chlorambucil has been researched along with Skin Neoplasms in 53 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Erythrodermic cutaneous T-cell lymphomas (CTCL) including Sézary syndrome have been successfully treated with daily administration of chlorambucil and prednisone (Winkelmann regimen)." | 9.09 | Treatment of erythrodermic cutaneous T-cell lymphoma with intermittent chlorambucil and fluocortolone therapy. ( Coors, EA; von den Driesch, P, 2000) |
| "Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins." | 7.65 | Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977) |
| "Erythrodermic cutaneous T-cell lymphomas (CTCL) including Sézary syndrome have been successfully treated with daily administration of chlorambucil and prednisone (Winkelmann regimen)." | 5.09 | Treatment of erythrodermic cutaneous T-cell lymphoma with intermittent chlorambucil and fluocortolone therapy. ( Coors, EA; von den Driesch, P, 2000) |
| "Prednimustine, a chlorambucil ester of prednisolone, was administered orally to 5 patients with mycosis fungoides in advanced tumour stage." | 5.04 | Prednimustine in mycosis fungoides: a report from the Scandinavian mycosis fungoides study group. ( Bergqvist-Karlsson, A; Hellbe, L; Molin, L; Thomsen, K; Volden, G, 1979) |
| "Thirteen consecutive patients with inoperable recurrent malignant melanoma were treated by immunochemotherapy with the use of chlorambucil noncovalently bound to goat or rabbit antihuman melanoma globulins." | 3.65 | Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease. ( Bodurtha, A; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST; Tai, J, 1977) |
| "Cell-surface localizing heterologous antibodies against the mouse EL4 lymphoma and a human malignant melanoma could be bound to chlorambucil without causing the loss of the alkylating activity of chlorambucil or interfering with the reactivity of the antibodies with their respective tumour cells." | 3.65 | Immunochemotherapy of cancer with chlorambucil-carrying antibody. ( Bodurtha, A; Cameron, D; Ghose, T; Guclu, A; MacDonald, AS; Norvell, ST, 1972) |
| "Bexarotene is a newly registered drug." | 2.42 | [Standard and experimental therapy of cutaneous T-cell lymphoma]. ( Beyeler, M; Dummer, R, 2003) |
| " Similar side effect intensity of BZA2 and dacarbazine was observed, whereas BZA1 was more toxic." | 1.33 | Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model. ( Bauder-Wüst, U; Eisenhut, M; Eskerski, H; Haberkorn, U; Wolf, M, 2006) |
| "Head and neck carcinomas and breast cancer had the highest incidence (5 and 3 cases, respectively)." | 1.26 | Primary malignant neoplasms associated with chronic lymphocytic leukemia. ( Franchi, F; Monfardini, S; Rilke, F; Santoro, A, 1980) |
| "Azathioprine was best tolerated, but gave only medium results whereas procarbazine, as a very potent drug, had the highest rate of side effects (especially depression of bone marrow, infections, gastrointestinal manifestations etc." | 1.25 | [Side effects in immunosuppressive therapy]. ( Thumb, N, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (62.26) | 18.7374 |
| 1990's | 7 (13.21) | 18.2507 |
| 2000's | 9 (16.98) | 29.6817 |
| 2010's | 4 (7.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Streu, E | 1 |
