chlorambucil has been researched along with Sensitivity and Specificity in 7 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast to MNNG (N-methyl-N'-nitro-N-nitrosoguanine), CLB and PAM were not toxic to E." | 1.31 | Polymyxin permeabilization as a tool to investigate cytotoxicity of therapeutic aromatic alkylators in DNA repair-deficient Escherichia coli strains. ( Hovinen, J; Salmelin, C; Vilpo, J, 2000) |
| " Using this assay in the present study, dose-response relationships of cytotoxicity, PFC response and histology in the spleen were evaluated in rats receiving alkylating agents." | 1.29 | Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents. ( Doi, T; Nagai, H; Suzuki, T; Tsukuda, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Vikram, A | 1 |
| Ramarao, P | 1 |
| Jena, G | 1 |
| Sheh, L | 1 |
| Chang, HW | 1 |
| Ong, CW | 1 |
| Chen, SL | 1 |
| Bailly, C | 1 |
| Linssen, RC | 1 |
| Waring, MJ | 1 |
| Silber, R | 1 |
| Degar, B | 1 |
| Costin, D | 1 |
| Newcomb, EW | 1 |
| Mani, M | 1 |
| Rosenberg, CR | 1 |
| Morse, L | 1 |
| Drygas, JC | 1 |
| Canellakis, ZN | 1 |
| Potmesil, M | 1 |
| Doi, T | 1 |
| Nagai, H | 1 |
| Tsukuda, R | 1 |
| Suzuki, T | 1 |
| Zhang, K | 1 |
| Yang, EB | 1 |
| Wong, KP | 1 |
| Mack, P | 1 |
| Salmelin, C | 1 |
| Hovinen, J | 1 |
| Vilpo, J | 1 |
1 trial available for chlorambucil and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemosensitivity of lymphocytes from patients with B-cell chronic lymphocytic leukemia to chlorambucil, fludarabine, and camptothecin analogs.
Topics: Antineoplastic Agents; B-Lymphocytes; Camptothecin; Cell Survival; Cells, Cultured; Chlorambucil; Ge | 1994 |
6 other studies available for chlorambucil and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Prior bleeding enhances the sensitivity of peripheral blood and bone marrow micronucleus tests in rats.
Topics: Animals; Blood Cells; Blood Specimen Collection; Bone Marrow Cells; Chlorambucil; Male; Micronucleus | 2007 |
Synthesis, DNA binding, and sequence specificity of DNA alkylation by some novel cyclic peptide-chlorambucil conjugates.
Topics: Alkylation; Amino Acid Sequence; Chlorambucil; DNA; Drug Carriers; Molecular Sequence Data; Peptides | 1995 |
Dose-response relationships of cytotoxicity, PFC response and histology in the spleen in rats treated with alkylating agents.
Topics: Animals; Antineoplastic Agents, Alkylating; Body Weight; Cell Count; Cell Survival; Chlorambucil; Cy | 1996 |
GSH, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Carrier Proteins; Chlorambucil; Dose-Respo | 1999 |
Polymyxin permeabilization as a tool to investigate cytotoxicity of therapeutic aromatic alkylators in DNA repair-deficient Escherichia coli strains.
Topics: Alkylating Agents; Antineoplastic Agents; Cell Division; Cell Membrane Permeability; Chlorambucil; C | 2000 |