chlorambucil has been researched along with Uveitis in 35 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Uveitis: Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report our experience with the use of chlorambucil for otherwise treatment-resistant uveitis and to assess its safety and efficacy." | 9.10 | Efficacy and safety of chlorambucil in intractable noninfectious uveitis: the Massachusetts Eye and Ear Infirmary experience. ( Baltatzis, S; Ekong, A; Foster, CS; Miserocchi, E; Roque, M, 2002) |
| "To evaluate the effects of short-term chlorambucil therapy in the management of uveitis due to Behcet's disease." | 9.09 | Short-term chlorambucil for refractory uveitis in Behcet's disease. ( Arslan, MO; Burumcek, EY; Durlu, Y; Ergen, A; Ipcioglu, SU; Mudun, BA, 2001) |
| "We have studied the long-term effects of chlorambucil treatment on the chromosomes of peripheral blood lymphocytes from patients with uveitis." | 7.67 | Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil. ( Casey, G; Dinning, WJ; Harris, H; Reeves, BR, 1985) |
| "Treatment with chlorambucil, 0." | 5.27 | Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease. ( Goldstein, NP; O'Duffy, JD; Robertson, DM, 1984) |
| "To report our experience with the use of chlorambucil for otherwise treatment-resistant uveitis and to assess its safety and efficacy." | 5.10 | Efficacy and safety of chlorambucil in intractable noninfectious uveitis: the Massachusetts Eye and Ear Infirmary experience. ( Baltatzis, S; Ekong, A; Foster, CS; Miserocchi, E; Roque, M, 2002) |
| "To evaluate the effects of short-term chlorambucil therapy in the management of uveitis due to Behcet's disease." | 5.09 | Short-term chlorambucil for refractory uveitis in Behcet's disease. ( Arslan, MO; Burumcek, EY; Durlu, Y; Ergen, A; Ipcioglu, SU; Mudun, BA, 2001) |
| "Intensive and prolonged systemic treatment with corticosteroids is recommended for the patients with first attack of VKH syndrome, where as regular treatment with chlorambucil is useful for control of chronic and recurrent uveitis seen in VKH syndrome." | 3.71 | [Therapeutic regimen in Vogt-Koyanagi-Harada syndrome]. ( Fu, T; Huang, X; Li, F; Wang, H; Yang, P; Zhong, H; Zhou, H, 2002) |
| "To determine the effectiveness of short-term high-dose chlorambucil in the treatment of sight-threatening uveitis and to ascertain the incidence of severe side effects, particularly late malignancy." | 3.71 | Long-term follow-up of patients treated with short-term high-dose chlorambucil for sight-threatening ocular inflammation. ( Fontanilla, FA; Goldstein, DA; Kaul, S; Sahin, O; Tessler, HH, 2002) |
| "We have studied the long-term effects of chlorambucil treatment on the chromosomes of peripheral blood lymphocytes from patients with uveitis." | 3.67 | Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil. ( Casey, G; Dinning, WJ; Harris, H; Reeves, BR, 1985) |
| "Twenty-five patients with severe, progressive, chronic uveitis who were poorly responsive or unresponsive to corticosteroid therapy received low-dose prednisone and cytotoxic immunosuppressive therapy." | 3.66 | Immunosuppressive therapy for severe chronic uveitis. ( Andrasch, RH; Burns, RP; Pirofsky, B, 1978) |
| "Ten out of 31 cases of severe corticosteroid-resistant uveitis showed a good clinical response to systemic chlorambucil therapy." | 3.65 | Immunosuppressive treatment of uveitis. ( Epstein, WV; Godfrey, WA; Hogan, MJ; Kimura, SJ; Nozik, RA; O'Connor, GR, 1976) |
| "Oral corticosteroids remain the main therapeutical choice in patients with uveitis not responding to topical treatment, however their chronic use can be very toxic, especially for bones (osteoporosis or growth retardation)." | 2.41 | [Treatment of uveitis with immunosuppressives: antimetabolites and alkylating agents]. ( Caspers-Velu, LE, 2001) |