| Taylor, F | 1 |
| Gear, R | 1 |
| Hoather, T | 1 |
| Dobson, J | 1 |
| Fontanilla, FA | 1 |
| Edward, DP | 1 |
| Wong, M | 1 |
| Tessler, HH | 1 |
| Eagle, RC | 1 |
| Goldstein, DA | 1 |
| Rivera, S | 1 |
| McClearen, JR | 1 |
| Reavill, DR | 1 |
| Mirabile, A | 1 |
| Devizzi, L | 1 |
| Gianni, AM | 1 |
| Cabras, A | 1 |
| Carbone, A | 1 |
| Velázquez, D | 1 |
| de Pablo, P | 1 |
| García, D | 1 |
| Ramírez, JR | 1 |
| Breton, AL | 1 |
| Poulalhon, N | 1 |
| Balme, B | 1 |
| Thomas, L | 1 |
| Dalle, S | 1 |
| WRIGHT, JC | 1 |
| LYONS, MM | 1 |
| WALKER, DG | 1 |
| GOLOMB, FM | 1 |
| GUMPORT, SL | 1 |
| MEDREK, TJ | 1 |
| Beyeler, M | 1 |
| Dummer, R | 1 |
| Stanway, A | 1 |
| Rademaker, M | 1 |
| Kennedy, I | 1 |
| Newman, P | 1 |
| Wolf, M | 1 |
| Eskerski, H | 1 |
| Bauder-Wüst, U | 1 |
| Haberkorn, U | 1 |
| Eisenhut, M | 1 |
| Robak, E | 1 |
| Jesionek-Kupnicka, D | 1 |
| Robak, T | 1 |
| Holub, A | 1 |
| Wawrzyniak, E | 1 |
| Bartkowiak, J | 1 |
| Bednarek, A | 1 |
| Constantinu, M | 1 |
| Urbanska-Rys, H | 1 |
| Fromer, JL | 1 |
| Sullivan, RD | 1 |
| Degos, R | 1 |
| Touraine, R | 1 |
| Belaich, S | 1 |
| Vachon, N | 1 |
| Geerts, ML | 1 |
| Hamers, J | 1 |
| Schwarze, EW | 1 |
| Kint, A | 1 |
| Roels, H | 1 |
| Lennert, K | 1 |
| Chanda, JJ | 1 |
| Callen, JP | 1 |
| Greenberg, J | 1 |
| Santoro, A | 1 |
| Rilke, F | 1 |
| Franchi, F | 1 |
| Monfardini, S | 1 |
| Wells, P | 1 |
| Wotherspoon, A | 1 |
| Burnet, NG | 1 |
| Tobias, JS | 1 |
| Marschalkó, M | 1 |
| Knobler, R | 1 |
| Soós, G | 1 |
| Berecz, M | 1 |
| Pálóczy, K | 1 |
| Rácz, I | 1 |
| Falk, S | 1 |
| Walther, F | 1 |
| Denk, R | 1 |
| Murphy, A | 1 |
| O'Keane, JC | 1 |
| Blayney, A | 1 |
| Powell, FC | 1 |
| Coors, EA | 1 |
| von den Driesch, P | 1 |
| Volk, AL | 1 |
| Vannucci, SA | 1 |
| Cook, W | 1 |
| Thompson, KA | 1 |
| Listinsky, CM | 1 |
| Everall, KD | 1 |
| Dowd, P | 1 |
| Davies, DA | 1 |
| O'Neill, GJ | 1 |
| Rowland, GF | 1 |
| Molin, L | 1 |
| Thomsen, K | 1 |
| Volden, G | 1 |
| Bergqvist-Karlsson, A | 1 |
| Hellbe, L | 1 |
| Kinlen, LJ | 1 |
| Sheil, AG | 1 |
| Peto, J | 1 |
| Doll, R | 1 |
| Schmitt, T | 1 |
| Mathiot, C | 1 |
| Benveniste, M | 1 |
| Varet, B | 1 |
| Levy, JP | 1 |
| Fazekas, T | 1 |
| Bach, K | 1 |
| Tóth, S | 1 |
| Bodor, F | 1 |
| Ghose, T | 3 |
| Norvell, ST | 3 |
| Guclu, A | 3 |
| Bodurtha, A | 2 |
| Tai, J | 1 |
| MacDonald, AS | 3 |
| Smith, PJ | 1 |
| Ekert, H | 1 |
| Campbell, PE | 1 |
| Hill, BH | 1 |
| Móller, TR | 1 |
| Brandt, L | 1 |
| Kónyves, I | 1 |
| Lindberg, G | 1 |
| Thumb, N | 1 |
| Mayou, SC | 1 |
| Cotter, FE | 1 |
| Norton, AJ | 1 |
| Davies, CL | 1 |
| Munro, DD | 1 |
| Harland, CC | 1 |
| Balsitis, M | 1 |
| Millard, LG | 1 |
| Williams, RE | 1 |
| Seywright, MM | 1 |
| Lever, R | 1 |
| Lucie, NP | 1 |
| Logan, RA | 1 |
| Smith, NP | 1 |
| Donat, J | 1 |
| Fernández-Delgado, R | 1 |
| Fernández, L | 1 |
| Jubert, A | 1 |
| Berk, PD | 1 |
| Goldberg, JD | 1 |
| Donovan, PB | 1 |
| Fruchtman, SM | 1 |
| Berlin, NI | 1 |
| Wasserman, LR | 1 |
| Shelley, WB | 1 |
| Shelley, ED | 1 |
| Grant, RM | 1 |
| Mackie, R | 1 |
| Cochran, AJ | 1 |
| Murray, EL | 1 |
| Hoyle, D | 1 |
| Ross, C | 1 |
| Dantzig, PI | 1 |
