent postoperative endophthalmitis in cataract surgery--520 consecutive cases. ( Snyder, HP, 1978)
"Neutropenic cancer patients were given carbenicillin, cephalothin, and gentamicin (CCG) during 51 evaluable episodes of fever of unknown origin."	5.04	A study of antibiotic therapy in fever of unknown origin in neutropenic cancer patients. ( Björnsson, S; Henderson, ES; Preisler, H, 1977)
"One hundred and three children with proved typhoid fever were treated with trimethoprim-sulphamethoxazole, and the results compared with those of a further 40 children treated with chloramphenicol."	5.03	Trimethoprim and sulphamethoxazole in typhoid fever in children. ( Rubidge, CJ; Scragg, JN, 1971)
"A 15-months-old boy developed agranulocytosis after administration of Chloramphenicol and Aminopyrine."	3.66	Neutrophil chemotactic defect and hypogammaglobulinemia. ( Alba, J; Fontán, G; García Rodriguez, MC; Lorente, F; Ojeda, JA, 1980)
"Hematologic abnormalities associated with penicillin compounds are uncommon, and neutropenia associated with ampicillin is reported even less frequently."	3.66	Reversible neutropenia associated with ampicillin therapy in pediatric patients. ( Kumar, A; Kumar, K, 1981)
"In 520 consecutive cataract extractions, 1 gm chloramphenicol has been given intravenously immediately before entering the anterior chamber of the eye with no known resultant blood dyscrasias and no bacterial endophthalmitis."	3.66	Intravenous chloramphenicol to prevent postoperative endophthalmitis in cataract surgery--520 consecutive cases. ( Snyder, HP, 1978)
"The report of a recent fatality due to agranulocytosis provoked an examination of the plausible mechanisms of neutropenia and agranulocytosis."	1.27	A new concept in the relationship between biochemical reaction mechanisms and molecular basis of agranulocytosis. ( Akintonwa, DA, 1984)
"Aplastic anaemia and agranulocytosis are uncommon but serious adverse effects of drug therapy."	1.27	Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms. ( Vincent, PC, 1986)
"Gentamicin in combination with cephalothin (Gent-Ceph) or with chloramphenicol (Gent-Chloro) was utilized in the treatment of 55 infections occurring in 49 cancer patients."	1.26	Therapy of infections in neutropenic patients: results with gentamicin in combination with cephalothin or chloramphenicol. ( Bodey, GP; Burgess, MA; Rodriguez, V; Valdivieso, M, 1976)
"Twenty-three episodes of drug-induced agranulocytosis admitted to the Beilinson Medical Center between 1960-1972 are reported."	1.25	Drug-induced agranulocytosis. A survey of twenty-three episodes. ( de Vries, A; Mintz, U; Pinkhas, J; Shaklai, M, 1975)

Research

Studies (97)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Participants With Robust Hematologic Recovery With Reticulocyte or Platelet Count

