chlorambucil and Teratoma studies

Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.

Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)

Research Excerpts

Excerpt	Relevance	Reference
"Based on the diagnosis of testicular neoplasm, orchiectomy was performed on September 7, 1983."	1.27	[Case report of a non-seminomatous testicular neoplasm indicating marked efficacy of a combination chemotherapy of VBL, ACTD, BLM, CDDP and EX (VAB-4 combination therapy)]. ( Ebihara, K; Hayashi, M; Urano, E, 1984)
"Sixteen patients with metastatic testicular cancer were treated with combination chemotherapy including cisplatin (CDDP) at 3- to 4-week intervals for two to five courses."	1.27	[Hypomagnesemia following chemotherapy of disseminated testicular tumors]. ( Hida, S; Nishimura, K; Nishio, Y; Okada, K; Okada, Y; Yoshida, O, 1988)
"The histologic diagnoses were six immature teratomas, five endodermal sinus tumors, four mixed germ cell tumors, and one nongestational choriocarcinoma."	1.27	Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary. ( Cain, JM; Hakes, TB; Lewis, JL; Pierce, VK; Pippitt, CH, 1988)
"Primary testicular neoplasms are not common childhood tumors, comprising about 1% of all childhood malignancies [1]."	1.26	Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management. ( Chu, JY; DeMello, D; McElfresh, AE; O'Connor, DM; Razek, AA, 1978)
"Of 250 testicular tumors treated up to May 1975 233 (93."	1.26	The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle. ( Vahlensieck, W; Weissbach, L, 1977)

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (93.62)	18.7374
1990's	3 (6.38)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
ROSENBLATT, MS	1
YANOFF, M	1
RAWSON, AJ	1
LEBHERZ, TB	1
HUSTON, JW	1
AUSTIN, JA	1
BOYCE, CR	1
APPERT, O	1
EDMONDS, LC	1
CARRERA, GM	1
Mackenzie, AR	1
Laplante, MP	1
Mount, BM	1
Vugrin, D	3
Whitmore, WF	3
Golbey, RB	4
Williams, SD	1
Loehrer, PJ	1
Einhorn, LH	1
Hayashi, M	1
Ebihara, K	1
Urano, E	1
Sablińska, B	1
Chu, JY	1
O'Connor, DM	1
DeMello, D	1
Razek, AA	1
McElfresh, AE	1
Vahlensieck, W	4
Weissbach, L	3
Smith, JP	1
Rutledge, F	1
Rodermund, OE	1
Brock, PR	1
Yeomans, EC	1
Bellman, SC	1
Pritchard, J	1
Tiuliandin, SA	1
Honda, N	1
Uchida, T	1
Mukai, N	1
Go, M	1
Yokoyama, E	1
Mashimo, S	1
Endo, T	1
Ishibashi, A	1
Koshiba, K	1
Shibuya, M	1
Toumieux, B	1
Lemarie, E	1
Lavandier, M	1
Hida, S	1
Nishimura, K	1
Nishio, Y	1
Okada, Y	1
Okada, K	1
Yoshida, O	1
Masuda, F	1
Nakada, J	1
Kondo, N	1
Takahashi, T	1
Mochizuki, A	1
Iizuka, N	1
Pippitt, CH	1
Cain, JM	1
Hakes, TB	1
Pierce, VK	1
Lewis, JL	1
Iwasaki, M	1
Kazama, T	1
Nakada, T	1
Katayama, T	1
Le Duc, A	1
Gisselbrecht, C	1
Le Doze, H	1
Mignot, L	1
Gödde, S	1
Skinner, DG	2
Leadbetter, WF	2
Wilkins, EW	1
Wilms, K	2
Bonadonna, G	1
van der Werf-Messing, B	1
Rathert, P	1
Terhorst, B	1
Lutzeyer, W	1
Astrakhan, VI	1
Monul, FA	1
Woodruff, JD	2
Protos, P	1
Peterson, WF	1
Ryssel, HJ	1
Sonntag, RW	1
Brunner, KW	1
Furnari, S	1
Pavone-Macaluso, M	1
Veroux, G	1
Mattea, E	1
Dees, JE	1
Nogales, FF	1
Oliva, HA	1
Julian, CG	1
Hartwich, G	1
Butzler, W	1
Ansfield, FJ	1
Korbitz, BC	1
Davis, HL	1
Ramirez, G	1
Moore, CA	1
Wider, JA	1
Marshall, JR	1
Bardin, CW	1
Lipsett, MB	1
Ross, GT	1

