chloramphenicol and Acute Myelogenous Leukemia studies

Research Excerpts

Excerpt	Relevance	Reference
"A young patient with acute myelogenous leukemia was treated with high-dose cytarabine (3."	7.68	Handling punctate keratitis resulting from systemic cytarabine. ( Friedland, S; Loya, N; Shapiro, A, 1993)
"Neutropenic cancer patients were given carbenicillin, cephalothin, and gentamicin (CCG) during 51 evaluable episodes of fever of unknown origin."	5.04	A study of antibiotic therapy in fever of unknown origin in neutropenic cancer patients. ( Björnsson, S; Henderson, ES; Preisler, H, 1977)
"A young patient with acute myelogenous leukemia was treated with high-dose cytarabine (3."	3.68	Handling punctate keratitis resulting from systemic cytarabine. ( Friedland, S; Loya, N; Shapiro, A, 1993)
"A population-based case-control interview study of 309 childhood leukaemia cases and 618 age and sex matched controls showed a significant dose-response relation between chloramphenicol and risk of both acute lymphocytic leukaemia (ALL) and acute non-lymphocytic leukaemia (ANLL), treatment for more than 10 days being associated with risks of 11."	1.27	Chloramphenicol use and childhood leukaemia in Shanghai. ( Brinton, LA; Fraumeni, JF; Gao, RN; Gao, YT; Jin, F; Linet, MS; Shu, XO, 1987)

Research

Studies (24)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Number of Participants With Robust Hematologic Recovery With Reticulocyte or Platelet Count

Timeframe	Studies, this research(%)	All Research%
pre-1990	21 (87.50)	18.7374
1990's	3 (12.50)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
MUKHERJI, PS	1
Klein, B	1
Bessler, H	1
Lewinski, UH	1
Cohen, AM	1
Djaldetti, M	1
Stacher, A	2
Lutz, D	1
Friedland, S	1
Loya, N	1
Shapiro, A	1
Lu, JC	1
Shi, LY	1
Björnsson, S	1
Preisler, H	1
Henderson, ES	1
Awwaad, A	1
Khalifa, AS	1
Kamel, K	1
Mappilacherry, TK	1
Chandra, S	1
Mitra, A	1
Shu, XO	1
Gao, YT	1
Linet, MS	1
Brinton, LA	1
Gao, RN	1
Jin, F	1
Fraumeni, JF	2
Shah, BM	1
Rogers, RT	1
Anderson, JC	1
Palmer, CA	1
Henderson, WG	1
Amiel, JL	2
Mathe, G	2
Schwarzenberg, L	2
Schneider, M	2
Choay, J	2
Trolard, P	2
Hayat, M	2
Schlumberger, JR	2
Jasmin, C	2
Cooper, MR	1
Hansen, KS	1
Maynard, CD	1
Elrod, IW	1
Spurr, CL	1
King, JB	1
Burns, DG	1
Edwards, LD	1
Böhnel, J	1
Deaton, JG	1
Levin, WC	1
Cohen, T	1
Creger, WP	1
Brauer, MJ	1
Dameshek, W	1
Seaman, AJ	1
Goh, KO	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized Trial of Immunosuppression in Aplastic Anemia Patients With Refractory Pancytopenia or Suboptimal Hematologic Response After h-ATG/CsA Treatment[NCT00065260]	Phase 2	54 participants (Actual)	Interventional	2003-11-06	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Number of participants with robust hematologic recovery with reticulocyte or platelet count ≥ 50,000/uL (NCT00065260)
Timeframe: 6 months

Percentage of Cumulative Incidence of Clonal Evolution in Participants

Intervention	Participants (Count of Participants)
r-ATG /Cyclosporine	9
Alemtuzumab (Campath-1H)	9

Percent of cumulative incidence of clonal evolution in participants to either paroxysmal nocturnal hemoglobinuria (PNH), myelodysplasia or acute leukemia. (NCT00065260)
Timeframe: 3 years

Percentage of Cumulative Incidence of Relapse in Participants

Intervention	Percentage of Cumulative Incidence (Number)
r-ATG /Cyclosporine	16
Alemtuzumab (Campath-1H)	5

Percentage of cumulative incidence of relapse of disease in participants (NCT00065260)
Timeframe: 3 year

Participants no Longer Meeting Criteria for Severe Aplastic Anemia.

Intervention	percentage of cumulative incidence (Number)
r-ATG /Cyclosporine	19
Alemtuzumab (Campath-1H)	9

Number of participants no longer meeting the criteria for severe aplastic anemia as measured by response to treatment at 6 months (NCT00065260)
Timeframe: 6 months

Percentage of Participants no Longer Meeting Criteria for Severe Aplastic Anemia.

Intervention	participants (Number)
	No Response	Partial Response	Complete Response
Alemtuzumab (Campath-1H)	17	9	0
r-ATG /Cyclosporine	18	9	0

Percentage of participants no longer meeting the criteria for severe aplastic anemia as measured by response to treatment (NCT00065260)
Timeframe: 3 months and 6 months