| Sugiura, K | 1 |
| Johnson, FD | 1 |
| Jacobs, EM | 1 |
| Cameron, D | 1 |
| Elalouf, C | 1 |
| Grupper, C | 2 |
| Couture, J | 1 |
| Deschênes, L | 1 |
| Gueguen, MH | 1 |
| Bourgeois-Spinasse, J | 1 |
| Rollier, R | 1 |
| Cherkaoui, A | 1 |
| Dupont, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter Phase 2 Study of Efficacy and Safety of Pegylated Interferon-alfa 2a in Polycythemia Vera Patients[NCT00241241] | Phase 2 | 40 participants | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for chlorambucil and Skin Neoplasms
| Article | Year |
|---|---|
Primary cutaneous marginal zone lymphoma as a complication of radiation therapy: Case report and review.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents, Hormonal; Antineoplastic Combin | 2010 |
[Standard and experimental therapy of cutaneous T-cell lymphoma].
Topics: Adrenal Cortex Hormones; Aminoquinolines; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Anti | 2003 |
[Metastatic malignant melanoma in treated non-Hodgkin's lymphoma].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Humans; Lymph Nodes; Lymphatic | 1996 |
Cutaneous presentation of nasal lymphoma: a report of two cases.
Topics: Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chlorambuci | 1998 |
Immunosuppressive and cytotoxic drugs in dermatology.
Topics: Animals; Antineoplastic Agents; Azathioprine; Azauridine; Bleomycin; Chlorambucil; Cyclophosphamide; | 1974 |
4 trials available for chlorambucil and Skin Neoplasms
| Article | Year |
|---|---|
Treatment of erythrodermic cutaneous T-cell lymphoma with intermittent chlorambucil and fluocortolone therapy.
Topics: Aged; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Disease-Free Surviv | 2000 |
Prednimustine in mycosis fungoides: a report from the Scandinavian mycosis fungoides study group.
Topics: Administration, Oral; Aged; Chlorambucil; Clinical Trials as Topic; Drug Combinations; Drug Evaluati | 1979 |
Therapeutic recommendations in polycythemia vera based on Polycythemia Vera Study Group protocols.
Topics: Acute Disease; Age Factors; Bloodletting; Chlorambucil; Combined Modality Therapy; False Positive Re | 1986 |
Results of administering B.C.G. to patients with melanoma.
Topics: Adult; Aged; Antibodies, Neoplasm; BCG Vaccine; Blood Cell Count; Cell Migration Inhibition; Chloram | 1974 |
44 other studies available for chlorambucil and Skin Neoplasms
| Article | Year |
|---|---|
Second malignancies in chronic lymphocytic leukemia.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Carcin | 2014 |
Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases.
Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined | 2009 |
Juvenile xanthogranuloma masquerading as melanoma.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Child; Chlorambucil; Cyclosporine; Diag | 2009 |
Treatment of nonepitheliotropic cutaneous B-cell lymphoma in an umbrella cockatoo (Cacatua alba).
Topics: Animals; Antineoplastic Agents; Bird Diseases; Chlorambucil; Cockatoos; Female; Lymphoma, B-Cell; Sk | 2009 |
MALT lymphoma and Kaposi sarcoma in an HIV-negative patient.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, | 2010 |
Primary cutaneous marginal zone B-cell lymphoma: An atypical case.