Article	Year
[A case report of extragonadal germ cell tumor with special reference to VAB-6 therapy]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bleomycin; Chlorambucil; C	1988
Chemotherapy of testicular tumors. Acta chirurgica Belgica, 1971, Volume: 70, Issue:4 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Bleomycin; Chlorambucil; Dactinomycin; Dysgermin	1971
The role of chemotherapy in the treatment of primary ovarian malignancy. Obstetrical & gynecological survey, 1969, Volume: 24, Issue:11 Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Ascites; Chlorambucil; Chromium; DNA Repl	1969

Article	Year
[Chemotherapy of immature ovarian teratomas]. Ginekologia polska, 1983, Volume: 54, Issue:10 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Clinical Trials as	1983
Advances in chemotherapy for gynecologic cancer. Cancer, 1975, Volume: 36, Issue:2 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug	1975

Article	Year
Chemical treatment of metastatic malignant teratoma of the testicle. Northwest medicine, 1963, Volume: 62 Topics: Chlorambucil; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Nitrofurazone; Terato	1963
PELIOSIS HEPATIS. AN ANATOMIC STUDY WITH DEMONSTRATION OF TWO VARIETIES. Archives of pathology, 1964, Volume: 77 Topics: Anatomy; Chlorambucil; Classification; Cyclophosphamide; Dactinomycin; Femoral Fractures; Geriatrics	1964
SUSTAINED PALLIATION IN OVARIAN CARCINOMA. Obstetrics and gynecology, 1965, Volume: 25 Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Ascites; Carcinoma; Chlorambucil; Dysgerminoma; Female; Gr	1965
[CYTOSTATIC TREATMENT OF A MALIGNANT EMBRYONAL MIXED TESTICULAR TUMOR]. Schweizerische medizinische Wochenschrift, 1965, Mar-27, Volume: 95 Topics: Chlorambucil; Dactinomycin; Drug Therapy; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metas	1965
EXTRAGENITAL CHORIOCARCINOMA. The Journal of pediatrics, 1965, Volume: 67 Topics: Autopsy; Brain Neoplasms; Child; Chlorambucil; Choriocarcinoma; Dactinomycin; Drug Therapy; Epistaxi	1965
Chemotherapy of metastatic testis cancer. Results in 154 patients. Cancer, 1966, Volume: 19, Issue:10 Topics: Adult; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Choriocarcinoma; Dactinomycin; Dy	1966
Lymphadenectomy for testicular carcinoma. Canadian journal of surgery. Journal canadien de chirurgie, 1982, Volume: 25, Issue:3 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Chor	1982
VAB-6 combination chemotherapy without maintenance in treatment of disseminated cancer of the testis. Cancer, 1983, Jan-15, Volume: 51, Issue:2 Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin;	1983
VAB-5 combination chemotherapy in prognostically poor risk patients with germ cell tumors. Cancer, 1983, Mar-15, Volume: 51, Issue:6 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisp	1983
Vinblastine, actinomycin D, bleomycin, cyclophosphamide and cis-platinum combination chemotherapy in metastatic testis cancer--a 1-year program. The Journal of urology, 1982, Volume: 128, Issue:6 Topics: Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin;	1982
Chemotherapy of advanced testicular cancer. Seminars in urology, 1984, Volume: 2, Issue:4 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined Modalit	1984
[Case report of a non-seminomatous testicular neoplasm indicating marked efficacy of a combination chemotherapy of VBL, ACTD, BLM, CDDP and EX (VAB-4 combination therapy)]. Gan to kagaku ryoho. Cancer & chemotherapy, 1984, Volume: 11, Issue:12 Pt 2 Topics: Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil;	1984