Timeframe	Studies, this research(%)	All Research%
pre-1990	95 (97.94)	18.7374
1990's	1 (1.03)	18.2507
2000's	1 (1.03)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
RADOMSKI, JL	1
NELSON, AA	1
DEICHMANN, WB	1
Chawla, AK	1
Laiq, SM	1
MERRILL, AJ	1
RANKIN, NE	1
HODGKINSON, R	1
CHMIELEWSKI, T	1
AUBERTIN, E	1
DULONG DE ROSNAY, C	1
BERNADAC, P	1
VEAUX, R	1
BELIAEVA, NV	1
LARRAIN, C	1
JIMENEZ, L	1
SATO, H	1
IWATA, M	1
SAGAWA, F	1
KAWASHIMA, T	1
YAMASAKI, Y	1
OKUBO, H	2
VUOPIO, P	1
NIKKILAE, E	1
TIMAFFY, M	1
MEYLER, L	3
LOB, M	1
CLEMENT, F	1
LIBANSKY, J	1
JEZKOVA, Z	1
CENIC, S	1
MAGAZINOVIC, V	1
HUGULEY, CM	1
BERNARD, R	1
CAP, J	1
ICHIMARU, M	1
CHIBU, K	1
PRUSAK, Y	1
LURIE, E	1
PAGE, AR	1
GSELL, O	1
MARTI, HR	1
HUBER, FB	1
SCHEEGANS, E	1
HAARSCHER, A	1
KUNTZMANN, F	1
LABRAM, C	1
VOLINI, IF	1
GREENSPAN, I	1
EHRLICH, L	1
GONNER, JA	1
FELSENFELD, O	1
SCHWARTZ, SO	1
GILL, PF	1
Akintonwa, DA	1
Adams, GR	1
Pearson, HA	1
Kunchev, K	1
Ribov, D	1
Lorente, F	1
Fontán, G	1
García Rodriguez, MC	1
Alba, J	1
Ojeda, JA	1
Kumar, K	1
Kumar, A	1
Warnecke, J	1
Fehrs, W	1
Mintz, U	1
Shaklai, M	1
Pinkhas, J	1
de Vries, A	1
Bernasconi, C	1
Duhamel, G	1
Najman, A	1
Gorin, NC	1
de Cillo, DM	1
Santana, MO	1
Mori, NS	1
Jamra, M	1
Snyder, HP	1
Björnsson, S	1
Preisler, H	1
Henderson, ES	1
Masera, G	1
Baronciani, D	1
Conti, A	1
Jankovic, M	1
Uderzo, C	1
Hellriegel, KP	2
Gross, R	1
Valdivieso, M	1
Bodey, GP	1
Burgess, MA	1
Rodriguez, V	1
Mumme, C	1
Maca, R	1
Dorn, CR	1
Coffman, JR	1
Schmidt, DA	1
Garner, HE	1
Addison, JB	1
McCune, EL	1
Gralla, EJ	1
Deptała, A	1
Niemierko, E	1
Sablińska, K	1
Keiser, G	1
Chaplin, S	1
von Mühlendahl, KE	1
Tornóczky, J	1
Tóth, A	1
Balikó, Z	1
Kolumbusz, L	1
Muth, L	1
Kósa, Z	1
Vincent, PC	1
Angela, GC	1
Di Siena, F	1
Varet, B	1
Gluckman, E	1
Reyes, F	1
Basch, A	1
Dreyfus, B	1
Ochi, Y	1
Miyazaki, T	1
Pisciotta, AV	2
Assmann, D	1
Gläser, U	1
VanOmmen, RA	1
Freedman, MH	1
Saunders, EF	1
Hilton, J	1
McClure, PD	1
Gracheva, NM	1
Eisenhauer, LA	1
Sande, MA	1
Overton, JW	1
Geary, CG	1
Beck, EA	1
Buehler, F	1
Armentrout, SA	1
Lüdin, H	1
Westwick, WJ	1
Allsop, J	1
Watts, RW	3
Cogan, DG	1
Truman, JT	1
Smith, TR	1
O'Gorman Hughes, DW	1
Blackburn, MJ	1
Andrews, TM	2
Howell, A	1
Chinn, S	1
Yunis, AA	1
Pershin, GN	1
Skorodumova, IV	1
Ruvidić, R	2
Mathé, G	1
Amiel, JL	1
Schwarzenberg, L	1
Choay, J	1
Trolard, P	1
Schneider, M	1
Hayat, M	1
Schlumberger, JR	1
Jasmin, C	1
Scragg, JN	1
Rubidge, CJ	1
Cacciola, E	1
Giustolisi, R	1
Romeo, F	1
Lombardo, T	1
Kantero, I	1
Mustala, OO	1
Palva, IP	1
Polak, BC	1
Wesseling, H	1
Schut, D	1
Herxheimer, A	1
Rolović, Z	1
Perović, Lj	1
Obradović, D	1
Davey, KW	1
Konchak, PA	1
Hansen, NE	1
Teixeira, PA	2
Sernada, DF	2
Chassagnon, C	1
Jocteur-Monrozier, D	1
McCurrach, PH	1
Park, JK	1
Perry, WL	1
Wiontzek, H	1
Fongi, EG	2
Prigollini, D	1
Fongi, BL	1
Armocida, CC	1
Kaplin, J	1
Juchum, W	1
von Deschwanden, P	1
Buschor, O	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Trial of Immunosuppression in Aplastic Anemia Patients With Refractory Pancytopenia or Suboptimal Hematologic Response After h-ATG/CsA Treatment[NCT00065260]	Phase 2	54 participants (Actual)	Interventional	2003-11-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of participants with robust hematologic recovery with reticulocyte or platelet count ≥ 50,000/uL (NCT00065260)
Timeframe: 6 months

Percentage of Cumulative Incidence of Clonal Evolution in Participants

Intervention	Participants (Count of Participants)
r-ATG /Cyclosporine	9
Alemtuzumab (Campath-1H)	9

Percent of cumulative incidence of clonal evolution in participants to either paroxysmal nocturnal hemoglobinuria (PNH), myelodysplasia or acute leukemia. (NCT00065260)
Timeframe: 3 years

Percentage of Cumulative Incidence of Relapse in Participants

Intervention	Percentage of Cumulative Incidence (Number)
r-ATG /Cyclosporine	16
Alemtuzumab (Campath-1H)	5

Percentage of cumulative incidence of relapse of disease in participants (NCT00065260)
Timeframe: 3 year

Participants no Longer Meeting Criteria for Severe Aplastic Anemia.

Intervention	percentage of cumulative incidence (Number)
r-ATG /Cyclosporine	19
Alemtuzumab (Campath-1H)	9

Number of participants no longer meeting the criteria for severe aplastic anemia as measured by response to treatment at 6 months (NCT00065260)
Timeframe: 6 months

Percentage of Participants no Longer Meeting Criteria for Severe Aplastic Anemia.

