chloramine-t and Intestinal-Perforation

An analysis and statistical evaluation of 1,157 cases of wound healing produced evidence to the effect that the rate of wound healing disorders could be substantially reduced by prophylactic peritoneal lavage, using 0.1 per cent chloramine-T solution. That reduction was from nine to 2.6 per cent in the author's cases. - In the context of perforations (n = 186), therapeutic peritoneal lavage, using chloramine-T, proved clearly superior to washing with physiological salt solution in coping with wound healing disorders. Here, the rate of such disorders was reduced from 22.4 to 8.3 per cent, and it dropped further to 4.5 per cent in those cases of perforation in which additional lavage was applied to the surgical wound proper.

Topics: Abdomen; Adult; Aged; Anti-Infective Agents, Local; Chloramines; Female; Humans; Intestinal Perforation; Male; Middle Aged; Peritoneal Lavage; Peritonitis; Surgical Wound Infection; Tosyl Compounds; Wound Healing