Childhood embryonal carcinoma of testis, report of two unusual cases, and the implication on clinical management. Medical and pediatric oncology, 1978, Volume: 4, Issue:2 Topics: Castration; Child, Preschool; Chlorambucil; Cyclophosphamide; Dactinomycin; Doxorubicin; Humans; Inf	1978
The combined surgical and chemotherapeutic approach to non-seminomatous cancer of the testicle. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 1977, Issue:60 Topics: Chlorambucil; Dactinomycin; Drug Therapy, Combination; Dysgerminoma; Humans; Ifosfamide; Lymph Node	1977
[Effect of a cytostatic triple-drug-interval therapy on human germinal epithelium]. Zeitschrift fur Hautkrankheiten, 1975, Apr-01, Volume: 50, Issue:7 Topics: Adult; Chlorambucil; Dactinomycin; Drug Therapy, Combination; Humans; Male; Methotrexate; Middle Age	1975
Cisplatin therapy in infants: short and long-term morbidity. The British journal of cancer. Supplement, 1992, Volume: 18 Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chlorambucil; Cisplatin;	1992
[Infusion of high doses of platidiam in the treatment of patients with germ cell testicular tumors]. Voprosy onkologii, 1990, Volume: 36, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Cyclophosphamide	1990
[A case of retrovesical embryonal cell carcinoma]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1991, Volume: 82, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Cisplatin; Combined	1991
[Non seminomatous germ cell tumors of the mediastinum treated successfully by the chemotherapy and surgical excision combination]. Annales de chirurgie, 1988, Volume: 42, Issue:2 Topics: Adult; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil;	1988
[Hypomagnesemia following chemotherapy of disseminated testicular tumors]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:1 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis	1988
[Treatment of nonseminomatous testicular tumor with liver metastases]. Hinyokika kiyo. Acta urologica Japonica, 1988, Volume: 34, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis	1988
Primary chemotherapy and the role of second-look laparotomy in non-dysgerminomatous germ cell malignancies of the ovary. Gynecologic oncology, 1988, Volume: 31, Issue:2 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Chorioca	1988
[Role of chemotherapy in the treatment of cancer of the testis in adults]. Presse medicale (Paris, France : 1983), 1985, Feb-09, Volume: 14, Issue:5 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chlorambucil; Choriocarcinoma; Cis	1985
[Transperitoneal lymph node excision and cytostatic postoperative treatment of malignant germinal testicular neoplasms]. Langenbecks Archiv fur Chirurgie, 1968, Volume: 322 Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Drug Synergism; Dysgerminoma; Humans; Lymph Node	1968
The surgical management of testis tumors metastatic to the lung: a report of 10 cases with subsequent resection of from one to seven pulmonary metastases. The Journal of urology, 1971, Volume: 105, Issue:2 Topics: Adolescent; Adult; Castration; Child; Chlorambucil; Dactinomycin; Follow-Up Studies; Humans; Lung Ne	1971
[Cytostatic treatment of malignant testicular neoplasms]. Deutsche medizinische Wochenschrift (1946), 1971, Nov-26, Volume: 96, Issue:48 Topics: Adult; Antibiotics, Antineoplastic; Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; D	1971
[Cytostatic therapy of malignant testicular tumors]. Minerva medica, 1973, Mar-14, Volume: 64, Issue:14 Topics: Antineoplastic Agents; Chlorambucil; Dactinomycin; Dysgerminoma; Humans; Male; Methotrexate; Plicamy	1973