Intervention	participants (Number)
	No Response	Partial Response	Complete Response
Alemtuzumab (Campath-1H)	17	9	0
r-ATG /Cyclosporine	18	9	0

Percentage of participants no longer meeting the criteria for severe aplastic anemia as measured by response to treatment (NCT00065260)
Timeframe: 3 months and 6 months

Article	Year
[TOXIC AND ALLERGIC REACTIONS OF THE BONE MARROW]. Zeitschrift fur Unfallmedizin und Berufskrankheiten. Revue de medecine des accidents et des maladies professionelles, 1963, Volume: 56 Topics: Agranulocytosis; Aminopyrine; Antineoplastic Agents; Benzene; Bone Marrow; Chloramphenicol; Drug Hyp	1963
[CONTRIBUTION TO THE CLINICAL PICTURE OF BONE MARROW DEPRESSION IN CHILDREN]. Ceskoslovenska pediatrie, 1964, Volume: 19 Topics: Agranulocytosis; Analgesics; Analgesics, Non-Narcotic; Anemia; Anti-Bacterial Agents; Anticonvulsant	1964
[Drug-induced agranulocytoses]. Blut, 1976, Volume: 32, Issue:6 Topics: Age Factors; Agranulocytosis; Aminopyrine; Bacterial Infections; Bone Marrow Examination; Chloramphe	1976
[Drugs and blood]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1985, Jan-15, Volume: 74, Issue:3 Topics: Adolescent; Adult; Agranulocytosis; Anemia, Aplastic; Anemia, Hemolytic; Anti-Inflammatory Agents, N	1985
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part I. Adverse drug reactions and acute poisoning reviews, 1986,Summer, Volume: 5, Issue:2 Topics: Agranulocytosis; Anemia, Aplastic; Bone Marrow; Cell Membrane; Chloramphenicol; Dibenzazepines; DNA	1986
[Iatrogenic hemopathies. Current aspects of drug effects on the formal elements of the blood]. Minerva medica, 1970, Dec-08, Volume: 61, Issue:98 Topics: Agranulocytosis; Analgesics; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial	1970
Immune and toxic mechanisms in drug-induced agranulocytosis. Seminars in hematology, 1973, Volume: 10, Issue:4 Topics: Agranulocytosis; Aminopyrine; Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Antithyroi	1973
Idiosyncratic hematologic reactions to drugs. Postgraduate medicine, 1974, Volume: 55, Issue:5 Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Macrocytic; Aspir	1974
Drug--induced bone marrow injury. Advances in internal medicine, 1969, Volume: 15 Topics: Adult; Agranulocytosis; Anemia, Aplastic; Bone Marrow Diseases; Child, Preschool; Chloramphenicol; H	1969
[Morphology of the side effects of drugs in humans]. Arkhiv patologii, 1969, Volume: 31, Issue:9 Topics: Adrenal Cortex Hormones; Agranulocytosis; Alopecia; Analgesics; Anti-Bacterial Agents; Breast; Chemi	1969
[Bone marrow damage caused by chloramphenicol]. Srpski arhiv za celokupno lekarstvo, 1969, Volume: 97, Issue:3 Topics: Agranulocytosis; Anemia, Aplastic; Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Ch	1969

Article	Year
A study of antibiotic therapy in fever of unknown origin in neutropenic cancer patients. Medical and pediatric oncology, 1977, Volume: 3, Issue:4 Topics: Adult; Aged; Agranulocytosis; Anti-Bacterial Agents; Carbenicillin; Cephalothin; Chloramphenicol; Cl	1977
Trimethoprim and sulphamethoxazole in typhoid fever in children. British medical journal, 1971, Sep-25, Volume: 3, Issue:5777 Topics: Agranulocytosis; Anemia, Aplastic; Blood; Child; Child, Preschool; Chloramphenicol; Female; Folic Ac	1971

