chloramine-t and Breast-Neoplasms

chloramine-t has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for chloramine-t and Breast-Neoplasms

Article	Year
(125)I labeling of clomiphene and biodistribution studies for possible use as a model in breast cancer imaging. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2016, Volume: 115 Clomiphene has growth-inhibitory effects of breast cancer cells, clomiphene was successfully labeled with (125)I via direct electrophilic substitution reaction with labeling yield 97%. It was obtained at optimum substrate amount of 0.5mg, Chloramine-T was used as an oxidizing agent at optimum amount of 25µg. Labeling reactions was done at pH 5 at ambient temperature. This study showed good in vitro and in vivo stability of the (125)I-clomiphene. The radiolabeled compound showed high ascetic fluid uptake of 18.12±0.27% at 30min post-injection. Solid tumor uptake of (125)I-clomiphene was 12.48±0.32% at 30min post-injection. This data revealed the localization of tracer in tumor tissue with high percent sufficient to use (125)I-clomiphene as a promising tool for the diagnosis of breast cancer. Topics: Breast Neoplasms; Cell Line, Tumor; Chloramines; Clomiphene; Estrogen Antagonists; Humans; Isotope Labeling; Tissue Distribution; Tosyl Compounds	2016

Article

Year

(125)I labeling of clomiphene and biodistribution studies for possible use as a model in breast cancer imaging.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2016, Volume: 115

Clomiphene has growth-inhibitory effects of breast cancer cells, clomiphene was successfully labeled with (125)I via direct electrophilic substitution reaction with labeling yield 97%. It was obtained at optimum substrate amount of 0.5mg, Chloramine-T was used as an oxidizing agent at optimum amount of 25µg. Labeling reactions was done at pH 5 at ambient temperature. This study showed good in vitro and in vivo stability of the (125)I-clomiphene. The radiolabeled compound showed high ascetic fluid uptake of 18.12±0.27% at 30min post-injection. Solid tumor uptake of (125)I-clomiphene was 12.48±0.32% at 30min post-injection. This data revealed the localization of tracer in tumor tissue with high percent sufficient to use (125)I-clomiphene as a promising tool for the diagnosis of breast cancer.

Topics: Breast Neoplasms; Cell Line, Tumor; Chloramines; Clomiphene; Estrogen Antagonists; Humans; Isotope Labeling; Tissue Distribution; Tosyl Compounds

2016