Article	Year
Acute myeloblastic leukaemia following chloramphenicol treatment. British medical journal, 1957, Jun-01, Volume: 1, Issue:5030 Topics: Chloramphenicol; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute	1957
Beneficial effect of chloramphenicol on pyrexia in patients with acute leukemia. Acta haematologica, 1980, Volume: 64, Issue:5 Topics: Adolescent; Adult; Chloramphenicol; DNA, Neoplasm; Female; Fever of Unknown Origin; Humans; Leukemia	1980
[Drug-induced leukemia]. Acta medica Austriaca. Supplement, 1982, Volume: 25 Topics: Antineoplastic Agents; Chloramphenicol; Drug-Related Side Effects and Adverse Reactions; Humans; Imm	1982
Handling punctate keratitis resulting from systemic cytarabine. Annals of ophthalmology, 1993, Volume: 25, Issue:8 Topics: Adult; Chloramphenicol; Corneal Opacity; Cytarabine; Glucocorticoids; Humans; Keratitis; Leukemia, M	1993
[A case-control study of childhood leukemia]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 1996, Volume: 17, Issue:4 Topics: Adolescent; Anti-Bacterial Agents; Case-Control Studies; Child; Child, Preschool; China; Chloramphen	1996
Vacuolization of leukocytes and bone marrow aplasia due to chloramphenicol toxocity. A childhood case followed by acute myeloblastic anemia. Clinical pediatrics, 1975, Volume: 14, Issue:5 Topics: Bone Marrow; Bone Marrow Diseases; Bone Marrow Examination; Child; Chloramphenicol; Female; Humans;	1975
Chloramphenicol and preleukaemia/leukaemia. The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:9 Topics: Aged; Chloramphenicol; Humans; Leukemia, Myeloid, Acute; Male; Preleukemia	1990
Chloramphenicol and preleukaemia/leukaemia. The Journal of the Association of Physicians of India, 1989, Volume: 37, Issue:9 Topics: Child, Preschool; Chloramphenicol; Female; Humans; Leukemia, Myeloid, Acute; Male; Precursor Cell Ly	1989
Chloramphenicol use and childhood leukaemia in Shanghai. Lancet (London, England), 1987, Oct-24, Volume: 2, Issue:8565 Topics: Child; Child, Preschool; China; Chloramphenicol; Dose-Response Relationship, Drug; Humans; Interview	1987
Chloramphenicol and preleukaemia/leukaemia. The Journal of the Association of Physicians of India, 1988, Volume: 36, Issue:5 Topics: Adolescent; Chloramphenicol; Humans; Leukemia, Myeloid, Acute; Male; Preleukemia; Typhoid Fever	1988
Septicaemia due to Pasteurella pneumotropica. Journal of clinical pathology, 1973, Volume: 26, Issue:6 Topics: Ampicillin; Cephaloridine; Chloramphenicol; Culture Media; Cytarabine; Daunorubicin; Erythromycin; G	1973
[Allogenic bone marrow graft after conditioning with only antilymphocytic serum in states of bone marrow aplasias]. La Presse medicale, 1970, Sep-26, Volume: 78, Issue:40 Topics: Adolescent; Adult; Antilymphocyte Serum; Bone Marrow Diseases; Bone Marrow Transplantation; Child; C	1970
Platelet survival and sequestration patterns in thrombocytopenic disorders. Radiology, 1972, Volume: 102, Issue:1 Topics: Adult; Aged; Azathioprine; Blood Platelets; Cell Survival; Chloramphenicol; Chromium Isotopes; Dexam	1972
Aplastic anaemia, oxymetholone and acute myeloid leukaemia. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1972, Oct-28, Volume: 46, Issue:43 Topics: Acute Disease; Aged; Anemia, Aplastic; Chloramphenicol; Humans; Leukemia, Myeloid, Acute; Male; Oxym	1972
Bone marrow graft in man after conditioning by antilymphocytic serum. British medical journal, 1970, Apr-18, Volume: 2, Issue:5702 Topics: Acute Disease; Adolescent; Adult; Agranulocytosis; Antilymphocyte Serum; Bone Marrow Transplantation	1970
Association between chloramphenicol, hypoplastic anemia and acute myeloblastic leukemia: a case report. Military medicine, 1969, Volume: 134, Issue:12 Topics: Adult; Anemia, Aplastic; Blood Platelets; Chloramphenicol; Humans; Leukemia, Myeloid, Acute; Leukocy	1969
[Effect of bacterial infections and their therapy on the course of acute leukoses]. Medizinische Klinik, 1966, Oct-07, Volume: 61, Issue:40 Topics: Adolescent; Adult; Aged; Blood Transfusion; Bone Marrow Examination; Chloramphenicol; Erythrocyte Co	1966
Systemic lupus erythematosus and acute myeloblastic leukemia. Report of their coexistence and a survey of possible associating features. Archives of internal medicine, 1967, Volume: 120, Issue:3 Topics: Bone Marrow; Chloramphenicol; Female; Hematocrit; Hemoglobinometry; Humans; Leukemia, Myeloid, Acute	1967
Acute myeloid leukemia following seven years of aplastic anemia induced by chloramphenicol. The American journal of medicine, 1967, Volume: 43, Issue:5 Topics: Androgens; Anemia, Aplastic; Blood Platelets; Blood Volume; Bone Marrow Cells; Chloramphenicol; Eryt	1967
Hypoplastic anemia and myeloblastic leukemia following chloramphenicol therapy. Report of three cases. The New England journal of medicine, 1967, Nov-09, Volume: 277, Issue:19 Topics: Adult; Anemia, Aplastic; Chloramphenicol; Chronic Disease; Female; Humans; Leukemia, Myeloid, Acute;	1967
Sequels to chloramphenicol aplastic anemia: acute leukemia and paroxysmal nocturnal hemoglobinuria. Northwest medicine, 1969, Volume: 68, Issue:9 Topics: Adolescent; Anemia, Aplastic; Child; Chloramphenicol; Female; Hemoglobinuria, Paroxysmal; Humans; Le	1969
Chloramphenicol, acute leukemia and chromosomal vacuolizations. Southern medical journal, 1971, Volume: 64, Issue:7 Topics: Bone Marrow; Bone Marrow Examination; Chloramphenicol; Chromosome Aberrations; Humans; Karyotyping;	1971

chloramphenicol and Acute Myelogenous Leukemia