Article	Year
The effects on the peripheral blood of the intermittent administration of chloramphenicol; a proposed test for granulocytopenic properties of a drug. Antibiotics & chemotherapy (Northfield, Ill.), 1955, Volume: 5, Issue:12 Topics: Agranulocytosis; Blood; Blood Platelets; Bone Marrow; Chloramphenicol; Humans; Pharmaceutical Prepar	1955
Haematopoietic growth factors in chloramphenicol-induced agranulocytosis. The Journal of the Association of Physicians of India, 2002, Volume: 50, Issue:5 Topics: Agranulocytosis; Anti-Bacterial Agents; Chloramphenicol; Granulocyte-Macrophage Colony-Stimulating F	2002
The danger of chloramphenicol (chloromycetin) therapy. Journal of the Medical Association of Georgia, 1952, Volume: 41, Issue:9 Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Chloramphenicol	1952
Disseminated aspergillosis and moniliasis associated with agranulocytosis and antibiotic therapy. British medical journal, 1953, Apr-25, Volume: 1, Issue:4816 Topics: Agranulocytosis; Anti-Bacterial Agents; Aspergillosis; Candidiasis; Chloramphenicol; Humans	1953
Blood dyscrasias associated with chloramphenicol. an investigation into the cases in the British Isles. Lancet (London, England), 1954, Feb-06, Volume: 266, Issue:6806 Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Chloramphenicol; Hematologic Diseases; Humans	1954
[Death in agranulocytosis consecutive to chloramphenicol therapy]. Polski tygodnik lekarski, 1955, Nov-07, Volume: 10, Issue:45 Topics: Agranulocytosis; Chloramphenicol; Death; Humans	1955
[Agranulocytosis in a woman with Malta fever & treated by chloramphenicol]. Journal de medecine de Bordeaux et du Sud-Ouest, 1957, Volume: 134, Issue:12 Topics: Agranulocytosis; Brucellosis; Chloramphenicol	1957
[Aplastic anemia and agranulocytosis in synthomycin therapy]. Sovetskaia meditsina, 1957, Volume: 21, Issue:8 Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Chloramphenicol; Humans; Tracheophyta	1957
[Agranulocytosis follwoing the use of chloramphenicol]. Revista medica de Chile, 1958, Volume: 86, Issue:10 Topics: Agranulocytosis; Chloramphenicol; Hyperthermia, Induced; Typhoid Fever	1958
[Infantile agranulocytosis accompanying sepsis (with clinical observations on the infantile granulocytopenia in the past 15 years)]. Showa Igakkai zasshi = The Journal of the Showa Medical Association, 1962, Volume: 22 Topics: Agranulocytosis; Chloramphenicol; Dexamethasone; Humans; Methicillin; Sepsis; Staphylococcal Infecti	1962
[CASE OF AGRANULOCYTOSIS THOUGHT TO HAVE BEEN CAUSED BY ANTIBIOTICS]. Jibi inkoka Otolaryngology, 1963, Volume: 35 Topics: Agranulocytosis; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic Agents; Blood Tr	1963
[BLOOD REACTIONS TO DRUGS]. Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1963, Volume: 26 Topics: Agranulocytosis; Aminopyrine; Analgesics; Analgesics, Non-Narcotic; Anemia; Anemia, Aplastic; Anti-B	1963
[CHLORAMPHENICOL-INDUCED BONE MARROW DAMAGE. 3 CASES]. Duodecim; laaketieteellinen aikakauskirja, 1963, Volume: 79 Topics: Agranulocytosis; Bone Marrow; Bone Marrow Diseases; Chloramphenicol; Geriatrics; Toxicology	1963
[ON CHLORAMPHENICOL-RELATED CASES OF PANCYTOPENIA]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1963, Aug-01, Volume: 18 Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Bone Marrow Transplantation; Chloramphenicol; Erythropoie	1963
[CHANGES IN THE BLOOD CAUSED BY DRUGS]. Nederlands tijdschrift voor geneeskunde, 1963, Nov-09, Volume: 107 Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Anemia, Hemolytic; Chloramphenicol; Chlorpromazine; Drug	1963
INVESTIGATIONS OF THE IMMUNOLOGICAL REACTIVITY IN HAEMOBLASTOSES. IV. THE BACTERICIDAL PROPERTIES OF THE SERUM AGAINST GRAM-POSITIVE MICROBES IN PATIENTS SUFFERING FROM LEUKAEMIA, MALIGNANT LYMPHOMA, MYELOMA, AND MYELOFIBROSIS. Neoplasma, 1964, Volume: 11 Topics: Aged; Agranulocytosis; Anti-Bacterial Agents; Bacteroides; Brucella; Chloramphenicol; Complement Sys	1964
