chlorambucil has been researched along with Sclerosis, Systemic in 16 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most patients with progressive systemic sclerosis (PSS) exhibit lung involvement." | 2.66 | Longitudinal changes in lung function and respiratory symptoms in progressive systemic sclerosis. Prospective study. ( Clements, P; Duann, S; Furst, DE; Gong, H; Greenwald, GI; Simmons, M; Tashkin, DP, 1987) |
| "Pyomyositis has become an increasingly recognized disease in temperate climates." | 2.37 | Pyomyositis in a patient with progressive systemic sclerosis. Case report and review of the literature. ( Baum, S; Minor, RL; Schulze-Delrieu, KS, 1988) |
| "In a study of 48 patients with systemic sclerosis (SSc)." | 1.28 | Elevated serum levels of soluble interleukin 2 receptor, interleukin 2 and neopterin in diffuse and limited scleroderma: effects of chlorambucil. ( Agopian, MS; Clements, PJ; Furst, DE; Peter, JB; Telian, NS, 1990) |
| " Although hematologic malignancies have been known to develop consequent to long-term use of alkylating agents, and bone marrow suppression is well known, acute myelofibrosis has not, to our knowledge, been reported as a complication of this therapy, nor has any specific myeloproliferative syndrome been described consequent to such therapy in a patient with PSS." | 1.26 | Acute myelofibrosis in progressive systemic sclerosis. Report of a case developing during long term chlorambucil therapy and discussion of pathogenetic factors. ( Chung, KB; Gisser, SD, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (87.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clements, P | 2 |
| Lachenbruch, P | 1 |
| Furst, D | 1 |
| Paulus, H | 1 |
| Olszewska, Z | 2 |
| Gisser, SD | 1 |
| Chung, KB | 1 |
| Dudek, H | 1 |
| Ansell, BM | 1 |
| Nasseh, GA | 1 |
| Bywaters, EG | 1 |
| Clements, PJ | 2 |
| Peter, JB | 1 |
| Agopian, MS | 1 |
| Telian, NS | 1 |
| Furst, DE | 3 |
| Hillis, S | 1 |
| Lachenbruch, PA | 1 |
| Miller, BL | 1 |
| Sterz, MG | 1 |
| Paulus, HE | 1 |
| Moreland, L | 1 |
| Alarcón, GS | 1 |
| Minor, RL | 1 |
| Baum, S | 1 |
| Schulze-Delrieu, KS | 1 |
| Greenwald, GI | 1 |
| Tashkin, DP | 1 |
| Gong, H | 1 |
| Simmons, M | 1 |
| Duann, S | 1 |
| Delespesse, G | 1 |
| Kennes, B | 1 |
| Duchateau, J | 1 |
| Dryll, A | 1 |
| Rousselet, F | 1 |
| Ryckewaert, A | 1 |
| Kahn, MF | 1 |
| Duguet, M | 1 |
| de Sèze, S | 1 |
| Marmont, A | 1 |
| Rossi, F | 1 |
| Bordo, D | 1 |
| Saporta, L | 1 |
| Godeau, P | 1 |
| Delrieu, F | 1 |
| Delbarre, F | 1 |
| Kostanecki, W | 1 |
| Mazurkiewicz, W | 1 |
| Górkiewicz, A | 1 |
| Zborzil, J | 1 |
| Cruchaud, A | 1 |
2 reviews available for chlorambucil and Sclerosis, Systemic
| Article | Year |
|---|---|
Pyomyositis in a patient with progressive systemic sclerosis. Case report and review of the literature.
Topics: Chlorambucil; Female; Humans; Middle Aged; Myositis; Scleroderma, Systemic; Streptococcal Infections | 1988 |
[Auto-immune diseases and immunodepressive therapy. II. Current clinical indications].
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Arteritis; Autoimmune | 1974 |
5 trials available for chlorambucil and Sclerosis, Systemic
| Article | Year |
|---|---|
The course of skin involvement in systemic sclerosis over three years in a trial of chlorambucil versus placebo.
Topics: Adult; Chlorambucil; Double-Blind Method; Female; Humans; Longitudinal Studies; Male; Middle Aged; S | 1993 |
[Immediate results of long-term treatment of systemic scleroderma with leukeran].
Topics: Adult; Aged; Chlorambucil; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; H | 1978 |
Immunosuppression with chlorambucil, versus placebo, for scleroderma. Results of a three-year, parallel, randomized, double-blind study.
Topics: Chlorambucil; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Immunosuppressive Agent | 1989 |
Comment on the article by Furst et al.
Topics: Chlorambucil; Clinical Trials as Topic; Humans; Immunosuppression Therapy; Research Design; Sclerode | 1989 |
Longitudinal changes in lung function and respiratory symptoms in progressive systemic sclerosis. Prospective study.
Topics: Adult; Chlorambucil; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Lung; Male; Midd | 1987 |
9 other studies available for chlorambucil and Sclerosis, Systemic
| Article | Year |
|---|---|
Acute myelofibrosis in progressive systemic sclerosis. Report of a case developing during long term chlorambucil therapy and discussion of pathogenetic factors.
Topics: Acute Disease; Adult; Bone Marrow; Cell Division; Chlorambucil; Female; Fibroblasts; Hematopoietic S | 1979 |
[Effect of leukeran on iron, copper, transferrin and ceruloplasmin levels in blood serum in systemic scleroderma after long-term treatment].
Topics: Adult; Aged; Ceruloplasmin; Chlorambucil; Copper; Female; Humans; Iron; Male; Middle Aged; Scleroder | 1979 |
Scleroderma in childhood.
Topics: Adolescent; Age Factors; Arthritis, Juvenile; Bone Diseases; Child; Chlorambucil; Diagnosis, Differe | 1976 |
Elevated serum levels of soluble interleukin 2 receptor, interleukin 2 and neopterin in diffuse and limited scleroderma: effects of chlorambucil.
Topics: Adult; beta 2-Microglobulin; Biopterins; Chlorambucil; Cytokines; Female; Humans; Interleukin-2; Mal | 1990 |
[Inflammatory rheumatisms and paraproteins excepting myeloma and Waldenström's disease. Study of 18 personal cases of this association].
Topics: Adult; Aged; Arthritis; Arthritis, Rheumatoid; Blood Protein Disorders; Chlorambucil; Electrophoresi | 1969 |
[Current aspects of immunosuppressive therapy of collagen diseases].
Topics: Arthritis, Rheumatoid; Asparaginase; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1973 |
[Generalized scleroderma. Treatment with immunosuppressive agents].
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Female; Humans; Immunosuppressive Agents; Male; | 1972 |
[Hair changes in immunosuppressive therapy].
Topics: Antineoplastic Agents; Azathioprine; Chlorambucil; Cyclophosphamide; Hair; Humans; Immunosuppression | 1971 |
[Immunosuppressive treatment of collagen diseases].
Topics: Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Collagen Diseases; Cyclophosphamide; Dermatomyosi | 1969 |