chlorambucil has been researched along with Sicca Syndrome in 13 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided." | 5.30 | Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy. ( O'Duffy, JD; Rodriguez, M; Wright, RA, 1999) |
| "Castleman disease is a rare cause of lymphoid hyperplasia and may result in localized symptoms or an aggressive, multisystem disorder." | 1.48 | Sjögren's and plasma cell variant Castleman disease: a case report. ( Abrahams, AD; Dei-Adomakoh, YA; Dey, DI; Quarcoopome, L; Segbefia, CI, 2018) |
| "Treatment with chlorambucil and prednisone improved the patient's function from being wheelchair bound to walking unaided." | 1.30 | Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy. ( O'Duffy, JD; Rodriguez, M; Wright, RA, 1999) |
| "Multicentric Castleman's disease (MCD), or multicentric angiofollicular lymph node hyperplasia, is an uncommon lymphoproliferative disorder which typically present with constitutional symptoms, multicentric lymphadenopathy, hepatosplenomegaly, effusions, and ascites." | 1.29 | Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash. ( Cripe, LD; Hall, BD; Kingsmore, SF; Sheldon, EA; Silva, OE; St Clair, EW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dei-Adomakoh, YA | 1 |
| Quarcoopome, L | 1 |
| Abrahams, AD | 1 |
| Segbefia, CI | 1 |
| Dey, DI | 1 |
| Kingsmore, SF | 1 |
| Silva, OE | 1 |
| Hall, BD | 1 |
| Sheldon, EA | 1 |
| Cripe, LD | 1 |
| St Clair, EW | 1 |
| Wright, RA | 1 |
| O'Duffy, JD | 1 |
| Rodriguez, M | 1 |
| Becq-Giraudon, B | 1 |
| Yver, L | 1 |
| Sudre, Y | 1 |
| Hurez, D | 1 |
| Gombert, J | 1 |
| Alcalay, D | 1 |
| Vasil'ev, VI | 1 |
| Simonova, MV | 1 |
| Safonova, TN | 1 |
| Mach, ES | 1 |
| Ferreiro, JE | 1 |
| Pasarin, G | 1 |
| Quesada, R | 1 |
| Gould, E | 1 |
| Blaylock, WM | 1 |
| Waller, M | 1 |
| Normansell, DE | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Zittoun, R | 1 |
| Lebon, P | 1 |
| Diebold, J | 1 |
| Ota, H | 1 |
| Tanaka, M | 1 |
| Ikeda, Y | 1 |
| Kunii, A | 1 |
| Rubens-Duval, A | 1 |
| Kaplan, G | 1 |
| Nobillot, A | 1 |
| Kuffer, R | 1 |
| Szpirglas, H | 1 |
| Orlowski, Z | 1 |
| Jedrzejewska, T | 1 |
1 review available for chlorambucil and Sicca Syndrome
| Article | Year |
|---|---|
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
1 trial available for chlorambucil and Sicca Syndrome
| Article | Year |
|---|---|
[Comparative evaluation of the treatment of Sjögren's syndrome with anti-rheumatic preparations].
Topics: Adolescent; Adult; Anti-Inflammatory Agents; Chlorambucil; Chloroquine; Clinical Trials as Topic; Dr | 1988 |
11 other studies available for chlorambucil and Sicca Syndrome
| Article | Year |
|---|---|
Sjögren's and plasma cell variant Castleman disease: a case report.
Topics: Adult; Anemia, Hemolytic; Castleman Disease; Chlorambucil; Diagnosis, Differential; Drug Therapy, Co | 2018 |
Presentation of multicentric Castleman's disease with sicca syndrome, cardiomyopathy, palmar and plantar rash.
Topics: Adult; Cardiomyopathies; Castleman Disease; Chlorambucil; Female; Foot; Hand; Humans; Prednisone; Sj | 1993 |
Improvement of myelopathy in Sjögren's syndrome with chlorambucil and prednisone therapy.
Topics: Adult; Chlorambucil; Drug Therapy, Combination; Glucocorticoids; Humans; Magnetic Resonance Imaging; | 1999 |
[Waldenstrom's disease associated with Sjögren's syndrome. Double IgM population (lambda and kappa). Response to chlorambucil].
Topics: Chlorambucil; Female; Humans; Immunoglobulin M; Middle Aged; Sjogren's Syndrome; Waldenstrom Macrogl | 1976 |
Benign hypergammaglobulinemic purpura of Waldenström associated with Sjögren's syndrome. Case report and review of immunologic aspects.
Topics: Adult; Autoimmune Diseases; Chlorambucil; Female; Humans; Purpura, Hyperglobulinemic; Sjogren's Synd | 1986 |
Sjögren's syndrome: hyperviscosity and intermediate complexes.
Topics: Antigen-Antibody Complex; Blood Protein Electrophoresis; Blood Viscosity; Chlorambucil; Chromatograp | 1974 |
[Sjögren's syndrome with pseudolymphoma].
Topics: Biopsy; Chlorambucil; Diagnosis, Differential; Female; Hodgkin Disease; Humans; Lymph Nodes; Lymphat | 1974 |
[A case of Sjögren's syndrome associated with macroglobulinemia which responded excellently to chlorambucil].
Topics: Adult; Chlorambucil; Female; Humans; Sjogren's Syndrome; Waldenstrom Macroglobulinemia | 1974 |
[Cryoglobulins, macroglobulins and the Gougerot-Sjogren syndrome. Treatment with chlorambucil and cyclophosphamide].
Topics: Arthritis; Biopsy; Blood Protein Disorders; Bone Marrow; Chlorambucil; Cryoglobulins; Cyclophosphami | 1974 |
[Gougerot-Sjorgen's syndrome and lymphoid hemopathies].
Topics: Aged; Biopsy; Chlorambucil; Female; Humans; Leukemia, Lymphoid; Lymphography; Lymphoma; Parotid Glan | 1972 |
[Immunosuppression in Sjogren's syndrome with a pseudo-leukemic lymphocyte reaction].
Topics: Adult; Autoimmune Diseases; Chlorambucil; Female; Humans; Immunosuppressive Agents; Prednisone; Sjog | 1970 |