ACTION OF ANTIBIOTICS ON ERYTHRO- AND LEUCOPOIESIS IN HEALTHY DOGS. III. ACTION OF CHLORAMPHENICOL AND COMBINED ANTIBIOTICS. Folia haematologica (Leipzig, Germany : 1928), 1963, Volume: 80 Topics: Agranulocytosis; Anemia; Anti-Bacterial Agents; Bone Marrow Diseases; Bone Marrow Examination; Chlor	1963
DRUG-INDUCED BLOOD DYSCRASIAS. II. AGRANULOCYTOSIS. JAMA, 1964, Jun-01, Volume: 188 Topics: Agranulocytosis; Analgesics; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Antipyretics; Antithyr	1964
[DRUG-INDUCED APLASTIC PANMYELOPATHY DUE TO CHLORAMPHENICOL IDIOSYNCRASY]. Belgisch tijdschrift voor geneeskunde, 1964, Feb-15, Volume: 20 Topics: Agranulocytosis; Anemia; Anemia, Aplastic; Chloramphenicol; Drug Hypersensitivity; Toxicology	1964
[CASE OF AGRANULOCYTOSIS SHOWING A LEUKEMOID REACTION DURING THE RECOVERY PHASE]. Naika. Internal medicine, 1964, Volume: 14 Topics: Adrenal Cortex Hormones; Agranulocytosis; Antipyrine; Blood; Bone Marrow Examination; Chloramphenico	1964
[DRUG-INDUCED AGRANULOCYTOSIS]. Harefuah, 1964, Jul-01, Volume: 67 Topics: Agranulocytosis; Aminopyrine; Chloramphenicol; Chlorpromazine; Diuretics; Humans; Organomercury Comp	1964
STUDIES ON THE LYMPHOCYTE RESPONSE TO INFLAMMATION. Annals of the New York Academy of Sciences, 1964, Aug-27, Volume: 116 Topics: Agranulocytosis; Aminopterin; Animals; Azaguanine; Biopsy; Chloramphenicol; Connective Tissue; Cyclo	1964
[BONE MARROW APLASIA DUE TO CHLORAMPHENICOL]. Medizinische Klinik, 1965, Jun-18, Volume: 60 Topics: Agranulocytosis; Anemia, Aplastic; Bone Marrow; Bone Marrow Diseases; Chloramphenicol; Hemorrhagic D	1965
[AN ADDITIONAL CASE OF AGRANULOCYTOSIS AFTER MEDICATION WITH CHLORAMPHENICOL]. Schweizerische medizinische Wochenschrift, 1964, Nov-14, Volume: 94 Topics: Agranulocytosis; Chloramphenicol; Geriatrics; Toxicology	1964
[FATAL AGRANULOCYTOSIS FOLLOWING CHLORAMPHENICOL THERAPY. DETECTION OF ANTIBODIES]. Archives francaises de pediatrie, 1965, Volume: 22 Topics: Agranulocytosis; Antibodies; Chloramphenicol; Drug Hypersensitivity; Drug Therapy; Infant; Toxicolog	1965
[Blood complications of medicinal origin. I. The risks of 2 drugs in current use: pyramidon and chloramphenicol]. Concours medical, 1962, Jul-21, Volume: 84 Topics: Agranulocytosis; Aminopyrine; Anemia; Anemia, Aplastic; Chloramphenicol; Humans; Risk	1962
Hemopoietic changes during administration of chloramphenicol (chloromycetin). Journal of the American Medical Association, 1950, Apr-29, Volume: 142, Issue:17 Topics: Agranulocytosis; Chloramphenicol; Hematopoietic System; Humans	1950
Agranulocytopenia following chloromycetin: report on two cases. The Medical journal of Australia, 1950, Jun-10, Volume: 1, Issue:23 Topics: Agranulocytosis; Chloramphenicol	1950
A new concept in the relationship between biochemical reaction mechanisms and molecular basis of agranulocytosis. Biochemical medicine, 1984, Volume: 32, Issue:2 Topics: Agranulocytosis; Aminopyrine; Autoantibodies; Biotransformation; Blood Proteins; Chloramphenicol; Ch	1984
Chloramphenicol-responsive chronic neutropenia. The New England journal of medicine, 1983, Oct-27, Volume: 309, Issue:17 Topics: Adolescent; Agranulocytosis; Chloramphenicol; Chronic Disease; Humans; Leukocyte Count; Male; Neutro	1983
[Impairment of hemopoiesis by chloramphenicol with a description of 2 fatal cases]. Vutreshni bolesti, 1982, Volume: 21, Issue:3 Topics: Adult; Agranulocytosis; Anemia, Myelophthisic; Chloramphenicol; Female; Humans; Middle Aged	1982
Neutrophil chemotactic defect and hypogammaglobulinemia. Acta paediatrica Scandinavica, 1980, Volume: 69, Issue:5 Topics: Agammaglobulinemia; Agranulocytosis; Aminopyrine; Chemotaxis, Leukocyte; Chloramphenicol; Humans; In	1980
Reversible neutropenia associated with ampicillin therapy in pediatric patients. Drug intelligence & clinical pharmacy, 1981, Volume: 15, Issue:10 Topics: Agranulocytosis; Ampicillin; Child, Preschool; Chloramphenicol; Female; Humans; Infant; Leukocyte Co	1981
[Local treatment with chloramphenicol]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 1998, Volume: 49, Issue:1 Topics: Administration, Topical; Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Chloramphenicol;	1998
