chlorambucil has been researched along with Seizures in 17 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anecdotal reports of chlorambucil-induced seizures have sporadically appeared, mainly in the nononcologic literature." | 8.79 | Chlorambucil-induced seizures. ( Cooper, DL; Khan, KK; Salloum, E, 1997) |
| "The clinical manifestations were acute renal failure and seizures." | 5.27 | Acute renal failure and seizures associated with chlorambucil overdose. ( Blank, DW; Hudman, C; Nanji, AA; Sanders, HD; Schreiber, DH, 1983) |
| "Anecdotal reports of chlorambucil-induced seizures have sporadically appeared, mainly in the nononcologic literature." | 4.79 | Chlorambucil-induced seizures. ( Cooper, DL; Khan, KK; Salloum, E, 1997) |
| "Chlorambucil neurotoxicity was observed in two children treated for frequently relapsing minimal change nephrotic syndrome." | 3.66 | Chlorambucil neurotoxicity: report of two cases. ( Ammenti, A; Müller-Wiefel, DE; Reitter, B, 1980) |
| "The clinical manifestations were acute renal failure and seizures." | 1.27 | Acute renal failure and seizures associated with chlorambucil overdose. ( Blank, DW; Hudman, C; Nanji, AA; Sanders, HD; Schreiber, DH, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (64.71) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giuliano, A | 1 |
| Lau, CP | 1 |
| Ma, B | 1 |
| Chan, AT | 1 |
| Blank, DW | 1 |
| Nanji, AA | 1 |
| Schreiber, DH | 1 |
| Hudman, C | 1 |
| Sanders, HD | 1 |
| Ammenti, A | 1 |
| Reitter, B | 1 |
| Müller-Wiefel, DE | 1 |
| Salloum, E | 1 |
| Khan, KK | 1 |
| Cooper, DL | 1 |
| Apaydin, S | 1 |
| Ozaras, R | 1 |
| Erek, E | 1 |
| Tahan, V | 1 |
| Altiparmak, MR | 1 |
| Celik, Y | 1 |
| Cetinkaya, A | 1 |
| Jourdan, E | 1 |
| Topart, D | 1 |
| Pinzani, V | 1 |
| Jourdan, J | 1 |
| Williams, SA | 1 |
| Makker, SP | 1 |
| Grupe, WE | 1 |
| Brock, PR | 1 |
| Yeomans, EC | 1 |
| Bellman, SC | 1 |
| Pritchard, J | 1 |
| Mirsky, AF | 2 |
| Bloch, S | 1 |
| Tecce, JJ | 2 |
| Lessell, S | 1 |
| Marcus, E | 1 |
| Donelli, MG | 1 |
| Rosso, R | 1 |
| Garattini, S | 1 |
| Pinel, JP | 1 |
| Chorover, SL | 1 |
| Testa, G | 2 |
| Lion, P | 3 |
| Semerano, A | 3 |
| Testa, GF | 1 |
| Brass, H | 1 |
1 review available for chlorambucil and Seizures
| Article | Year |
|---|---|
Chlorambucil-induced seizures.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Chlorambucil; Humans; Lymphoma, Non-Hodg | 1997 |
16 other studies available for chlorambucil and Seizures
| Article | Year |
|---|---|
Suspected chlorambucil-related neurotoxicity with seizures in a dog.
Topics: Animals; Antineoplastic Agents, Alkylating; Chlorambucil; Dog Diseases; Dogs; Lymphoma; Seizures | 2013 |
Case of chlorambucil-induced seizure.
Topics: Aged; Chlorambucil; Humans; Lymphoma, Non-Hodgkin; Male; Seizures | 2006 |
Acute renal failure and seizures associated with chlorambucil overdose.
Topics: Acute Kidney Injury; Adult; Chlorambucil; Creatinine; Humans; Male; Seizures | 1983 |
Chlorambucil neurotoxicity: report of two cases.
Topics: Adolescent; Child, Preschool; Chlorambucil; Electroencephalography; Female; Humans; Myoclonus; Nephr | 1980 |
Chlorambucil-induced seizure in a patient with nephrotic syndrome.
Topics: Adult; Chlorambucil; Glomerulonephritis, Membranous; Humans; Male; Nephrotic Syndrome; Seizures | 1999 |
Chlorambucil/prednisone-induced seizures in a patient with non-Hodgkin's lymphoma.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Drug | 2001 |
Seizures: a significant side effect of chlorambucil therapy in children.
Topics: Adolescent; Child; Child, Preschool; Chlorambucil; Female; Humans; Infant; Male; Seizures | 1978 |
Cisplatin therapy in infants: short and long-term morbidity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chlorambucil; Cisplatin; | 1992 |
Visual evoked potentials during experimentally induced spike-wave activity in monkeys.
Topics: Animals; Brain; Cerebral Cortex; Chlorambucil; Electrodes, Implanted; Electroencephalography; Electr | 1973 |
On the neurotoxic effects induced by alkylating agents.
Topics: Alanine; Animals; Anti-Bacterial Agents; Antimetabolites; Azaserine; Behavior, Animal; Central Nervo | 1966 |
Inhibition by arousal of epilepsy induced by chlorambucil in rats.
Topics: Animals; Arousal; Cerebral Cortex; Chlorambucil; Electrodes, Implanted; Electroencephalography; Elec | 1972 |
The analysis of visual evoked potentials during spike and wave EEG activity.
Topics: Animals; Cerebral Cortex; Chlorambucil; Computers; Electroencephalography; Epilepsy, Absence; Evoked | 1968 |
[On an unusual aspect of experimental myoclonus epilepsy].
Topics: Age Factors; Animals; Brain; Cats; Chlorambucil; Electroencephalography; Heart; Myoclonus; Seizures | 1969 |
[Aspects of centroencephalic epilepsy reproduced in the rabbit by administration of chlorambucil].
Topics: Animals; Brain; Chlorambucil; Electrocardiography; Electroencephalography; Heart; Rabbits; Seizures | 1968 |
[Effects of some anticonvulsants on centroencephali epilepsy reproduced in the rabbit by intravenous and carotid administration of chlorambucil].
Topics: Animals; Anticonvulsants; Carotid Arteries; Chlorambucil; Injections, Intra-Arterial; Injections, In | 1968 |
[Therapeutic possibilities in chronic glomerulonephritis].
Topics: Adolescent; Adult; Azathioprine; Chlorambucil; Chronic Disease; Glomerulonephritis; Humans; Immunosu | 1969 |