| "Uveitis was total in 72% of cases." | 1.29 | [Outcome of Behçet disease in ophthalmologic practice in Morocco]. ( Benchekroun, N; Berraho-Hamani, A; Chaoui, Z; el Aouni, A; Hajji, Z; Ouazzani, B, 1995) |
| "Treatment with chlorambucil, 0." | 1.27 | Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease. ( Goldstein, NP; O'Duffy, JD; Robertson, DM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (68.57) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Birnbaum, AD | 1 |
| Oh, F | 1 |
| Sahin, O | 2 |
| Little, DM | 1 |
| Tessler, HH | 2 |
| Goldstein, DA | 2 |
| Yang, P | 1 |
| Wang, H | 1 |
| Zhou, H | 1 |
| Zhong, H | 2 |
| Li, F | 1 |
| Huang, X | 1 |
| Fu, T | 1 |
| Palmer, RG | 1 |
| Doré, CJ | 1 |
| Denman, AM | 1 |
| O'Connor, GR | 3 |
| O'Duffy, JD | 1 |
| Robertson, DM | 1 |
| Goldstein, NP | 1 |
| Dinning, WJ | 5 |
| Martenet, AC | 1 |
| Niessen, F | 1 |
| Campinchi, R | 2 |
| Bloch-Michel, E | 1 |
| Cunningham, ET | 1 |
| Demetrius, R | 1 |
| Frieden, IJ | 1 |
| Emery, HM | 1 |
| Irvine, AR | 1 |
| Good, WV | 1 |
| Ouazzani, B | 1 |
| Benchekroun, N | 1 |
| el Aouni, A | 1 |
| Hajji, Z | 1 |
| Chaoui, Z | 1 |
| Berraho-Hamani, A | 1 |
| Van Gelder, RN | 1 |
| Kaplan, HJ | 1 |
| Caspers-Velu, LE | 1 |
| Lightman, S | 1 |
| Kok, H | 1 |
| Miserocchi, E | 1 |
| Baltatzis, S | 1 |
| Ekong, A | 1 |
| Roque, M | 1 |
| Foster, CS | 1 |
| Fontanilla, FA | 1 |
| Kaul, S | 1 |
| Mudun, BA | 1 |
| Ergen, A | 1 |
| Ipcioglu, SU | 1 |
| Burumcek, EY | 1 |
| Durlu, Y | 1 |
| Arslan, MO | 1 |
| Andrasch, RH | 2 |
| Pirofsky, B | 2 |
| Burns, RP | 2 |
| Ardouin, M | 1 |
| Urvoy, M | 1 |
| Perraut, JP | 1 |
| Scherf, J | 1 |
| Miller, B | 1 |
| Zonis, S | 1 |
| Perkins, ES | 3 |
| Reeves, BR | 2 |
| Pickup, VL | 1 |
| Lawler, SD | 1 |
| Nozik, RA | 2 |
| Godfrey, WA | 2 |
| Epstein, WV | 2 |
| Kimura, SJ | 2 |
| Hogan, MJ | 2 |
| Johnston, CA | 1 |
| Teitelbaum, CS | 1 |
| Casey, G | 1 |
| Harris, H | 1 |
| Pouliquen, Y | 1 |
| Binet, JL | 1 |
| Bonnet, M | 1 |
| Abdalla, MI | 1 |
| el-D Bahoat, N | 1 |
| Aronson, SB | 1 |
| Martin, B | 1 |
8 reviews available for chlorambucil and Uveitis
| Article | Year |
|---|---|
[Therapy of endogenous uveitis. Immunosuppression].
Topics: Adult; Azathioprine; Child; Chlorambucil; Cyclophosphamide; Humans; Immunosuppressive Agents; Procar | 1980 |
Immunosuppression in uveitis therapy.
Topics: Administration, Oral; Administration, Topical; Animals; Arrestin; Azathioprine; Chlorambucil; Cyclop | 1999 |
[Treatment of uveitis with immunosuppressives: antimetabolites and alkylating agents].
Topics: Adult; Aged; Antimetabolites; Antineoplastic Agents, Alkylating; Azathioprine; Child; Chlorambucil; | 2001 |
Developments in the treatment of uveitis.
Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Antimetabolites; Antineoplastic Agents, Alkylating; | 2002 |
Cytotoxic drugs in treatment of nonmalignant diseases.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Arthritis, Rheumatoid; Azathioprine; Chlor | 1972 |
[Immunodepressors in ophthalmology].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Antibiotics, Antineoplastic; Antilymphocyte Se | 1971 |
Recent advances in the study of uveitis.
Topics: Adult; Antibodies; Antigen-Antibody Reactions; Aqueous Humor; Azathioprine; Cell Migration Inhibitio | 1974 |
The uvea.
Topics: Anaphylaxis; Animals; Azathioprine; Chlorambucil; Epidemiologic Methods; Humans; Methotrexate; Stero | 1969 |
2 trials available for chlorambucil and Uveitis
| Article | Year |
|---|---|
Efficacy and safety of chlorambucil in intractable noninfectious uveitis: the Massachusetts Eye and Ear Infirmary experience.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Child; Child, Preschool; Chlorambucil; C | 2002 |
Short-term chlorambucil for refractory uveitis in Behcet's disease.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Behcet Syndrome; Child; Chlorambucil; Female; | 2001 |
25 other studies available for chlorambucil and Uveitis
| Article | Year |
|---|---|
Chlorambucil and malignancy.