Drug-induced agranulocytosis. A survey of twenty-three episodes. Medecine interne, 1975, Volume: 13, Issue:3 Topics: Adolescent; Adult; Aged; Agranulocytosis; Aminopyrine; Anti-Infective Agents; Anti-Inflammatory Agen	1975
[Granulocytopenias due to drugs (author's transl)]. Haematologica, 1979, Volume: 64 Suppl Topics: Agranulocytosis; Aminopyrine; Antithyroid Agents; Chloramphenicol; Drug Hypersensitivity; Humans; Ne	1979
[Current aspects of agranulocytosis (15 cases)]. Annales de medecine interne, 1977, Volume: 128, Issue:3 Topics: Acetaminophen; Adult; Aged; Agranulocytosis; Ajmaline; Aminopyrine; Anti-Inflammatory Agents, Non-St	1977
[Secondary blood dyscrasias due to drugs and chemical agents. Study in patients hospitalized in the Hematology Service of the Hospital das Clínicas of the F.M.U.S.P. from 1955 to 1975]. Revista do Hospital das Clinicas, 1978, Volume: 33, Issue:1 Topics: Adolescent; Adult; Aged; Agranulocytosis; Anemia, Aplastic; Anemia, Hemolytic; Anti-Infective Agents	1978
Intravenous chloramphenicol to prevent postoperative endophthalmitis in cataract surgery--520 consecutive cases. Annals of ophthalmology, 1978, Volume: 10, Issue:8 Topics: Agranulocytosis; Cataract Extraction; Chloramphenicol; Drug Evaluation; Endophthalmitis; Humans; Inf	1978
[Hemopathies caused by drugs in children: aplastic anemia, agranulocytosis, megaloblastic anemia]. Minerva pediatrica, 1978, Sep-30, Volume: 30, Issue:18 Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents;	1978
[Drug induced disorders of granulopoiesis]. Haematology and blood transfusion, 1978, Volume: 21 Topics: Agranulocytosis; Aminopyrine; Anemia, Aplastic; Bone Marrow Diseases; Chloramphenicol; Granulocytes;	1978
Therapy of infections in neutropenic patients: results with gentamicin in combination with cephalothin or chloramphenicol. Medical and pediatric oncology, 1976, Volume: 2, Issue:1 Topics: Agranulocytosis; Bacterial Infections; Cephalothin; Chloramphenicol; Drug Therapy, Combination; Ente	1976
[Agranulocytosis from the point of view of the general practitioner. In memory of Edgar Reye (30.5.1882-11.12.1945) (author's translation)]. MMW, Munchener medizinische Wochenschrift, 1976, Mar-05, Volume: 118, Issue:10 Topics: Adult; Agranulocytosis; Aminopyrine; Chloramphenicol; Diagnosis, Differential; Family Practice; Fema	1976
Hematology mediquiz. Case 6. Medical times, 1975, Volume: 103, Issue:3 Topics: Adult; Agranulocytosis; Anemia, Megaloblastic; Bone Marrow Diseases; Bone Marrow Examination; Chlora	1975
Neutropenia and salmonellosis in hospitalized horses. Journal of the American Veterinary Medical Association, 1975, Jan-01, Volume: 166, Issue:1 Topics: Agranulocytosis; Animals; Chloramphenicol; Colitis; Feces; Female; Gentamicins; Horse Diseases; Hors	1975
Adverse drug reactions. The Veterinary clinics of North America, 1975, Volume: 5, Issue:4 Topics: Abnormalities, Drug-Induced; Acute Kidney Injury; Agranulocytosis; Anemia, Aplastic; Anemia, Hemolyt	1975
[Clinical and hematological analysis of acute granulocytopenia]. Polski tygodnik lekarski (Warsaw, Poland : 1960), 1989, Apr-03, Volume: 44, Issue:14 Topics: Acute Disease; Adult; Aged; Agranulocytosis; Anti-Inflammatory Agents, Non-Steroidal; Chloramphenico	1989
[Agranulocytosis after chloramphenicol eyedrops]. Deutsche medizinische Wochenschrift (1946), 1987, Jan-23, Volume: 112, Issue:4 Topics: Agranulocytosis; Bone Marrow; Chloramphenicol; Female; Humans; Infant; Ophthalmic Solutions	1987
[Management of drug-induced agranulocytosis associated with severe septicemia]. Orvosi hetilap, 1985, Jun-02, Volume: 126, Issue:22 Topics: Adult; Aged; Agranulocytosis; Chloramphenicol; Female; Humans; Leukocyte Transfusion; Lithium; Lithi	1985
Drug-induced aplastic anaemia and agranulocytosis. Incidence and mechanisms. Drugs, 1986, Volume: 31, Issue:1 Topics: Agranulocytosis; Aminopyrine; Anemia, Aplastic; Animals; Bone Marrow; Chloramphenicol; Chlorpromazin	1986
