chlorambucil has been researched along with Sarcoidosis in 14 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
Sarcoidosis: An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1) PURPOSE: To demonstrate usefulness of chlorambucil in patients with severe sarcoidosis unresponsive to, or intolerant of, corticosteroids." | 7.68 | Chlorambucil treatment of sarcoidosis. ( Israel, HL; McComb, BL, 1991) |
| "Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids." | 7.66 | Chlorambucil in sarcoidosis. ( Kataria, YP, 1980) |
| "The widely accepted standard therapy for cutaneous sarcoidosis includes corticosteroids, antimalarials, and methotrexate." | 4.84 | Cutaneous sarcoidosis therapy updated. ( Badgwell, C; Rosen, T, 2007) |
| "1) PURPOSE: To demonstrate usefulness of chlorambucil in patients with severe sarcoidosis unresponsive to, or intolerant of, corticosteroids." | 3.68 | Chlorambucil treatment of sarcoidosis. ( Israel, HL; McComb, BL, 1991) |
| "Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids." | 3.66 | Chlorambucil in sarcoidosis. ( Kataria, YP, 1980) |
| "Prednisone dosage was successfully tapered to 10 to 20 mg/d without worsening symptoms in 10 (38%) of the 26 patients studied." | 2.68 | Therapeutic considerations in patients with refractory neurosarcoidosis. ( Agbogu, BN; Sewell, C; Stern, BJ; Yang, G, 1995) |
| "Sarcoidosis is a systemic granulomatous disease that the epidemiology remains unknown." | 2.41 | [Non-steroid therapy for sarcoidosis]. ( Konishi, M; Takahashi, K; Yoneda, K; Yoshimoto, E, 2002) |
| "Chlorambucil was effective on both diseases." | 2.38 | [Association of sarcoidosis and Waldenström's macroglobulinemia]. ( Boulitrop-Morvan, C; Camus, P; Collet, E; Dalac, S; Lambert, D, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konishi, M | 1 |
| Yoneda, K | 1 |
| Takahashi, K | 1 |
| Yoshimoto, E | 1 |
| RAEVSKII, IG | 1 |
| Badgwell, C | 1 |
| Rosen, T | 1 |
| Hughes, GS | 1 |
| Kataria, YP | 2 |
| O'Brien, TF | 1 |
| Chanda, JJ | 1 |
| Callen, JP | 1 |
| Sahgal, SM | 1 |
| Sharma, OP | 1 |
| Agbogu, BN | 1 |
| Stern, BJ | 1 |
| Sewell, C | 1 |
| Yang, G | 1 |
| Collet, E | 1 |
| Boulitrop-Morvan, C | 1 |
| Dalac, S | 1 |
| Camus, P | 1 |
| Lambert, D | 1 |
| Israel, HL | 3 |
| McComb, BL | 1 |
| Palazzo, E | 1 |
| Oberling, F | 1 |
| North, ML | 1 |
| Lang, JM | 1 |
| Mayer, S | 1 |
| Waitz, R | 1 |
| Westcott, JL | 1 |
| Noehren, TH | 1 |
| Goldstein, RA | 1 |
| Becker, KL | 1 |
| Moore, CF | 1 |
3 reviews available for chlorambucil and Sarcoidosis
| Article | Year |
|---|---|
[Non-steroid therapy for sarcoidosis].
Topics: Anti-Inflammatory Agents; Antimalarials; Azathioprine; Chlorambucil; Chloroquine; Cyclophosphamide; | 2002 |
Cutaneous sarcoidosis therapy updated.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Allopurinol; Animals; Anti-Inflammatory Agents | 2007 |
[Association of sarcoidosis and Waldenström's macroglobulinemia].
Topics: Chlorambucil; Female; Humans; Middle Aged; Sarcoidosis; Skin Diseases; Waldenstrom Macroglobulinemia | 1992 |
2 trials available for chlorambucil and Sarcoidosis
| Article | Year |
|---|---|
Therapeutic considerations in patients with refractory neurosarcoidosis.
Topics: Adult; Azathioprine; Chlorambucil; Cyclophosphamide; Cyclosporine; Female; Humans; Immunosuppressive | 1995 |
The treatment of sarcoidosis.
Topics: Chlorambucil; Clinical Trials as Topic; Humans; Methotrexate; Placebos; Prednisone; Sarcoidosis | 1970 |
9 other studies available for chlorambucil and Sarcoidosis
| Article | Year |
|---|---|
[EXPERIENCE IN THE USE OF CHLORBUTENE IN LYMPHOGRANULOMATOSIS].
Topics: Chlorambucil; Hodgkin Disease; Sarcoidosis | 1963 |
Sarcoidosis presenting as biliary cirrhosis: treatment with chlorambucil.
Topics: Chlorambucil; Diabetes Mellitus, Type 1; Diagnosis, Differential; Humans; Liver; Liver Cirrhosis, Bi | 1983 |
Necrotizing vasculitis (angiitis) with granulomatosis.
Topics: Azathioprine; Chlorambucil; Cyclophosphamide; Diagnosis, Differential; Granuloma, Lethal Midline; Gr | 1984 |
Fatal herpes simplex infection during chlorambucil therapy for sarcoidosis.
Topics: Chlorambucil; Female; Herpes Simplex; Humans; Lung Diseases; Middle Aged; Sarcoidosis | 1984 |
Chlorambucil in sarcoidosis.
Topics: Adult; Chlorambucil; Dermatitis; Drug Therapy, Combination; Female; Humans; Lung Diseases; Middle Ag | 1980 |
Chlorambucil treatment of sarcoidosis.
Topics: Adult; Chlorambucil; Female; Humans; Lung; Male; Middle Aged; Radiography; Sarcoidosis; Sarcoidosis, | 1991 |
Sarcoidosis in a patient with cold haemagglutinin disease.
Topics: Adult; Agglutinins; Anemia, Hemolytic, Autoimmune; Autoantibodies; Azathioprine; Bronchi; Chlorambuc | 1972 |
Bronchial stenosis in chronic sarcoidosis.
Topics: Aged; Airway Obstruction; Bronchial Diseases; Chlorambucil; Constriction; Female; Humans; Middle Age | 1973 |
The infrequency of hypercalcemia in sarcoidosis.
Topics: Adolescent; Adult; Blood Proteins; Chlorambucil; Female; Filtration; Humans; Hypercalcemia; Magnesiu | 1971 |