Topics: Antineoplastic Agents, Alkylating; Chlorambucil; Databases, Factual; Follow-Up Studies; Humans; Neop | 2010 |
[Therapeutic regimen in Vogt-Koyanagi-Harada syndrome].
Topics: Adolescent; Adult; Child; Chlorambucil; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Me | 2002 |
Chlorambucil-induced chromosome damage to human lymphocytes is dose-dependent and cumulative.
Topics: Adult; Behcet Syndrome; Chlorambucil; Chromosomes, Human; Dose-Response Relationship, Drug; Female; | 1984 |
The use of immunosuppressive agents in diseases of the eye.
Topics: Child; Chlorambucil; Cyclosporins; Eye Diseases; Female; Humans; Immunosuppressive Agents; Inflammat | 1983 |
Chlorambucil in the treatment of uveitis and meningoencephalitis of Behçet's disease.
Topics: Adolescent; Adrenal Cortex Hormones; Adult; Behcet Syndrome; Chlorambucil; Female; Humans; Male; Men | 1984 |
Treatment of uveitis.
Topics: Adrenal Cortex Hormones; Chlorambucil; Humans; Immune Tolerance; Uveitis | 1981 |
[Value and complications of immunosuppressive therapy in uveitis of Behcet's disease or of other etiology. Apropos of 40 cases].
Topics: Adult; Aged; Azathioprine; Behcet Syndrome; Child; Chlorambucil; Drug Therapy, Combination; Female; | 1982 |
Vogt-Koyanagi-Harada syndrome in a 4-year old child.
Topics: Alopecia; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Blindness; Child, Preschool; | 1995 |
[Outcome of Behçet disease in ophthalmologic practice in Morocco].
Topics: Adult; Behcet Syndrome; Chlorambucil; Cyclosporine; Eye Diseases; Female; Humans; Male; Morocco; Pre | 1995 |
Long-term follow-up of patients treated with short-term high-dose chlorambucil for sight-threatening ocular inflammation.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Child; Chlorambucil; Female; Follow-Up S | 2002 |
Immunosuppressive therapy for severe chronic uveitis.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Chlorambucil; Chronic Disease; Drug | 1978 |
[Pars planitis and Behçet's syndrome].
Topics: Adult; Behcet Syndrome; Chlorambucil; Ciliary Body; Humans; Male; Uveitis | 1978 |
[Steroid resistant uveitis treated with chlorambucil].
Topics: Chlorambucil; Drug Resistance; Female; Humans; Middle Aged; Steroids; Uveitis | 1977 |
Immunosuppressive therapy of severe chronic uveitis.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Chlorambucil; Female; Humans; Male; Prednisone; U | 1976 |
Management of chronic uveitis.
Topics: Behcet Syndrome; Chlorambucil; Chronic Disease; Follow-Up Studies; Humans; Uveitis | 1976 |
Immunosuppressives in uveitis. A preliminary report of experience with chlorambucil.
Topics: Adult; Behcet Syndrome; Chlorambucil; Endophthalmitis; Female; Follow-Up Studies; Humans; Leukopenia | 1975 |
A chromosome study of patients with uveitis treated with chlorambucil.
Topics: Adult; Chlorambucil; Chromosome Aberrations; Female; Humans; Male; Middle Aged; Uveitis | 1975 |
Editorial: Immunosuppressive treatment for uveitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Chlorambucil; Humans; Immunosuppressive Agents; Methotrexate; | 1975 |
Immunosuppressive treatment of uveitis.
Topics: Chlorambucil; Humans; Immunosuppressive Agents; Uveitis | 1976 |
Magnetic resonance imaging in Vogt-Koyanagi-Harada syndrome.
Topics: Administration, Oral; Adult; Chlorambucil; Diagnosis, Differential; Female; Humans; Magnetic Resonan | 1990 |
Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil.
Topics: Chlorambucil; Chromosome Aberrations; Female; Follow-Up Studies; Humans; Lymphocytes; Male; Uveitis | 1985 |
[A study of the treatment of uveitis with immunosuppressors].
Topics: Adrenal Cortex Hormones; Adult; Chlorambucil; Crystallins; Female; Hemagglutination Tests; Humans; M | 1968 |
The use of chlorambucil in intractable idiopathic uveitis.
Topics: Adolescent; Arthritis, Rheumatoid; Behcet Syndrome; Blood Cell Count; Blood Platelets; Chemical Phen | 1974 |
Long-lasting remission of Behcet's disease after chlorambucil therapy.
Topics: Adrenal Cortex Hormones; Adult; Arthritis; Behcet Syndrome; Chlorambucil; Erythema Nodosum; Female; | 1973 |
Infiltration of the iris in chronic lymphatic leukaemia.
Topics: Acetazolamide; Chlorambucil; Chronic Disease; Glaucoma; Humans; Intraocular Pressure; Iris; Leukemia | 1968 |