[Acute drug cytopenia. Apropos of 11 cases]. Annales de medecine interne, 1971, Volume: 122, Issue:4 Topics: Adult; Aged; Agranulocytosis; Aminopyrine; Anemia; Antithyroid Agents; Blood Transfusion; Bone Marro	1971
[Case of granulocytopenia aggravated by the administration of antithyroid agent and chloromycetin]. Horumon to rinsho. Clinical endocrinology, 1972, Volume: 20, Issue:4 Topics: Adult; Agranulocytosis; Antithyroid Agents; Bronchitis; Chloramphenicol; Female; Humans; Hyperthyroi	1972
[Drug-induced hematologic disorders in Japan]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 1974, Volume: 15, Issue:3 Topics: Adolescent; Adult; Aged; Agranulocytosis; Antithyroid Agents; Chloramphenicol; Drug Hypersensitivity	1974
[Side effects and hazards of current antibiotic- and chemotherapy]. Zeitschrift fur arztliche Fortbildung, 1974, May-01, Volume: 68, Issue:9 Topics: Agranulocytosis; Anemia, Aplastic; Anti-Bacterial Agents; Bronchial Spasm; Cephalosporins; Chloramph	1974
Untoward effects of antimicrobial agents on major organ systems. The Medical clinics of North America, 1974, Volume: 58, Issue:3 Topics: Agranulocytosis; Amphotericin B; Anemia, Aplastic; Anemia, Hemolytic; Anti-Bacterial Agents; Ataxia;	1974
Residual abnormalities in acquired aplastic anemia of childhood. JAMA, 1974, Apr-08, Volume: 228, Issue:2 Topics: Adolescent; Age Factors; Agranulocytosis; Anemia, Aplastic; Bone Marrow Examination; Child; Child, P	1974
[Medicamentous agranulocytosis as a manifestation of drug induced disease]. Terapevticheskii arkhiv, 1974, Volume: 46, Issue:1 Topics: Adult; Agranulocytosis; Aminopyrine; Aspirin; Chloramphenicol; Drug-Related Side Effects and Adverse	1974
Drug-induced blood dyscrasias. The Nursing clinics of North America, 1972, Volume: 7, Issue:4 Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Macrocytic; Anticoagulants; Blood Coag	1972
In vivo antagonism between gentamicin and chloramphenicol in neutropenic mice. The Journal of infectious diseases, 1973, Volume: 128, Issue:2 Topics: Agranulocytosis; Animals; Chloramphenicol; Drug Antagonism; Gentamicins; Mice; Neutrophils; Phagocyt	1973
Blood and neoplastic diseases. Acquired aplastic anaemia. British medical journal, 1974, May-25, Volume: 2, Issue:5916 Topics: Adrenal Cortex Hormones; Agranulocytosis; Androgens; Anemia, Aplastic; Antibody Formation; Blood Tra	1974
Early hematological abnormalities associated with chloramphenicol therapy. Helvetica medica acta, 1972, Volume: 36, Issue:4 Topics: Agranulocytosis; Anemia; Blood Platelet Disorders; Bone Marrow; Bone Marrow Cells; Chloramphenicol;	1972
A study of the effect of some drugs which cause agranulocytosis on the biosynthesis of pyrimidines in human granulocytes. Biochemical pharmacology, 1972, Jul-15, Volume: 21, Issue:14 Topics: Agranulocytosis; Amidohydrolases; Aspartate Carbamoyltransferase; Blood Proteins; Carbimazole; Carbo	1972
[Diseases due to drugs]. Nederlands tijdschrift voor geneeskunde, 1973, Jan-13, Volume: 117, Issue:2 Topics: Agranulocytosis; Anaphylaxis; Chloramphenicol; Drug-Related Side Effects and Adverse Reactions; Huma	1973
Optic neuropathy, chloramphenicol, and infantile genetic agranulocytosis. Investigative ophthalmology, 1973, Volume: 12, Issue:7 Topics: Agranulocytosis; Autopsy; Bacterial Infections; Child, Preschool; Chloramphenicol; Choroid; Female;	1973
Studies on chloramphenicol. II. Possible determinants and progress of haemopoietic toxicity during chloramphenicol therapy. The Medical journal of Australia, 1973, Dec-29, Volume: 2, Issue:26 Topics: Adolescent; Age Factors; Agranulocytosis; Child; Child, Preschool; Chloramphenicol; Erythrocyte Coun	1973
Drug-induced neutropenia-effects of drugs on granulocyte protein synthesis in vitro. Clinical science and molecular medicine, 1973, Volume: 45, Issue:3 Topics: Agranulocytosis; Chloramphenicol; Chlorpromazine; Humans; Leukocytes; Neutrophils; Phenylbutazone; P	1973
The effects of drugs that cause neutropenia upon colony formation by bone marrow cells in semi-solid agar. Clinical science and molecular medicine, 1974, Volume: 46, Issue:5 Topics: Agar; Agranulocytosis; Animals; Bone Marrow; Bone Marrow Cells; Cell Division; Cells, Cultured; Chlo	1974