Topics: Aged; Anemia, Hemolytic, Autoimmune; Antibodies, Monoclonal, Murine-Derived; Antigens, CD; Antineopl | 2010 |
OBSERVATIONS ON THE USE OF CANCER CHEMOTHERAPEUTIC AGENTS IN PATIENTS WITH MYCOSIS FUNGOIDES.
Topics: Alkylating Agents; Anti-Bacterial Agents; Antineoplastic Agents; Carbamates; Chlorambucil; Dactinomy | 1964 |
Cutaneous B-cell lymphoma of nails, pinna and nose treated with chlorambucil.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Ear Neoplasms; Ear, Extern | 2004 |
Alkylating benzamides with melanoma cytotoxicity: experimental chemotherapy in a mouse melanoma model.
Topics: Animals; Antineoplastic Agents, Alkylating; Benzamides; Chlorambucil; Dacarbazine; Disease Models, A | 2006 |
Primary cutaneous marginal zone B-cell lymphoma in a patient with chronic lymphocytic leukaemia.
Topics: Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Chromosome Deletion; Chromosomes | 2007 |
Continuous arterial infusion chemotherapy for lymphoma and other cutaneous malignant tumors.
Topics: Chlorambucil; Cyclophosphamide; Humans; Injections, Intra-Arterial; Lymphoma; Male; Middle Aged; Ski | 1967 |
[The treatment of Kaposi's disease by chlorambucil (chloraminophene)].
Topics: Aged; Chlorambucil; Female; Humans; Male; Middle Aged; Sarcoma, Kaposi; Skin Neoplasms | 1967 |
Mycosis fungoides and lymphoplasmacytoid immunocytoma in the same patient. A case report.
Topics: Chlorambucil; Cytoplasm; Female; Hematologic Tests; Humans; Immunoglobulin lambda-Chains; Immunoglob | 1984 |
Necrotizing vasculitis (angiitis) with granulomatosis.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Diagnosis, Differential; Granuloma, Lethal Midline; Gr | 1984 |
Epithelioid sarcoma.
Topics: Adolescent; Chlorambucil; Cisplatin; Humans; Male; Prognosis; Radiography; Sarcoma; Scalp; Skin Neop | 1982 |
Primary malignant neoplasms associated with chronic lymphocytic leukemia.
Topics: Breast Neoplasms; Chlorambucil; Colonic Neoplasms; Cyclophosphamide; Female; Head and Neck Neoplasms | 1980 |
Cutaneous B-cell lymphoma with subsequent laryngeal involvement.
Topics: Aged; Chlorambucil; Humans; Laryngeal Neoplasms; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Radi | 1995 |
[Extracorporeal photopheresis in the therapy of Sézary syndrome].
Topics: Administration, Oral; Blood Component Transfusion; Chlorambucil; Combined Modality Therapy; Humans; | 1993 |
Composite mycosis fungoides and B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carmustine; Chlorambucil; Combined Modality Therapy; | 2002 |
Treatment of melanoma by passive humoral immunotherapy using antibody drug synergism.
Topics: Animals; Antineoplastic Agents; Chlorambucil; Drug Synergism; Goats; Humans; Immunoglobulins; Immuno | 1977 |
Collaborative United Kingdom-Australasian study of cancer in patients treated with immunosuppressive drugs.
Topics: Adolescent; Adult; Aged; Australia; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Follow-Up | 1979 |
[Auto-immune hemolytic anemia associated with Kaposi's sarcoma. Report of a new case (author's transl)].
Topics: Aged; Anemia, Hemolytic, Autoimmune; Chlorambucil; Female; Humans; Immune System Diseases; Lymphatic | 1979 |
[Familial occurrence of chronic lymphatic leukemia. HL-A antigen and cytogenetic studies].
Topics: Aged; Chlorambucil; Chromosome Aberrations; Chromosomes, Human, 21-22 and Y; HLA Antigens; Humans; L | 1978 |
Immunochemotherapy of malignant melanoma with chlorambucil-bound antimelanoma globulins: preliminary results in patients with disseminated disease.
Topics: Adolescent; Adult; Aged; Antibodies, Neoplasm; Chlorambucil; Dacarbazine; Female; Humans; Hypersensi | 1977 |
Improved prognosis in disseminated histiocytosis.