The treatment of pulmonary metastases of malignant teratoma of the testis. Clinical radiology, 1973, Volume: 24, Issue:1 Topics: Chlorambucil; Dactinomycin; Humans; Lung Neoplasms; Male; Methotrexate; Neoplasm Metastasis; Pneumon	1973
[Bleomycin for malignant tumours of the genitals of the male (author's transl)]. Der Urologe. Ausg. A, 1974, Volume: 13, Issue:2 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Bleomycin; Carcinoma, Squamous Cell; Chlorambucil	1974
[The combined chemotherapy of testicular tumors resistant to sarcolysin]. Voprosy onkologii, 1967, Volume: 13, Issue:4 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Cyclophosphamide;	1967
Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis. American journal of obstetrics and gynecology, 1968, Nov-01, Volume: 102, Issue:5 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin	1968
[Treatment of choriocarcinoma and malignant testicular neoplasms in internal medicine]. Helvetica medica acta. Supplementum, 1967, May-28, Volume: 47 Topics: Chlorambucil; Choriocarcinoma; Cyclophosphamide; Dactinomycin; Dysgerminoma; Humans; Lung Neoplasms;	1967
Cancer chemotherapy in urology. Urologia internationalis, 1971, Volume: 26, Issue:4 Topics: Adenocarcinoma; Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites; Chlorambucil; Cobal	1971
Operative and cytostatic treatment of germinal tumours of the testis. International urology and nephrology, 1973, Volume: 5, Issue:1 Topics: Adolescent; Adult; Antineoplastic Agents; Castration; Child; Child, Preschool; Chlorambucil; Cyclic	1973
Metastatic embryonal cell carcinoma of testis: an apparent 8-year cure. The Journal of urology, 1973, Volume: 110, Issue:1 Topics: Adult; Chlorambucil; Dactinomycin; Humans; Lung Neoplasms; Lymphography; Male; Methotrexate; Neoplas	1973
Peritoneal gliomatosis produced by ovarian teratomas. Obstetrics and gynecology, 1974, Volume: 43, Issue:6 Topics: Adult; Chlorambucil; Dactinomycin; Fallopian Tubes; Female; Glioma; Humans; Hysterectomy; Methotrexa	1974
[Secondary tumors in hemoblastoses during cytostatic treatment]. Medizinische Klinik, 1971, Oct-22, Volume: 66, Issue:43 Topics: Adrenal Gland Neoplasms; Aged; Antineoplastic Agents; Bronchial Neoplasms; Busulfan; Carcinoma; Chlo	1971
The surgical management of testis tumors. The Journal of urology, 1971, Volume: 106, Issue:1 Topics: Adolescent; Adult; Castration; Child; Child, Preschool; Chlorambucil; Choriocarcinoma; Dactinomycin;	1971
Triple drug therapy in testicular tumors. Cancer, 1969, Volume: 24, Issue:3 Topics: Adolescent; Adult; Chlorambucil; Choriocarcinoma; Dactinomycin; Humans; Male; Methotrexate; Middle A	1969
The place of chemotherapy in the treatment of testicular tumors. JAMA, 1970, Jul-06, Volume: 213, Issue:1 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chlorambucil; Choriocarcinoma; Chorionic Gonadot	1970
Triple chemotherapy in the treatment of metastatic testicular neoplasms. The Journal of urology, 1968, Volume: 100, Issue:4 Topics: Adult; Chlorambucil; Choriocarcinoma; Dactinomycin; Humans; Male; Methotrexate; Neoplasm Metastasis;	1968
Sustained remissions after chemotherapy for primary ovarian cancers containing choriocarcinoma. The New England journal of medicine, 1969, Jun-26, Volume: 280, Issue:26 Topics: Adolescent; Adult; Child; Chlorambucil; Choriocarcinoma; Chorionic Gonadotropin; Dactinomycin; Dysge	1969

chlorambucil and Teratoma

Research Excerpts

Research

Studies (47)

Authors

Reviews

Trials

Other Studies