Bone marrow graft in man after conditioning by antilymphocytic serum. British medical journal, 1970, Apr-18, Volume: 2, Issue:5702 Topics: Acute Disease; Adolescent; Adult; Agranulocytosis; Antilymphocyte Serum; Bone Marrow Transplantation	1970
[Schultz's agranulocytosis. Clinical and hematological study]. Haematologica, 1971, Volume: 56, Issue:11 Topics: Adult; Agranulocytosis; Chloramphenicol; Drug Hypersensitivity; Female; Humans; Tonsillitis	1971
Drug-induced agranulocytosis, with special reference to aminophenazone. IV. Children. Acta medica Scandinavica, 1972, Volume: 192, Issue:4 Topics: Agranulocytosis; Aminopyrine; Child; Child, Preschool; Chloramphenicol; Female; Finland; Humans; Inf	1972
Blood dyscrasias attributed to chloramphenicol. A review of 576 published and unpublished cases. Acta medica Scandinavica, 1972, Volume: 192, Issue:5 Topics: Adolescent; Adult; Age Factors; Aged; Agranulocytosis; Anemia, Aplastic; Bone Marrow Diseases; Child	1972
[Blood dyscrasia following use of chloramphenicol]. Srpski arhiv za celokupno lekarstvo, 1969, Volume: 97, Issue:3 Topics: Adult; Agranulocytosis; Anemia, Aplastic; Bone Marrow Diseases; Chloramphenicol; Female; Humans; Mal	1969
Agranulocytosis. Dental case report. Oral surgery, oral medicine, and oral pathology, 1969, Volume: 28, Issue:2 Topics: Agranulocytosis; Child; Chloramphenicol; Humans; Male; Mastoiditis; Noma; Oral Manifestations; Perio	1969
[Leukopenia]. Tandlaegebladet, 1969, Volume: 73, Issue:4 Topics: Agranulocytosis; Anti-Bacterial Agents; Antineoplastic Agents; Cachexia; Chloramphenicol; Collagen D	1969
[Agranulocytosis caused by chloramphenicol. Presentation of one case]. Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:3 Topics: Agranulocytosis; Chloramphenicol; Female; Humans; Middle Aged	1968
[Agranulocytosis caused by chloramphenicol. Report of a case]. Hospital (Rio de Janeiro, Brazil), 1968, Volume: 74, Issue:3 Topics: Agranulocytosis; Blood Cell Count; Chloramphenicol; Female; Humans; Middle Aged	1968
[A case of reversible agranulocytosis uring treatment of abscess of the lung. Discussion on the responsible drug]. Journal de medecine de Lyon, 1969, Jun-05, Volume: 50, Issue:166 Topics: Agranulocytosis; Chloramphenicol; Humans; Lung Abscess; Male; Middle Aged	1969
The effects of some drugs which induce agranulocytosis on the metabolism of separated human polymorphonuclear leucocytes and lymphocytes. British journal of pharmacology, 1970, Volume: 38, Issue:3 Topics: Agranulocytosis; Aminopyrine; Chloramphenicol; Chlorpromazine; Depression, Chemical; Glucose; Humans	1970
[Chloramphenicol therapy]. Blut, 1970, Volume: 20, Issue:2 Topics: Agranulocytosis; Anemia, Aplastic; Biliary Tract Diseases; Bronchitis; Chlamydia Infections; Chloram	1970
[Bone marrow lesions following viral hepatitis]. Die Medizinische Welt, 1970, Jul-25, Volume: 30 Topics: Aged; Agranulocytosis; Autoimmune Diseases; Bone Marrow Diseases; Chloramphenicol; Hepatitis A; Huma	1970
[Iatrogenic agranulocytosis and massive pulmonary embolism]. Prensa medica argentina, 1970, Dec-25, Volume: 57, Issue:43 Topics: Agranulocytosis; Chloramphenicol; Dexamethasone; Diagnostic Errors; Female; Humans; Medication Error	1970
[Chloramphenicol panmyelopathy in a child]. Wiener medizinische Wochenschrift (1946), 1970, Jul-25, Volume: 120, Issue:30 Topics: Agranulocytosis; Anemia, Aplastic; Ascites; Bone Marrow Diseases; Child; Chloramphenicol; Female; He	1970
Early detection of bone-marrow injury due to drugs. The Medical letter on drugs and therapeutics, 1969, Jul-11, Volume: 11, Issue:14 Topics: Agranulocytosis; Anemia, Aplastic; Antineoplastic Agents; Bone Marrow Diseases; California; Chloramp	1969
[Cytologic changes following stimulation of hematopoiesis]. Schweizerische medizinische Wochenschrift, 1966, Sep-17, Volume: 96, Issue:37 Topics: Agranulocytosis; Chloramphenicol; Drug Hypersensitivity; Female; Hematopoiesis; Humans; Lectins; Leu	1966

chloramphenicol and Agranulocytosis