Topics: Adolescent; Bone Neoplasms; Child; Child, Preschool; Chlorambucil; Female; Humans; Infant; Liver Neo | 1976 |
Immunosuppressive drug therapy as a potentiator of skin tumours in five patients with lymphoma.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chlorambucil; H | 1976 |
Immunochemotherapy of human malignant melanoma with chlorambucil-carrying antibody.
Topics: Aged; Animals; Antibodies, Neoplasm; Antigens, Neoplasm; Cell Membrane; Chlorambucil; Cross Reaction | 1975 |
Therapeutic effect of Leo 1031, an alkylating corticosteroid ester; in lymphoproliferative disorders. II. Lymphocytic lymphoma.
Topics: Adult; Aged; Bone Marrow; Chlorambucil; Drug Evaluation; Drug Therapy, Combination; Esters; Female; | 1975 |
[Side effects in immunosuppressive therapy].
Topics: Alopecia; Amenorrhea; Anemia; Azathioprine; Bacterial Infections; Chlorambucil; Female; Humans; Immu | 1975 |
A cutaneous B-cell lymphoma of novel immunophenotype.
Topics: Adult; Blotting, Southern; Chlorambucil; Female; Humans; Immunophenotyping; Lymphocytes; Lymphoma, B | 1991 |
Sézary-type cutaneous T-cell leukaemia. Response to Winkelmann regimen.
Topics: Adult; Chlorambucil; Female; Humans; Leukemia, T-Cell; Lymphoma; Prednisolone; Prognosis; PUVA Thera | 1990 |
Angiotropic B-cell lymphoma (malignant angioendotheliomatosis): failure of systemic chemotherapy.
Topics: Aged; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; F | 1990 |
Cutaneous presentation of prolymphocytic leukaemia.
Topics: Chlorambucil; Coformycin; Humans; Leukemia, Lymphoid; Leukocyte Count; Male; Middle Aged; Pentostati | 1988 |
[Histiocytosis X: localized and disseminated forms. Apropos of 13 cases].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child, Preschool; Chlorambucil; Comb | 1986 |
A histologically occult lymphoma revealed by electron microscopy.
Topics: Aged; Biopsy; Chlorambucil; Demeclocycline; Diagnosis, Differential; Humans; Lymphoma; Male; Microsc | 1985 |
Chemotherapy of induced skin tumors in mice.
Topics: Alkylating Agents; Animals; Antimetabolites; Antineoplastic Agents; Benz(a)Anthracenes; Busulfan; Ca | 1968 |
Chemotherapy of metastatic malignant melanoma. Experience with 73 patients.
Topics: Adult; Aged; Antineoplastic Agents; Chlorambucil; Colchicine; Cyclophosphamide; Cytarabine; Eye Neop | 1971 |
Immunochemotherapy of cancer with chlorambucil-carrying antibody.
Topics: Aged; Animals; Antibodies; Cell Membrane; Chlorambucil; Fluorescent Antibody Technique; Goats; Human | 1972 |
[Localized malignant reticulosis ameliorated by chloraminophene].
Topics: Adult; Chlorambucil; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Skin Neoplasms | 1969 |
[Chemotherapy of solid tumors].
Topics: Antineoplastic Agents; Child; Chlorambucil; Cyclophosphamide; Dactinomycin; Drug Synergism; Fluorour | 1970 |
[Mycosis fungoides. A form of pleuropulmonary origin with cutaneous sclerodermiform manifestations. Treatment by application of nitrogen mustard].
Topics: Chlorambucil; Cortisone; Humans; Male; Mechlorethamine; Middle Aged; Mycosis Fungoides; Skin Neoplas | 1971 |
[Dermato-fibroma developing for 60 years].
Topics: Adult; Aged; Child; Chlorambucil; Female; Fibroma; Humans; Middle Aged; Skin Neoplasms | 1969 |
[A case of cutaneous leukemia].
Topics: Aged; Chlorambucil; Diagnosis, Differential; Female; Humans; Leprosy; Leukemia, Lymphoid; Skin Neopl | 1969 |
[Remarks apropos of a case of Kaposi's disease].
Topics: Aged; Chlorambucil; Humans; Male; Sarcoma, Kaposi; Skin Neoplasms | 1970 |