chlorambucil has been researched along with Sjogren's Syndrome in 13 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided." | 5.30 | Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy. ( O'Duffy, JD; Rodriguez, M; Wright, RA, 1999) |
| "Castleman disease is a rare cause of lymphoid hyperplasia and may result in localized symptoms or an aggressive, multisystem disorder." | 1.48 | Sjögren's and plasma cell variant Castleman disease: a case report. ( Abrahams, AD; Dei-Adomakoh, YA; Dey, DI; Quarcoopome, L; Segbefia, CI, 2018) |
| "Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided." | 1.30 | Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy. ( O'Duffy, JD; Rodriguez, M; Wright, RA, 1999) |
| "Multicentric Castleman's disease (MCD), or multicentric angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder which typically present with constitutional symptoms, multicentric lymphadenopathy, hepatosplenomegaly, effusions, and ascites." | 1.29 | Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash. ( Cripe, LD; Hall, BD; Kingsmore, SF; Sheldon, EA; Silva, OE; St Clair, EW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dei-Adomakoh, YA | 1 |
| Quarcoopome, L | 1 |
| Abrahams, AD | 1 |
| Segbefia, CI | 1 |
| Dey, DI | 1 |
| Kingsmore, SF | 1 |
| Silva, OE | 1 |
| Hall, BD | 1 |
| Sheldon, EA | 1 |
| Cripe, LD | 1 |
| St Clair, EW | 1 |
| Wright, RA | 1 |
| O'Duffy, JD | 1 |
| Rodriguez, M | 1 |
| Becq-Giraudon, B | 1 |
| Yver, L | 1 |
| Sudre, Y | 1 |
| Hurez, D | 1 |
| Gombert, J | 1 |
| Alcalay, D | 1 |
| Vasil'ev, VI | 1 |
| Simonova, MV | 1 |
| Safonova, TN | 1 |
| Mach, ES | 1 |
| Ferreiro, JE | 1 |
| Pasarin, G | 1 |
| Quesada, R | 1 |
| Gould, E | 1 |
| Blaylock, WM | 1 |
| Waller, M | 1 |
| Normansell, DE | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Zittoun, R | 1 |
| Lebon, P | 1 |
| Diebold, J | 1 |
| Ota, H | 1 |
| Tanaka, M | 1 |
| Ikeda, Y | 1 |
| Kunii, A | 1 |
| Rubens-Duval, A | 1 |
| Kaplan, G | 1 |
| Nobillot, A | 1 |
| Kuffer, R | 1 |
| Szpirglas, H | 1 |
| Orlowski, Z | 1 |
| Jedrzejewska, T | 1 |
1 review available for chlorambucil and Sjogren's Syndrome
| Article | Year |
|---|---|
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
1 trial available for chlorambucil and Sjogren's Syndrome
| Article | Year |
|---|---|
[Comparative evaluation of the treatment of Sjögren's syndrome with anti-rheumatic preparations].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Chlorambucil; Chloroquine; Clinical Trials as Topic; Dr | 1988 |
11 other studies available for chlorambucil and Sjogren's Syndrome
| Article | Year |
|---|---|
Sjögren's and plasma cell variant Castleman disease: a case report.
Topics: Adult; Anemia, Hemolytic; Castleman Disease; Chlorambucil; Diagnosis, Differential; Drug Therapy, Co | 2018 |
Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash.
Topics: Adult; Cardiomyopathies; Castleman Disease; Chlorambucil; Female; Foot; Hand; Humans; Prednisone; Sj | 1993 |
Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy.
Topics: Adult; Chlorambucil; Drug Therapy, Combination; Glucocorticoids; Humans; Magnetic Resonance Imaging; | 1999 |
[Waldenstrom's disease associated with Sjögren's syndrome. Double IgM population (lambda and kappa). Response to chlorambucil].
Topics: Chlorambucil; Female; Humans; Immunoglobulin M; Middle Aged; Sjogren's Syndrome; Waldenstrom Macrogl | 1976 |
Benign hypergammaglobulinemic purpura of Waldenström associated with Sjögren's syndrome. Case report and review of immunologic aspects.
Topics: Adult; Autoimmune Diseases; Chlorambucil; Female; Humans; Purpura, Hyperglobulinemic; Sjogren's Synd | 1986 |
Sjögren's syndrome: hyperviscosity and intermediate complexes.
Topics: Antigen-Antibody Complex; Blood Protein Electrophoresis; Blood Viscosity; Chlorambucil; Chromatograp | 1974 |
[Sjögren's syndrome with pseudolymphoma].
Topics: Biopsy; Chlorambucil; Diagnosis, Differential; Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphat | 1974 |
[A case of Sjögren's syndrome associated with macroglobulinemia which responded excellently to chlorambucil].
Topics: Adult; Chlorambucil; Female; Humans; Sjogren's Syndrome; Waldenstrom Macroglobulinemia | 1974 |
[Cryoglobulins, macroglobulins and the Gougerot-Sjogren syndrome. Treatment with chlorambucil and cyclophosphamide].
Topics: Arthritis; Biopsy; Blood Protein Disorders; Bone Marrow; Chlorambucil; Cryoglobulins; Cyclophosphami | 1974 |
[Gougerot-Sjorgen's syndrome and lymphoid hemopathies].
Topics: Aged; Biopsy; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Lymphography; Lymphoma; Parotid Glan | 1972 |
[Immunosuppression in Sjogren's syndrome with a pseudo-leukemic lymphocyte reaction].
Topics: Adult; Autoimmune Diseases; Chlorambucil; Female; Humans; Immunosuppressive Agents; Prednisone; Sjog | 1970 |